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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Environmental Analysis for Spreading Areas of Scleroderma Disease in Babylon Governorate Muthik A. Guda
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The aimed of this study is to estimate Scleroderma infections in Babylon Governorate (2016). Locations and number of infected people were detected. The number of infected people reached 17. Those patients were admitted in the government hospitals. A statistical questionnaire was prepared for this study which includes patient's name, gender, age, occupation, address, date of admission to the hospital, date of discharge, and patient's condition. The results of this study found that female' infections were more than males. Scleroderma disease complications caused a change inside immune system, fibrosis, and damage in small blood vessels. It was also found that most of the infections are in Hilla district and less concentrated in the Kefel area. This may be correlated to the population density, lack of health awareness; municipal services, poor infrastructure as well as industrial activities were mostly concentrated inside the city. Further studies related geospatial and environmental variables could help our findings to detect a wide range of patients and related that with site variables.Keywords: Environmental Pollution, Hilla City, Air Pollution, Scleroderma Disease.
Isolation and Characterization of Alkaloids in Peganum Harmala. L Seeds and Detect their Antibacterial Activity against Multidrug-Resistant Acinetobacter Baumanii Bacteria Zainab J. Qasim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Objectives: The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii (A. baumanii) has raised concern in health care settings in Iraq. Peganum harmala  Linn. (P. harmala) is a small genus of Zygophyllaceae family which widely grows widely in Iraq, Middle East, North Africa, Australia and America. One of the important features of P. harmala alkaloids is their bactericidal activity that is comparable with that of common antibiotics, which have many adverse effects. This study aimed to investigate the antimicrobial effect of methanol extract of P. harmala and its derived alkaloids like harmine and harmaline against A. baumanii. Also their synergism activity in combination with synthetic antibiotic was evaluated. In addition, the cytotoxicity of this extract in its derived active compound was evaluated on human lymphocyte. Methods The primary antibacterial activity were assessed using agar well diffusion method for crude extract and total alkaloids. Minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) were also detected of crude extract, total alkaloids, harmine and harmaline, by using checkerboard method, the present study investigated the combination of harmala seed active compounds with available antibiotics namely: tigecycline, colistin, meropenem, amikacin and levofloxacin against ten of A. baumanii strains. Moreover, the cytotoxicity of methanolic crude extract of P. harmala and its derived alkaloids were studied on human lymphocyte by MTT (thiazolyl blue tetrazolium dye) colorimetric method. Results: For the two tested compounds, methanolic crude extract and total alkaloids within the range of 50 mg/ml to 10 mg/ml concentrations, the total alkaloids exhibited the most potent antibacterial activity against A. baumanii in a dose-dependent manner. the total alkaloids also exhibited the lowest level of MIC and MBC medians 32, 64 μg/ml respectively, whereas harmine and methanolic crude extract showed relatively moderate activity with MIC and MBC medians (96 and 256) (256 and 512) μg/ml respectively, and harmaline had the least inhibitory effect with MIC and MBC median 256 and 768 μg/ml respectively. According to the result of MTT colorimetric method, all concentrations of ≥ 256 μg /ml for harmine, harmaline and total alkaloids and of ≥ 512 μg /ml for methanolic crude extract caused lymphocyte cell death over 50%. For the combinations between harmala seed active compounds and available synthetic antibiotics, the best results were found in the combination between total alkaloids with tigecycline, it was found that 8 out of 10 had synergistic effect (FIC ≤ 0.5) against bacteria while only two had additive effect (FIC= 0.75); combination with colistin showed that only 4 out of 10 had synergistic effect (FIC ≤ 0.5) while 6 out of 10 had additive effect (>0.5-≤1). However, in the combinations with amikacin, meropenem and levofloxacin, all the samples showed indifference effect. Conclusion: Despite the strong antimicrobial effects of high concentrations of P. harmala seeds on A. baumanii, high cell toxicity of this plant would restrict its in vivo therapeutic use. However combination therapy such as the one resulted from synergism between antibiotic and plant extract can be used to minimize the possible toxic effects.Keywords:  Acinetobacter baumanii, Peganum Harmala seeds, Alkaloids, Harmine, Harmaline, antibacterial activity, and synergism.
