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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Synthesis, Characterization and Biological Evaluation of Some 2-Azetidinones Derivative from Benzimidazole and Used as Anti-Fungicide Agents Ahmood Kh. Jebur Al-Joubory
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Reaction of benzimidazole with ethyl chloro acetate to give ethyl –N–benzimidazole acetate (M1) which was used the reaction with hydrazine hydrate to yield N- benzimid azole aceto hydrazide (M2). The reaction of compound (M2) with different aromatic aldehydes gave compounds hydrazone (M3, M4). (P-Hydroxy (or Chloro) benzylidine) -N- aceto hydrazide benzimidazole. Then the compounds (M3, M4) reacted with chloro acetyl chloride in presence of tri ethyl amine using DMF as solvent to obtain 2-azetidinones compounds (M5, M6). The structures of all the newly synthesized compounds were confirmed by elemental analysis and FT-IR, 1H NMR and 13C NMR as well as melting point. Some of these compounds showed good antimicrobial activity (M1-M6) and anti-bacterial activity (M1-M6) Antibacterial activity of some prepared compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and E.coli (Gram negative). Some the compounds showed high inhibition activity against bacteria and two fungi (Candida albicans).Keywords: Benzimidazole, Schiff bases, Ester, Heterocyclic compounds.
Serum Monoamine Oxidase (A and B) Activities and Oxidative Stress Status in Iraqi Infertile Women Undergoing In Vitro Fertilization Shatha Abdul Wadood Al- Shammaree
Journal of Global Pharma Technology Volume 11 Issue 07
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Serum monoamine oxidase (MAO-A and B) activities were measured in 98 infertile women undergoing in vitro fertilization (Intracytoplasmic Sperm Injection ICSI) attending Kamal AL-Samaree Hospital for Infertility and In Vitro Fertilization at Baghdad after treatment with standard long protocol. Methods: Participants in the study were 98 infertile women subdivide according to infertility cause into PCOS, Unknown cause, and Male factor cause. The activities of MAOs, some antioxidant, and oxidant parameters (catalase, thiol levels, and lipid peroxidation product (MDA) were measured. Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH/FSH ratio, TSH and prolactin were measured. Results: The activities show significant variations among the three infertility groups. Serum MAOs activities (MAO-A, MAO-B) in sera of PCOS (P<0.01), as well, MDA, and total thiol levels were higher significantly when compared with other groups .While, the activity of catalase was lower significantly (p<0.001). Conclusion: Our study reveals the existence of an imbalance between serum oxidant and antioxidant status in infertile women with PCOS undergoing IVF.Keywords: Monoamine Oxidase Activity, Ovary Polycystic Syndrome, Unknown Infertility, Oxidative Stress.
Effective of Lemongrass (Cymbopogon citratus L.) Essential Oil Incorporated in Chitosan-Based Edible Coating to Extend Hen Egg Shelf-Life during Storage N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Hen egg is one of the finest foods, offering human a complete balance of essential nutrients with proteins, vitamins, minerals and fatty acids with huge biological value. Eggshells have been regarded as natural protective barriers of eggs. However, eggs encounter different problems, such as weight loss, interior quality deterioration, and microbial contamination. Chitosan has attracted much attention owing to its extraordinary performance such as well-forming, low gas permeability, biocompatibility, strong antimicrobial attributes. Our present research focused on the application of lemongrass (Cymbopogon citratus L.) essential oil incorporated in chitosan-based edible coating to extend egg shelf-life during storage. This research was conducted from 2018 to 2019 in the scientific laboratory of Soc Trang Nanotech Ltd. Results revealed that 0.4% lemongrass oil incorporated with chitosan 1.5% was appropriated to extend hen egg shelf-life for 8 weeks. Chitosan incorporated with lemongrass essential oil coating is considered an efficient and practical way to preserve eggs at room temperature.Keywords: Hen egg, Lemongrass essential oil, Chitosan, coating, Shelf-life, storage.
