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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 42 Documents
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Search results for , issue "Volume 11 Issue 6." : 42 Documents clear
The Effect of Ethanolic Extract of Mangosteen Peel As Adjuvant Therapy to TNF-Α And IL-10 in Wistar Rats Infected with M.tuberculosis H37rv Indah Widyaningsih
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This study was an experimental study of wistar rats infected with M. tuberculosis H37 Rv and then given isoniazid  INH as an anti-tuberculosis drug and ethanolic extract of mangosteen peel as adjuvant therapy. Method: Rats infected with M tuberculosis H37rv 106 Mc Farland, as 100µl intratracheal. Rats were randomly divided into six groups control (K1), rats infected with M tuberculosis H37rv  only (K2), and rats infected with M tuberculosis H37rv and then treated with INH 100,200, 300 and 400 mg/kg body weight/ day (P1, P2, P3 and P4, respectivelyAfter administration of 4 weeks of therapy, the rats were sacrificed and the right lung  tissue was  collected to measured the levels of TNF α and IL 10 by using  ELISA. Results  The mean level of TNF α was found in the lowest P2 group compared to the treatment group (P1, P3 and P4) and the control was 24.16pg/ml. The  level of  IL 10 was found in the lowest P2 group compared to the treatment group (P1, P3 and P4) and the control was 232.75pg/ml. Ethanolic extract of mangosteen peel has a significant effect on decreasing levels of TNF α with a value of P = 0.000 <0.005 and IL 10 with a value of p = 0.001 <0.005.  Conclusion  Ethanolic extract of mangosteen peel is effective in reducing levels of TNF α and IL10 in adjuvant tuberculosis therapy, especially at doses of 200mg/kgbw/day, in smaller or larger doses there is an increased possibility of interaction between INH  and the active substances in the extract. Therefore further studies are needed to find the cause.Keywords: M.tuberculosis, Mangosten, TNFα, IL10.
The Use of Diuretics on Hepatic Cirrhosis Patient with Ascites Didik Hasmono
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Hepatic cirrhosis with ascites complication increases the mortality up to 50% in a matter of years. Diuretics are a class of drugs that are often used as choices. The pattern of diuretics use of hepatic cirrhosis patient with ascites in the hospital needs to be studied further because if the use is not appropriate, it will potentially lead to drug related problems that affect patient management. Aim: to examine the pattern of diuretics use of hepatic cirrhosis patient with ascites which undergoing treatment in the hospital inpatient unit. Method: a descriptive and retrospective study using medical records. Criteria for inclusion of the sample were (1) Hepatic cirrhosis patient with ascites complication (2) Age> 20 years (3) Receive diuretic therapy (4) Complete medical record. The exclusion criteria were patient who was hospitalized for less than 3 days. Study samples were recorded on the data collection sheet. Sampling with time limited sampling method. Result: The total number of patients who met the inclusion criteria was 45 patients. The diuretics which most used was furosemide, both in single doses and in combination with Spironolactone. The hepatic cirrhosis patient with ascites in this study not only received diuretic therapy, but patient also received other drugs that used to prevent and overcome complication. In drug interaction, the potential use of Spironolactone with Potassium (KCl or KSR) preparation increases the risk of hyperkalemia. Conclusion: Most of the diuretic therapies obtained by hepatic cirrhosis patient with those who were hospitalized which have been in accordance with the available guidelines.Keywords: As cites, Drug Related Problems, Diuretics, Hepatic Cirrhosis.
The Effect of Educational Exercises and Added Weights in Some Kinematic Variations of the Performance Angle of the Shudder Effect on the Horizontal Bar of Youngsters Nada Ibrahim Abdulreda
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of the research was to prepare educational exercises and weights to improve and develop some kinetic variables for the performance angles of the skill of the generator on the young Horizontal bar machine and also to identify the kinetic variables for the performance angles of the skill either hypothesized. The research and training program had a positive effect on some kinetic variables for performance angles of the skill of the catalyst, Statistical significance between the results of the tribes and Posttests of the research sample in some kinetic parameters of the performance angles of the skill of the generator on the brain of young people. The researcher used the experimental method in designing a single group as well as the use of video imaging and determined the research community in a deliberate manner. The pilot experiment was conducted. The experiment was carried out by a group of six players, aged 10-13 years. And then the tests of the Pre group of research and then were applied educational exercises and exercises with weights added two (14) week and the existence of three training units per week and the number of educational units and training (42) training unit and when the program was completed tests dimensionality and processing the results statistically. The fourth part included presentation, analysis and discussion of the results. The researchers concluded that the educational exercises and the added weights contribute to the improvement of some kinematic variety of the performance angles of the skill of the skeletal system in the brain of young people and recommended the use of educational exercises and exercises in weights added to other skills in the gymnastic and other devices. The trainers should take into account the values of the biochemistry variables that have been achieved when training the performance angles of the skill of the generator on the brain of young people.Keywords: Educational Exercises, Weights Kinematic Variations, Performance Angle, Shudder Effect and the Horizontal bar.
