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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
The Effect of Silver and Titanium Dioxide Nanoparticles on Fungi Isolated from Patients in Babylon City Ali Mahmoud Shaker
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The samples of skin, hair and nail were collected from 50 dermatophytosis patients who are admitting to Marjan Teaching Hospital in Hilla-Babylon province during the period from August 2018 to September 2018. Out of the dermatophytosis patients, there are 32 males and 18 females, the patients age ranges from 15 to >45 years. Potato Dextrose Agar and dermatophyte test medium agar had used for isolation of fungi. For identification of isolated fungi had used microscopic examination after staining the sample with methylene blue. According to the results of this study, the males are 64.3% while females are 35.7% with dermatophytosis patients. The most age groups are between (31-45) years with dermatophytosis recorded (46%). From the result found most cases present in skin 52%. In order to determine the minimum inhibitory concentration of silver nanoparticles, microdilution method was used in 96-well microplates. The concentrations of 1000, 500, 250, 125, 62.5, 31.25, 15.625, 7.81and 3.9 ppm were prepared from silver nanoparticles. From the result was found the IC-50 and IC-90 of SNPs for Trichophyton strains were estimated at 283.78 and 848.76 ppm, respectively. The IC-50 and IC-90 of SNPs for Candida albicans were estimated at 5.77 and 25.99 ppm, respectively. For A. niger, the IC 50 and IC 90 of SNPs were 69.49 and 632.08 ppm, respectively. The IC 50 and IC 90 of SNOs for Mucor were 25.53 and 354.75 ppm, respectively. While In order to determine the minimum inhibitory concentration of titanium dioxide nanoparticles, microdilution method was used in 96-well microplates. The concentrations of 32, 16, 8, 4, 2, 1, 0.5, 0.25and 0.125 mg/ml were prepared from titanium nanoparticles. From the result was found the IC 50 and IC 90 of TiO2 nanoparticles for Trichophyton strain were estimated at 6.89 and 23.63 mg/ml, respectively. The IC 50 and IC 90 of TiO2 nanoparticles for C. albicans were 3.49 and 19.5 mg/ml, respectively. The IC 50 and IC 90 of TiO2 nanoparticles for A. niger were 8.82 and 23.67 mg/ml, respectively. The IC 50 and IC 90 of TiO2 nanoparticles for Mucor were 8.82 and 23.67 mg/ml, respectively.Keywords: Dermatophytes, silver nanoparticles, Titanium dioxide nanoparticles, Minimum Inhibitory Concentration, Aspergillus niger.
Synthesis and Characterization of Heterocyclic Compounds and Polymers with Studying the Biological activity for some of them Dhefaf H. Badri
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This paper deals with the preparation of new monomers and polymers which including heterocyclic unit. The diacid chlorides compounds [1-3] were prepared from the reaction of glutaric acid, adipic acid, terephthalic acid with thionyl chloride.  Succinic acid reacted with ethanol to produce compound [4]. Compound [4] reacted with hydrazine hydrate to obtain succinic hydrazide [5].Compound [5] reaction with CS2 and KOH in absolute ethanol to produce compound [6].The polymers [7-12] have been created by  reacting diacid chlorides compounds [1-3] with compound[5] or [6] in dry pyridine with some drops of DMF. The topology of produced compounds has characterized through their spectral and analytical data as in FT-IR spectra, Thermal analysis [DSC, TGA] and Antibacterial activity investigated using dual bacteria kinds.Keywords: Succinic hydrazides, Oxadiazole, Heterocyclic polymers.
Review on Traditional Use of Nephroprotective Plants in Kerala Praseeda KG
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
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Abstract

Our mother nature is an abundant treasure of medicinal plants. Many of the plants have active constituents like alkaloids, benzoquinones, catechols, carotenoids, flavonoids, glycosides, flavanol glycosides, steroid glycosides, glycoalkaloids, terpenoids, monoterpenoids, diterpenoids, triterpene saponins, sterols and polyphenols which are proved to be having tissue rejuvenation property. Which can be made use in critical conditions like nephropathy which can be curable only with kidney transplantation or dialysis, which are even unaffordable to common man. It will be very useful to isolate active ingredients from easily available medicinal plants which can be effectively used for conditions like Chronic Kidney Disease. India is a country which extensively follows different forms of medications like allopathy, Ayurveda, siddha and unani among them traditional system of medicine is considered to be pretty much important. The biodiversity of India helps traditional healers to explore vast possibility of it. Modern medicine gets ample support by evaluating and isolating natural, semisynthetic, and synthetic derivatives of effective phytoconstituents of herbs. The information’s regarding such medicinal plants is exclusively possessed by certain tribal communities all over India. This article also points towards some plants used by traditional healers of different tribal communities of Kerala.Keywords: Nephroprotective, Herbal medicine, Tribal communities.
