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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Synthesis, Characterization, Thermal Study, Biological Activity and Corrosion Inhibition of New Ligand Derived from Butanedioyl Dichloride and Some Selective Transition Metal Complexes Enass J. Waheed
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The new ligand [N1,N4-bis((1H-benzo[d]Glyoxalin-2-yl)carbamothioyl)Butanedi amide] (NCB) derived from Butanedioyl diisothiocyanate with 2-aminobenz imidazole was used to prepare a chain of new metal complexes of Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Pd(II), Ag(I), Cd(II) by general formula [M(NCB)]Xn ,Where  M= Cr(III), n=3, X=Cl; Mn(II), Co(II), Ni(II), Cu(II), Pd(II), Cd(II) ,n=2 , X=Cl; Ag(I), n=1, X=NO3. Characterized compounds on the basis of 1H, 13CNMR (for (NCB), FT-IR and U.V spectrum, melting point, molar conduct, %C, %H, %N and %S, the percentage of the metal in complexes %M, Magnetic susceptibility, thermal studies (TGA),while its corrosion inhibition for mild steel in Ca(OH)2 solution is studied by weight loss. These measurements indicate that (NCB) coordinates with the metal ion in a hexadentate manner through the sulfur and nitrogen atoms and the octahedral structure of these complexes is suggested. The anti-bacterial activity of the complexes against two types of bacterial Staphylococcus Aureus (+) and Escherichia Coli (_) for the metal complexes was higher than for free ligand (NCB).Keywords: Butanedioyl dichloride, Corrosion inhibition, Biological activity.
Synthesis, Characterization and Study Thermal Stability of New Polythiadizole Derivatives / Silica Nanocomposites Maha T. Sultan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

New nanocomposites containing polythiadizole were synthesized by free radical polymerization and examined their thermal properties. All monomers, polymers and nanocomposites were characterized by FT-IR spectroscopy. The thermal stability were investigated by thermo gravimetric (TG), differential scanning calorimetry (DSC) and differential thermal analysis (DTA). Synthesis of polymer and their nanocomposite had characterization by FT-IR, thermogravimetry (TG), Diffraction scanning callomatry DSC, Differential Thermal analysis DTA,the state of the nanocomposite were evaluated via X-ray diffraction (XRD).The results of thermal analysis showed that nanocomposite more stable than their polymers.  Keywords: Thermal stability, Polymers, Thiadiazole, Nano composite.
Role of Biofilm in Reinfection in Catheter-associated Urinary Tract Infection in Iraqi Women Likaa Mahdi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Women hinge on knowledge of antimicrobial susceptibility patterns in the Iraq country of the practitioner. We conducted a survey of antimicrobial susceptibilities of 72 urine samples from catheterized women patient.  Isolates recovered from urine samples April 2014 to July 2014, samples collected from urinary catheterized women patient in Al-Yarmouk hospital in Baghdad/ Iraq. Resistance uropathogen (E. coli, Acinetobacter baumannii, Enterobacter Spp, Enterococcus faecalis, Klebsiella Pneumoniae, Proteus mirabilis) isolates to Amoxicillin and Gentamicin combined with high biofilm formation.  Escherichia coli are the majority common micro objects concerned in community-acquired -UTI in women. UTI which was cause by uropatho-genic; Isolates can eventually re-infection Acinetobacter baumannii (n=6), E. coli (n = 9), Enterococcus faecalis (n=3), Klebsiella Pneumoniae (n=2), Enterobacter Spp. (n=2) and Proteus mirabilis (n=5). The production of E. coli biofilms in-vitro was considerably common with strains the causes the biofilms. Biofilm assay could be supportive to select required patients for healing advance to eliminate unrelenting biofilm-formation.
