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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 53 Documents
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Search results for , issue "Volume 11 Issue 01." : 53 Documents clear
Modeling of the Effect of Socio-Economic Factors on the Accessibility of Medical and Pharmaceutical Care to the Population (on the Example of Sudan) Ievtushenko Olena M
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction. The availability of pharmaceutical care is closely connected with the health care system and may be influenced by many factors. The heterogeneity of factors determines the need for their ranking and selection, determining the degree of their mutual influence on each other and on the level of morbidity in the country. The purpose. The aim of the study was the modeling of the availability of medical and pharmaceutical care (for example, Sudan). Materials & Methods. For the analysis, the following factors were selected: share of the state’s population in the total population of Sudan, share of the state’s area, share of doctors in the total employed population of Sudan, territorial accessibility of medical care, growth rates of the pharmacy network in the state, territorial accessibility of pharmaceutical care, share of expenditures on medicines in the subsistence minimum of Sudanese. To determine the degree of influence of these factors on the incidence rate, correlation and regression analysis was used; the models obtained were tested for adequacy, including the normal distribution of residuals. Research results and discussion. As a result of the study, a number of models were obtained, of which the optimal one was chosen according to the corrected coefficient of determination. It was revealed that the main accessibility factors affecting the incidence of infectious diseases are the territorial accessibility of pharmaceutical care, the share of drug costs in the subsistence minimum of Sudanese, and the growth rate of the pharmacy chain. Conclusions. In accordance with the proposed model, it is possible to determine not only the level of morbidity, but also to simulate the level of accessibility of pharmaceutical care to the population of a separate municipality, to develop, based on the analysis performed, certain organizational, administrative or legislative measures.Keywords: Pharmacy, Accessibility, Medical care, Pharmaceutical care, Modeling, African countries, Sudan.
The Role of Autologous Adipose Derived Neural Progenitor Cells with Cognitive and Motoric Function in Cerebral Palsy Purwati .
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Introduction: Cerebral palsy (CP) is primarily a disorder of movement and posture due to neurological damage before, during, or within five years of birth that prevents the brain from developing properly. Supportive treatments, medications, and surgery may conduct, but no optimal results have been obtained. The main goal of this study was to investigate the effectiveness of the intraventricular implantation of adipose derived neural progenitor stem cells in post-cerebral palsy patients. Methods: 14 patients were included in this study. Small adipose tissue was isolated by small lipopectomy under local anesthesia, cultured and derived become neural progenitor cells. Intraventricular implantations were performed in the operating room. Patients were evaluated based on the Gross Motor Function Classification System (GMFCS) according to their motor skills before and after treatment in 12 months. The assessment includes cognitive functions, motoric functions and spasticity changes. Descriptive statistics are provided. Results and Discussion: Ten of twelve CP patients (83.33%) had a significant improvement after treatment. The improvement ranged from 1 to 3 levels on the GMFCS score, and improvement was most pronounced in motor skills and cognitive skills. There were no serious adverse events reported, limited to mild headaches, fever or vomiting, and all side effects resolved within few days. Conclusion: Because of the small sample size and non-randomized trial performed, we could not reach a definitive conclusion regarding the potential of intraventricular implantation. However, this small study shows that repeated intraventricular implantation of autologous adipose stem cells is advantageous.Keywords: Cerebral palsy, GMFCS, stem cell, Adipose tissue, Neural progenitor cells, Intraventricular implantation.
The Activity Test of Ethanol Extract in Hibiscus Leaves (Hibiscus Tiliaceus L.) as the α-Glucosidase Enzyme Inhibitor by Using ELISA (Enzyme Linked Immunosorbent Assay) Reader Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Hibiscus leaves (Hibiscus tiliaceus L.) was a plant from the family of Malvaceae, which contained triterpenoid, saponins, flavonoids, and polyphenols compounds that functioned as antidiabetic mellitus. The purpose of this study was to determine the activity of α-glucosidase enzyme inhibitor from the ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.). The test was carried out through in vitro by using α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida (PNPG) substrate, and measured by ELISA reader. The simplicia was macerated with alcohol 96%. The reaction of α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida substrate produced yellow p-nitrofenol. The reaction product was measured at a wavelength of 405 nm. The results showed that ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.) had activity as an inhibitor of α-glucosidase enzyme with Inhibitor Consentration IC50 37.98 µg / mL and could be categorized as active.Keywords: Hibiscus tiliaceus L., Hibiscus leaves, Α-glucosidase enzyme inhibitor.