The Effect of Heat Shock on Anopheles Arabiensis Patton (Diptera: Culicidae) Larvae Muna Abd Al-Wahed Banian
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The objective of this study was to examine the effect of heat shock on Anopheles arabiensis larvae and for controlling mosquitoes. Samples of larvae were collected from Iraq. The larvae were exposed to various temperatures 30, 35, 40, 45 and 50°C for 10 minutes (as heat shock period). Larval mortality was recorded. The data was analyzed to calculate the quantity of heat (kj) that was added, the corrected mortality, the regression line and the correlation coefficient. It was found that heat shock of 30°C has no effect on larvae, but heat shock of 35, 40, 45 and 50°C produced mortality, while heat shock of 30 and 35°C has no effect on some aquatic organisms. The heat shock of 40.6°C and 48.94°C produced mortality in 50% and 95% of larval populations, respectively. The study showed that the heat shock of 40°C can be used to control the aquatic stages (Larvae) of mosquito (Anopheles arabiensis). The results of this work could be further tested in small pools, man- wholes of the bath rooms small containers used to keep drinking water and water pot, “zeer”
Synthesis and Characterization of Some New Pyrazole Derivatives Nisreen H. Kar
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work contain many steps starting from esterification of  isophthalic acid to yield diester compound [I] which was converted to their acid hydrazide [II], then the later compound reacted with ethylacetoacetate  to  yield pyrazol-5-one compound [III]. Afterword added acetyl chloride to give the compound [IV], the reaction of this compound with theiosemicarbazide led to produce a new carbothioamide compound [V], which was reacted with ethyl chloro acetate to yield the thioxoimidazolidin compound [VI]. The condensation reactions of this compound with different substituted aldehyde give new alkene derivatives [VII] a-d. The synthesized compounds were characterized by melting points, FT-IR, 1H-NMR and Mass spectroscopy.Keywords: Pyrazole, Heterocyclic, Isophthalic acid, Acid hydrazide, Alkene derivatives.
Effect of Frozen Storage on Nutritional Chemical Quality of Shrimp (Exopalaemon Styliferus) from the South of Iraq Mahdi Hassan Hussain
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The aim of this research is to investigate the influence of frozen storage at -20°C for six month on nutritional chemical quality of shrimp Exopalaemon styliferus that include moisture, PH. protein, fat, volatile basic nitrogen (TVB-N), trimethylamine nitrogen (TMAN), Free fatty acid (FFA) Formaldehyde (FA) content, thiobarbituric acid reactive substances (TBARS) and astaxanthin. Results of present study indicated that values of PH, TVB-N, TMAN, FFA, FA and TBARS were increased with increasing time during frozen storage. However, values of moisture, protein, fat and astaxanthin were decreased during storage.Keywords: Frozen storage, Shrimp, Nutritional quality, TVB-N, TMA, Formaldehyde.