Adsorption Ability and Kinetic of (Congo Red, Methyl Green) Dyes on Iraqi Siliceous Rocks Israa Mohammed Tawfeeq
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this study used Iraqi Siliceous Rock powder (SRP) as a suitable surface to study removing of dyes, which are they [Cong red dye (CR) and Methyl green dye (MG)]. Adsorption isotherms and the factors which influence the adsorption process such as temperature and salt effect were studies. Adsorption isotherms of (CR) were found to be comparable to Temkin equation according to Giles classification. Adsorption isotherms of (MG) were found to be comparable to Freundlich equation according to Giles classification. The adsorption process on surface was studies at various temperatures. The results indicate that the adsorption of (CR) on surface decreased with increasing temperature (Exothermic process), while the adsorption of (MG) on surface increased with increasing temperature (Endothermic process). According to above results of thermodynamic functions (ΔG, ΔS, ΔH) were calculated.  The salt effect of adsorption of (CR, MG) dyes at (293 K) were studied .The adsorption quantity for (MG) increasing with increasing the salt solution, while the adsorption quantity for (CR) dye decreasing with increasing the salt solution.  The Kinetics of adsorption process of (CR, MG) dyes on surface were studied. The results were treated according to (Lagergren equation). The Kinetics experimental data properly correlated with First-order kinetic model.Keywords: Siliceous Rock, Adsorption, Congo red Dye, Methyl Green Dye.
Correlation between Selective and Non-selective α-Blocker Drugs with Age, Prostate Volume and Different Benign Prostate Hyperplasia (BPH) Indicators Islam Abdul Rasool Hashim
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: This study aimed to evaluating  the correlation between(age, prostate size) and different BPH indicators such as ( PSA , IPSS , testosterone , estrogen ,Testosterone/Estrogen {T/E} ratio ) among two groups (one treated with selective and  another treated with non-selective α-blocker drugs) and untreated group. Methods: The study is a randomized control clinical trial carried out in Urology department during the period from September /2018 to May /2019.The study was based on 60 cases of symptomatic Benign Prostatic Hyperplasia, 30 patients treated with selective α-blocker drug (tamsulosin) and 30patients treated with non-selective α-blocker drug (alfuzosin) and 30 cases of newly diagnosed patients with BPH but did not take treatment for BPH disease, the range of their age was between (50-90). The variables age, prostate size, PSA, IPSS, testosterone, estrogen, T/E ratio were examined and appropriate statistical tests were employed for data analysis. Results: The results showed that there was a significant difference in correlation between age with IPSS and between age with  testosterone (p≤0.05)among treated and untreated groups and also showed a significant difference in linear  correlation between PSA ,Testosterone, Estrogen indicators levels and the  prostate size (p≤0.05) among treated and untreated groups  Conclusion: In men with biopsy-proven BPH , both International Prostate Symptom Score IPSS and testosterone increased and altering with ageing. Prostate size demonstrated significant positive correlations with Prostate Specific Antigen PSA, Testosterone, Estrogen among treated and untreated groups in this study.Keywords: BPH, Testosterone, Estrogen, PSA, IPSS, Tamsulosin, Alfuzosin.
Microscopic Hair Shaft Analysis in Iraqi Population Taghreed K.S Al-Ashoer
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Hair is a biological evidence contributing important role at a crime scene. Microscopic hair analysis can help to identify of a suspect in forensic investigation. The principle of this study was to find diagnostic aspects of the hair shaft from the Arab Iraqi population through compound light and scanning electron microscopy examination and analysis of the shaft diameter, medullary index, ovoid body and medulla type for human scalp hair shaft in forensic analysis in the crime scene investigation. The investigation under compound light microscope included 76 out of 100 samples because of 24 hairs samples were deep black view and photos showed no data. The shaft diameter range of hair samples was 34.75 to 115µm.The medulla type classified into four groups as absent type (78%), continuous (13 %), fragment (8%) and interrupted type (1%). The medullary index of human hair was observed in ranging from 0.083- 0.189. The ovoid bodies in hair shaft samples were absent (80%) and present (20%) of all samples. In this study reported that no significant differences in shaft diameter, medullary index, medulla type and ovoid body among male and female groups. The scanning electron microscope results indicated that high amount of hair shaft damage and the difference between the individuals in outer cuticle scale pattern showed that all samples were imbricate type, while chipped, lifting, jagged and smooth reported 17%, 8%, 4%and 1%, respectively.Keywords: Hair shaft, Microscopic analysis, SEM, Iraq.
