cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
 1   2   3   4   5 
Search results for , issue "Volume 11 Issue 04." : 74 Documents clear
Nasal Carriage of Methicillin Resistant Staphylococcus Aureus among Medical Personnel of Salah Al-Din Hospitals using Classical Method and PCR Technique Nihad Abdul-Hussain Jafar
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.625 KB)

Abstract

Objectives: To screen medical personnel of four hospitals at Salah Al-Din governorate for MRSA, and to compare between the classical method and PCR method for detection of Staphylococcus aureus and MRSA. Materials and Methods: A total of 279 nasal swabs were taken from medical personnel of four hospitals in Salah al-Din (Salah Al-Din General Hospital, Tikrit Teaching Hospital, Samarra General Hospital and Baiji General Hospital). Staphylococcus aureus isolates diagnosed by both classical methods based on morphology, coagulase test, DNase test and mannitol salt agar fermentation, and by PCR by detection of femA gene .The isolates diagnosed as MRSA using classical method by its sensitivity to Cefoxitin in disc diffusion method and by detection of mecA gene with PCR. Results: The results showed that out of the 279 swabs taken from the medical staff of four hospitals in Salah al-Din, 88 were isolated as S. aureus (31.5%) using the classical method used in the hospitals of the governorate under study, and 58 (65.9 %) of them were methicillin resistant S. aureus using the Cefoxitin antibiotic method. However, the PCR results showed that only 57 isolates (20.4%) were diagnosed as S. aureus and that the number of isolates of S. aureus that possessed the mecA gene was only 24 isolates (42.1%) from the total isolates. Conclusion: The classical methods used in most Iraqi hospitals are not accurate in diagnosing S. aureus isolates and MRSA isolates, since 31 (35.2 %) isolates of the 88 isolates were misdiagnosed as S. aureus by the classical method. Furthermore, 34 (58.6 %) isolates of S. aureus were misdiagnosed as MRSA by the classical disc diffusion method.Keywords: MSRA, Nasal carriage, Meca.
Cosmos caudatus Leaf Ethanol Extract Inhibit Growth and Viability through Membrane Permeability and Apoptosis in Candida albicans Agustina Tri Endharti
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.119 KB)

Abstract

Objective: Candidiasis is the most common fungal gynecological disease in humans. Essentially, the use of antifungal such as Fluconazole has reportedly increased resistance to candidiasis by 7%. The flavonoid has been shown to be used as an antifungal in Candida albicans. Cosmos caudatus contains 51% of Quercetin. To prove the influence of the use of flavonoid antifungal of quercetin group on the growth, viability, membrane permeability, and apoptosis of the C. albicans. Methods: The SV-1148 coded C. albicans isolate was obtained from the Microbiology Laboratory of Brawijaya University, Malang, Indonesia. Initially, the isolate was grown in Sabouraud Dextrose Agar (SDA) medium. The samples were divided into negative and positive control groups of fluconazole (60µg/ml) and difference concentrations (5%, 10%, 20%, and 40%) of leaves ethanol extract of C. caudatus. Results:  Concentration of 40% ethanol extract C. caudatus has Minimum Inhibitory Concentration (MIC) of 30%. This result showed that 40% ethanol extract C. caudatus was able to provide the best growth resistance which was characterized by the absence of colonies from C. albicans. The data of Influx Assay Iodide increased membrane permeability of C. albicans to disrupt cell membranes and induce apoptosis. The percentage of apoptosis increased after treatment of 40% ethanol extract C. caudatus in the culture of C. albicans. Conclusion: C. caudatus has antifungal activity and can be used as an herbal drug in C. albicans infection.
Pharmacodynamics and Hepatoprotective Properties of Drugs Affecting Metabolic Processes in Patients with Drug-Induced Liver Injury on the Background of Specific Antituberculosis Therapy Anna V. Berestova
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.34 KB)

