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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 81 Documents
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Search results for , issue "Volume 11 Issue 03" : 81 Documents clear
Biochemical Observations in Patients Suffered From Acute and Chronic Kidney Diseases with Reference to Thyroxi Omar K Hassan
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Blood samples of acute kidney injury (AKI) patients (20) ;chronic kidney disease(CKD) patients (20) and normal persons(20), were collected from the central dialysis unit and private clinical diagnostic laboratories in Mosul city/Iraq during the period from (Jan. to March.2018), for investigation of blood urea, serum creatinine, serum thyroxin (T4) and serum total protein, Albumin and Globulin. Results reviled that only urea and creatinine were significantly reduced in AKI patients, but all studied parameters except albumin were significantly reduced in CKD patients in comparison with normal persons. Health significance of all parameter s levels was discussed.
Clinical Study for Oxidative Stress and Lipid Profile Levels in Patients with Cardiac Arrhythmias Mohammed. L. A. Al-Baaj
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Cardiac arrhythmia is a disturbance heart rhythm. Most types of arrhythmia are not serious, while there are some that types can be life threatening promptly because it impacts the pumping action of the heart substantially, enough to disrupt blood supply to the body, potentially leading to sudden cardiac death. The present study is designed to determine the levels of (MDA) (malondialdehyde) as a marker for lipid peroxidation , in addition, measurement  the level of lipid profile (cholesterol TCH, triglyceride TG, high density lipoprotein HDL, low density lipoprotein LDL, very low density lipoprotein vLDL, in patients of cardiac arrhythmia. The study includes (110) subjects with average age (62.0±3.0) years and the average of BMI was (27.80 ± 3.0 kg/m2) which were divided into five groups: (20) patients of (AF), (17) Patients of (SVT), (20) patients of (VT), (18) patients of (PVCs) and (35) clinically healthy subjects, who were attend blood bank to blood donation as control groups. The study aims to shed a light on the correlation between oxidants and lipid profile  in patients with cardiac arrhythmia .The results show that there were a significant increases in serum concentrations of  each of (MDA) ,(TCH), (TG), (LDL) and (vLDL)  in all  of patients groups in comparison with control group (P≤0.05), as for level of (HDL) there was a significant reduction (P≤0.05) In patients of AF in comparison with each one of study groups, also there was a significant increase in concentrations of  MDA of  patients of  VT compared with each of AF, SVT, PVCs (P≤0.05) and non-significant increase in serum concentrations of MDA  between SVT and AF ,while there was slightly significant increase  between each of AF and SVT compared with PVCs(P≤0.05). On the other hand Pearson’s correlation coefficient analysis showed a positive correlation between MDA level and each lipid profile parameter, except HDL which showed a negative correlation in all groups of cardiac arrhythmia.Key words: Arrhythmia, AF, SVT, PVCs, VT, Oxidative stress and MDA.
Analysis of Genetic Distance and Similarity in Some Radish Cultivars (Raphanus sativus L.) by Random Amplified Polymorphic DNA (RAPD) Markers A. K. H. Al-Tufaili
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The random amplified polymorphic DNA (RAPD) assay is a useful method for to Detection Genetic Distance and Similarity among cultivars. In the present study, The DNA of the five Radish genotypes were screened with 5 primers generated reproducible and easily storable RAPD profiles with a number of amplified DNA fragments ranging from 9 to 12. The number of polymorphic ranged from 5 to 9 with an average reached 7.4 fragments ̸ primers with the polymorphic percentage ranged from 41.66%to 90%. The number of monomorphic ranged from 0  to 5  and was total of the monomorphic 10 with an average reached 2 fragments ̸ primers with the monomorphic percentage was 0% to 41.66%. A maximum genetic distance value was obtained in Local white radish and white radish Hybrid F1 reached 0.662. While a minimum genetic distance value was seen between Local red radish and Local white radish reached 0.458. The least genetic similarity was between the two cultivars Local red radish and Local white radish 40%. This study shows that the genetic diversity among radish cultivars can be used to improve plant growth, especially medical active compounds production in addition to increasing the plant yield and improve the quality. Keywords: Radish, Genetic Diversity, Molecular marker, RAPD.
Synthesis and Biological Activities of Some New Derivatives Based on 2-amino-5-mercapto-1, 3, 4-Thiadiazole Containing Imide, β-Lactam Rings Iftikhar Ahmed Hussein
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

