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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Ameliorative Role of Vitamin C against Toxicity by Food Additive in the Male Rats Afyaa Sabah Nasir
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Food additives are widely used in the food for example MSG present in variety types of food so the current study is proposed to evaluate the protective role of vitamin C in the male white rats for 30 days. The results showed the significant increase (p<0.05) in the levels of liver functions tests and lipid profile as well as significant decrease (p<0.05) in the biochemical parameters include total protein and albumin. Also, the histological examination for liver tissues demonstrate the histopathological change include degeneration, bleeding and necrosis. So that, the results appear MSG is highly toxic and treatment with vitamin C can to decrease the toxic effect for MSG in the biochemical parameters and histological changes in the liver tissues.Keywords: MSG, Liver functions, Vitamin C and rats.
Determine The PH Domaine of PLC-gamma in the Egg of Starfish during Fertilization Rana Hussein Naser
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The PLC gamma function in fertilization has been indispensable over the years of researches. The fertilization and the insight communications with the human beings, plants and animals started from the beginning of human life. In this study, the PH-domain of PLCγ will be fused with GFP and this PH-GFP fusion protein will be used for localization studies in the starfish Patiria miniate.Keywords: Domaine; PLC-gamma; egg; Fertilization
Evaluation of Antioxidant (GSH, CAT, SOD) and MDA in Iraqi Women with Breast Cancer Mohammed Ayyed Najm
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Oxidative stress is considered to be involved in the pathophysiology of all cancers. The aim of this study is to examine oxidative stress and antioxidant status in patients with breast cancer by evaluation of the serum levels of lipid peroxidation products as malondialdehyde (MDA) and glutathione, catalase, Superoxide dismutase (GSH, SOD, CAT) of 30 new diagnoses with malignant breast cancer in and 30 healthy women were determined. Significant high levels of GSH, SOD, CAT were detected in control compared to patients with breast cancer (p<0.0001). Serum MDA levels of the patients were higher compared to the controls (p<0.0001). Keywords: Breast Cancer, Malondialdehyde, Catalase, Superoxide Dismutase, Glutathione.
Synthesis and Characterizations of Chitosan/EDTA/PVA Nanofiber for Antimicrobial Applications Ammar M. Hamza
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The aim behind this study was to fabricate thermally crosslinked Chitosan. (CS)/ Ethylenediaminetetraacetic acid (EDTA)/ Poly (vinyl alcohol) (PVA) and pure chitosan as nano fiber mats. The CS/EDTA/PVA nanofibers and/or pure chitosan were prepared using elctrospinning technique. The suitable cross linking ratio and cross linking times for CS/EDTA/PVA nanofiber were look into. The scanning electron microscopy and X-ray Diffraction was utilized to investigate influence of adding polymers to chitosan on the morphological and diameter of the nanofiber. The FTIR was carried out to evaluate the spectroscopic properties and functional groups which present in the compounds. The antimicrobioal test was examined by using Staphylococcus Aureus which is a spherical gram-positive bacterium and common test for antimicrobial applications. The result of antimicrobials test was made the CS/ESTA/PVA as nano fiber is viable materials for biomedical applications.Keywords: Antibacterial, Biopolymer, Nanostructure, Physical properties.
Cloud Point Extraction for the Separation, Preconcentration and Spectrophotometric Determination of Trace Copper (II) In Herbal Plants Samples Using New Synthesized Reagent Azhar A. Ghali
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

A new Cloud point extraction method was showed determination and preconcentration of copper in plant and herbs. The final products of analysis are complex of Cu (II) with new reagent is 6-(4-bromophenylazo) m-anisidine [6-(4BrPAA)]  in Triton X-114. Centrifuge is used after that, then the surfactant-rich phase is diluted by ethanol (1.5) mL after separation. Then measurement of the copper was done by spectrophotometry at 512 nm. The complexing agent concentration, pH, Triton X-114, centrifuge rate, time and temperature are important analytical parameters. The used analytical methods in the study are included limits of detection, molar absorptivity, linear range, quantification and sandell sensitivity, factors of improvement and preconcentration. Linear range was (0.007-1.50) μg mL-1 of Cu (II). The quantification limits and detection were (0.0199 and 0.0059) μg mL-1 of Cu (II), consequently. The cations and anions influence was examined; it is represent the method which used for evaluation the copper amount in the herbal plants samples.Keywords: Copper (II); 6-(4-bromo phenylazo) m-anisidine [6-(4BrPAA)]; Triton X-114; spectrophotometry; Cloud-point extraction.
Impact of Sub-Minimal Inhibitory Concentrations of Ciprofloxacin, Amikacin and Gentamicin on the Production of Staphylococcus aureus β- Toxin ʺThe Biofilm Ligaseʺ Thikra Adnan Jawad Banimuslem
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Beta toxin (β- toxin) plays an important role in Staphylococcus aureus infections by two mechanisms: sphingomyelinase cytotoxic activity and biofilm ligase activity. The biofilm ligase activity is considered as a promising property for biofilm matrix establishment. The present study investigated the influence of sub minimal inhibitory concentrations (sub-MICs) of ciprofloxacin, amikacin and gentamicin on the capacity of S. aureus (wound isolates) to produce β-toxin and form biofilm. After determination of the MIC for each antibiotic, bacteria were grown in sub-MICs of these antibiotics then the ability of beta hemolysin production and biofilm formation were evaluated. The results indicated that 1/8 MICs of all antibiotics have induced  β- toxin  and biofilms whereas  the 1/2 MICs were inhibitory and a high correlation between the  β- toxin  production and biofilm formation has been observed in all isolates under the influence of antibiotics, when the  β- toxin decrease, the biofilm also decrease.Keywords: S aureus, β- toxin, biofilm, sub-MIC, ciprofloxacin, amikacin, gentamicin.
A Morphological Study and a New Species Registration of Genus Xerophloea Germa, 1839 Sp.nov. From sub-family Ledrinae Fairmai, 1855 of the Leafhopper (Hemiptera: Cicadellidae) in Iraq Rawa&#039; J. H. Al-Kaissy
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The external morphology was studied and registered for a new species of genus Xerophloea Germa, 1839 where the samples were collected during the seventh month in 2018 of the Adhamiyah region in Baghdad city, Iraq and 3♀ using the light trap. The samples were diagnosed using taxonomic keys and the parts of insect were described and photographed successively, the adult insect, vertex, head, pronotum, mesonotum, abdomen, the front wing, as well as female genitalia, using Lucida’s camera.Keywords: Hemiptera, Cicadellidae, Ledrinae.
Telmisartan Spongelike Particles as Oral Capsule II: Factors Affecting Formulation Hussam H. Tizkam
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Telmisartan  (TEL) is selective angiotensin II receptor blocker sued in the management of cardiovascular disorders. It is a class II drug according to Biopharmaceutics Classification System (BCS). The aim of current study is to prepare TEL sponge like particles (SP) as a drug delivery system and investigate the different variables that may affect the formulation in order to enhance the solubility and dissolution rate thereof. The TEL SP formulations were prepared by quasi-emulsion solvent diffusion method using Eudragit E100 as SP forming polymer at drug: polymer ratio of (5:1). The effect of solvent type of internal phase, internal phase volume, stirring rate, stirring time, plasticizer concentration, surfactant concentration, external phase volume, and drying temperature on the formulation of TEL SP were investigated. Twenty five TEL SP formulations were prepared and filled into hard gelatin capsule. They were investigated and characterized for production yield, loading efficiency and in vitro drug release in 0.1N HCl (pH 1.2). Results showed that the best TEL SP formula was F15 which was prepared using 5ml of dichloromethane (DCM) as an internal phase solvent, 0.05 g of polyvinyl alcohol (PVA) as a surfactant, 1 g of sodium chloride as a porogen, 1 ml of glycerol as a plasticizer, 200 ml of water as an external phase solvent, 1000 rpm for 1 hr as the stirring rate and time, and 40 0C as a drying temperature. The F15 showed good production yield (82%), loading efficiency (73%), and fast dissolution rate in 0.1 N HCl (more than 80% drug release in less than 15 min). The in vitro release study showed that F15 had significantly better release characteristic (p < 0.5) when compared to both the pure TEL and the reference commercial tablet Micardis®. Finally, one can conclude that the SP technology can be a promising alternative way for the formulation of poorly water soluble drugs, such as TEL, into immediate release formulation.Keywords: Telmisartan, Sponge like, solubility, Eudragit E100.
Preparation and Characterization of (PMMA-PVC-MWCNTs) Nanocomposite for EMI Shielding Application Hatam Mohsin Shareef
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The (PVC-PMMA-MWCNTs) nanocomposites have prepared by Solution cast technique with different concentrations of CNTs (0, 0.5, 1, 1.5, 2, 2.5), casted in a clean glass plate. The structures of nanocomposites have been studied. The structural properties include Fourier Transform infrared spectroscopy (FTIR), scanning electron microscope (SEM). The effect of  radar in the range (8-12) GHZ  on (PVC-PMMA-MWCNTs) nanocomposite films, were studied as applications for shielding from Electromagnetic Interference (EMI), and has been noticed that the shielding effectiveness increases with the increase of concentration of MWCNTs.Keywords: Blend polymer, Cast method, MWCNTs, PMMA, PVC.
Physicochemical Analysis of Nephelium Lappaceum Seed Fat and its Application in Topical Formulations Gouri Kumar Dash
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Nephelium lappaceum L. (Family- Sapindaceae), popularly known as ‘Rambutan’, is well known for its edible fruits with delicious taste and flavour in Southeast Asia. The fruits are deseeded during processing in the canning industry and considered as a waste by-product. The seeds contain good amount of fatty material and has been claimed to be a source of natural edible fat. The objective of the study was to report the physicochemical parameters of the seed fat together with formulation of few topical preparations such as creams and lotions containing the seed fat that would offer new prototype formulations containing natural ingredients. The physicochemical analysis of the seed fat such as melting point, saponification value, acid value, ester value and peroxide value were studied. The GC-MS analysis of the seed fat was carried out to find its chemical composition. Further, two topical preparations such as creams and lotions were prepared using the seed fat and evaluated using standard recommended procedures. The seed fat was compatible to be used as an ingredient in the bases of creams or lotions. Keywords: N. lappaceum seed fat, Physicochemical analysis, GC-MS analysis, Topical formulations

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