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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 53 Documents
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Search results for , issue "Volume 11 Issue 01." : 53 Documents clear
Review on Cyclic Adenosine Monophosphate signaling pathway (cAMP), DLK Signaling Pathway, RAS/RAF Signaling, Retinoic Acid Signaling, Phosphatidylinositol 3-kinase (PI3K) as the Signaling Pathways Involved in Peripheral Neuronal Generation Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Neuronal regeneration is the physiological process wear, after neuronal injury, the body stimulates mechanisms of self-healing. Thus, through coordinated different processes and signaling that involves diverse molecules in the body, the nerves are able to regain, to some extent, their initial capability to transduce and convey signals. After, neuronal injury, there is a defect in the normal signal transduction. This presents with different symptoms depending on the system in which the nerve belongs. This may be mortar or sensory. Injury to mortar neurons means the supply of the muscle innervated is cut off. This, therefore, implies that the muscle will not have enough power or will become spastic. It is in response to this injury, that the nerve, through some intricate intrinsic signaling pathways, is able to regenerate in order to return the normal physiologic functioning of the body. Methode of this paper is summed up with systemic reviews of articles in the same topic under study. The articles were searched using the Pubmed search engine and were all in English. None of the articles was translated. The inclusion and exclusion criteria was guided by PRISMA guide, as a predetermined outline. The result of this article is out of forty-three, eight articles were selected as eligible, this is because they met the PRISMA criteria and had adequate relevant and supporting experiments to back the signaling pathway under study.  These articles had a clear and elaborate outline of the whole signaling pathway, the associated molecules, the interconnections between the pathways, supporting experiments and even recommended research in the same field or topic. The comparison of the strengths of facts backing the individual pathways was used to determine the pathway that is most involved, or that can be presumes the “mother” signaling pathway in the process of neuronal regeneration.Keywords: Neuronal regeneration, Neuronal injury, Signaling pathway.
Pervasiveness, Related Hazard Factors and Antimicrobial Defenselessness Example of Campylobacter Species among Dogs Hayder Hamzah Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Campylobacteris the most widely recognized bacterial cause for enteric sickness for the both humans and animals around the world. Over 90% of human Campylobacteriosisin industrialized nation’s results from utilization of debased chicken items, just as beef and milk. Drinking water and swimming water may likewise be a source of disease. To a lesser degree, contact with other nourishment animal species, wild birds, and pet dogs and cats has been related with human Campylobacteriosis. Ingestion of as few as 500 living beings can prompt contamination. At the point when center signs happens, early signs create after a brooding time of 1 to 7 days and incorporate fever, defame, spewing and migraine, which by and large last 1 to 3 days, trailed by as long as multi week of watery to ridiculous loose bowels and stomach torments. Zoonoses may be contracted from dogs and cats through introduction to their feces, parturient fluids, salivation, respiratory outflows, scratches, skin, conceal, pee, or outside parasites. Pollutions may be parasitic, bacterial, infectious or viral. Campybacteriosis has a higher rate in AIDs quiet than all in all populace causing extreme, frequently bleeding, looseness of the bowels and cramping, queasiness and fever. Most Campylobacter infections in canines and man are brought about by C. jejuni. Proof shows that contact with infected dogs, particularly diarrhoeic dogs can increase hazard of obtaining C jejuni..
Effects of Solvent Composition on Profile of Total Extracts, Phenolic Compounds, and Antifungal Activity of Sterculia quadrifida R.Br Bark Rollando Rollando
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Faloak bark extract has antibacterial, antioxidant and anticancer potential but no optimal solvent has found to extract the active compounds of faloak bark. Therefore, it is necessary to optimize the solvent against the faloak bark. This study aims to determine the optimum solvent of methanol, ethyl acetate, petroleum ether, and water in order to produce an optimal response value in the extract, total phenolic, and inhibitory results in antifungal tests. Extracts obtained through reflux extraction for 2 hours and extract yield calculated. The extract results tested to determine the total phenolic content and inhibition of antifungal test. The determination of the optimum solvent composition carried out using Rstudio v.3.2.2 software with ANOVA parametric test or Kruskal-Wallis non-parametric test and using Design Expert v.11 software with Simplex Lattice Design (SLD) method. The results showed that the solvent composition of faloak bark extract (Sterculia quadrifida R.Br) in giving the yield of extract, total phenolic, and optimal antifungal inhibition was methanol:water 0,438:0,562.