Partial Purification of Leucine Aminopeptidase and its Correlation with Some Biochemical Parameters in Sera of Subclinical Hyperthyroidism and Hyperthyroidism Patient Noorhan Khalid Shafeeq
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The study aimed to purify of Leucine aminopeptidase (LAP) from sera of hyperthyroidism patients and its relation to some thyroid hormones (TSH, T3, T4) of subclinical hyperthyroidism and hyperthyroidism patients with lipid peroxidation levels that may be play a role in this diseases. Specimens were collected during the time from Nov 2017   until Jan 2018 from Endocrine and Diabetes Center, blood samples were   collected from fifty healthy control and one hundred patients, patients were divided into two groups consisted of (50) with hyperthyroidism and (50) with subclinical hyperthyroidism. The aged for all subjects ranged (15-60) years with body mass ranged ((25- 29) kg/m2. The purification is done by addition of ammonium sulfate, dialysis, ion exchange chromatography by using DEAE -Sepharose and gel filtration chromatography by using Sepharose 6B. FT3, FT4, TSH, LAP, peroxynitrite, malondialdehyde were determined. Results showed the precipitate and concentrated protein appeared five peaks after eluted with Tris- HCl (50 mM, pH 7.0 in ion exchange column, LAP located in the first peak (wash fraction) and the second peak (elution fraction eluted with 0.1 M NaCl), also, results showed single peak for both first and second peaks after eluted in gel filtration chromatography following steps by using sodium dodecyl sulfate-polyacrylamide gel. As well as results showed a non- significant elevation in   BM, FT3 and   FT4 in subclinical-hyperthyroidism group when compared to the control group. And a highly significant elevation in LAP, peroxynitrite and MDA levels in the patient group compared to the control group, while a highly significant decrease in TSH   levels was found in the patient group compared to the control group. Results showed a non-significant elevation in BMI in hyperthyroidism group when compared to the control group., also, showed a highly significant elevation in FT3, FT4 LAP, peroxynitrite and MDA levels in the patient group compared to the control group, while a highly significant decrease in TSH levels was found in the patient group compared to the control group. From this study, it is concluded   Leucine aminopeptidase    which partial purification from sera of hyperthyroidism   patients   by ion exchange chromatography and gel filtration   chromatography   have  two  isoenzymes  ,also, concluded a highly significant elevation in LAP, peroxynitrite and MDA levels in the patient group compared to the control group , in addition to their correlation with thyroid hormone in the patient group, compared to the control group indicate that  these parameters have an effect on these diseases.Keywords: Leucine aminopeptidase, Subclinical hyperthyroidism, Hyperthyroidism, Subclinical hypothyroidism, Hyperthyroidism, Lipid peroxidation.
Adsorption Study of Diclofenac Potassium on Mint in Aqueous Solutions According to the Freundlich and Langmuir Equations Mohammed Abdullah Ahmed
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Diclofenac NSAIDs is one of the most commonly prescribed pharmaceutical however its removal from wastewater is only 21-40% which explains their presence in surface water, groundwater and even in drinking water of different countries. This causes environmental and Eco toxic issues, in this context many methods have been proposed for its removal from wastewater. We are proposing a new method for the removal of diclofenac by using adsorption method and using mint as an adsorbing agent this proposes a useful and Eco friendly technique that might be implacable on a large scale in the future.Keywords: Adsorption, Diclofenac, mint.
Effects of Ciprofloxacin and Trimethoprim on Phagocytic Activity of Polymorph Nuclear Cells, TNF-α and Complement Components Concentration in Patients with Bacterial Urinary Tract Infection Wafaa Sadeq Al-Wazni