Effectiveness of Drying Methods to Callisia Fragrans Tea Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Herbal tea is a polyherbal formulation of different medicinal plants that is a rich source of antioxidant. Tea manufacturing processes can greatly affect the oxidation of tea polyphenols. Callisia fragrans is an herbaceous plant with small white fragrant flowers and waxy leaves. Its leaves are used for treatment of different skin diseases, burns and join disorders owing to its biologically active flavonoids, neutral glycol and phospholipids and fatty-acid. In order to better utilization of Callisia fragrans was functional herbal tea, the effect of different drying methods such as sun drying, microwave drying and oven drying to the total phenolic, total flavonoid and antioxidant capacity was investigated. Results revealed that microwave drying was the best option to stabilize the valuable components in this plant during drying.Keywords: Callisia fragrans, Total phenolic, Total flavonoid, Antioxidant, Drying, Herbal.
Bioequivalence Study of Morphine Hydrochloride Oral Solution versus Immediate Release Tablets Geliya Gildeeva; Andrey Belostotsky; Ekaterina Ezhova; Vladimir Yurkov
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Comparative study of bioequivalence and safety of Morphine Hydrochloride 2 mg/ml oral solution (T) and Morphine Hydrochloride 10 mg immediate release film-coated tablets (R) after single dose administration (1 ampoule 5 ml, 2 mg/ml / 1 tablet 10 mg) by healthy subjects under fasting conditions. Methods: Open-label, single dose, 2-period crossover, randomized design study in 42 healthy subjects under fasting conditions. Test product: Morphine Hydrochloride 2 mg/ml oral solution (FSUE «Moscow Endocrine Plant», Russia) was compared with the reference product Morphine Hydrochloride 10 mg Immediate Release Tablets (FSUE «Moscow Endocrine Plant», Russia) under fasting conditions. The statistical method is testing for Cmax, AUC0-t and AUC0-∞. Bioequivalence study was based upon the 90% confidence interval (90% CI) for the test and reference geometric mean ratio. Bioequivalence was to be assumed if 90% CI fell within the recommended acceptance interval 80%; 125%.Results:Forty-two subjects completed the study. Both Morphine T and Morphine R exhibited peak plasma Morphine concentrations of ~13 ng/ml. 90% CIs of the ln-transformed values of Morphine AUC0-t and Cmax were within 80% to 125% range for bioequivalence. The most common adverse events were anemia and headache. These data show that, in these subjects, Morphine T was bioequivalent to Morphine R, a treatment for pain with well-established efficacy and safety profiles.
Role of Sequencing Genetic for 708 T>A of Cholesterol 7α Hydroxylase (CYPA17) in Patient with Gallstone Disease Antesar Rheem Obead
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

AIM: To investigated the association of the CYP7A1 gene polymorphism and analyze the sequencing of CYP7A1 gene   with development of gallstone disease in Iraq population. Methods: The polymorphism were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two group match by age and sex: patient with gallstone (n=140) and stone-free control (n=140).Result: Novelty single nucleotide   polymorphism   in upstream of   CYP7A1 gene   was founded for   PCR amplification   708 T >A in patient with gallstone and conformed by sequencing data and allelic frequencies in patient and control for T of CYP7A1 gene  38.2% vs 54.6% were significant (p=0.0001).Conclusion: The result have been demonstrated that association between the polymorphism of 708 T> A for CYP7A1 gene and an effect on cholesterol 7 α hydroxylase serum level with high prevalent of gallstone disease.Keywords: CYP7A1, Gallstone, Polymorphism, Sequencing analyzing.