Efficacy and Safety of Canagliflozin Compared to Sitagliptin and Glimepride as Add- on Therapy in T2DM Yazan A. Bataineh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Diabetes type II is a progressive disease and associated with many complications. Metformin is the first-line pharmacological therapy for type II. However, there is a second anti-diabetic drug can be added for patients who do not achieve sufficient glycemic control with metformin. In this study, we assess the efficacy and safety of newly approved anti-diabetic drugs Canagliflozin compared to Sitagliptin and Glimepiride patient with type II diabetes. Basically, 210 diabetic patients have received Canagliflozin 300 mg or Sitagliptin 100 mg or Glimepiride 4 mg for at least 16 weeks. Previously, the patient's glycemic state was uncontrolled by Metformin monotherapy. Glycated hemoglobin and Fasting blood glucose changes were used as an efficacy assessment from the baseline after metformin discontinuation. The safety profile was determined by comparing patient’s lipid profile, renal function, BUN, renal function and uric acid. Our results had shown a significant reduction in HBA1c and FBS in the three groups after 4 months of treatment (p <0.05). However, there was no significant change in the reducing effect between the three drugs (p= 0.704, 0.521). Canagliflozin and Glimepiride produce more reduction in triglycerides than Sitagliptin through the treatment period, although it is not significant, the change in the effect was significantly higher in Canagliflozin and Glimepiride comparing to Sitagliptin. Unlike Canagliflozin, Glimepiride and Sitagliptin produce a significant reduction in LDL after 4 months of treatment (p = 0.0318, 0.047) and significant difference in the effect (p = 0.042). Canagliflozin cause a significant elevation in LDL after the initiation of therapy (p= 0.034). The effect of Canagliflozin was significantly higher on HDL comparing to Glimepiride and Sitagliptin throughout the treatment (p = 0.048) and as a difference in the effect (p =0.043). Canagliflozin and Glimepiride produce a significant elevation in BUN comparing to Sitagliptin (p = 0. 004, 003), whereas, Canagliflozin and Sitagliptin produce a higher reduction in GFR than Glimepiride. Glimepiride is significantly elevates serum uric acid comparing to Canagliflozin and Sitagliptin with p= 0.0406. Conclusion: Canagliflozin, Sitagliptin, and Glimepiride are effective add-on therapy with metformin for proper control of blood glucose in T2DM. Canagliflozin and Glimepiride improve TGs and LDL greater than Sitagliptin. Sitagliptin produces less elevation in BUN than Canagliflozin and Glimepiride. Canagliflozin and Sitagliptin required renal monitoring throughout treatment.
Characterizations of Lavender Flowers Extracts and Study of their Effects on Peroxidase Activity and Some Microorganisms Falah S. Al-Fartusie
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Herbal medicinal plants have been used traditionally to treat diseases in addition to commercial use. Therefore, this study is designed to extract the most important components of lavender flowers herbal and study their biological activities against some important species of bacteria and fungi as well as against peroxidase activity. The study also includes a description of Lavender flower extract using UV-Vis and GC-MS techniques. In this study, three extracts (ethanolic, cold aqueous and hot aqueous extracts) were prepared by maceration (1gm/50ml solvent). UV-Vis spectroscopy was revealed peaks embedded in a significant functional range (200-400) nm, which may be attributed to unsaturated functional groups and hetero atoms (S, N, O). The results showed an inhibitory effect of the cold and hot aqueous extracts on the activity of peroxidase. Kinetic study demonstrated that the cold extract caused a non-competitive inhibition while hot extract caused a mixed type inhibition. The kinetic parameters obtained by Lineweaver-Burk plot, in the presence and absence of lavender extracts respectively, indicated that the Km values were (0.0007, 0.001) mM while Vmax values were (95.23, 125) U/L for cold aqueous extract, while the Km values were (0.0028, 0.003) mM, and Vmax values were (80.64, 112.5) U/L for hot aqueous extract. Antibacterial and antifungal effects against isolates in our study showed that ethanolic extract is more potent than aqueous extracts which could be predominantly the result of highly account of active phenolic compounds that presence in Lavender herbal ethanolic extract. The results of the current work support the traditional use of the studied plant and suggest that some botanical extracts, particularly ethanolic extract, have compounds with antibacterial properties that can be used as antibacterial agents in new drugs to treat infectious diseases caused by pathogens. The most effective extracts can be subjected to therapeutic antibacterial isolation and further medical evaluation.Keywords: Lavender; GC-MS; UV-Vis; Peroxidase; Antibacterial; Antifungal.