New series of 2-amino-5-mercapto-1,3,4-thiadiazole derivatives compounds are synthesized [S1-S4], then converted to Schiff′s base [S5-S10] which is reacted with chloro acetyl chloride due to the existence of  ????-Lactam compound[S11-S16]. The prepared derivatives are identified by infrared spectra studies, 1HNMR, and physical properties. The antibacterial strains have been investigated: an activity has been shown against Gram (+ve) bacterial (stapylococus and Gram (- ve) bacteria (Esherichiacoli).Key words: 1, 3, 4-Thiadiazole, Schiff bases, Heterocyclic rings, Biological activity.
Synthesis and Characterization of 6- (4- Acetylphenyl azo) - 3 -Aminobenzoic Acid Complexes for Some Transition Metals Abaas Obaid Hussein
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Azo dye 6-(4-acetylphenyl azo)-3-aminobenzoic acid was produced by grouping the diazonium salt from 4-aminoacetophenone for 3-aminobenzoic acid. Geometry of azo - ligand was resolved on origin of elemental analysis, spectroscopic studies such as 1H and 13CNMR, FTIR and UV-Vis. Handling produced azo ligand for transition metal chelates at aquatic ethanol for a 1:2 metal: ligand ratio, as well in perfect pH. The metal chelates have been described by utilizing atomic, absorption flame, elemental analysis, FTIR, and UV-Vis, as well conductivity and magnetic susceptibility mechanism. Nature for produced compounds, have been studied, obeyed mole ratio as well, methods of continuous, variation, Beer's law yielded up a condensation rate (1×10-4 - 3×10-4M).  High molar were absorbtivity, were observed for complex solutions. On origin data a tetrahedral geometry were assigned for the produced complexes. Biological activity of the produced compounds was assayed. Keywords: Metal chelate, Azo dyes, Complexes, Biological activity.
Incidence and Sensitivity Pattern of Klebsiella Pneumoniae, Escherichia Coli and Pseudomonas Aeruginosa in a Tertiary Care Hospital Rahul Radhakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

Objective: Antimicrobial resistance is a serious problem worldwide and differs from region to region. This study was carried out to determine the incidence and sensitivity pattern of gram negative bacteria mainly Klebsiella pneumoniae (K. pneumoniae), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) in our region and discuss the general issues related to antimicrobial resistance. Methods: Retrospective study was carried out in 6 months. Samples of urine, blood, pus, CSF and miscellaneous samples (fluids, swabs, sputum and stool) were collected from indoor and outdoor patients for isolation and antimicrobial susceptibility of K. pneumoniae, E. coli and P. aeruginosa were carried out in the Department of Microbiology in a Tertiary care Hospital.Results: Out of the 800 samples analyzed 618 showed growth,where 427 samples were isolated and it constitutes E.coli (43.32%), K. pneumoniae (33.02%) and P. aeruginosa (23.65%). Both E.coli and K. pneumoniae showed highest sensitivity for doxycycline (73%; 65% resp.) and second highest for levofloxacin (68%; 62% resp.), whereas, P. aeruginosa showed highest 55% sensitivity for amikacin followed by 46% for levofloxacin. β-lactam antibiotics and aminoglycosides showed high mean resistance (K.pneumoniae-81%, E.coli-77%, P. aeruginosa-84.4%) and (K. pneumoniae-73%, E. coli-59%, P. aeruginosa-68%) respectively.Conclusion: The data indicates high resistance among the gram-negative bacteria for β-lactam and aminoglycoside antibiotics. This study concludes that a proper awareness about antibiotics is essential as well as proper measures is to be implemented to control irrational use of antibiotics in this region. Keywords: Antibiotics;  Antimicrobial sensitivity; Gram-negative bacteria; Resistance
Evaluating the Efficacy of Bio-Sanitizer S1 in Disinfecting Contaminated Elastomeric Chains Mohammed Nahidh
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Special consideration for the elastomeric chains must be paid in order to prevent their contamination. The purpose of this study was to test the efficacy of Bio-sanitizer S1 in disinfection the contaminated elastomeric chains.  Materials and methods: Three types of elastomeric chains of short types from three companies were utilized in this study. The as-received elastomeric chains were checked for bacterial and fungal growth using Blood, MacConkey and Sabouraud dextrose agars. Elastomeric chains contaminated by saliva of orthodontic patients were checked for bacterial and fungal growth using the same media. After disinfecting the contaminated elastomeric chains, they were cultured again in the same agars to test the efficacy of Bio-sanitizer S1 as compared to chlorhexidine 0.2%. One-way ANOVA test was used for comparison. Results: As-received elastomeric chains from all companies were free from bacterial and fungal contaminations. The contaminated chains had no growth at all after disinfection with Bio-sanitizer S1 and chlorhexidine. Conclusions: Bio-sanitizer S1 acts as efficacious as chlorhexidine in disinfecting the contaminated elastomeric chains with the disadvantages of longer immersion time associated with the latter.Keywords: Elastomeric chain, disinfection, colony forming units.
Determination of Mefenamic Acid using 8-hydroxy quinoline as a Precipitating Agent and Low Pressure Mercury Lamp (184.9 & 253.7 nm) as a Source of Irradiation using of ISNAG Continue Flow Fluorimeter Hussein Fares Abd-Alrazack
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A new, simple, sensitive and fast method for the determination of Mefenamic acid in pure form and drugs (tablets) by continuous flow feed analysis via measurement of diverged beam of light by ISNAG_-fluorimeter (homemade instrument). The method based on the reaction of the Mefenamic acid with 8-HQ to form yellow precipitate. Optimum parameters have been studied to increase the sensitivity for the developed method. The linear dynamic range for the instrument response versus Mefenamic acid concentration was 0.005-7 mmol/L while the L.O.D was 0.216 µg/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The correlation coefficient (r) was 0.9956 while percentage linearity (R2%) was 99.12%. RSD % for the repeatability (n=8) was lower than 0.2% for the determination of Mefenamic acid, with concentration of 2, 5 mmol/L respectively. The developed method was applied successfully for the determination of Mefenamic acid in pharmaceutical tablets. A comparison was made between the newly developed method with the classical method (UV-Vis spectrophotometry at wavelength 285nm, and Turbidemtric method) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted values of each individual company with calculated t-value at 95% confidence interval from developed method.Keywords: Mefenamic acid, Flow injection analysis, Homemade instrument.
Antibacterial Activity of New Synthesized Derivatives 3- Substituted Imidazo Benzothiazole from 2- amino- benzothiazole Zainab Amer
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

In this study, bromophenyl phencyl bromide was activated with 2-amino-benzothiazole to prepare 2-bromophenylimidazo (1, 2-a) benzothiazole [1]. Then prepare 2-bromophenyl imidazo (1,2-a) benzothiazol-3-carbaldyhade [2] of the interaction of 2-bromophenyl imidazo (1,2-a) benzothiazol [1] with the presence of POCl3, DMF and CH3Cl. After that I attended derivatives of Schiff bases [A1-A3] were synthesized from the reaction of 2-bromo phenyl imidazo (1, 2-a) benzothiazole-3-carpaldehyde [2] with different primary aromatic amines. New derivatives of oxazepine [B1-B3] were prepared from the interaction of amino compounds [A1-A3] with malic anhydride. The amino compounds [A1-A3] were then reacted with phenyliso cyanide to prepare new beta-lactam compounds [C1-C3]. At last, Schiff bases [A1-A3] were reduced to prepare new amino derivatives of imidazo (1, 2-a) benzothiazole [D1-D3]. All prepared compounds were characterized by melting point and FT-IR. Some of them characterized by 1H-NMR and13C-NMR spectra. Also, antibacterial activities to some prepared derivatives were studied by using different bacteria.Keywords: 2-amino-benzothiazole, Schiff bases, Oxazepine, Beta-Lactam, Reduction, Antibacterial activity.
Evaluation the Effects of Fe3O4 Nanoparticles on Biofilm Genes Expression Patterns in Acinetobacter baumannii using Quantitative Real-Time Polymerase Chain Reaction Assay Haider Turky Al-Mousawi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

We selected Acinetobacter baumannii isolate from different clinical sources (wounds, burns, urine, sputum, blood and throat) that ability to produce strong biofilm formation, Nanotechnology technique is used in this study, Synthesis magnetic iron oxide nanoparticles Fe3O4 NPs using co-precipitation method and detailed physical-chemical characterization, the results show is very fine crystalline sizes reach to 11±1 nm by XRD ,with mostly spherical in shape and average nanoparticles size at (40- 47) nm by SEM and AFM respectively. The minimum inhibitory concentration (MIC) and sub-MIC test of Fe3O4 NPs at concentrations (15.75 to 2000) μg/ml toward A.baumannii isolates had been determined using Tube broth method. The best sub-MIC concentration of Fe3O4 NPs was 125μg/ml with a significant difference at p˃0.05 enhanced bacterial adhesion inhibitory on polystyrene surface of microtiter plates and consequently caused biofilms. The results of investigate gene expression of biofilm formation CsuE gene with reference 16SrRNA gene by RT-qPCR technique before and after treatment with Fe3O4 NPs show a significant difference at p˃0.05 in Cycle threshold (Ct) values for gene expression for CsuE gene of the isolates.  Therefore these treated enhance a significant difference lowest of expression gene fold value for CsuE gene and up-regulated at physiological biofilm, while 16SrRNA gene confirmed as well suitable housekeeping gene because do not appear any variations of expression before and after Fe3O4 NPs treated.Keywords: Acinetobacter baumannii, Fe3O4 NPs, Biofilm Formation, Biofilm gene and gene expression.

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