Role of-Added Sugar in Pediatric-Obesity Ayad Thabt Noaman
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Added sugars, sweeteners of calories brought to the office or throughout processing and then training on foods, are the most important taxpayer for energy according to aged 2 years but older comes from added sugars. This level is higher than estimated due to 1976-1977 (12.1%), although it is significantly below the estimated 16.9% for 1998 after 2001, it exceeds encouraging guidelines. The biggest contributors to sugars brought in according to American diet are sugar-sweetened beverages, and adolescents are the biggest consumer. Since the devastation about added sugar linked to including weight problems as well as a lot of poor eating or physical repercussions, it is critical that pediatricians, after being aware of this amount, help this association and then after staying familiar with techniques that may Additionally use counseling for at risk patient and their family.
Inducement of Agarwood Resin Using Various Chemical Formulation of Stem Tissue (Aquilaria malaccensis) Husni Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Agarwood is described as fragrance wood that is usually derived from the trunk of genus Aquilaria which have been infected by a particular disease. The main focus of this research is to study the effectiveness of four chemical inoculants applied into 6 year old karas tree (A. malaccensis) plantations in Slim River, Perak, Malaysia using dripping techniques. The inoculants used were labelled as A, B, C and D. Commercial inoculant, labelled as K, was used for comparison purposes and control labelled as N. After eight months of inoculation, the karas tree were cut down and discoloured tissue samples were collected.  Solvent extraction methods using dichloromethane (DCM) was carried out to obtain the resin crude extract from the plant tissue. Resin crude extract were then analysed using gas chromatography-mass spectrometry (GC-MS). The results showed that all chemicals successfully stimulated agarwood production. Inoculant A produced the highest crude extract recovery (8.63%) compared to inoculants B (7.45%), D (6.55%), C (5.95%), K (1.89%) and N (0.49%). GC-MS analysis revealed that aromatic compounds, sesquiterpenes, monoterpenes, sterols, alkanes and fatty acid methyl ester were identified from DCM extract. As an outcome, inoculant A is the best to be used as stimulant for agarwood due to product highest yield. This finding will hopefully contribute to new types of inoculants production in agarwood industries in Malaysia.Keywords: Agar wood, artificial inoculation, Chemical inducement, Aquilaria malaccensis, Malaysia
Effect of Extract Cocor Bebek (Bryopyllum pinnatum) to the Amount of Th17 Cells Spleen and Levels of IL-17A Serum in Mice Balb/C Pregnant Model of Systemic Lupus Erithematosus Umi Kalsum
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

This study aims to determine a way to reduce the number of Th17 cells spleen and serum levels of IL 1A heart in mice Balb /C pregnant models with Systemic Lupus Erythematosus. This was studied, using mice Balb / C pregnant models with SLE. This study is divided into 5 groups: negative control, positive control, and treatment provision Bryophyllum Pinnatum dose of 10.5 mg/day, 21 mg/day and 42 mg/day.  The Th cell number 17 was measured through flow cytometry. Levels of IL 17A were measured using the ELISA method. The data was analyzed using the Kruskal Wallis test. Giving bryophyllum Pinnatum dose 21mg / day (2.79 ± 1.484) has been proven to reduce the number of Th17 cells in mice Balb / C pregnant models with SLE when compared to the other dose treatment. Although, it did not significantly affect (p> 0.05).There was no difference with the increased levels of IL bryophyllum Pinnatum 17A in Balb / C mice pregnant models with SLE (p> 0.05). Conclusion: Giving bryophyllum Pinnatum has been proven to reduce the number of Th 17 cells in mice pregnant models with SLE.Keywords: Systemic Lupus Erythematosus (SLE), Bryopillum Pinnatum, Th17, IL 17A.
Incidence of Lesions of Organs and Systems in Iron Deficiency Anemia in Children and Its Predictive Significance in the Development of Diseases of Internal Organs Albert Giliazev
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

This article deals with the study of the incidence of somatic pathology in children with iron deficiency anemia. It is shown that children with anemia more often have respiratory pathology, and less often - endocrine diseases. Somatic pathology is almost equally diagnosed in boys and girls and predominates in young children. The authors established the importance of iron deficiency anemia in the development of diseases of internal organs, determining the time of formation and nature of the disease, as well as increasing the risk of involvement of a number of organs and systems in the pathological process.     Keywords: Iron deficiency anemia, children.

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