cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 4 Documents
 1 
Search results for , issue "Volume 11 Issue 04 (2019) April 2019" : 4 Documents clear
Comorbidity of the Metabolic Syndrome: Hyperuricemia, Gallstone Disease, Hormonal Disorders Raisa A. Aringazina
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.932 KB)

Abstract

This article presents relationships between metabolic syndrome and gallstone disease, hyperuricemia, hormonal disorders and point out the most relevant picture for today. In the review the general pathogenetic mechanism of endothelial dysfunction formation in metabolic syndrome and hyperuricemia is revealed and described. Shown, that hyperuricemia is a marker of the metabolic syndrome. The symptoms of metabolic syndrome increase with increasing levels of hyperuricemia. The review found that it is obesity and insulin resistance are common leading risk factors for progression metabolic syndrome and gallstone disease. No association between gallstone disease and dyslipidemia unlike metabolic syndrome. Obesity is a common factor in the relationship between metabolic syndrome, gallstone disease and hormonal disorders. Insulin resistance is a common factor metabolic syndrome and polycystic ovary syndrome, the leading factor in the course of metabolic syndrome in menopause, hypopituitarism, and gallstone disease. Also, insulin resistance is a common factor in the comorbidity of gallstone disease and postmenopausal conditions. Obesity and insulin resistance are common factors of metabolic syndrome and benign prostate hyperplasia. Keywords: Metabolic syndrome, Uric acid, Gallstone disease, Hyperuricemia, Hormonal disorders.
Phytochemical Evaluation of Ethanolic Extract of Cassytha Filiformis (Linn) Through GC-MS Analysis P. Sudha Kesavarthini
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Medicinal plants have had a crucial role in human culture and civilization. The present study was carried for the preliminary phytochemical analysis of the ethanolic extract of the plant Cassytha filiformis (Linn) belongs to the family Lauraceae. Bioactive constituents in the ethanolic extract of Cassytha filiformis (Linn) was analysed by GC-MS analysis. In GC-MS analysis, around one hundred and fifty eight compounds were present, in which many compounds where not reported for their biological properties. The presence of various bioactive compounds confirms the application of Cassytha filiformis (Linn) for various diseases by traditional use.Keywords: Cassytha filiformis (Linn); Lauraceae; GC-MS analysis.
Formulation, Characterization and In-Vitro Evaluation of Dasatinib Loaded Solid Lipid Nanoparticles for Oral Delivery Mohamed Yasir Arafath
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: Dasatinib (DST) is a BCS Class II drug having very low solubility and high permeability. The absolute bioavailability of DST is about 14 to 34% due to an extensive first-pass effect. For improving the bioavailability of DST, solid lipid nanoparticles (SLNs) were developed using triglycerides (trimyristin, tripalmitin, and tristearin). Methods: Hot homogenization followed by ultrasonication method was used to prepare DST-SLNs. The prepared SLNs were characterized for particle size, Poly dispersity index (PDI), Zeta potential (ZP), Entrapment efficiency (EE) and Drug Content. Invitro release studies using dialysis bag method in 0.1N Hcl and pH 6.8 Phosphate buffer were conducted. Results: DST-SLNs prepared with Dynasan-118(E4) having the size of 150.73nm, PDI of 0.20, ZP of -29.1 mV with 93.56% of EE were optimized. In addition, long-term physical stability of the optimized SLNs was investigated at refrigerated and room temperature for 180days and it was stable for long period. FTIR and DSC studies revealed that no interaction between the drug and lipids. Scanning electron microscopic studies showed nearly spherical shape particles with increased polydispersity index. Formulation containing Dynasan-118(E4) showed highest percentage drug release among all the prepared SLNs. Release of drug from DST-SLNs (F4, S4, and E4) followed Higuchi, the best fit with the highest correlation coefficients were shown in Higuchi plot. The mechanism of release is by diffusion controlled as indicated by R2 value of Higuchi and n value of Korsemeyer-Peppas equation. Conclusion: Dasatinib loaded solid lipid nanoparticles is a good drug delivery system with desirable release characteristics.
Isradipine Loaded Solid Lipid Microparticles for improved Oral Drug Delivery: preparation, solid state characterization and pharmacokinetic evaluation PALANISAMY VISHNU
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Purpose: The objective of the study was to develop and evaluate the isradipine (ID) loaded solid lipid microparticles (SLMs) for enhanced oral delivery. ID is a dihydropyridine calcium channel blocker, having low oral bio-availability (15-24%) due to poor aqueous solubility and also hepatic first-pass metabolism.Methods: ID-SLMs were developed by hot homogenization coupled with ultrasonication method followed by lyophilized. The prepared SLMs were optimized. Solid state characterization and surface morphology of SLMs were analyzed using FTIR, DSC, XRD and SEM, respectively. The physical stability of optimized formulation was studied at refrigerated and room temperature for 6 months. Further, single dose oral bioavailability study was conducted in male Wistar rats compared to suspension at a dose of 5 mg/kg body weight.Results: ID-SLMs prepared with Dynasan-114 (ID8) having particle size, PDI, ZP and entrapment efficiency (EE) of 618.2±4.01 nm, 0.408±0.020, -25.9 mV and 94.85±3.61%, respectively and was physically stable for 6 months. Formulation ID8 SLM showed faster release, has less particle size and more zeta potential. FTIR and DSC, XRD studies revealed that no interaction between the drug and lipids, and conversion of drug to amorphous form. SEM studies showed nearly spherical shaped particles. From in vivo studies, indicated that 2.69-folds enhancement in the bioavailability of SLM compared with control.Conclusion: Thus, the results conclusively demonstrated the role of SLMs for significant enhancement in vivo effect of ID. 

Page 1 of 1 | Total Record : 4

 1 

Filter by Year

2019 2019


Reset
Filter By Issues
All Issue Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue