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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Can Maternal Age at Menopause Predict Daughters Antimullerian Hormone in Babylon? Hanan Abduljabbar Al-Taee
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: daughter fertility potential is possibly related to her mother fertility and age at menopause. This study aims to determine any relationship between maternal age at natural menopause with anti mullerian hormone of mid reproductive age daughters. Design: questionnaire survey and blood sample of women attending gynecology clinic in Babylon\ Iraq from June 2014 - July 2018 .Subjects and Methods: this cross sectional study, collected questionnaire data from 106 (N=106) mother daughter pairs who fulfilled the study inclusion criteria out of a random population. For this analysis, young women (daughters) between the ages of 16 and 35 years, who provided a blood sample for anti mullerian hormone and their mother’s age at natural menopause were selected. Assessment of relationship between maternal age at menopause and their counterpart daughter anti mullerian hormone was done. Result: Person correlation for association of mother age at natural menopause with daughter anti mullerian hormone shows insignificant association. Conclusion: our selected mother-daughter pairs show no association between maternal age at natural menopause and serum anti mullerian hormone level.Keywords: Maternal menopause, Anti mullerian hormone (AMH), Fertility, Mid reproductive age women.
Synthesis, Spectroscopic Characterization, and Biological Evaluation of Some Transition Metal Complexes from C16H19N3O3S Ligand Sura K. Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

A first series of transition metal complexes were synthesized from the ligand Methyl -6- [2-(benzyl ideneamino) -2- (4-hydroxyphenyl) acetamido]-2, 2-dimethyl -5-oxo-1-thia 4-azabicyclo [3.2.0] heptane-3-carboxylate with appropriative metal salts. The complexes were characterized by spectral methods such as FTIR, Uv-Visible, and Atomic absorption as well as some physical properties, molar conductivity and magnetic moment measurements. The results showed that the proposed structures of these complexes are Octahedral, except Co II is a tetrahedral geometry. The biological activities of these complexes were studied using two types of bacteria (Staphylococcus aures, Echerchia coli) in addition to Candical albicans c. albicans that gave results a good activity than the free ligand.
Absorption Resonance Energy Transfer between Organic Dyes (Cumarin and Rohdamain ) Wajeha Abdle Diam
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The spectral properties absorption of two laser dyes types, C480 and R610, the mixture was investigated. These types  of laser dyes  belong to Coumarinoids  and  Xanthenes  family were dissolved  using  ethanol  as solvent to prepare samples with range of ratios (1:1,  1:2,  1:3 and 1:4)  from  Cumarin  480 (C48) to Rohdamin 610 (R610) concentered in (10-410-5,10-6) M/L at room temperature. The achieved results pointed out an increase in the absorption intensities with the increasing of the concentration of the day type R610 from 10-6 and 10-5 to 10-4   M/L.the same thing for C480which are absorved in agreement with Beer-Lambert law and the finished results Pointed that  the absorption peak was moved toward the short wavelengths (BLUE SHIFT) when increasing the ratioconcentration.  Keywords: Dye laser, Fluorescence resonance energy transfer, Silica gel matrices. Absorption spectrum.
Incorrect Use of Antibiotics Asmaa Khalid Salman
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The present study aims to determine the information about the safe and appropriate antibiotic which can be utilized among the undergraduate students of medical and dental colleges. The formula that was applied in the current study was an integrated self-administration approach. We found that dental students were more aware of the instructions provided by the doctor. They resorted to specialized assistance from healthcare professionals. Nevertheless, the observed difference between males and females in the medical profession in this study was significant where the females were more aware of self-medication compared to males. Furthermore, The findings of this research provide evidence about the self-medication prevalence. There was a sudden increase in the misuse of antibiotics other than being used for medicinal purposes. In dealing with this challenge, relevant healthcare bodies can play an important role in ensuring that self-medication is curbed through effective regulatory mechanisms. At the same time,  they can offer information about the proper use of medications and various kinds of prescriptions.Keywords: Self-medication, Dental students, Antibiotic resistance.