Influence of Blanching, Frying and Storage on the Physicochemical Properties and Shelf Life of Fried Taro (Colocasia Esculenta) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Taro (Colocasia esculanta) tubers have the great importance of functional foods. Taro tubers are important sources of carbohydrates as an energy source. Taro tubers provide a number of desirable nutritional and health benefits such as anticancer activity, phenolic acid and phytochemicals. Taro deteriorates rapidly as a result of its high moisture. The high perishability of taro during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. The major challenge for the food industry is to produce low fat fried product with desirable texture, color and flavor. This research has been focused on different parameters of blanching, drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and anthocyanin; extending product shelf life during packaging and preservation. Results revealed that blanching 95oC in 30 seconds with ascorbic acid of 0.15 g/100g taro, frying 2.0 cm of taro chip in soybean oil heating at 155oC in 2 minutes was appropriated. Fried taro chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried taro products. Frying of taro chips is carried out to convert the tubers to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Taro chip, Blanching, Frying, Shelf life, Anthocyanin, flavonoid.
Production of Pickled Mustard Greens (Brassica Juncea) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Mustard greens are fresh during the harvesting season but perishable under the prevailing conditions of temperature and humidity as well as lack of adequate storage facilities. An alternative way of preserving surplus mustard greens could be fermented to pickle products. Preservation of the mustard green by fermentation can eliminate the undesired taste and improve flavor of the vegetable. Therefore we explored a lactic fermentation from mustard greens by focusing on the effect of different parameters such as blanching time and temperature as pre-treatment, salt concentration, fermentation time to physicochemical, microbial and sensory characteristics of pickled mustard greens. Experimental results revealed that blanching raw mustard green in water heated at 95oC in 10 seconds, 6% salt in 12 days of fermentation was appropriated to get a pleasant pickled mustard greens quality. Mustard greens pickles are considered as one of the health supplements.Keywords: Mustard greens, Lactic fermentation, Salt, blanching, Physicochemical, Microbial, Sensory.
Comparison between Low Flow and High Flow Sevoflurane Isocapnic Technique to Achieve Early Recovery after Surgery (ERAS) Adinda Putra Pradhana
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective. The purpose of this study was to compare recovery time between low flow and high flow sevoflurane isocapnic anesthesia techniques, as well as the total consumption of sevoflurane.Design. This study was an observational single-blind randomized trialSetting. Operating room.Patients. Total 40 patients from both gender, 18 to 60 years old, BMI 18.5-29.99 kg/m2 with physical status ASA I or II, that scheduled for elective surgery under general anesthesia approximately between 3-5 hours were selected for this study.Intervention. Selected patients divided randomly into two groups (n=20 each). First group was given low flow sevoflurane, delivered with initial flow 6 L/min until MAC 0.9 or expiration level of sevoflurane 2.2 vol% then reduced flow to 0.5 L/min; second group with high flow technique  4L/min after induction.Measurement. The duration of operation, duration of anesthesia, time reaching of BIS 75, eye-opening with command, extubation, moving into the recovery room and when reaching Modified Aldrete score 10.Main Results: Based on statistics, sample characteristics, hemodynamic conditions, length of anesthesia and number of fentanyl were not significantly different. There was a significant difference on post anesthesia recovery time between low flow and high flow anesthesia time BIS 75: 1.7 (± 0.801) vs 7.05 (± 3.956), p<0.001, eye-opening time: 5.45 (± 3.82) vs. 14.86 (± 7.945 ), p<0.001, extubation time: 5.8 (± 2.783) vs. 15.29 (± 8.776), p<0.001, moving into recovery room: 15.35 (± 5.133) vs. 23.52 (± 12.213), p=0.021, time reaching modified aldrete 10: 8.95 (± 4.211) vs. 29 (± 18,091), p<0.001).Conclusion: Recovery time after general anesthesia using low flow sevoflurane isocapnic anesthesia technique is faster than the high flow anesthesia technique with less sevoflurane consumption.
Effect of Frying And Storage on the Quality and Shelf Life of Fried Sweet Potato (Ipomoea Batatas) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Sweet potato is the seventh most important crop in terms of global production. Sweet potatoes are rich in antioxidants, such as phytophenolics and carotenoids which also provide distinct flesh colours. The high perishability of sweet potato roots during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. Consumers are increasingly health conscious and trends are moving toward foods with low oil content. This research has been focused on different parameters of drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and carotenoid; extending product shelf life during packaging and preservation. Results revealed that frying 2.0 cm of sweet potato chip in soybean oil heating at 150oC in 2 minutes was appropriated. Fried sweet potato chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried sweet potato products. Frying of sweet potato bars is carried out to convert the roots to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Sweet potato chip, Frying, Shelf life, Carotenoid, Flavonoid, Vaccum.