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Objective: This study was  designed to determine the effect of repeated use of Ciprofloxacin and Trimethoprim antibiotic on some signs of innate immunity of urinary tract infections’ patients such as phagocytes activity of polymorphonuclear cells in vitro and in vivo, TNF-α and Complement components concentration. Material and methods: Urine specimens were collected from 100 person (40 patients with UTI before begin treatment with antibiotics,40 patients after 3 days of treatment and 20 healthy person as control). One part of urine speciemine used for direct microscopically examination (DME) to detect the UT infection after the clinical diagnosis by specialist physician. Then second parts of the urine specimens, which gave appositive result to DME test, were cultured on blood and MacChonkey agar to isolated pathogenic bacteria and confirm sever infection in-patient. Five milliliters of blood were collected from patients (who confirmed having UTI by clinical, DME and lab culture diagnosis) to use for determine some signs of innate immunity. Results: Escherichia coli bacteria was the most common isolates (40%) from both studied groups followed by S.aureus (20%) , Pseudomonas aeruginosa and Klebsiella pneumonia (8.8%) of each and  Proteus mirabilis (2.5%). Most E.coli isolates were resistant to Trimethoprim (78%) and Ciprofloxacin (50%) antibiotics. The total WBCs count increased in patients with UTI before (13.2×106 cell/ml) and after treatment (10.5×106 cell/ml) with antibiotic compared to control (6.4×106 cell/ml) but the total WBCs count begin to decrease in patients after treatment with antibiotic in compared to patients before treatment. The result also show no significant increase in the concentration of C3(142.9,150.5 mg/dl) and C4 (26.5, 30.7 mg/dl) in patient before and after treatment respectively in compared to control but there is no noticeable deference in the concentration of these proteins between two studied groups. While the concentration of TNF-α was significantly increased in serum of patients before (256.6 pg/ml) and after (197.2 pg/ml) treatment in compared to control (155.3 pg/ml) group. Phagocytes activity of PMNs cell was evaluated by measuring the phagocytic index, a significant decrease observed in phagocytic index to reach 60% in patients before treatment and 52% in-patient after treatment compared to control group 65% after 90 minutes. Conclusions: study the effects of Trimethoprim and Ciprofloxacin on the activity of PMNs in vitro showed positive effect of Ciprofloxacin antibiotic while Trimethoprim antibiotic has negative effect on the phagocytic cells.Keywords: UTI, E. coli, PMN, Trimethoprim, Ciprofloxacin.
New Metal Complexes Derived from Mannich-Base Ligand; Synthesis, Spectral Characterisation and Biological Activity Safaudeen A. Hussain
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

In this work, the preparation of a new bidentate Mannich-base ligand and its metal complexes are reported. The formation of the ligand (R)-2-((R)-(4-(dimethylamino) phenyl)-(phenyl-amino) methyl) cyclohexan-1-one (HL) was achieved from the reaction of dimethylaminobenzaldehyde, aniline and cyclohexanone in a 3:3:5 mole ratio, respectively. The reaction of the ligand with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions in a 2:1 (L:M) mole ratio resulted in the isolation of monomeric complexes. The ligand and its metal complexes were characterised using a range of analytical and spectroscopic techniques including; elemental microanalysis, magnetic susceptibility, conductance FT-IR, electronic spectra, electrospray mass spectroscopy and 1H, 13C-NMR spectra. The characterisation data indicated the isolation of six and four coordinate monomeric complexes with the general formula; [M(HL1)2(Cl)2].(H2O)2 (where M= Mn(II), Co(II), Ni(II), Cu(II)) and [M(HL1)]Cl2.(H2O)2 (where M= Zn(II) and Cd(II)). The ligand and its complexes were screened against several bacterial strains and fungi species. The obtained data indicated that the complexes are more active against several kind of organism, under survey, compared with the free ligand.Keywords: Mannich-base ligand; Monomeric metal complexes; Structural study; Biological activity.
Synthesis, Characterization and Antibacterial Study of Selected Metal Complexes Derived from Modified of PVA Ruwaidah S. Saeed
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A new ligands(modifier polymers) L1, L2, L3 , L4 and L5 were prepared according to method [8]  by reaction of polyvinyl alcohol(PVA) withi(acid chloride)[1]a or [2,3]a,b in dimethyl formamide. The Ligands were characterized by (FT-IR), (UV- Vis) and (1H-NMR) spectra some of them. Synthesis some transition metals complexes of these ligands and described via (FT-IR, UV-Vis) spectra, [Thermo gravimetric analysis (TGA), Differential Scanning Calorimetry (DSC)], (SEM) and antibacterial activity was screened thought two types of bacteria. The octahedral geometrical was suggested for Co+2, square Planer geometrical was suggested for Ni+2and tetrahedral geometrical was suggested for Cd+2Keywords: PVA; Metal complexes; Antibacterial.

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