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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Synthesis, Spectral Characterization and Biological Activity of 2- [2‾ - (1-Amino -1, 5- Dinitrophenyl) azo]-Imidazole Abd Al-Sadda HK
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The preparation and spectral identification of ligand 2-[1‾-(1-Amino- 1,5-Dinitrophenyl) azo]-Imidazole (ADNPAI) were prepared by reacting a dizonium chloride salt solution of 2,4-Dinitrophenylhydrazine with imidazole in alkaline ethanol solution. Azo dye ligand Prepared have been characterized by analytical data, Infrared, Electronic spectral data, XRD, SEM, Thermal analysis (TG-DSC-DTG), UV-Vis, and magnetic susceptibility. The biological activity azo dye ligand were tested invitro against the sensitive organisms Staphylococcus aureus (Gram-positive) and Escherichia coli, Pseudomonas aeruginosa (Gram-negative) by agar plate different technique. The activity data show appearance the ligand azo dyes prepared apparent highly active against to all the bacteria species tested.Keywords: Azo imidazole, ADNPAI, Thermal analysis, SEM, Antibacterial.
Herbal Tea Production from Mimosa Pudica N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Drying is the most popular and basic method for post-harvest storage of herbs because it permits for the quick preservation of the herbal qualities of the herb material in a simple manner. Mimosa pudica is considered as a promising herbal candidate to undergo further exploration as evident from its pharmacological properties. Objective of this study focused on the effect of blanching temperature and time; oven drying temperature and storage condition to total phenolics (mg/g), total flavonoids (mg/g), ferric reducing/antioxidant power (FRAP or TE, mg/g), radical-scavenging activity DPPH (IC50, mg/mL) and sensory score of the dried Mimosa pudica tea. Results showed that Mimosa pudica should be blanched in hot water 95oC at 5 seconds in the present of citric acid 0.5% and then beeing dried by oven dryer at 50oC until 10.0% moisture. The final herbal tea could be preserved under vacuum in aluminum foil at 28oC to maintain flavonoid content for 12 months.Keywords: Blanching, Drying, Ferric reducing power, Flavonoids, Herbal, Mimosa pudica, Phenolics, radical-scavenging activity.
Purification, Beneficiation and Activation of Iraqi Attapulgite Clay Mineral Nadhum Gharb Taher
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This study aimed to obtain a pure activated Attapulgite mineral to use it as adsorption surface in our search, because of its importance in removing impurities, desulfurization, decolorizing, neutralizing, and deodorizing of petroleum fuel. The large specific surface area and high cation exchange capacity of Attapulgite make it suitable in our work. However, the adsorption capacity of natural Attapulgite is limited, new activated pure Attapulgite clay was synthesized by purification and beneficiation Attapulgite to increase its ability to use in our search and other various fields, particularly in the petroleum refining. The pure activated calcined Attapulgite characterized by FT-IR spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). Attapulgite mineral was purified by floatation with the dispersed swelled sodium methyl acrylate granules leaving other impurities of clay mineral and sand in the bottom of the vessel. Therefore many peaks in FT-IR spectrum were disappeared comparing with the FT-IR spectrum of crud material. The disappearance of calcium carbonate peaks at (29.3556) 2 Ɵ was observed due to the purification of Attapulgite from other mineral impurities using sodium methyl acrylate, while the peaks of the Attapulgite remained clear. SEM images of pure activated Attapulgite show a high resolution with an accurate vision of needle- shaped structure.Keywords: Desulfurization; Beneficiation; Attapulgite; Adsorption; Surface.
Antimicrobial Action of Allium Sativum and Elettaria Cardamomum against Streptococcus mutans and Lactococcus Raffinolactis Detachment of Tooth Rot Ashraf Sami Hassan
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Twenty specimen from individuals endure tooth rot in various age from Hospitals of the city of Baghdad, segregate analyze of the phenotypic qualities by development of these microorganisms on the way of life media, minute determination and tests biochemical depending on a framework vitek 2 ,where the outcomes demonstrated the microscopic organisms that cause tooth rot is Streptococcus mutans and Lactococcus raffinolactis in equivalent extents, natural adequacy of watery concentrates of Allium sativum and Elettaria cardamomum against the microbes, from the outcomes demonstrate that disengages of Streptococcus mutans was the most touchy to the fluid concentrate comparator with microbes Lactococcus raffinolactis that indicated less impact towards our concentrates under review, On the other hand, the outcomes demonstrated that the fluid concentrate of the Elettaria cardamomum it is best against the development of bacterial species under review contrasted and fluid concentrate of Allium sativum.Keywords: In vitro, Herbal extracts, Antimicrobial activity, Dental pathogens.
Evaluation of Communicable Diseases Control Surveillance System Quality at Primary Health Care Centers in Kirkuk Governorate Mohammed F. Khalifa
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: To evaluate the communicable diseases control surveillance system structure, process, and outcome and it is quality throughout indicate level of usefulness of surveillance system characteristics of completeness, timeliness, usefulness, sensitivity, positive predictive value (PPV), specificity, representativeness, simplicity, flexibility, acceptability, and reliability. Methodology: descriptive evaluation study is conducted on primary health care centers in Kirkuk  Governorate from October 14th 2017 to  May 1st 2018.A probability sample of (30) unit which is selected from communicable disease of surveillance system units. Data were collected throughout the utilization of the adopted questionnaire and interview technique. Questionnaire has been selected for primary health care centers consists of (80) items. Results: The study results indicate that communicable disease surveillance system structure is adequate in primary health care centers and primary health care sectors. While, the system experienced inadequate surveillance system process in primary health care centers and primary health care sectors. Recommendations: The study recommends that further research studies can be conducted on large-scale sample size and local, as well as national levels studies can be steered. Sufficient and efficient staff can be appointed to take the accountability for employing the communicable disease surveillance system in order to achieve maximum benefits from the system.Keywords: Evaluation, Communicable Diseases Control Surveillance System, Primary Health Care Centers.
Genetic Relationship among Some Isolates of Rhizoctonia Solani Isolated from Some Infected Tomato Plants (Solanum lycopersicum L) Intissar Al-Salami
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This study was carried out in the laboratory of Plant Virology at the Department of plants protection/ College of Agriculture/ University of Karbala to isolate and diagnose some isolates of fungi isolated from infected tomato plants in Najaf and Karbala provinces, Iraq. These isolates were diagnosed by using the polymerase chain reaction (PCR) technique and identifying the nucleotide sequence generated from PCR-amplified products using the universal primer pair ITS1 and ITS4.  The analysis of nucleotide sequences, obtained from amplifying PCR Products, using the Basic Local Alignment Search Tool (BLAST) showed that all identified isolates belong to the fungus R. solani. From comparing the nucleotide sequences of the identified R. solani isolates, it was revealed a clear genetic variation among them as well as with other isolates of the same fungus previously registered in the National Center for Biotechnology Information (NCBI). The results also showed that two isolates among the other R. solani isolates were not previously registered in NCBI; their nucleotide identified sequences were deposited under the accession numbers: MH520074 and MH520071.Keywords: Rizoctonia solani, Tomato, PCR, Nucleotide sequence, and ITS1-ITS4.
Clinical Study of Vitamin D3 Deficiency and some Trace Elements in Autism Husam M. Kredy
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Autism is a disorder of nerve growth characterized by weak social interaction and verbal and nonverbal communication, as well as restricted behavior and stereotypes. The subjects of the study were 90 autistic children with varying degrees of severity (mild, moderate and severe) who were diagnosed with DSM-IV, thirty children in each group and 30 healthy children (age and sex were identical). The boys and girl ratio involved in this study was 4:1, and they were 4-12 years of age. The study showed a significant elevation in the levels of Cu and Pb in the blood sample of autistic children when compared to a healthy control group. The elevation was much pronounced in severe group subjects when compared among autistic groups mild and moderate. The levels of Zn and Vitamin D3 were significantly decreased in autistic children when compared to control. The Zn and Vitamin D3 showed significant variation in blood of severe group children when compared to control group and other study groups. The correlation between Zn and Vitamin D3 in these patient groups were positive. Whereas the correlation between Zn and each of (Cu and Pb) in these patient groups were negative.Keywords: Autism, Children, Blood, Trace Elements, Vitamin D3.
Synthesis, Identification, Theoretical and Experimental Studies for Carbon Steel Corrosion Inhibition in Sea Water for New Urea and Thiourea Derivatives linkage to 5-Nitro Isatin Moiety Suaad Mohammed Hussain Al-Majidi
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This research includes synthesis of some new  heterocyclic derivatives of 5-Nitroisatin namely 5-Nitro-3-(Ethyl imino acetate)-2-oxo indole (1), 5-Nitro-3-[(imino Aceto) urea]-2-oxo indole (2), 5-Nitro-3-[(imino Aceto)thiourea]-2-oxo indole (3), and 5-Nitro-3-[(imino Aceto) phenylthiourea]-2-oxo indole (4), and characterized by FTIR, 1H-NMR and  some physical properties. Theoretically, the inhibition efficiency parameters with physical properties were calculated to ensure for possibility using these compounds as inhibitors. Experimentally, studying the chosen compound of the corrosion inhibition efficiency for carbon steel in 3.5% NaCl solution by isatin derivative is chosen theoretically as the best inhibitor using potentiodynamic polarization.Keywords: Isatin derivatives, Schiff bases, Corrosion inhibitor, DFT quantum mechanical calculation.
Study the Expression of Tumor Growth Factor β (TGF β) in Mice Organs after Exposure to Aflatoxin B1 using Immunohistochemistry Technique Nada H. A. L. Al-Mudallal
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Background: Aflatoxin B1(AFB1) had high toxicity and carcinogenecity effects on human and animals tissues and capable of affecting both the cellular and humoral immune responses resulting in impairments in cellular immunity hence decreasing the host resistance to infections. Objectives: The current study aimed to evaluate the effects of purified aflatoxine B1 on the expression of TGF β in liver, spleen and kidney of experimental mice and estimate it's concentration by using immunohistochemistry IHC technique. Methodology: Mature Swiss albino mice (male) were used in this study, animal were provided from the National Centre for Drug Control and Research /Baghdad. To study the expression of Transforming growth factor beta (TGF-β) in mice, sixteen mice (divided into four groups) were orally admenestred with (9mg/k.g.b.w., 6mg/k.g.b.w. and 3mg/k.g.b.w.) of purified aflatoxin B1 (isolated and extracted from Aspergillus flavus ) with control group (without any treatments) and the mice of each group were sacrificed after two weeks. The blood samples of the mice were collected and samples from liver, kidney and spleen were dissected out from each mouse. The expression of TGF β in these organs was estimated using immunohistochemical technique.  Results: Immunohistochemistry technique revealed that an increase in the expression of TGF β in mice liver, kidney and spleen in comparison with control group. The concentration of TGF β increased with the increase in the concentrations of purified AFB1 that had been given to the treated mice. The highest expression and concentrations of TGF β were investigated in liver, spleen and kidney respectively after treated the mice with 9m.g. /b.w. (90%) concentration of purified AFB1 which represented the affected toxic dose of this toxin. AFB1 at concentrations 6m.g/b.w. (60%) and 3m.g/b.w. (30%) also increased the expression of TGF β but lesser than (90%).Conclusion This study can be concluded that purified aflatoxin B1 (9mg/k.g, 6mg/k.g and 3mg/k.g) which represented (90%, 60% and 30%) concentrations respectively were elevated the expression of TGF-β of mice tissues that treated with these concentrations after comparison with the control. The expression of TGF-β in mice organs increased with the increased in the concentrations of purified aflatoxin B1 using immunohistochemistry technique. AFB1 90% concentrations represented the affected toxic dose and had the highest effectiveness onto the expression of TGF-β in mice organs (liver, spleen and kidney) after treated with this aflatoxin and the highest expression of TGF-β was noticed in liver, spleen and kidney respectively.  Further investigations are required to evaluate the acute and /or chronic effect of aflatoxin B1 on other cytokines expression with determining the histopathological studies of acute and /or chronic effect of aflatoxin on other organs such as lung,muscles, heart, brain, spleen and intestine are required.Keywords: TGF-β3, Gliotoxin, immunohistochemical technique
Effect of Adding Flax Seed to Bread Flour which Produced in the Laboratory and Study its Quality Properties Ibtihal I. M
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The aim of this current research was to Knowledge effect of addition of Flax seed at different percentages to bread flour and pop loaf bread was prepared that addition 10 % from Flax seed flour to bread flour resulting in increasing the percentages of moisture, ash, fat, fiber and protein. The result showed no significant differences in the moisture content, low value of gluten content and falling number. Was noticed in all treatment. Specific volume, it is the same for all treatments. Sensory evaluations of loaf bread appear no significant difference between control 100 % wheat flour and 10 % Flax seed. And found that the bread of both types was acceptable. Therefore this conclusion we can point out that the Flax seed can be used with the flour to prepare the flat bread. To improve the deffency of gluten.Keyword: Bread, Flax seed, Gluten, Fiber.

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