Abstract

Objective. Data on pharmacodynamics and hepatoprotective properties of taurine, ursodeoxycholic acid and their combinations in the treatment and prevention of drug-induced liver injury on the background of specific anti-TB therapy is presented. In the study course, a retrospective analysis of primary medical documentation of 270 patients was carried out. Materials and Methods. These patients were undergoing antituberculosis therapy in regional clinical tuberculosis hospitals during 2013-2016. Clinical studies were conducted in the regional clinical tuberculosis hospital in 2016-2018. At the clinical stages, 100 patients were examined. Results and Discussion. A retrospective analysis showed that in a real clinical practice, anti-TB therapy is canceled even with a moderate increase of the transaminase level. Temporary cancellation and correction of specific therapy led to a slowed-down x-ray dynamics and an increase in the length of hospital stay. It also helped to reduce clinical manifestations of liver injury and decreased enzyme activity in most patients for 8-14 days, though the transaminases absolute values remained above the reference values. Conclusion. Taurine intake in dose of 1000 mg/day for the pharmacological correction and prevention of drug-induced liver injury showed high drug efficacy both in monotherapy and combination with ursodeoxycholic acid. Taurine shows an immunomodulatory effect in patients with tuberculosis, with increase of CD3, CD4, CD16, immuno-regulatory index and decrease of CD8, the level of cytokines IL-4, IL-6 and TNF-α.Keywords: Drug-induced liver injury, Specific antituberculosis therapy, Pharmacodynamics, Hepatoprotectors, taurine, Ursodeoxycholic acid.
Relationship Plasma Concentration of Zonulin with Severity Level of Autism Based on Criteria of Diagnostic and Statistical Manual of Mental Disorders-5 (Dsm-5) Nanik Setijowati
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.433 KB)

Abstract

Background: This study was aimed to prove whether there is relationship between plasma concentration of zonulin and severity level of autism based on criteria of diagnostic and statistical manual of mental disorders-5 (DSM-5). In Indonesia, this kind of research has never been done, considering the incidence of autism is also increasing. Methods: The participants of this research were 38 autistic (level 1=17, level 2=12 and level 3= 9) and 35 control children. The blood plasma of all participants was taken to determine the plasma concentration of zonulin. The observation sheet was based on the DSM-5 as an instrument to determine the diagnosis of autistic children. Data were analyzed using Mann-Whitney and Anova test. Results: There was a significant difference plasma concentration of zonulin between autism and control (p = 0.002) with 32 ± 18 vs 47 ± 22.5, respectively. There was slightly different between plasma concentration of zonulin and severity level of autisme (p=0.239) with 32±19, 27±18, 40±15, respectively. Cut-off point 8 ng/mL (Sensitivity 97.4%, Spesificity 2.9%). Conclusion: This finding can be concluded that plasma concentrations  of zonulin were slightly related with severity, and the highest is at level 3.
Adsorption and Photocatalytic Degradation of Crystal Violet Dye by using Cadmium Sulfide in Aqueous Solutions Aseel M. Aljeboree
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.979 KB)

Abstract

Chemical methods were used to synthesized cadmium sulfide thin films in a mixed phase which testing for wastewater treatment through the photocatalytic degradation. Specific region of light (UV) was used to remove the organic pollutant which commonly destroy the environmental such Crystal violet dye forming what we could it wastewaters. The testing solutions were degraded under visible-light irradiation using the CdS thin films. Structural studies of the CdS photocatalyst refer to the hexagonal and cubic phases with good crystallinity and uniformly and homogenous distributed over all the sites of support with less agglomerations.  The morphology analysis mostly shown induces porosity, which mostly enhance intercalating dyes. The optical band-gap energy of sample within film was 2.35 eV, which explained the high photcatalytic behavior in the degradation of the non-biodegradable Crystal violet dye. As accepted the semiconductor/ UV-light were succeed to declaration of day which shows good acceptable results. The surprised was the efficiency of degradation or deceleration was rises very high as compare with the same conditions of reaction in room temperature in addition to increases with raises of concentration from 0.5 to 4 g/L. Keywords: Cadmium sulfide, Photcatalytic degradation, Adsorption, Crystal Violet dye.   
Combination of Chitosan and Lemongrass (Cymbopogon citratus) Essential Oil as Edible Coating to Cantaloupe (Cucumis melo L) Quality and Shelf Life during Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.643 KB)

