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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Synthesis, Characterization and Antibacterial Activities of Some Heterocyclic Compounds from valproic Acid Drug Ahmed Yousif Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

With a view to reducing the acidic effect of valproic acid, its carboxylic group has been recoated to produce 5-membered and 6-membered heterocyclic rings. Heterocyclic derivative as -Thiadiazole, Imidazole, -Oxazine, Quinazoline, Pyrazole and Oxadiazole. Derivatives of valproic acid were prepared by cyclization under different reaction states to produce a good yield. The microbial inhibitory effect of these compounds was assessed in vitro against Gram-positive and Gram-negative bacteria as well as tested against two strains of bacteria (Escherichia coli and Staphylococcus aureus compared with starting material. Compounds (4, 5, 8) showed the highest antibacterial as well as antifungal activities. All compounds have been characterized by IR, 1H NMR and C.H.N analysis.Keywords: Valproic acid, Thiadiazole, Imidazole,-oxazine, Quinazoline, Pyrazole, Oxadiazole, biologically active compounds.
He-Ne Monochromatic Light with Selenium nanoparticles as Medical Technique Hassan Tuhmaz
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

In this study, the photo-thermal dealing of cancer with Se nanoparticles is studied. This processes for tissue under the influence of heat by a laser source with dose injection the selenium nanoparticles on the affected area. The bio-heat equation is solved by numerical simulation methods. Results are summarized in the effect on the increase of temperature at different time stages. These results appeared that the depth diffusion increasing heat raising during the increasing the time duration of exposure. Thus, it concludes the peak value of depth with controlled temperature.Keywords: Selenium nanoparticles; Heat raising; Medical technique.
Efficacy of Ultrasound on Pre-fermentation Maceration in Red Dragon Fruit Winemaking Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Ultrasound has recently been applied to evaluate the possible effect on color and flavor extraction at different stages of the winemaking process. Red color and aromatic compounds are localized in the skin cells and their release is facilitated by mechanical actions, disruption of tissues and cells, temperature and alcohol. Red dragon fruit has various nutrients, vitamins and minerals and medicinal values. Our present research focused on the effect of power and time of ultrasound as pretreatment maceration in red dragon fruit winemaing. Results revealed that using ultrasound power 270 w in 20 minutes as a pre-treatment on crushed red dragon fruit for the extraction of polyphenol, aromas. The application of ultrasounds allowed a significant reduction of the maceration duration and to get high-quality wine with high alcohol content, total phenolic, and good sensory characteristics.Keywords: Red dragon fruit, Ultrasound, Maceration, Power, Duration, Winemaking.
Spin Compensation Temperatures in the Mean-field Theory of a Mixed Spin-3/2 and Spin-7/2 Blume-Capel Ising Model Hadey K. Mohamad
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this research it has been constructed the ground-state phase diagram of a mixed spin-3/2 and spin-7/2 Blume-Capel Ising system on a square lattice in theplane. Magnetic phase transitions, in a molecular based magnet, are tested using mean field method (MFM). The equilibrium magnetizations can be achieved by minimizing the free energy which is vital for locating and spin compensation points as well. By utilizing mean field theory (MFT) on principles of Bogoliubov inequality of the free energy, it has been investigated the spin compensation phenomena. In particular, characteristic ferrimagnetic features have been shown depending on the negative values of the different single-ion anisotropies, acting on the atoms and atoms, respectively.Keywords: Blume-Capel Ising model; Ground-state phase diagram; Compensation temperature; Magnetic free energy.
Ability of Staphylococcus spp. Isolated from Meningitis Patients to Adhesion Luma Abdulhady Zwain
