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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 81 Documents
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Search results for , issue "Volume 11 Issue 03" : 81 Documents clear
Thermal Properties of Epoxy Resins and Phenol Formaldehyde Component with Differential on the Mixing Ratios and Reinforced by Nanoparticles Mustafa Ahmed Rajab
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The research aims to study the mechanical properties (tensile strength, hardness, Impact) and thermal properties of epoxy resin and phenol formaldehyde by varying the mixing and strengthening ratios of the nanoparticles. First: (the effect of different mixing ratios between epoxy resins and phenol formaldehyde), and secondly: (nanoparticles containing both magnesium oxide and zirconium oxide) on both mechanical and thermal properties.Keywords: Mechanical and Thermal Properties, Composite Material, Mixing ratios.    
The Risk of Bone, Joint and Inflammatory Bowel Disorders in Patients Treated with Angiotensin-Converting Enzyme Inhibitor Drugs Firas Fadhil Alyaseen
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objective: the aim of this study is to describe the adverse effects and disorders of angiotensin-converting enzyme inhibitor drugs treatment in patients with various cardiac diseases who prescribed those treatments. It also evaluates the risk of angiotensin-converting enzyme inhibitor drugs on long term therapy of patients.  Subjects and methods: this cross-sectional study was carried out in Al Hussein-teaching hospital at Al Nasiriya city, south of Iraq. The research started at November 2016 until April 2017. Eighty one patients (52) males and (29) females], age (34-77 years) were enrolled in this study. All of the patients were diagnosed with cardiac diseases by specialist doctors and currently on angiotensin-converting enzyme inhibitor drugs for long term therapy. The data collected from patients through a questionnaire list designed and developed for this study. The list concerned with the disorders and drugs-related data in addition to the patients' general data. The collected results were analyzed in order to construct tables, figures and other necessary research requirements.  Results and conclusions: in this study, most of the cases are treated with angiotensin-converting enzyme inhibitor drugs for hypertension (97.5%), and captopril represents the most popular of them (52 %). The most common significant results among the disorders associated with angiotensin-converting enzyme inhibitor treatment in patients were osteoporotic back pain (79 %), osteoarthritic joint pain (87.65 %), and gastrointestinal disorders like constipation, abdominal pain and chest pain were (66.7%), (53%), and (56.8%) respectively.Keywords: Bone, Joint, Inflammatory Bowel Disorders, Angiotensin.
Synthesis, Characterization and Biological Evaluation of Esters Derived from Sulfamethoxazole Drug Inas S. Mahdi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A series of novel esters compounds have been prepared from the reaction of sulfamethoxazole drug with α-chloro acetyl chloride then reaction of the resulting compound with various carboxylic acids and carboxylic drugs. The modern ester has been diagnosed by 1HNMR, FTIR spectral data and their physical properties and some of them were screened for their antibacterial activity.Keywords: Sulfamethoxazole, Esters, Antibacterial activity.
The Epidermal Growth Factor Receptor Expression in Leptin-Treated Traumatic Oral Ulcer in Rats Sabreen S. Abed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Back ground: The injured tissues need to activate their cellular responses in order to restore their normal histological architecture. Leptin has a significant effect on wound healing by enhancing the expression of many biological molecules and cytokines. The present study   aimed to evaluate the effect of topical application of recombinant leptin on induced traumatic oral ulcer healing by mean of immunohistochemical localization of EGF-R. Materials and methods:  Forty eight male Albino rats with body weight between (200 -270 gm) and age between 2-3 months, were subjected to traumatic ulcer with 8 mm diameter by surgical blade no.15 on the right side of the buccal mucosa. The animals divided into two groups; control group: the ulcer treated daily with sterilized distilled water, the experimental group: the ulcer treated daily with 10µl of 1 µg/ml recombinant leptin. The rats were sacrificed at 3,7,10 days. The specimens were taken for immunohistochemical study to detect the expression of EGF-R in both control and study groups. Results: The present study showed that the recombinant leptin increased the expression of EGF-R in the ulcer area only at 3rd day of ulceration by both epithelial and mesenchymal cells with highly significant differences than control group. Conclusion: leptin accelerated the healing process in oral mucosal ulcer by increase the expression of EGF-R in early healing period than control.Keywords: leptin, Oral mucosa, Ulcer, EGF-R.