Abstract

Cantaloupe (Cucumis melo L.) is an important source of bioactive compounds, which are considered to be health beneficial. Chitosan and its derivatives have a wide range of applications, for example thickening, film formation, metal binding and antimicrobial activity. Lemongrass (Cymbopogon citratus) contains various phytoconstituents such as flavonoids and phenolic compounds, terpenoids and essential oils, which may be responsible for the different biological activities. The objective of this study was to evaluate the combination of chitosan with lemongrass essential oil as edible coating to improve the quality and extend the shelf life of Cantaloupe (Cucumis melo L.) during storage. Cantaloupe fruits were coated in different formulas of chitosan: lemongrass essential oil (0.15%: 0.15%, 0.20%: 0.1%, 0.25%: 0.05%, respectively). The uncoated fruits were used as control samples. Then, cantaloupe fruits were preserved at ambient temperature (28°C) and cool storage (4°C). The effectiveness of edible coating in cantaloupe fruit quality and shelf life was evaluated by estimating weight loss, firmness, total soluble solids, total acidity, ascorbic acid, carotenoid content, microbial proliferation (total bacterial, yeast and mold) and sensory acceptability at beginning and during 16 days of storage. The results obtained showed that 0.20%: 0.1% (chitosan: lemongrass essential oil) as edible coating could reduced weight loss; maintained firmness, total soluble solids, total acidity, ascorbic acid and sensory score; delayed the change in cartenoid content and microbial proliferation. The coated fruits had a shelf life of 16 days (4oC) or 12 days (28oC) under storage.Keywords: Cantaloupe, Chitosan, lemongrass essential oil, Coating, Shelf life.
The Validity Assessment of E-Cadherin Expression to Differentiate Ductal and Lobular Type Invasive Breast Carcinoma I Gusti Ayu Sri Mahendra Dewi
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (498.577 KB)

Abstract

Introduction: Currently, breast cancer is one of the leading causes of cancer related death in women worldwide. The diagnosis of breast cancer still depends on biopsy to determine the histopathological subtype and the nature of the cancer. However, the subtypes alone could not differentiate between lobular and ductal carcinoma. Therefore, this study aimed to evaluate the validity of E-cadherin expression as biomarker to differentiate ductal and lobular invasive breast carcinomas. Methods: An analytic observational cross sectional study was conducted using 47 biopsy samples of ductal and lobular type invasive breast carcinoma examined at Anatomical Pathology Laboratory Faculty of Medicine, Udayana University/ RSUP Sanglah Denpasar in 2017. The samples were evaluated using H & E staining while E-cadherin expression was examined by using Immunohistochemistry technique (IHC). Pearson chi-square was performed to analyze the data with p-value less than 0.05 was considered significant or valid. Result: Descriptive statistics showed that the samples were homogeneous in term of age between ductal and lobular types (p=0.668). Breast cancer was found to be more prevalent on the left breast compared to the right one in both in ductal and lobular types. IHC staining showed that E-cadherin expression was significantly lower in lobular types (9.1% positive) compared to ductal (60.0% positivity) and, thus, can be used to differentiate them (p=0.000). Conclusion: E-cadherin expression was a valid biomarker to differentiate ductal and lobular type invasive breast carcinoma. More comprehensive study with larger number of samples is required to assess the generality of this findingKeywords: E-cadherin, Breast carcinoma, Ductal type, Lobular type.
Autonomic Function in Peripheral Nerve Regeneration Especially in Radial and Ulnar Nerve Injuries after Microsurgery: A Systematic Review Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.674 KB)