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A total 248 clinical samples of cerebrospinal fluid (CSF) were collected from meningitis patients, for the period of July to October 2018 from the Child Protection Teaching Hospital in the Medical City Compound in Baghdad. All isolates were identification depending on macroscopic, microscopic, biochemical tests and definite with Vitek-2 compact system. The results showed a growth in 42 samples.  Sixteen isolates of Staphylococcus spp. were obtained from samples .The number of the percentage of isolates according to species as follow: 7/16) 44%) of S. epidermidis, 3/16 (19%) of S. hominis, 3/16)19%) of S. haemolyticus, 2/16 (12%) of S. aureus, 1/16 (6%) of S.warneri. The ability of isolates on adhesion were studied and the results showed the use polystyrene plates, that the number of adherent cells of S. epidermidis was 230 cells / field, S. hominis was 62 cells / fields, whereas S. aureus was 3 cells / field, while in S. haemolyticus >300 cells / field, finally the number of cells in each field of S.warneri reached 40 cells / field.  In use epithelial cells (Vero cell line), the results of our current study we observed that, the number of all Staphylococcus spp. in zero dilution were >300 cfu. and  S. epidermidis, S .hominis, S. aureus, S. haemolyticus , S. warneri were (85,120,>300 , ,>300  ,>300 )cfu respectively   at 1:10 dilution, while  at the dilution 1:100 the number were(9,30, >300, >300 ,292)cfu respectively.Keywords: Staphylococcus spp., Meningitis, Adhesion.
Electrosynthesis of Polythiophene/Cr2O3 Nanocomposite as a Model of Health Topics (Water Treatment) Hanaa Kadtem Egzar
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A Nanocomposite film consisting of Cr2O3 and polythiophene (PT), has been successfully fabricated on a stainless steel substrate (SS) by a simply electrochemical deposition method. The fabrication mechanisms are based on electrolytic deposition ELD method of Cr2O3 thin film and electropolymerization deposition of PT. The papered Cr2O3 and PT/Cr2O3 were characterized by FT-IR, FESEM, TEM, XRD, and Raman spectra. Electrochemical degradation of Reactive Blue 4 (RB4) was studied by Cr2O3 and PT/Cr2O3 coated anodes in the existence of sodium chloride as a supporting electrolyte to investigate the effect of polythiophene /Cr2O3 Nano composite coating. The color removal efficiencies were 51.7% and 92 % respectively for above anodes, after 25 minutes of electrolysis at applied potential 3V.Keywords: Nanocomposite, Electrolytic deposition, Electrodegradation.
Indirect Method for Determination Desferal in Pure and Pharma-ceutical Formulations Using Cerium (IV) As a Chelating Element Ashraf Saad Rasheed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: The present study includes indirect analytical method for the determination of the drug desferal (DSFM) in some pharmaceutical dosages using molecular absorption. DSFM was usually used for treating such diseases like Thalasemia and Alzheimer. Methods: The proposed method is built on reaction between DSFM and cerium (IV) ion to forms an orange chelate complex (λ max = 443 nm) at pH 6. Results: The optimal experimental condition for the chelate formation: pH=6; concentration of Ce(IV) (30 mg L-1); maximum reaction time (10 min.); lmax=443 nm; metal -to- ligand (1:1) ratio.  Analytical figures of merits: linear dynamic range (1-110) mg L-1; r = 0.9996, S = 0.9996 mg.cm-2), D.L (0.167) mg L-1; Erel. % 1.26; recovery% 100.2; RSD% 1.460.Conclusion: The developed method was successfully applied to the estimate of DSFM in pharmaceutical samples.Keywords: Desferal, Spectrophotometric, Cerium sulfate tetrahydrate, Pharmaceutical dosages.
New Diquinazoline Derivatives: Synthesis and Evaluation of Anti-Bacterial Activity Ameer A. Hussein
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Oxazine and quinazoline has a very important in organic chemistry especially in hetero cyclic fields. this research consist the preparation of 4H,4'H-2,2'-bibenzo[d][1,3]oxazine-4,4'-dione compound (1) from di acid chloride with 2-aminobenzoic acid in pyridine as solvent to give compound (2) 3,3'-diamino-2,2'-biquinazoline-4,4'(3H,3'H)-dione .compound 2 include free amino group .this compound was reacted with maleic and phthalic anhydride for synthesized of cyclic imide compounds (3,4).another reaction for compound 2 with some substituted aromatic aldehyde for prepared of some novel Schiff bases (5-9) contains quinazoline ring. compound 1 was treated with sulfathiazole and sulfadiazine for synthesized of sulfa compounds contains sulfone amide groups (10,11).compounds (12,14) were prepared from the reaction of  4H,4'H-2,2'-bibenzo[d][1,3]oxazine-4,4'-dione with some primary amine p-aminoacetophenone ,p-amino acetanilide to product of (12,13) but compound 14 was prepared from reaction of of compound 1 with 3-amino-2-phenylquinazolin-4(3H)-one to give compound 14 consist four rings of quinazoline. all synthesized compounds were measured for antibacterial activity and the structures of quinaolines were confirmed by thin layer chromatography, melting points ,Fourier transform infrared, H-NMR, elemental analyzer.Keywords: Dioxazine, Diquinazoline, dicyclicimide,antibaterials.

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