Effect of Chitosan-Lemongrass Essential Oil-Xanthan Gum Coating on the Shelf Life of White Mushroom (Pleurotus ostreatus) N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Mushrooms (Pleurotus ostreatus) are rich in nutrients, such as minerals, vitamins, amino acids, carbohydrate. They have thin and porous epidermal structure with high respiration rate comparing to other fruits and vegetable. They are highly perishable and lose quality very quickly right after harvesting. Mushroom shelf-life is usually short under normal handling and distribution. Therefore, mushrooms must be taken care to maintain their freshness and commercial value. Chitosan has been found to be non-toxic, biodegradable, biofunctional, biocompatible, antimicrobial and antifungal activities. Lemongrass essential oil has stability properties of water vapor permeability of films made based on chitosan. Xanthan gum is one biopolymer promising for food packaging. Our present research focused on the effect of chitosan-lemongrass essential oil-xanthan gum coating on the shelf life of white mushroom (Pleurotus ostreatus). Results revealed that a composite of chitosan-lemongrass essential oil-xanthan gum coating (2.0%: 2.5%: 2.0%) could maintain the quality and extend the shelf-life of mushroom for 7 days of storage.Keywords: Pleurotus ostreatus, chitosan, lemongrass essential oil, xanthan gum, coating, shelf-life
Estimation of Adiponectin Hormone and Antioxidants Levels in Type 2 Diabetic Patients in Dhiqar Province Ahmed Abdul Redha Jallod
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present study was aimed to investigate the changes associated with type II diabetes in the level of adiponectin and antioxidants: (Catalase, Glutathione, Superoxide dismutase and Vitamin C). Seventy Samples (taken from male patients) were collected in cooperation with the Specialized Center for Diabetes and Endocrinology in the Directorate of Health in Thi-Qar Governorate. The numbers of healthy samples were 30. The results  showed a significant decrease (P≤ 0.05) in the level of adiponectin and antioxidants (catalase, glutathione and vitamin C) in diabetic patients, while it was observed that there was a significant increase in the level of antioxidant superoxide dismutase in diabetic compared with the control group. Moreover, the effect of both the smoking and age on the level of adiponectin and antioxidants was studied. The results showed a significant decrease in the level of adiponectin and catalase in smoking diabetic patients compared to non-smokers. On the other hand, the study showed that there was a significant increase in the level of superoxide dismutase in smoking patients compared to non-smokers.  As for the effect of age, the results showed a significant increase in superoxide dismutase with aging in patients with diabetes, while there was a significant decrease in the levels of both glutathione and vitamin C with aging.Keywords: Diabetes mellitus, Adiponectin, Antioxidants.
Corrosion Protection of Stainless Steel by Electro Polymerization of 4- (2-Hydroxy Benzamido) -4- Oxobut- 2 -Enoicacid and Study its Biological Activity Sana A. Habeeb
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Poly4-(2-hydroxy benzamido)-4-oxo but-2-enoi cacid (PHOE) was prepared by the electrochemical polymerization of 4-(2-hydroxy benzamido)-4-oxobut-2-enoicacid (HOE) monomer on stainless steel (St.S)   asanti -corrosion coating.  Atomic Force Microscope (AFM), Fourier transform infrared techniques (FTIR) and cyclic voltammetry were used to characterize the properties and the structure of the polymer layer.  The corrosion behavior of  uncoated and coated  St.S were estimated from Tafels plots using Potentiostatic  technique in 0.2 M HCl solution as  corrosive environment  at temperature range( 293 – 323) K. Nanomaterials such as  graphene and Nano ZnO in the different concentrations were added to monomer solution to improve the corrosion resistance  of  St.S surface so that  the results showed  that the values of  corrosion  protection efficiency  for  polymeric  coating increase with adding Nanomaterials . In addition the kinetics and thermodynamics parameter were calculated for St.S corrosion   before and after polymeric coating in the acidic medium, moreover, the influence of the prepared polymer on some strains of bacteria was studied.Keyword: Anti-corrosion, Electrochemical polymerization, Stainless steel, Coating, Antibacterial activity.