Effectiveness of an Education Program on Nurses̕ Practices toward Preventing Central Venous Catheter Related Infection in Al-Nasiriya Hospitals Khalida M Khader
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Background: Central venous catheters are routinely used in Intensive Care Units (ICU) to provide vascular access. They are used to access a large vessel (internal jugular, subclavian or femoral) to monitor central venous pressure (CVP), administer fluids, blood products, total parental nutrition (TPN), and medications. Patients in Intensive Care Units are at a higher risk for infection due to multiple factors such as age, severity of illness, and underlying disease conditions combined with a critical illness. So, educational programs concerning this essential subject can be of imperative benefit for both patient and nurse. Objective: To evaluate the effectiveness of an educational program on nursesꞌ practices toward preventing central venous catheter related infection in ICU.  Methodology: A quasi experimental study design is carried out at AL-Nasiriyah hospitals from 19th of October 2017 to the 6st of June 2018 and a probability (Random) sample of (60) nurses who have been working in the ICU .those nurses are divided into two groups, study and control groups, each group consisted of (30) nurses. To measure the effectiveness of nursing educational program through the use of practice checklist includes (46) items concerning preventing central venous catheter related infection in ICU. Reliability of instrument was determined through the use of test and retest and the instrument validity was determined through a panel of (14) experts. Results: The results showed a positive effectiveness of educational program. It also shows that there are highly significant differences in the study group between pre and post-tests at significance level P ≤ 0.05. Conclusion: The study concluded that the nurses working at ICU have the minimum level of experience in preventing central venous catheter related infection and need educational program and sessions. Recommendation: The study recommended that providing an educational program should be ongoing for nurses to enhance their skills about the preventing central venous catheter related infection.Keywords: Effectiveness, Education Program, Nursesꞌ Practices, Prevention, Central Venous Catheter, Infection.
Synthesis and Characterization of New Copolymers Containing Subs.-1,3,4-Oxadiazole Ring Raghad Hamed Ismail
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

New copolymers were prepared from monomer (5-vinyl-1H-tetrazole),which prepared from reacted acrylonitrile with sodium azide in presence zncl2 and another monomer was Methyl acrylate. comonomers were polymerization using[BPO]with heating to(80-90)c◦.The second step was prepared copoly acid hydrazide,Then reacted with different aromatic carboxylic acid in presence(pocl3)to optain subs.1,3,4-oxadiazole ring pendant on copoly(5-vinyl-1H-tetrazole-MA) .The prepared copolymers were characterized by FT-IR, and copolymers some of them 1H-NMR, and T.G.Keywords: acrylonitrile, Sodium azide, Copolymerization, Acid hydrazide, 1,3,4-Oxadiazole.
Assessment of Noise Pollution and its Impact on Human Health in Hilla City Haydder Radhi Kadhim
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Noise pollution is type of air pollution, it is unwanted sounds that reduce quality of person life via effect on normal activity like. It can disturb sleep, cause cardiovascular and psychophysiological effects, Material and method level of noise measured in five types of regions in hilla city during each season of year in two reading (morning and evening) with outside and inside building, then  comparative the results with international and local level of sounds, in addition to estimate effect it on human healthy. This work is down by using a precision sound level meter digital instrument as noise meter. Result this study showed that some selected regions of hilla city were over normal level of sounds which make this regions suffered of noise pollution Conclusion this noise may be pollution lead to effects on physiological and psychological state of human.
Effect of Botulinum Toxins Injection on Liver Enzyme and Histochange of Liver and Kidney of Female Rats Rana Talib Al-Muswie
Journal of Global Pharma Technology Volume 11 Issue 07
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The present work aimed to study the effect of Botulinum toxins on liver enzyme ,Urea ,Creatinine and histological change of liver and kidney .Two doses 0.1 and 0.2 ml of Botulinum toxins were used and the animals were injected Intramuscular administration of botulinum toxin for 1 day as two dose only. The alanine aminotransferase (ALT) level in the rats of the control group (A) is significantly lower (P<0.05) than both the rats group (B) treated with Botulinum toxins and group(C). The aspartate aminotransaminase (AST) level in the rats of the control group is significantly lower (P<0.05) than both the rats treated with Botulinum toxins. Also, The results showed a significant increase in the level of urea and Creatinine of the female rats treated with Botulinum toxins compared with control group, In the histologicaly, the results showed vaculation in hepatocytes, and infiltration of inflammatory cells in liver of group (B), while in group (C), there was inflammatory cells, detachment of some hepatocytes, and congestion in area of Portia,. Kidney of group B showed congestion of blood cells and increase number of nuclei. In kidney of group C there was an increase in the number of nuclei, edematous glomerulus, and glomerular lobulation.Keywords: Botulinum toxins; Liver Enzyme, Urea, Creatinine, Liver, Kidney.

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