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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 93 Documents
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Search results for , issue "Volume 11 Issue 05." : 93 Documents clear
Synthesis and Characterization of New Schiff Bases Derivative from 2, 5ـ Dimarcaptothiadiazole Israa Taha Ibraheem
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

This research includes synthesis of new heterocyclic containing Schiff bases derivatives of 2, 5ـdimarcapto thiadiazole. The preparation process started by the reaction of  2,5ـdimercaptoـ1,3,4ـthiadiazole (1) with ethyl chloroacetate to give diethyl 2,2`-(1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl)diacetate (2). Compound (1) reacted with hydrazine hydrate to give 2, 5ـbis (mercaptoـacetichydrazide) 1, 3, 4ـthiadiazole (3). The reacted with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new Schiff bases derivatives (4-13).Keywords: 2, 5ـ dimercaptoـ1, 3, 4ـthiadiazole, Schiff bases.
Phenotypic and Genotypic Characterization of Some Virulence Factors among Proteus mirabilis Isolated from Clinical Samples in Al-Najaf Al-Ashraf/ Iraq Ahlam Kadhum Al-Yasseen
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study aimed to investigate the phenotypic and genotypic pattern of some virulence factors in Proteus mirabilis isolates from clinical samples. A total of 110 urine samples were collected from patients with urinary tract infection from both sexes and 100 vaginal swabs were collected of women with vaginal infections during the period from October 2017 to January 2018. The results of primary isolation and identification of bacterial isolates depending on microscopic, culturing on CHROM agar and biochemical test showed that 36.3% of isolates were belong to Proteus while the results of PCR techniques that used to confirmed identification using 16SrRNA revealed that 27.2% of isolates were belong to Proteus mirabilis. Variable results in the ability of bacterial isolates to produce protease and hemolysin have been obtained in which 30% and 100% of bacterial isolates gave positive results respectively. Also the results of PCR technique showed that all isolates (100%) were possess zap A, rsb A and mrp A encoding for the production of protease, protein that regulates  bacterial swarming behavior and mannose resistant pilli (MR /P) respectively by the appearance of amplicons with molecular weight  552, 485 and 366 bp.Keywords:  Genotypic; Proteus mirabilis; Phenotypic; and Clinical Samples.
Study the Effect of Some Growth Factors on the Production of L-Asparaginase Enzyme by Fungal Isolate Aspergillus flavus Walla H. Shuker
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Nine filamentous fungi from infection fruits and vegetables .Seven isolated were of high productivity for L-Asparaginase enzyme compared with other isolates, this isolates were Aspergillus flavus, A.niger, Pencillium sp., Fusarium sp., Aspergillus flavus was the best isolate for Asparaginase production, depending on diameteron pink colour on the medium plates. Studied the effect of nitrogen and carbon sources, and PH the resulted revealed that the maximum Asparginase production was the following condition: PH 6.0, Glocose as a carbon source, Ammonium sulphate was (121.28) U/100ml.
Application of Cinnamaldehyde-Chitosan Coating to Prolong Shelf-Life of Grapefruit (Citrus Maxima) N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Grapefruit (Citrus Maxima) is one of the most important citrus fruit cultivated in Vietnam. Its stability is quite short under ambient temperature. The edible coating could keep textural properties, sensory appearance and control respiration rate of fruits by functioning as a semipermeable vapor and gas barrier to regulate the moisture and gases in the package. Chitosan is recognized as safe and has been widely applied as a successful carrier for incorporating with the antimicrobial agents. The objective of this research was to prolong the fresh fruit quality of grapefruit by using cinnamaldehyde-chitosan coating. The results indicated that 1.0% cinnamaldehyde-chitosan application could maintain the highest fruit quality properties such as weight loss, decay rate, firmness, sugar, acidity, and vitamin C. By this application, the storage life of grapefruit could be extended to 28 days under ambient temperature.Keywords: Grapefruit, cinnamaldehyde, chitosan, coating, storage.
Molecularly Imprinted Solid-phase Extraction for the Selective Determination of Ciprofloxacin Designer Drugs in Pharmaceutical Preparations Yehya Kamal Al-Bayati
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

We have developed a new method with high sensitivity, low cost and high stability. Using a functional monomer, this method is based on a molecular polymer (MIP).Which is 2 (Trifluoromethyl) acrylic acid (TFMA), 3 (Trimethoxysilyl) propylmethacrylate (TMSA),suitable cross  linker and ciprofloxacin (CPF) template for the production of monolithic solid  phase micro  extraction (SPME) fiber. Used_ UV. Vis_ as (detector).All these analytical methods used to extract, preconcentration and selective Ciprofloxacin determination (CPF). Competence, The stability and duration of the manufactured fiber plays a fundamental and indispensable role in SPME. The aim of this study is to examine the factors influencing the polymerization and extraction procedures, as well as to explain the selectivity of the manufactured fiber in the CPF solution. Also related and unrelated compound selectivity .Under optimum conditions. For five patients repeated experiments for three measurements the relative standard deviations) RSD percent are range of at (10ـ50)ppm of CPFH)Percentage (2.57ـ3.25). The relative recoveries obtained for CPF are within the range of (95.40 ـ 99.28) in spiked human urine samples.Keywords: Ciprofloxacin / Molecularly imprinted polymer solid-phase extraction / UV. Vis.
Investigation on the Effect of Origin of Carbon Steel Reinforcing Bar on the Corrosion Behavior in Artificial Concrete Solution Abdulkareem M.A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The corrosion of steel reinforcing bar in concrete is very important point in fractures and damage of concrete building structures, many factors play important role in this problem. This research focuses on the effect of the origin of the carbon steel reinforcing bar on the corrosion parameters in simulate concrete solution (artificial), consisted of (Ca (OH) 2 (2gm), KOH (22.44mg), Noah (8mg). Two familiar types in the Iraqi local markets were followed, namely; locally produced sample and Ukrainian imported samples. Tafel plots and cyclic polarization procedures were conducted to estimate the corrosion parameters and pitting susceptibly of the two types using three electrodes potentiostat.The effect of temperature and some thermodynamic functions were measured in the range 20 to 50ᴼC. The microstructure and morphology was imaged using optical and atomic force microscope (AFM) respectively.Keywords: Steel reinforcing, Concrete solution, Artificial, Tafel.
Purification and Characterization of Alliinase from Iraqi Garlic (Allium sativum) Iman Hadi Al-Taai
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The study including purification and characterization of alliinase (EC: 4.4.1.4, Cys sulfoxide lyase, alliin lyase) from Iraqi garlic. Enzyme extraction with sodium phosphate buffer, pH 6.5, the extract was precipitated by addition of an ammonium sulfate with saturation (30-70)%. Gel filtration chromatography was done to purification enzyme by ÄKTA Pure 25 apparatus using superdex 200 column, three peaks were obtained with a good enzyme activity and an enzyme purity were identified by the absence of denaturation substances for protein SDS. Characteristics of pure enzyme showed that optimum pH for an activity was 6 and optimum pH for the stability was between 6-8, while optimum temperature for an activity and the stability were 35°C, 30-45°C respectively. Effect of ions Na, K, Mg+2, Fe+2, Zn+2, and Mn+2 was found stimulate enzymatic reaction while Ca+2, Ni+2, Cu+2 and Hg+2  inhibit the enzymatic reaction. Standard alliin used to determine a value of Km and Vmax and found to be 0.35M and 121.5 µmol/ml/min. respectively. The molecular weight of pure enzyme by electrophoresis technique with the presence of SDS was equal to 49 KDa.Keywords: Alliinase, Alliin lyase, Iraqi garlic, Purification, ÄKTA Pure 25.
Synthesis, Characterization and Biological Effect Study of Some New Azo and Azo–Chalcone Compounds Derived from 2, 6-Diaminopyridine Nihad I. Taha
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of this work was to prepare azo and azo-chalcones derivatives out of 2, 6- diaminopyridine (2, 6-DAP) which has extensive use in the synthesis of pharmaceutical compounds. The azo-diamine (S1-S6) was prepared from the coupling reaction of diazonium salt prepared from various substituted aromatic amines with 2, 6-diaminopyridine. The product (S1) was reacted in basic condition with one equivalent of different substituted aromatic aldehydes in methanol to give ten new azo-chalcones (S2-S11) in good yields. The final products were identified by their physical properties besides their UV-visible, FTIR and 1H NMR spectra. Biological activity of the compounds (S1-S6) was investigated and compounds (S1 and S2) showed high activity against B. subtilis and E. coli.Keywords: Azo- Chalcone, 2, 6-Diaminopyridine, diazonium salt, Pyridine.
Assessment Knowledge of Pregnant Women about Gestational Diabetes in Primary Health Care Centers at Al Nassiriya City/Iraq Doaa Sami Rashash
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The American Diabetes Association (ADM) certified that the Gestational Diabetes Mellitus (GDM) was separated any grade of the intolerance of glucose with a nonset or fist recognition at the time of pregnancy. Objectives: The study aims at assessing the knowledge of pregnant women of Gestational Diabetes Mellitus (GDM), which includes screening importance, risk factors and post- partum follow-up. Methodology: A sample of 50 women was selected from primary health care centers in Nasiriyah. The data was collected by interviewing women. The questionnaire was designed and consisted of demographic components and variables and risk factors that contribute to gestational diabetes to pregnant women. The validity and reliability of the questionnaire was determined by conducting a pilot study. Statistical and statistical procedures were used to analyze the data. Results: The study results showed that most of them ranging from age (21-25) years and the highest proportion of them graduated from primary school and less, most of them housewives with enough to some extent. There were statistically important variances between the knowledge of pregnant women about gestational diabetes and demographic data at a value of p less than 0.05. Recommendations:  Visit prenatal clinics until late pregnancy, meaning that there is little chance to educate illness on GDM and how they can help prevent it. While doctors are proactively trying to change this, the results of this study suggest that continuing education is necessary to improve awareness of GDM, and early prenatal education is likely to be important and that the Department of Health is setting up workshops on pregnancy. Nurses midwives at primary health care centerKeywords: Assessment, Knowledge, Pregnant, Gestational Diabetes Mellitus.
Synthesis, Thermal and Electrochemical Properties of Four New Bis Oxadiazole Copolymers Based on Azo Monomer Juman A. Naser
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Four new copolymers were synthesized from reaction of bis acid monomer 3-((4-carboxyphenyl)diazenyl)-5-chloro-2-hydroxybenzoic acid with five diacidhydrazide in presence of poly phosphoric acid. The resulted monomers and copolymers have been characterized by FT-IR, 1H-NMR, 13C-NMR spectroscopy as well as EIMs technique. The number averages of molecular weights of the copolymers are between 4822 and 9144, and their polydispersity indexes are between 1.02 and 2.15. All the copolymers show good thermal stability with the temperatures higher than 305.86 °C when losing 10% weight under nitrogen. The cyclic voltammetry (CV) measurement and the electrochemical band gaps (Eg) of these copolymers are found below 2.00 ev.Keywords: Oxadiazole, Copolymer, Azo, Monomer, Thermal Properties, Electrical Properties.

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