Synthesis, Characterization and Antimicrobial Activity of Novel Symmetrical and Unsymmetrical Thiadiazole Derivatives as Potential Carbonic Anhydrase Inhibitor in E. Coli Ammar H. Al-Dujaili
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Ten compounds of 2, 5-disubstitutedamido-1, 3, 4-thiadiazole, 3, 5-disubstituted-amido-1, 2, 4-thiadiazole and a Schiff base of 1, 3, 4-thiadiazole derivatives were synthesized. The structures were characterized by elemental analysis and different spectroscopic techniques and their biological activities were evaluated. All the synthesized compounds were screened for their antimicrobial activity against Staphylococcus aureus and Escheriochia coli, and antifungal activity against Candida albicans and a clinical isolate of Candida albicans. Most of the compounds have shown significant antibacterial and antifungal activity. When compared with the standard antimicrobial agents. The induced fit study of Schiff base derivative showed that the compound has potential inhibitory effect on bacterial β carbonic anhydrase with binding score of (-33.681 kJ/mol).Keywords: Thiadiazole;  Antibactrial activity;  Antifungl activity; Amid; Coli.
Isolation and Purification of the Z-disc from Vertebrate Myofibrils Samer N. Khalaf
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The Z-disc is located within the I-band between neighboring sarcomeres (the fundamental unit of contraction within the muscle). It is composed of approximately 40 proteins, mostly α-actinin. Recent studies have reported that this part of the sarcomere is an active structure that contributes to the sensing mechanism and signaling pathways that control muscle activity. Several mutations occur in the Z-disc proteins and cause many diseases. In addition, the interactions between these proteins are not understood yet. Thus, many attempts have been made to isolate a well-preserved Z-disc that would help to understand the interactions between its proteins and treatment of different diseases, particularly some cardiac diseases. Different strategies have previously been applied to isolate the Z-disc from insects, for example, but these were harsh conditions that caused damage to the Z-disc. Herein, mild conditions were applied to extract a well-preserved Z-disc from vertebrate myofibrils. Our procedure was primarily based on two steps; homogenisation of myofibrils into A-bands and I-bands after digestion of titin with trypsin, and then depolymerising actin through gelsolin. Phase contrast light microscope, SDS-PAGE analysis and electron microscopy with negative staining were employed for visualization. Myofibrils were prepared successfully in a suitable quality (striated and single myofibrils) and quantity. Titin was cleaved using trypsin and the A-band and I-band were partially separated. Furthermore, our findings showed partially depolymerisation of actin filaments with gelsolin. The mild conditions used were considered a promising start to a successful method for isolation of Z-discs from vertebrates.Keywords: Z-discs, Sarcomere length, Titin, Trypsin, Actin, Gelsolin.
An Opinion about the Current Development and Immunity of Zika Vaccines Ibrahim M S Shnawa
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The current available developing zika virus vaccines and virus immunity are being stated.  All the known vaccine classes have been attempted for evolving human zika approved vaccine(s).At the experimental preclinical level both preventive and therapeutic vaccines are known. While on clinical level, neither preventive nor therapeutic zika vaccines are globally approved for public human use   till now. Zika vaccine immunity in mice monkeys and to lesser extent in man has shown to be dependent on the nature of the active immunogen forming the investigational vaccine. Different vaccine design may affect different immune response types. The vaccine immunity in mice and monkeys are rather different from that of man though they are of mammalian lineage. Live attenuated and inactivated whole virus vaccines induced virus neutralizing zika antibody responses .Zika DNA vaccine makes induced cell mediated immunity .mRNA vaccines showed antibody and cell mediated immunity. The  features of  zika infection versus zika vaccine immunity can be summarized as :i- Virus neutralizing antibody responses ,ii-antibody response reduces local and systemic viremia associated with immune protection ,iii- post challenge sterile immunity ,iv- antibody dependent immune enhancement of other related viruses ,v-zika  pathologic autoantibody mediate nervous  immune tissue injuries ,and v-zika specific monoclonal antibodies were found valid for immunotherapy of zika infection based onto passive immune effect of mAb at the experimental level.  Having an in hand global approved zika vaccine will needs   around five to ten years to be attained.Keywords: Antibody, Autoantibody
Evaluation of Dental Diseases of Pregnant Women in Tikrit Governorate in Iraq Sulafa K. Banoosh
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Aim: is to find any relation between the dental diseases and pregnancy. Material and meathods: 100 pregnant ladies their age between (19-40) year’s old.33 pregnant ladies in the first trimester, 33 pregnant ladies in the second trimester, and 34 pregnant ladies in the third trimester. All healthy looking and were accepted to be in this study. Stimulated salivary samples collected according to special instructions. The pH estimated at the time of collection and the salivary flow rate was estimated by divided the volume of saliva in collecting tubes in milliliter per minutes (ml/min). Oral examination was done using plane mouth mirror and dental explorer. And all teeth was examined for caries lesions and recorded by (DMFt) index according to criteria depicted by oral health survey of world health organization (WHO). Plaque index for dental plaque thickness and calculus index was used also for recording the periodontal conditions. Results: The results of the current study revealed that the dental caries severity represented by DMFt index had significant differences in the third trimester than the other trimesters and negatively relative with the salivary pH in the third trimester during pregnancy the (p< 0.05). Conclusion: There were a relation between the dental caries severity and pregnancy this could be due to the fact that the anxious and restless and exhausted in addition to nausea and vomiting that make the routine oral hygiene practices more difficult.Keywords: Trimester, DMFt, WHO, Plaque index, PH.
