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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 93 Documents
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Search results for , issue "Volume 11 Issue 05." : 93 Documents clear
Virulence Factors of Uropathogenic Escherichia coli in Diabetic Patients of Al-Muthanna Province Elaf Lateef Neamah Al-Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Background and aims: There are evidences that patients with diabetes have an increased risk of asymptomatic bacteriuria and urinary tract infections (UTIs). UTIs are the most common bacterial infection in diabetic patients. The present study aimed to describe the characteristics of E. coli of Al-Muthanna province patients with urinary tract infection by identifying the virulence genes (FimH, Pap and HlyA). Material and methods: The study population included 240 diabetic and non-diabetic patients with UTIs as well the healthy control, Urine and blood sample was collected at Al Hussein Educational Hospital, between October 2017 to July 2018. Serum sample were collected and stored for immunological tests. Standard protocol was followed to isolate and identify organism and the data were analyzed using Microsoft Excel 2013. Results: Of the total 240, The results  of the study  were  41 (33.3%)  isolates  of  Diabetes  patients (DM group), 42(34.1%) isolates of Non-Diabetes  patients (ND group) with  urinary pathogenic  E. coli (UPEC)  and selected 40 (32.5%) of control group.  The age  duration of  46-61  years  were  most prevalence  of  UPEC  infections either  DM group  (56.1%) or  ND group (35.7%)  while  the gender  factor was shown significantly in DM and ND females (78.1% and 97.6% respectively ) compare to  males.  Twenty two  (53.7%) of diabetes urban  community  were  found to have UPEC infections while the rural infected  population were 19 (46.3%),  Non-diabetes  group  were recoded  17 (40.5%) , 25 (59.5%) positive cases of UPEC in urban  and rural  communities respectively. Fimbriae  severity virulence  genes of  DNA (fimH , pap) and  alpha-hemolysis  gene (HlyA)  of  were  extracted  of  83  UPEC isolates,  it was  then  identified  using the PCR amplification technique. The results  of molecular  diagnosis  shown that fimH was  detected  in  78%  in DM  patients  had  higher  than of  ND  patients (57%) of UPEC strains while the  percent of  Pap and HlyA were (31.7%, 12.2%) in DM patients compare to  ND patients  (Pap /38.1%)  and  (HlyA /7.1%)  of  UPEC  strains  respectively. Conclusion: UTIs are frequent in diabetic patients. For the reason of the great proportion of asymptomatic forms among diabetic patients, the urine culture should be performed in all hospitalized patients with diabetes.
Study of Lipids Profile Levels in Patients with Hypothyroidism in Al-Muthanna Province Duaa Hamad Hamza
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of this study was to investigate the changes that occurred on lipids profile levels of patients with hypothyroidism in al-muthanna province. The current study is carried out in the ‘specialized center of endocrinology and diabetes’ in Al- Muthanna province. The study included 200 individuals (100 patients with hypothyroidism and 100 controls).The patients and control divided to three groups according to ages. The ages were between (20-49) years. The results show a significant increase at(P<0.05) in ( Total cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low density lipoproteins (VLDL) levels of patients comparing with control group in all age groups .In this study concluded that hyperlipidemia is associated with hypothyroidism. These enhance the risk for development of atherosclerosis and coronary artery disease.Keywords: Hypothyroidism, Total cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, Very low density lipoproteins.
Investigation of Immunomodulation Effects of Ethanolic Neem Seeds (Azadirachta indica) Extract on Induced Immune Response in BALB/C Mice with Vibrio alginolyticus Whole An Ihsan Dhari Awad
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The Current study  was  studied the immunomoduatory  potentials  of Ethanolic Neem seed    extract in treated mice with Vibrio alginolyticus whole antigen through estimation the phagocytic activity of and lymphocyte proliferations as well as  estimation of  the serum fractions to evaluate the humoral immune response . The study was divided into 4 groups:  Group (I) was included treated mice with normal saline. Group II was included  mice treated with Vibrio alginolyticus  antigen only , Group,(III): included mice were treated with  (200 ug /Kg) of the neem extract combination with  Vibrio alginolyticus  antigen ,finally , Group IV included mice were treated with  (300 ug /Kg) of the neem extract combination with  Vibrio alginolyticus  antigen. The results of NBT index and MTT test were revealed group III and group IV showed highly significant increase (P≤ 0.05) comparison with other Groups .More further results of gel electrophoresis in current study were showed the level of Gamma globulin serum, Alpha-1 level, Alpha-2 level, Alpha-beta level were highly significantly in Group III and Group IV comparison with other groups. In other hands in this study the results were showed there is no significant difference between group III and group IV in NBT index and MTT test as well as Gel electrophoreses. Depending on the results of current study   the Ethanolic Neem extract had a positive immunomodutory effect on the induced immune response.Keywords: Neem Seeds extract, Immunomodulatory Effects, Vibrio alginolyticus whole antigen, Immune response.
Certain Blood Lipid Profile and Immunological Alterations Accompanied Vascular Inflammation in Hypertensive Patients Lamees M. Al-Janabi
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The current study was conducted to examine certain blood biochemical and immunological changes associated with high blood pressure in hypertensive patients. Hundred blood samples were collected from normal and hypertensive people, at Al-Hussein teaching Hospital, for assessment of Fatty lipids such as total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein as well as the study of IL-1β and TNF-α genes expression levels. The results of hypertensive patients showed significant increase of T. Cholesterol , TG and LDL and significant decrease of HDL, whereas the molecular analysis revealed significant increase in the expression ranks of both IL-1ß and TNF-ɑ genes in comparison with normal people. In conclusion, hypertension could be accompanied by lipidemia and decreased immunity.Keywords: Hypertension, Lipid profile, Immunity IL-1β, TNF-α.
Arterial Hypertension and Diabetes Mellitus: Therapy with Telmisartan, Interrelation Modeling, Approaches to Diagnosis and Complex Therapy Evgeniya Malashenko
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Diabetes mellitus (DM) is an illness for an increasing number of people. Among the consequences that DM leads in the first place can be called degradation changes in the body, ultimately leading to limited physical capabilities. In DM, one of the related phenomena is a high risk of cardiovascular diseases (CVDs). This is due to the following factors: a) already the presence of risk factors before the DM development; b) the presence of obesity; c) arterial hypertension (AH). AH is present in 75-80% of patients with DM type 2, with half of them die. Due to the fact that AH and DM have a pathogenetic relationship, this fact naturally increases the risk of death. On the basis of data from Polyclinic No. 3 in St. Petersburg (Russia), a group of 200 patients with DM (female, age range 45-65) with concomitant AH were selected. The control group consisted of 100 females of the same age. Therapy was carried out with Telmisartan, with a dosage of 85 mg for a period of 8 weeks. As a result of the therapy, telmisartan has shown a positive effect on such parameters as carbohydrate metabolism and insulin resistance, as well as lipid metabolism. For patients with metabolic syndrome, during the period of therapy, telmisartan was noted to significantly (p≤0.05) reduce the rates associated with lipid metabolism. First of all it affected the cholesterine rate in the blood .Also obtained reliable data on the triglycerides reduction (TG), from 1.67 mmol/l 2.0 times more than half of the patients (41% of 75% who had elevated TG levels) undergoing telmisartan therapy. In addition, a decrease in the load on the AH time index, as well as a decrease in microalbuminuria rate was noted in patients. This indicates the organ-protective effect of telmisartan therapy. Permanent control of blood pressure is of primary importance for CVD prevention in patients with DM. When prescribing an antihypertensive agent, it is necessary to take into account RAAS-blocking drugs (renin-angiotensin-aldosterone system). Telmisartan has shown a positive effect on carbohydrate metabolism, reduced the elevated lipids levels (in particular, TG), and also affected insulin resistance.Keywords: DM (diabetes mellitus), AH (arterial hypertension), CVD (cardiovascular disease), telmisartan.
Malondialdehyde and Antioxidant Vitamins in Breast Cancer Iraqi Patients Firas A. Hassan
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The present research was proceeded to explore the situation of plasma anti-oxidative vitamins (E andC) and lipid peroxidation on sixty no patronize breast cancer patients and 30 salutary women. Alteration in the standard for “total antioxidant capacity”, malondialdehyide (MDA), Nitreic oxide (NO) were temperate in specimen patients influenced through breast tumor. The effect detected that plasma vitamin E and vitamin E regulated for the aggregated of cholesterol and triglycerides diminished significantly in patients group (p 0.01). The grade of (MDA) increment significantly in patients as contract to the control. considerable variation were also spotted amidst patients together (non-metastatic and metastatic) breast cancer according  respects specimen(NO) that were minimize in metastatic by contrast together non-metastatic breast tumor.Keywords: Vitamin C, Lipid peroxide, Total Antioxidant capacity, Nitric oxide.
Dermatoglyphics and Type 2 Diabetes Mellitus: Review Falah S. Al-Fartusie
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Study of epidermal ridges on the skin covers the palmar and plantar surface of hands and soles, and is known as Dermatoglyphics (also known as fingerprints). Dermatoglyphics patterns are genetically determined and are affected by environmental factors in the uterus. After their formation, they remain stable, unchanged, and are not affected by postnatal environment or age. Dermatoglyphics can serve as a reliable marker of individual identification, as they can be a morphological trait, and a mirror to explain genetic and environmental factors in the first trimester of pregnancy. Diabetes is a chronic disease with serious complications if not managed well. In fact, 90% of diabetics are type 2 diabetes mellitus, multifactorial metabolic syndrome. T2DM will not be diagnosed until the long-term complications. Early diagnosis and treatment are very important to prevent long-term complications of the disease (such as retinopathy, neuropathy, nephropathy), and predicting people with high risk of T2DM can be useful in preventing disease and complications. In this review, we will discuss dermatoglyphics, and the main results of researchers who studied Dermatoglyphics for T2DM patients.Keywords: Dermatoglyphics, T2DM, Arch, Loop, Whorl, Ridge count.
The Effects of Varieties Sources of Omega- 3 Fatty Acids on Diabetic Male Rats Eman A. Al-Rekabi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The aim of the present study was to investigate the effects of varieties sources of omega-3 on blood parameters, lipid profile and liver enzymes in diabetic male rats. Fish oil and flaxseed oil were used and the animals were maintained with (0.5ml/animal/day). The results indicated that the treatment of diabetic male rats with fish oil and flaxseed oil caused a significant increase (P<0.05) in Hb and PCV and caused a significant decrease (P<0.05) in WBC in compared with diabetic male rats. The results showed a significant decrease in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and liver enzymes, whereas it explained a significant increase in high density lipoprotein (HDL) of  diabetic male rats treated with fish oil and flaxseed oil when compared with diabetic male rats. The study suggested that fish oil and flaxseed oil especially may be as antidiabetic.Keywords: Diabetic male rats; Omega-3; Fish Oil; Flaxseed Oil; Blood parameters; Lipid profile; Liver enzyme.
Investigation of Melanin in Dermatophytes that Isolated from Primary Schools Students Abbas Abdel Hussein Mohi
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The study was conducted on four types of dermatophytes, including Trichophyton rubrub, T. mentagrophytes, Microsporium audouinii and M.canis. For isolated samples from primary school students under the age of sixteen, samples were collected from different areas of tinea capitis, tinea corporis and then identified the fungal infections to distinguish it from, other infections, such as eczema and traditional sensitivity, the diagnosis was done by direct examination of 10% KOH and then SDACC to observe the fungal structures where Morphological Description was identified. The fungus stimulated the production of melanin dye using a PDA medium for the four species. Melanin was detected in two ways copper silver sulfide (AgCuS) and light microscopy where the melanin was presented in the fungal structures of the hyphae and Conidial. The second method was grown for twenty-one days. Melanin was extracted and the melanin concentrations and carefully were observed using the scanning electron microscopy.Keywords: Melanin; Primary school; and Dermatophytes
Synthesis and Identification of New Macrocyclic Ligand and Study its Pharmaceutical Properties as Anti-bacterial Reagent by Using Molecular Docking Study Ali M. Mohamed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The macrocyclic ligand (5, 7, 12, 14-tetraisobutyl-5, 12-dimethyl -1, 4, 8, 11-tetraazacyclotetradeca-7, 14-diene) was prepared by the reaction between ethylene diamine and 4-methyl pentan-2-one with the help of the perchloric acid as a precipitant reagent. It characterized by FTIR, 1HNMR and UV –Visible techniques. The prepared macrocyclic ligand combine with protein by the application of molecular docking study and it compared with a well-known and standard drug which is gentamycin. The results indicated that the recorded compound is very effective against the toxic bacteria on its cell area and may be in the future become an effective treatment regent by conduct further studies.Keywords: Macrocyclic ligand, Molecular Docking, Gentamycin, Staphylococcus aureus.

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