Analysis on Advantages and Disadvantages GAP 43 as Neuroregenaration Marker Examination in Rat Sciatic Nerve Injury Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Analysis focuses on the advantages as well as the disadvantages of using Growth Associated Protein 43 (GAP-43) as a neuroregeneration marker examination tool in a rat sciatic nerve injury examination. The sources of this research were attained from past scientific publications that had been published on the NCBI website. The research is unique because no past researches have ever been performed to ascertain the advantages and disadvantages of GAP-43 as a neuroregeneration marker examination tool in a rat sciatic nerve injury examination. The analysis will focus mostly on a research that was published on September 10, 2016. It focused on the GAP-43, a growth associated protein used in the treatment of a sciatic nerve injury in a Norway rat. The keywords used to attain the access the publication included GAP-43, neuroregeneration marker and sciatic nerve injury. The results of the search yielded a total of twenty-six full journal articles from PubMed Central and one scientific and medical abstract citation from PubMed. These are all publications that contain information pertaining GAP-43 and its applications. The materials for inclusion in the research were all journals summarizing the effects of GAP-43 on a sciatic rat. The participants of this review were program professor and myself. The materials for exclusion in the research included all publications with the exception of peer-reviewed scientific journals and publications from the PubMed or NCBI website. The conclusion of the study revealed that although GAP-43 has a few disadvantages, it is an effective neurogenerational marker in a rat sciatic nerve injury examination.Keywords: GAP 43, Neuroregenaration marker, Sciatic nerve injury
Chemoprofiling of Active n-Hexane Fraction as Alpha-Glucosidase Inhibitors from Kanunang (Cordia myxa L.) Leaves from Enrekang South Sulawesi Ahmad Najib
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Kanunang (Cordia myxa L.) is a native plant from tropical Asia. This study aims to determine the profile of chemical compounds contained in leaves of Kanunang (Cordia myxa) which can inhibit alpha-glucosidase enzyme. Extraction of Kanunang leaves was done by maceration method using ethanol 96% solvent for 3 days then filtered and thickened with rotary vacuum evaporator. Resulting extract with yield value of 5%. The extract was fractionated using conventional column method with n-hexane: ethyl acetate (10: 0) eluent. The n-hexane fraction was tested using the GC-MS instrument with the following condition; injector temperature 250°C, initial oven temperature 70°C, up to 325°C increasing 10°C/minute. The results obtained was 24 compounds which have alpha-glucosidase enzyme inhibitors activity with maximum abundance at RT 12:43, as 9,12,15-Octadecatrienoic Acid, methyl ester (C19H32O2) compound.Keywords: Cordia myxa L.; Chemical profile; GC-MS; Alpha-glucosidase.
Carboxy Methyl Cellulose (Cmc) As Edible Coating to Extend Shelf Life of Duku (Lansium Domesticum) During Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Duku fruit (Lansium domesticum Corr.) is a tropical fruit which contains a variety of nutrients especially vitamins and minerals that are health beneficial. It has a sweet sour taste, fresh, a little seed and has a thin skin. Duku fruit contains several phytochemicals that possess high antioxidant activities. Severe pericarp browning, fruit drop, moisture loss, off-flavor and chilling injury are the predominant problems in harvested longkong fruit during handling and storage. The postharvest handling of duku fruit aims to prolong its quality and value, but it is not yet adequately developed. It is necessary to use postharvest techniques for the extension of duku shelf life. Application of carboxy methyl cellulose (CMC) as edible coating could be considered as a useful approach to maintain its product quality during preservation. Ojective of the present study focused on the effect of carboxy methyl cellulose (CMC) coating on some physicochemical, microbial and sensory characteristics of duku during preservation. Optimal results showed that weight loss, pH, total soluble solids, titratable acidity and ascorbic acid; total plate count; sensory characteristics could be maintained at appropriate levels by coating duku with 1.5% carboxy methyl cellulose (CMC). The present study attempted to investigate some of the most significant findings to extend the shelf life of duku fruit.Keywords: Duku, Carboxy methyl cellulose, Coating, Preservation, Physicochemical, Microbial, sensory
Technical Aspects Affecting to Jackfruit (Artocarpus Heterophyllus) Beverage Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Jackfruit (Artocarpus heterophyllus) is a tropical climacteric fruit. It is one of the commonly consumed foods in Vietnam. Its fesh in fully ripen stage can be eaten directly as a fruit. Jackfruit contains a wide range of phytonutrients such as carotenoids that can act as antioxidants. The jackfruit fesh is highly perishable and ofen undergoes favour loss, tissue sofening, and cut surface browning. During the jackfruit havesting season, excessive supply of the fruit causes the price of jackfruit decreasing dramatically. This fruit is underutilized in commercial scale processing. Therefore we have our tried to add value to the jackfruit fruit. One method of adding value to fresh jackfruit is processing it into drink. We carried out the investigation of extraction (ratio of water: jackfruit, temperature and time of blanching); juicy mixture; preservation. Our result showed that the jackfruit drink having the best quality when extracting with water: jackfruit pulp ratio (70:30) at 85 oC in 3 minutes. The sample was then cooled to 37°C before the addition of pectinase enzyme at 0.09%. The juice was then incubated in a water bath at 37°C in 30 minutes. After the incubation process, the juice was heated in a water bath at 100°C for 2 minutes to inactivate all enzymes present. The hydrolyzed jackfruit juice will be formulated with sugar 2.5%, citric acid 5%, carrageenan 0.06%. Jackfruit drink shelf-life could be maintained for 12 months.Keywords: Jackfruit, Artocarpus heterophyllus, Beverage, Carrageenan, Pectinase, shelf-life