Correlation of Radiographic Parameter with Functional Outcomes in Pediatric Supracondylar Humerus Fractures (SCHF) Treated with Close Reduction and Percutaneus Pinning (CRPP) Irsan Kesuma
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background Humerus supracondylar fracture is one of the most common elbow injuries and this injury approximately includes 16.6 % of all fractures in children(1). Until now, one of the current treatment for a displaced supracondylar humeral fracture is closed reduction of  the fracture is using the percutaneous skeletal fixation(4). The Baumann angle and Carrying angle  of the humerus has been a commonly used as an outcome measure for supracondylar fractures in children(6,7). The aim of this study was to evaluate the radiographic parameter with functional outcomes in pediatric Supracondylar Humerus Fractures (SCHF) treated with CRPP. Materials and Method This was a cross sectional observational study conducted on a consecutive series of supracondylar humerus fracture patients. It involved patients in Sardjito General hospital that were diagnosed as supracondylar humerus fracture treated with close reduction percutaneous pinning. Several parameters were reviewed, including Bowmann angle, Carrying angle, age at injury, sex, right or left extremity, Gartland fracture type, mechanism of injury, operative or nonoperative treat­ment intervention. Then, the functional outcome of the subjects in this study was measured using QuickDASH score which is the short form of  DASH score. Chi Square test and Independent T Test was using as the statistical analysis for this study. Result This study included 78 out of 104 supracondylar humeral fractures. 26 patients were excluded from this study. Out of 78 patients, 25 (32%) were in girls and 53 (68%) were in boys. The mean duration of follow-up all patients was 35 months. During the first data-collection, the mean Baumann angle of the humerus was found to be 72.76 ° (range 55.00 ° to 87.00 °, SD 6.17 °) . This was not significantly different from the data obtained during the second data-collection (mean 72.98 °, range 65° to 80 °, SD 6.21 °). Carrying angle pre operatively was found (mean 10.80 °, range 2 ° to 17°, SD 3.12 °). And not significantly different from post operatively (mean 10.94 °, range 2° to 18 °, SD 3.23 °). There was  no functional interference with normal social activities, sports performing, and a activities of daily living, and no functionally limiting symptoms Conclusion This study showed that good functional outcome with better carrying angle was achieved in patient with SCHF patients treated with CRPP.
Effect of Anticoagulant on Acetylsalicylic Acid and Salicylic Acid Analysis in Plasma In Vitro with High Performance Liquid Chromatography Yahdiana Harahap
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background: Evaluation of the anticoagulant effect and analysis of acetylsalicylic acid (ASA) and salicylic acid (SA) is important. Full validation of in vitro methods using citrate anticoagulant in the form of CPD-A has previously been done, whereas in the implementation of in vivo studies, EDTA and heparin were used as anticoagulants. Based on EMEA 2011, if there are anticoagulant changes in validated analysis methods then partial validation should be performed. Objective: This study aims to evaluate the effect of different types of anticoagulants on the analysis of ASA and SA in plasma after being preceded by partial validation. Materials and Method: Analysis was performed using high pressure liquid chromatography column C18 (Waters, ReliantTM 5μm; 250 x 4.6 mm); mobile phase acetonitrile - phosphate buffer 20 mM (35:65) with pH 2.5; 1.0 mL/min flow rate; column temperature 35˚C; 14 minutes of time analysis with furosemide as internal standard. Results: Accuracy and precision in plasma citrate, heparin, and EDTA analysis fulfilled linear calibration curves in ASA and SA. Stability and recovery of ASA and SA in plasma with different anticoagulants showed no significant difference, however the peak area response ratio for the three types of anticoagulants between plasma with anticoagulant heparin-citrate and EDTA-citrate showed significant difference and plasma with heparin anticoagulant provides a larger area than plasma with EDTA anticoagulants. Conclusion: From this experiment, the analytical methods obtained were considered to meet the validation requirements for use of citrate, heparin, or EDTA anticoagulants based on EMEA 2011.
Emerging Developmental Genetic Model Platform in Holometabolous Insects Rehal Jehad Husain
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

The wide variety on grasshopper kind up to expectation is bent according to practical genetic studies is thriving rapidly then affords much instant research possibilities between developmental yet evolutionary biology. Nanotechnology is an interdisciplinary research field. The holometabolous bugs characterize a disproportionate percentage regarding brute diversity yet are for that reason well positioned after grant model species because of a large variety of developmental processes. Here we discuss emerging holometabolous fashions or review some recent breakthroughs. Nanoparticle-mediated cloth shipping according to flora then superior biosensors because of directness farming are viable only through nanoparticles yet Nano chips. Nano encapsulated conventional fertilizers, pesticides, and herbicides help within the gradual and sustained launch about nutrients yet agrochemicals ensuing of the precise degree to the plants. Nanotechnology-based drive into viral disease detection kits are also turning into popular and are useful of fast then promptly detection of viral diseases. In that article, the strong usage or benefits regarding nanotechnology between directness agriculture are discussed. The contemporary nanotechnology-based equipment yet techniques hold the potent in accordance with address the variety of problems regarding conventional agriculture then can revolutionize this sector.

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