Preparation and Characterization of Folated Chitosan/Magnetic Nanocarrier for 5-Fluorouracil Drug Delivery and Studying its Effect in Bladder Cancer Therapy Sharafaldin Al-Musawi
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Among the vigorous anticancer factors, 5-Fluorouracil (5-FU) has been presented fantastic capability against several types of tumor cells. Chitosan-covered super paramagnetic iron oxide nanoparticles (CS-SPION) were synthesized and applied as a nano-carrier for loading of 5-FU (CS-5-FU-SPION) through a reverse micro emulsion technique. In the final preparation process the nanosystem was folic acid functionalized (FA-CS-5-FU-SPION) for targeted therapy purposes. This nanoformulation was studied towards bladder cancer cell lines. Each size and morphology characteristic was evaluated by zeta sizer, AFM and FESEM. Fluorescence microscopy was used to determining the cell internalization rate of prepared nanosystem. Cell viability and apoptosis were surveyed by MTT assay and flowcytometry method respectively. The data indicated that the prepared FA-CS-5-FU-SPION has spherical shape with 79 ± 13 nm average diameter size and appropriate polydispersity rate. Additionally, the remarkable drug loading efficiency (~73%) was notable. This FA-CS-5-FU-SPION also demonstrated sustained release of 5-FU at 37 ◦C in both phosphate and citrate buffer solutions separately. Then the MTT assay and flow cytometry study indicated significant cell toxicity and apoptosis induction by FA-CS-5-FU-SPION. The results supported the fact that FA-CS-5-FU-SPION had become greatly represented antitumor characteristics. In the other hands no adverse outcome were reported for normal cells. Furthermore, it became proved that the FITC-labeled FA-CS-5-FU-SPION, has an effectively entrance into cancerous cell and stimulate cell death and apoptosis.Keywords: Nanoformulation, Chitosan, 5-Fluorouracil, Magnetic nanoparticle, Bladder cancer.
Assessing Levels of Domestic Violence among Secondary-School Students in Al-Nasiriya City/ Iraq Maan Hameed Ibrahim Al-Ameri
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Introduction: Violence is the intentional use of physical force against oneself, another person, or groups that result in injury, death, psychological harm, mal-development or deprivation(1). Domestic violence (also named domestic abuse or family violence) is a pattern of behavior which involves violence or other abuse by one person against another in a domestic setting. Child exposure to domestic violence constitutes a prevalent concern nationwide. Over 15 million children are estimated to live in households in the U.S. in which at least one incident of physical domestic violence has occurred in the previous year. Lifetime of childhood exposure rates to physical domestic violence in the U.S. have been projected at approximately 16% (2). Family violence described by the law on protection and treatment of child abuse in the United States which was issued that the abuse and neglect. Minimum is any act of talk or failed to act the part of a parent or caregiver that result in death, harm physical, verbal violence, emotionally dangerous, sexual abuse, sexual exploitation and any act or failure to act resulting in imminent danger of serious harm(3). Objectives: The purpose of the study is to assessing levels of domestic violence among secondary-school students in the Al-Nasiriya city and to find out any association between levels of domestic violence and some demographic characteristics. Methodology: A descriptive study was achieved from October, 20th, 2017 to July, 1st, 2018. A non-probability (purposive) sample of 600 students with age ranged between12 and 18 year was chosen from ten secondary schools (simple random sampling). A designed questionnaire was used for the study and it consists of two parts:  part one contains demographic characteristics of the students which include age, gender, class, residency, income, house, level of education and occupation of father and mother, number of kids and order of kid; part two is the scale domestic violence (Zahra Abdel-Hamezah Hadi, 2013). This part is composed of (39) item and is divided into (3) sections domains; they are verbal violence which is composed of (10) items; Physical violence which is composed of (13) items and psychological violence which is composed of (16) items. The statistical analysis was achieved by using the descriptive statistics: frequency, percentage, distribution and inferential analysis such as Chi2.  Results: Six hundred questionnaires were completed.  60.0% of sample is intermediate. 66.8% of sample is male, 25.3% of the students are in first class, 78.8% of sample is city, 46.3% of sample is monthly  income almost enough, 27.7% of father is secondary graduate and  42.5 of mother is illiterate, 60.2% of sample occupation of father is free work and 88.7% of mother is house keeper. The severity of domestic violence of the participants ranged from mild 54.7% of the verbal violence; moderate 39.3% of physical violence; and mild 34.2%of psychological violence.  Conclusion: The present study revealed that more than half of student are intermediate, and also more than half of the student are male, less than half of student are first class, more than half of student are city, less than half of income are almost enough, less than half of education father are secondary graduate and mother education are illiterate, more than half job of father are free work and job of mother are house keeper. 54.7% more than half of student are verbal violence, 39.3% less than half of physical violence and 34.2% of psychological violence. Recommendation: Necessity to provide for the services rehabilitation victims of domestic violence by supporting the role of social researcher in school and at home. Intensifying programs related to family guidance in order to increase family awareness through the various media. Urge concerned parties to establish laws legislation and deterrent systems to deal with cases of domestic violence. To spread awareness among the members of the community about the seriousness of this phenomenon.Keywords: Domestic violence, Student, School, Nasiriya city.

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