Assessment of Lipid Profile and Cytokine (IL-13, TGF-β) with sICAM-1in Patients Infected with Intestinal Parasite (Entamoeba histolytica, Giardia lamblia and Blastocystis hominis) Esra I. Wahid-Aldeen
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Tests were assessed in sera of 150 patients infected with intestinal parasites of E.histolytica (50 case), Giardia lamblia (50 case) and Blastocystis hominis (50 case), as well as 20 apparently healthy controls whom attended to Children Hospital , Kirkuk General Hospital And Azadi teaching Hospital in Kirkuk city-Iraq, from February- August 2017. Biochemical parameters include a lipid profile, while immunological parameters include serum level of IL-13, TGF-β and soluble intracellular adhesion molecule-1) sICAM-1 (. Biochemical parameters showed a significant correlation between low serum lipid levels in infected intestinal parasites especially in the level of cholesterol was significantly decreased in patients infected with G.lamblia (107.36 ± 10.82 mg/dl) and E.histolytica(110.88 ± 9.45 mg/dl) compared to control group and patients infected with B.hominis (P ≤ 0.05) . The level of T.G. and VLDL also showed significantly decreased in patients infected with E.histolytica(57.52 ±8.73 mg/dl) compared to control and patients infected with B.hominis, while all patients showed a significant decrease in HDL level. Serum level of IL-13 and sICAM-1were significantly increased in all patients infected with intestinal parasite, while there was a significantly increased serum level of TGF-β in patients infected with B.hominis and E.histolytica, the current study conclude that intestinal parasite work to consumed fat from the host because it cannot synthesize it by itself , and this result suggest ­­a role of IL-13 pathogenesis of intestinal parasitic infection ,also the  increase in the level of TGF-β and sICAM-1 in B.hominis patient may suggest that TGF-β causes increased expression of endothelial ICAM-1and neutrophil-mediated intestinal injury.Keywords: Entamobea histolytica, Giardia lamblia, Blastocystis hominis, sICAM-1, IL-13, TGF-β, Lipid Profile.
Human Herpesvirus-6 in Relapsing Remitting Multiple Sclerosis Ansam W
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. HHV-6 has been implicated in the pathology of relapsing Remitting MS. Objective: Study the relation between HHV-6 viremia and relapsing remitting MS. Methods: A case-control study conducted on MS patients. fifty blood samples were collected from relapsing-remitting MS patients-thirty samples from the patients at the time of remission and twenty samples from the patients at the time of relapse and fifty blood samples from apparently healthy controls. Viral DNA extracted from plasma samples, and then, HHV-6 DNA detected and measured by quantitative real-time PCR. Anti HHV-6 IgG and IgM  antibodies measured by ELISA. Results: HHV-6 was detected in 22% (11/50) of MS patients, in 45% (9/20) of relapsing patients and 6.77% (2/30) in remission, while none of the controls was positive for the virus, (P=0.0013) (OR=11.45, P=0.045) (RR=2.9, P= 0.0003). IgG was positive in 48% (24/50) of MS patients and 56% (28/50) of the controls, (P=0.42). While IgM was positive in only 4% (2/50) of MS patients in the relapsing group, (P=0.49).Conclusion: HHV-6 could have a role in the pathology of relapses in MS patients and high viral load might be an indicator of relapse.Keywords: Relapsing-remitting MS, HHV-6, Real time PCR, IgG, IgM. 