Determination of Residual Monomer in Heat Cured of Acrylic Resin Denture Base Material after strengthening it with Titanium Nanotubes Sahar Abdulrazzaq Naji
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Objectives: The objective of this introductory study was to investigate, for the first time, the impacts of incorporation of titanium nanotubes to polymethyl methacrylate (PMMA) on the remaining monomer content of the  of PMMA denture base. Methods: Forty-five specimens of heat polymerizing acrylic resin were prepared according to ISO 20795-1:2013. Divided into three groups (n=15) Methyl methacrylate was mixed with 0% (control), 2.5 weight %, and 5 weight % titanium dioxide nanotubes. TiO2 nanotubes were prepared using alkaline hydrothermal process. Gas Chromatography analyses GC-MS was used as an analytical monitoring method to quantify the remaining monomer in the cured samples. Data  were analyzed using ANOVA and Tukey's test (p < 0.05). Results: residual monomer content significantly reduced in both modified groups with TiO2 nanotubes 2.5and 5w% (0.0783,0.1407, %) respectively) compared with the unmodified group (0.1567%). Conclusion: supporting of acrylic cured acrylic denture base with TiO2 nanotubes reduces the residual monomer content significantly, which improves the physical, chemical and biological properties of the acrylic denture base material.Keywords: Acrylic resin; GC-MS; Methyl methacrylate; Residual monomer; TiO2 Nanotubes.
Evaluation PAHs Contamination Level in the Breast Milk of Women in Al-Diwaniyah city, Iraq- a Case Study Faiq F. Karam
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Human milk is an important bio indicator for the exposure with some pollutants like polycyclic aromatic hydrocarbons. Breast milk samples from 68 women were live in Al-Diwaniyah city were collected in this study. Thirteen of poly cyclic aromatic hydrocarbons were investigated in all samples using gas chromatography coupled with mass spectroscopy. The samples were divided into three groups according to the age range (less than 20 years, 20-30 years and 31-40 years). Eight samples were the control for this study from the rural mothers. The mothers were all them non-smokers. The samples were collected during 2017 from different regions located in Al-Diwaniyah City.Keywords: Breast milk, Polycyclic aromatic hydrocarbons, Pollution in Al-Diwaniyah City, Gas Chromatography, Exposure to pollutants.
Morphometric Assessment of the Cerebellum of the Pre-implanted albino Rats Embryos after Maternal Exposure to AgNPs Israa Hassan Ali
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Cerebellum (cb) is the most important and sensitive part of the central nervous system (CNS) after cerebrum. The exposure to any infection during embryogenesis produces abnormalities in the cerebellum function and morphology that effect on behavioral of offspring later. In the present study we used 30 mature female pregnant albino rats divided in to three groups, each group contain 10 females: G1 was considered the control group received D.W only, while G2 group treated orally with (2mg/kg /day) suspension of silver nanoparticles (AgNPs) and G3 group treated orally with (20mg/kg/day) AgNPs. The embryos retrieved in different embryonic days from ED12 to ED21. In this study morphometric analysis was measured in the developing albino rats cerebellum after maternal exposure to two concentrations of AgNPs from pre- implantation period until delivery . we measured the morphometric parameters  (area, perimeter, anterior-posterior diameter APD and transverse diameter TD) of the selected embryonic days; ED12,ED15,ED18, and ED21 and retrieved the embryos from these days. The morphometric results in the control group(G1) showed that increased significantly (P≤ 0.05) in the area of the developing cerebellum from ED12 until reach the optimal level in the end of gestation at ED21 (14.0815mm2 to 18.969 mm2 respectively), perimeter (9.804 mm2 to 16.267 mm2) and TD (52.6308µm to 431.6 µm),while the APD value was increased significantly (P≤ 0.05) at ED12 and ED15 only (367.0041 µm, 454.011 µm )respectively but the orientation growth of the cerebellum decreased significantly (P≤ 0.05) at the later stage of the development at ED18 and ED21(364.48 µm, 225µm) respectively. In the present research both  concentrations of the AgNPs (2mg and 20 mg/kg/ B.Wt) showed changes in the dimensions of the developing cerebellum cortex according to the studied morphometric parameters; in the 2 mg/kg/ B.Wt, the area of the developing cerebellum cortex was increased significantly (P≤0.05) from ED12 (47.437mm 2) and reached to maximum growth at ED18 (130.220 mm2), while it is growth inhibited at ED21( 68.909 mm2) compared to control group, the values of the developing cerebellum cortex perimeter increased significantly (P≤0.05) from ED12 until ED15 (0.964 mm 2, 2.548 mm 2)  respectively compared to control group; TD values of the developing cerebellum cortex increased significantly (P≤0.05) from ED12 until ED15 also (259.341 µm,436.203 µm) respectively compared to control group. While the APD of the developing cerebellum cortex was decreased significantly (P≤0.05) during late development of the cortex at ED18 and ED21(330.415 µm, 131.5 µm) respectively as in the control group. In G3 group which treated with 20mg/kg/ B.Wt concentration of AgNPs, the similar results of area were showed as in the lower concentration, area of the developing cortex increased significantly (P≤0.05) from ED12(80.11mm 2) and reached to maximum growth at ED18(140.56 mm2) and lower after that. the values of the developing cerebellum cortex perimeter increased significantly (P≤0.05) from ED12 until ED15 (0.256 mm2, 0.543 mm2)  respectively compared to control group; while in the APD and TD values the effect of the higher concentration of the AgNPs was more effect on these dimensions; APD values decreased significantly (P≤0.05) at ED15 (360.48 µm ) and not reach to the complete growth, also in TD values decreased at ED15 (400.5744 µm) and do not reach to maximum growth at end embryonic development compared to the embryonic development timing in the control group.Keywords:  AgNPs, Pre-implantation, Cerebellum, ED, Albino rats.
Cyperus Rotundus L. Phenols Extracts Enhance the Anticancer Effect of Oncolytic Newcastle Disease Virus on Digestive System Neoplasms Ahmed Majeed Al-Shammari
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

This study created novel cancer therapy consist of a combination of Secondary metabolites compound (Phenols) extracted from Cyperus rotundus L. and oncolytic Newcastle disease virus (NDV) which showed cytotoxic activity against different cancer cell lines in vitro. Moreover, it is safe and less toxic on normal cell lines. Three cancer cell lines were used, esophagus cancer cell line (SKG), mouse hepatocellular carcinoma cell line (HC), Human rectal cancer cell line (HRT), and normal cell line Rat Embryo Fibroblast (REF). MTT cell viability assay was used and analyzed for possible synergism using the Chou-Talalay analysis method. In vitro study showed that combination therapy of NDV with Phenols extract had enhanced synergistic anticancer activity on all cancer cell lines tested. Moreover, combination therapies showed antagonism and less cytotoxic effect on normal REF cell line.Keywords: Cancer cell line, Combination therapy, Newcastle virus, phenols, Cyperus rotundus.
Effectiveness of Chitosan-Based Edible Coating on Wax Jambu (Syzygium samarangense) N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Chitosan is a biodegradable material derived from chitin. It is used in agriculture industry. It has an antifungal property. Cinnamic acid is known as the agent of antimicrobial. Cinnamic acid is rarely used in single coating but tend to be used in combination coating. Coating is used to protect the food and conserve their shelf life. Wax jambu (Syzygium samarangense) fruits have a thin red skin and are delicate; they need to be picked by hand twice a week and handled with care. The fruits of S. samarangense are also having several medicinal properties they are highly perishable under post-harvest condition. This problem is an obstacle to the production of wax jambu for export. Objective of this study focused on the effectiveness of chitosan-based as edible coating on wax jambu (Syzygium samarangense) to extend its product’s shelf life. Results showed that wax jambu (Syzygium samarangense) was coated by 1.5% chitosan and 3.5 mM cinnamid acid which were appropriated to extend its shelf life for 10 days under ambient condition. Chitosan coatings can be used for storage of highly perishable fruits as it had showed increase in the shelf life of wax jambu. Chitosan ensures to slow down senescence by preventing respiration and transpiration.Keywords: Chitosan, Cinnamid acid, Coating, Shelf life, Syzygium samarangense.
Molecular Detection of hlyA Gene from Escherichia coli hemolytic isolated from Intestinal and Urinary Tract infections Raid Razzaq Ojaimi
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

An Intestinal and Urinary tract infection is a common clinical problem worldwide. In this study 76 isolates Escherichia coli were isolated from midstream urine specimens only 30 isolates show ability to hemolysis, and 80 isolated Escherichia coli from diarrhea specimens only 10 isolates show ability to hemolysis. In this study, hlyA gene responsible for hemolysin production were detected, from fifteen clinical isolate distributed on 10 isolates of urine and 5 isolates of diarrhea of E.coli collected from 40 isolates for hemolysin produced by using PCR techniques. hlyA gene was present in all isolates. Keywords: Hlya, Escherichia coli, Hemolysin.

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