Abstract

This literature review seeks to understand the difference in autonomic function of radial and ulnar nerve injuries after microsurgery. During this surgery, additional damage to nerves is also experienced. This research focused on peer-reviewed articles from Pubmed-NCBI database. This is a medical database which features medical peer-reviewed articles on various illnesses treatments and outcomes. The eligibility criteria used were that the article must be full text, published within the past 10 years, written in English language, and featured the keywords-radial nerve injury, ulnar nerve injury and microsurgery. There was no specific characteristic for participants as all individuals with injury were considered. The search from the database yielded 121 initial articles. Of this number, 33 were excluded for being editor comments and no full texts. This had led to 88 remaining articles which were further screened to remove articles written in other languages and those which were older than 10 years. This featured a total of 43 articles. Of this remaining total, only 30 articles were used. The other 15 were excluded as a result of research reliability issues. The procedures used in the articles featured a lot of limitations which questioned the validity of their results. This paper concludes with a summary of the analysis of the difference in autonomic function of the radius and ulna after microsurgery.Keywords: Autonomic function, Radial nerve, Ulnar nerve, Microsurgery.
In Silico Approach : Beta Glucan and AdhO36 Combinations enhance the Th1 immune response against Salmonella Typhi infection Hidajah Rachmawati
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.654 KB)

Abstract

Background: Typhoid fever caused by Salmonella Typhi remains as an infectious disease that still becomes a health problem, especially in developing countries due to its fairly high morbidity. Vaccine development efforts, particularly about proteins that play a role in enhancing immunity, are adhesin protein (Protein AdhO36) and the addition of immunoadjuvant Beta Glucan that can improve the cellular immune system.Objective: This study was aimed to predict the ligand-receptor bonds (Dectin1-Beta Glucan; TLR2-Beta Glucan, TLR4-Beta Glucan) and the ligand-receptor bonds (Dectin1-AdhO36; TLR2-AdhO36, TLR4-AdhO36).Method: To determine the binding affinity of the bond between Beta-Glucan and Dectin1, TLR2, and TLR4, a molecular approach was specifically used using PyRx 0.8. Whereas to find out the interaction between Adh036 and target proteins Dectin1, TLR2, and TLR4, Patchdock software was used. The results of the interaction would be visualized using PyMol software. Amino acids involved in docking interactions were identified using KFC protein hotspots.Results and Conclusion: The result indicated  the binding affinity between receptor Dectin1-ligand Beta Glucan and Beta Glucan TLR2  was (-6.5 kcal/mol), and TLR4-Adh036 shown the highest interaction strength with global energy -1462.6.  This results shown the potential effect of AdhO36 and Beta Glucan combinations  enhanced cellular immunity against Salmonella Typhi infection.Keywords: AdhO36, Beta Glucan, TLR2, TLR 4, Dectin-1. In Silico
Fabrication and Study the Structure, Optical and Dispersion Parameters of PMMA with InCl3 Additive Nadir Fadhil Habubi
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (767.386 KB)

Abstract

Polymethyl methacrylate films are prepared by casting method with various content of InCl3 (2, 4%). X-ray diffraction (XRD) and optical microscope are used to determine the structural properties. Transmittance that determined using UV-Visible spectrophotometer and optical parameters also calculated. Urbach energy values increase with the increasing of InCl3 and energy gap decreased from 3.849 eV of pure PMMA films to 3.230 eV of PMMA-4% InCl3. Dispersion parameters are determined using Wemple-DiDomenico model. Refractive index data at infinite wavelength was found to obey single oscillator model.Keywords: PMMA, Dispersion parameters, Composite, Optical properties.

Page 1 of 8 | Total Record : 74

 1   2   3   4   5 

Filter by Year

2016 2019


Reset
Filter By Issues
All Issue Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue