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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Quality of Dried Gourami (Osphronemus gouramy) under Different Drying Methods Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Fish is an important source of high-quality protein essential for human consumption. Fish is a highly perishable foodstuff with a very short shelf life. Drying is a complex thermal process in which unsteady heat and moisture transfer occur simultaneously. The drying process effects on protein quality and composition of fish. Gourami (Osphronemus gouramy) has high nutrient content. However it has a short shelf life. It’s necessary to remove its moisture content via drying. In our current study, the effect of different drying methods such as sun drying, microwave drying and oven drying to the quality of dried gourami (Osphronemus gouramy) was investigated. Results clearly revealed that microwave drying was the best selection to get a perfect dried fish quality for a long term storage.Keywords: Osphronemus gouramy, Sun drying, Microwave drying, Oven drying, Water activity, Histamin, Aerobic plate count, Shelf life.
DFT Method, Molecular Orbital’s, and Electronic Spectra Study for Characterization the Biological Activity of New Ebselen [2-phenyl-1, 2- Benzisoselenazol-3(2H)-one] Derivatives Ahmed Abdul Sattar Ali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Glutathione peroxidase (GPx) is one of the most potent antioxidant enzymes that is based on the selenium metal ion in the active site and plays an important role in reducing hydrogen peroxide and lipids. As low levels of GPx lead to an increase in hydrogen peroxide levels and thus cause direct damage to living tissue and many diseases infection. The number of selenium-containing compounds has been developed for their ability to treat or minimize peroxides. Ebselen “2-phenyl-1, 2- benzisoselenazol-3(2H)-one” is one of the most promising compounds as an antioxidant and have been shown to mimic the glutathione peroxidase activity in vitro. In this paper, seven different chemical derivatives of ebselen (a compound scientifically proven as an antioxidant) were designed by replacing or adding chemical groups and studying the effect of these changes on the behavior and effectiveness of the compound by studying the electron density of the central atom (selenium), HOMO, and LUMO. The stable geometrical shape of the compounds was also determined by calculating frequencies, bond energies and ion extraction for derivative compounds. On the other hand, the polarity of these derivatives and their solubility were calculated as well as the calculation of the Mulliken charge and electronic spectra measurements “infra Red (IR), UV-visible”. Some of the compounds were characterized by having a better biologic effect than Ebselen while some of the derivatives were reversed.Keywords: Glutathione peroxidase (GPx), Ebselen, HOMO, LUMO, Density Functional Theory (DFT), Becke3-Lee-Yang-Parr (B3LYP).
Synthesis, Characterization and Spectrophotometric Studies of New Hydrazone Derived from Ethyl benzoate Sajid H. Guzar
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present work includes synthesis and characteriation of new hydrazone derived from ethyl benzoate. Firstly, benzoate hydrazide [A] has been synthesized from the condensation of ethyl benzoate with hydrazine.Then the benzoate hydrazide was reacted with phenylisothiocynate to prepare [B]. Cyclization reaction of product [B] with sodium hydroxide produced terazole derivative [C].On the other hand, alcylation reaction of compound [C] with chloroethylacetate in the presence of Sodiumacetatetrihydrate  as a catalyst resulted [D]. The acid hydrazide derivative [E] has been synthesized by the reaction of compound [D] with hydrazine hydrate . Finaly,  hydrazone derived [M] was synthesized by the condensation reaction of the acid hydrazide [E] with 5-bromo-2-hydroxy benzaldehyde . The synthesized compounds were characterized by UV-Visible, FT-IR, 1H-NMR ,13C-NMR and Mass spectra. Analytical spectrophotometric study of the complexes  of Lead (II),Cobalt(II) and Cadmium (II) with the hydrazone[M]  was achieved. At a pH value of 7.0. lead, cadmium and cobalt salts reacted with [M] to form a 1:1 yellow, 1:1green, and 1:1 viole complexes  with absorption peaks at 397, 389 ,and 396 nm, respectively. Under the optimal conditions, Beer’s law was obeyed over the ranges  of 0.01- 0.000001 The apparent molar absorptivity and Sandell’s sensitivities were 8.5 ×102,8.0 ×103, and 9.8 ×102 L·mol−1·cm−1 respectively, and 0.00964, 0.00600, and 0.00275 µg·cm-2 respectively. The detection limits were found to be 32.75, 41.85, and 40.66 µg/mL-2 respectively.Keywords: Hydrazones Schiff base, Ethyl benzoate, Analytical studies. Introduction
Chemotaxonomical Study of Some Species Belonging to the Genus Scabiosa l. (Dipsacaceae) in Iraq Khazal Dh. Wadi Al-Jibouri
Journal of Global Pharma Technology Volume 11 Issue 07
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The current study is a comparative chemotaxonomical study of five species species belonging to the genus Scabiosa L. from Dipsacaceae (Caprifoliaceae) ,wildly grown in Iraq which are S.palaestina L., S. calocephala Boiss ,S. persica Boiss., S. leucactis Patzak. and S. brachycarpa Boiss.et Hoh. The study done by using Gas Chromatography Mass Spectrometry (GC-MS), the results helped in isolation species by distinguishing them with their own chemical compounds. All the studied species participated in a single chemical compound Oleic Acid, but the species varied in the number of chemical compounds. S. brachycarba contains (18) chemical compounds, S. leucactis contained (14) compounds, S. persica recorded (21) compounds and S. calocephala contained (28) compounds which was the highest among the studied species and the record (6) compounds in the S. palaestina, which was the lowest species. The species varied in distinguished compounds of each species, S. persica was distinguished by (4) chemical compounds S. brachycarba (3) distinct compounds while S. leucactis was characterized by (4) compounds, whereas S. calocephala (4) compounds and finally S. palaestina characterized by a single compound.Keywords: Scabiosa, Dipsacacea, Chemotaxonomy.