Synthesis and Characterizations of New Pyrazoles and Study the Toxic Effect of the Compounds in Hella and RD Cancer Cells lines Fadhil Lafta Faraj
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

New Pyrazole Derivatives have been synthesized by reaction of 2-(5-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with hydrazine and substituted phenylhydrazine. The chemical purity of the new synthesized compounds was tested by TLC and the chemical structures were characterized by, FT-IR, 1H, and APT 13C NMR. The biological activity of the new synthesized compounds was conducted to investigate the toxic effect of these compounds on the growth of tumor cells represented by the line of HeLa cell line and the human muscle cancer RD in the laboratory. The study included exposure period 24 and 48 hours, and showed good and different results. Keywords: Pyrazole Derivatives, Hydrazine and substituted phenylhydrazine, Hella and RD Cancer Cells lines.
Study the Chemical Compassion of Gallstone and its Relationship to Acute Cholecystitis Ameerah M. Zarzoor
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

All over the world cholelithiasis is a main reason of morbidity. Gallstones are public between the general people; many people are ignorant of their presence because they not commonly cause symptoms. The detached of this revision was to conclude the chemical conformation of gallstones and any relationship between the composition of the stone and initiation of acute cholecystitis. For 50 patients (13 males and 37 females), the chemical composition of gallstones was tested. (46 %) of the sample are in age groups (40-50) years old. A seventy four of study participants were female. In 50 gallstone, cholesterol stones 27 (54 %), mixed stone 20 (40 %)   and pigment stones was 3 (6 %). The modifier of female:  male was (5.3:1). The  studying  shown  that Cholelithiasis occurrence  in  the age  group 40-50   ( 23 cases)   is  maximum  follow them   13, 9 and 5 cases for  age  groups  30-39,  51-61  and  62 years  old and  more respectively. About 62% of patients  with  cholelithiasis have  acute  cholecystitis Conclusion: In Al-Kut city  cholesterol gall stones  is  great   incidence   as  associated  to mixed  & pigmented  gall stones and  most patients with cholelithiasis have  acute cholecystitisKeywords: Gall stone, Cholelithiasis, Cholesterol, Bilirubin, Calcium.
Estimation Free Cyanide on the Sites Exposed of Organisms Mortality in Sura River /November 2018 Reyam Naji Ajmi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Inductively coupled plasma mass spectrometry   (ICP-MS) and high-performance liquid chromatography hyphenated were used cyanide determination. Samples preparation, digestion, and extraction efficiency. Analytical methods for the determination of total acute toxicity of cyanide at temperatures from 4- 24 and dissolved oxygen 6.1±0.4 mg/L on different stages of five basic sites of Euphrates rivers water were more sensitive at lower temperatures. Results have been obtained from analysis of water samples with recoveries of 88.1% to 100 % and Relative Standard Deviations (RSD) of <0.05 %. This study proves the potential application of the newly developed method for the analysis of free cyanide in river waters while the study time we could not get any kind of fish especially after the mortality in November 2018.Keywords:  Hydrogen Cyanide, Euphrates, River water.
Anti-brain Cancer Activity of New (N, O) Bidentate Schiff Base Ligand and its Metal Ion Complexes Hayder Muneam A.M.
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Anti-brain cancer activity was studied by treated it with new bidentate Schiff base ligand and its metal ion complexes. The ligand 2-(((Z)-1-(4-(((E)-4-(dimethyl amino) benzylidene) amino) phenyl) ethylidene) amino) phenol and its metal ion complexes have been characterized by using FT-IR, UV. visable, 1H-NMR,13C-NMR, mass spectroscopy, thermal analysis, (CHN) analysis, atomic absorption, magnetic susceptibility and molar conductivity. The octahedral geometry was suggested for all the synthesized complexes with the bidentate ligand in (1:2) mole ratio of metal: ligand. The M (II) complexes were having neutral nature while the Fe(III) was an electrical according to the magnetic susceptibility. Copper ion complex has been shown a good anti-brain cancer activity than other complexes and the ligand.Keywords: Schiff base, Anti-brain cancer, Metal ion complexes, Bidentate ligand.   

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