Application of Soy Protein Isolate Edible Coating for Mangosteen (Garcinia Mangostana) Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Recently, the mangosteen has been noted to be an abundant source of a class of polyphenols known as xanthones It has a variety of health promoting properties including anti-inflammatory, anti-oxidant, and anti-cancer activity. Mangosteen fruits have a storage and marketable postharvest life of not more than one week under tropical conditions. In order to have supply of this fruit between harvest seasons, which ranges from two to four months depending on local production, it is necessary to use postharvest techniques for the extension of mangosteen shelf life. Application of soy protein isolate as edible coating could be considered as a useful approach to maintain its product quality during preservation. Ojective of the present study focused on the effect of soy protein isolate coating on some physicochemical, microbial and sensory characteristics of mangosteen during preservation. Optimal results showed that weight loss, pH, total soluble solids, titratable acidity and ascorbic acid; total plate count; sensory characteristics could be maintained at appropriate levels by coating mangosteen with 1.5% soy protein isolate.Keywords: Mangosteen, Soy protein isolate, Coating, Preservation, Physicochemical, Microbial, Sensory.
Flagellin Immunization against Urinary Tract Infection Caused by p. Mirabilis Astabraq A. Al-Sodanii
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective Proteus mirabilis is dimorphic a (gram negative bacteria that alternates between a rod –shaped swimmer stage and multinucleate, highly elongated swarming stage. Methods  Urine Samples collected from three hospitals in Baghdad city from adult and child patients Suffering from urinary tract infections for 6 months .The samples get reached 1152 distributed among the patients old between few days to 80 years most patients living in hospital with urinary tract catheter , 56 samples of Proteus mirabilis were identified after isolation and diagnosis of bacterial species in different methods because there different complications in UTIs Patients specially Stone formation ,  catheter obstruction , and renal damage. Results these bacteria were diagnosis in api 20 E and vitek2 system and one isolate of Proteus mirabilis was selected for the study according to distance movement by measurement (swarming motility). Flagellin which is the flagella protein was extracted and predicated, followed by SDS-polyacrylamide gel electrophoresis for protein molecular weight estimation and  concentration of protein counted by Bradford method ,then immunization protocol were tested in Albino rabbits in different concentrations 10,20,40 microgram from flagella protein then immunoglobulin antibody IgG ,IgM in serum were tested by single radial immunoglobulin diffusion plate , positive results  showed raised the concentrations of these antibodies with high significant differences .Immunized  females rabbits was tested to ascending urinary tract infection challenge by inoculation 145×107">  cfu from P.mirabilis and tested in 1 , 3 , 7 , 14 days , any  females rabbits didn’t show urinary tract infection by P.mirabilis  when urine culture tested and, the concentration of IgG , IgM  antibody in balance also showing white blood cells in normal range .While rabbits females that inoculated by 145×107">  cfu in positive control group showed urinary tract infection by P. mirabilis  after 7 days post inoculation the tested urine culture showed raised in IgG , IgM and white blood cells concentration. Conclusions In the present study, flagellin protein immunization in rabbit showed that there are rising in IgM and IgG titers. After challenging by ascending urinary tract infection, we showed neutralization of IgG and IgM and white blood cells.Keywords: Flagellin, P. Mirabilis, UTI, Vaccine.
Various Factors Affected the Production of Pickled Chinese Jiaotou (Allium Chinense) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Chinese jiaotou is fresh during the harvesting season but perishable under the prevailing conditions of temperature and humidity as well as lack of adequate storage facilities. An alternative approach of preserving surplus Chinese jiaotou could be fermented to pickle products. Preservation of the Chinese jiaotou by lactic fermentation can eliminate the undesired taste and improve flavor of the vegetable. Therefore we explored a lactic fermentation from Chinese jiaotou by focusing on the effect of different parameters such as salt soaking concentration, sun drying time and CaCl2 soaking as pre-treatment; sugar concentration and fermentation time to physicochemical, microbial and sensory characteristics of pickled Chinese jiaotou. Experimental results revealed that 15% salt is soaking, sun drying in 6 hours, 0.4% CaCl2 soaking as pre-treatment for raw Chinese jiaotou; then 6% sugar in 21 days of fermentation was appropropriated to get a pleasant pickled Chinese jiaotou quality. Chinese jiaotou pickles are considered as one of the health supplements.Keywords: Chinese jiaotou, Pickle, Lactic fermentation, Soaking, Drying, Sugar, Salt.

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