Association of TCF7L2 Gene with Familial Combined Hyperlipidemia in Diabetes Mellitus Type 2 Females Iraqi Patients Najwa Sh Ahmed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Genomic polymorphisms of transcription factor7 like 2 {TCF7L2} gene are scanned to be powerfully related to diabetes mellitus type 2 (DM2) in female Iraqi population. The point of this examination was to break down the relationship of TCF7L2 gene polymorphisms with DM2 in a very female populace of Iraq. Familial combined hyperlipidaemia (FCHL) is described by hypercholesterolaemia, hypertriacylglycerolaemia, or both. Also, instabilities in glucose metabolism are normally realized in FCHL. Thus, we guessed that TCF7L2 may add to the genetic  defenselessness for this basic dyslipidaemia.. Techniques: 70 DM2  female patients and 60 healthy samples were chosen for the current study. Has been conducted designedly of one primer for amplification to scan the gene and using PCR technique with sequencing. We examined the impact of the TCF7L2 variations on FCHL and its segment characteristics triacylglycerol (TG), apolipoprotein B (ApoB) and  total cholesterol (TC). The Results: For total participants, the (T/C vs. TG + GT) were significantly greater in samples with DM2 than in healthy controls, and FCHL, TC, ApoB or glucose for DM2 were associated with T>C and G>T .This result revealed that the risk of DM2 was raised by the existence of the T>C and G>T genotype of TCF7L2 gene in Iraqi female. The frequency  of the T allele in TCF7L2 gene was greater in DM2 patients than in healthy samples. Conclusions: Our analysis proposed that the genetic polymorphisms of TCF7L2 were significantly related with high T>C and G>T in FCHL families with DM2 in the female populace of Iraq.Keyword: DM2 ;TCF7L2; FCHL; Hypertriacylglycerolaemia.
Synthesis of New 2, 4, 5-triphenyl imidazole Derivatives Derived from benzoin and Studying their Biological Activity Rana S. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this work a series of new 2, 4, 5-triphenyl imidazole derivatives were synthesized. In the beginning, compound [1] was formed from the reaction of benzoin and benzaldehyde in the presence of ammonia, which was reacted with sodium hydride in DMF to obtain imidazole salt. This salt was reacted with adipoyl chloride to give compound [2]. Acid hydrazide derivative [3] was obtained from the reaction of compound [2] with hydrazine hydrate.  After that Shiff bases [4-9] have been synthesized from the reaction of compound [3] with different aromatic aldehydes. These new formed compounds were diagnosed by 13C-NMR, 1H-NMR for some of them (in Ahl-Albate University in Jordan) and FT-IR spectroscopy (In Baghdad University). All of the prepared products have been studied their biological activities toward two kinds of bacteria. These products showed good efficacy to moderate toward bacteria.Keywords: Imidazole, Shiffs bases, Biological activity.
Animal Model of Pancytopenia and Bone Marrow Function Diagnosis of Domestic Rabbits Mohammed E. Mansur
Journal of Global Pharma Technology Volume 11 Issue 07
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The present research aims at showing the effects of extracts of some plants seeds (Nigella sativa, Medicago sativa, Eruca sativa, Ocimum basilicum, Vitis vinifera, Portulaca oleracea) in animals that are induced by a type of drug Azathioprine as animal model of pancytopenia. Several reports have shown that plant extracts are used as an alternative to chemotherapy in many cases of diseases. The research was conducted on forty white rabbit (five weeks old), after weaning, weighing between 500-700 grams, the method of work included eight groups, the numbers of blood cell types that indicate the effectiveness of bone marrow were measured ( RBC, WBC, Thrombocytes, IRF, IPF,IGs, Schistocytes, reticulocyte and ANC),the extracts showed different effects in terms of their ability to improve or re-develop bone marrow to produce blood cells, Ocimum basilicum extract showed a higher effect than the rest of the extracts in pancytopenia treatment, which gave a clear effect on improving bone marrow efficiency.