Detection of the Effectiveness Metabolic Production of Pseudomonas Fluorescence towards Inhibition of Growth Fusarium Graminearum and Production to Zeralenone Wisam Jasim Abed Ali
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The study aimed to conduct a survey of fungi associated with the rice crop and focus on Fusarium graminearum and the detection of its ability to produce of zeralenone. 50 samples of local and imported rice were collected in the city of Diwaniyah. The results showed a wide spread of fungi in local and imported rice samples, where the fungi are isolated Aspergillus spp, Fusarium spp., Alternaria spp. , Penicillium spp., Rhizopus spp. and Mucor spp. by ratio (32,24,20,8,8,8) %. Results of ELISA examination were shown four species of Fusarium graminearum were produced of zeralenone by rate 33.3%. The results showed the effectiveness of metabolic products of bacteria showed high efficacy to inhibit the growth of F. graminearum and inhibit the production of zeralenone at four concentrations of metabolic products from Pseudomonas fluorescence (250, 500, 750, 1000) mg/l.Keywords: Fusarium graminearum, Zeralenone, Pseudomonas fluorescence.
Study of Evolution of Multi Drug Resistance Protues spp. Isolated from Patient Suffering from UTI Ali Jaffar Saleem
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Clinical isolates of proteus spp. (30 isolates) were obtained from patients suffering from UTI from Baghdad Medical City hospital during the period between 1st December/2016 till 1st April 2017. The isolates were identified by culturing on MacConkey agar and blood agar then diagnosed by performing some morphological and biochemical tests. Proteus spp distributed in this study to P.mirabilis 23(76.6%) and P.vulgaris 7 (23.3%). In this study 17/30 (56.6%) of the sample were isolates from female and 13/30 (43.3%) isolates from male. Antibiotic susceptibility test for three antibiotics was performed using disc diffusion method. The percentage of highest resistance in proteus spp. isolates reached 80% (24/30) for Ampecillin and 76.6% (23) for Piperacillin while lower reached 50% (15/30) to Imipenim. Detect the resistance rates according to the sex of the patients showed significant differences for resistance to Imp in female 33.3% (10/30) compared with 16.6% (5/30) in male and for Amp, Pip in male 33.3% (10/30), 33.3% (10/30) compared with 46.6% (14/30), 43.3% (13/30) in female respectively.
Synthesis of New Heterocyclic Derivatives from Thiophenol and Evaluation their Biological Activity Noor Y. Jaber
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

S-Chloroacetyl thiophenol (A) was synthesized by reaction of thiophenol with chloroacetyl chlorid, then the product (A) was reacted with hydrazine hydrate to give hydrazide derivative (B), which was introduced in different synthetic methods to produce either Schiff bases derivatives or to produce heterocyclic compounds. All compounds were confirmed by their melting point, FT-IR spectra, 1H-NMR, 13C-NMR spectrum and studying the possibility for their application as antibacterial and antifungal agents to some of them.Keywords: Thiopohenol, Hydrazen hydrate, Schiff bases.

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