Screening for Heme Oxygenase Enzyme among Clinical Isolates of Escherichia Coli Isolated from Urine Sample Murtadha K. Alkreami
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A total of (150) urine sample were obtained from different patient which is (male, female and pediatric) who are suffering from urinary tract infection and are using catheter indwelling, who are admitted to the merjan teaching hospital in Hilla city for a period rang from (July to September 2018), only 36 isolates (24%) were diagnosis as E. coli. Three genes related to heme oxygenase production and transported are studied. These genes are (chuA, chuS and chuT) and the result showed that 26 isolates (90%) from total sample carry chuA in genetic marker and 25 isolates (85%) from total sample carry chuS in genetic marker and only 18 isolates (58%) from total sample carry chuT in genetic marker, and the total positive results of isolates which carry all these three genetic marker in genomic material is only 15 isolates. These (15) isolates were undergone for induction and production of HO-1 enzyme, through detection of beliverdin in chochlate agar and also through estimation free iron spectrophotometrically. The results showed that all isolates gave positive results for enzyme production through production of biliverdin and high levels of free iron when compared to control groups.  Moreover, two different antibiotics are used to show their effect on enzyme activity, and the results revealed that neomycin and ciprofloxacin have an effect on enzyme activity in the presence of imidazole buffer.
Antimicrobial Effect of Blue Light Cure and Antibiotics Combination on Serratia Merasences Isolated from Apical Root Canal Hadeel Mizher Younis
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objectives: To evaluate the phototoxic influence on the serratia merasences potentially by the antimicrobial effect of blue light cure and antibiotics combination. Methods: The growth of serratia merasences samples has been found after being exposed to blue light cure with and without the existence of antibiotics (metronidazole, doxycycline) on the brain heart infusion broth for (15, 20, 35, 60, and 70 sec) and then cultured on mitis media to determine its effect. Results: The present study manifested that the bacterial growth was reduced after the exposure to blue light for (60 and 70 sec) in the absence of antibiotics. While, the combination of blue light laser for (35 sec) with the concentration of antibiotics doxycycline and metronidazole (64 Mg/ml, 128 Mg/ml), respectively has yielded 95% growth inhibition. The result revealed the direct antimicrobial influence of light cure and antibiotics metronidazole, doxycycline) combination on the serratia merrasences isolations. Conclusions: The influence of an antibacterial synergistic between antibiotics and blue light used has been noticed. The blue light cure in combination with antibiotics (metronidazole, doxycycline) applied to the tooth infection could be a substitution to observe as an extra minimum treatment of antibacterial.Keyword: Blue light cure, Antibiotics, Microorganisms.   
Antioxidant and Antimicrobial Activities of Phenolic Compounds Producing from Local Isolate Aspergillus niger Noor Shukur Ahmed
Journal of Global Pharma Technology Volume 11 Issue 07
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The aim of the present research was to examine the phenolic contents; antioxidant and antimicrobial activities of alcoholic extract for Aspergillus niger biomass. The Phenolic compounds were extracted from biomass of isolate by Ethel alcohol, and identified BY using the high performance liquid chromatography analysis (HPLC).  The results were compared with the standard phenolic compounds. This study has found that generally, the biomass extract contains gallic acid, rutin and kampferole. However, the phenolic compounds were extracted by different solvents including: ethyl acetate, methanol and ethanol. The highest concentration of phenolic compounds (264.3.µg/ml) was obtained from the ethanolic extract. Ethanolic extract was screened for antimicrobial activity by using the holes diffusion method against five selected pathogenic bacterial strains which include each of Staphylococcus aureus, Bacillus cereus, Pseudomonase, Escherichia coli, and Klebsella pnuemoniae. We found that compared to G- bacteria, the extract shows high antimicrobial activity against G+ bacteria. On the other hand, Antioxidant activity was determined by measuring the reduction power, and 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging activity. Moreover, we found that the antioxidant activity had been maximizing ethanolic biomass extract (106.1, 92) % respectively, while ethyl acetate and methanol extracts (59.5, 10) % and (49.4, 5.5) % respectively.Keywords: Antioxidants, Antimicrobial, DPPH, Reducing power, HPLC, Aspergillus niger.

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