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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 42 Documents
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Search results for , issue "Volume 11 Issue 6." : 42 Documents clear
Comparison of the Training Skills of the Handball Trainers for the First and Second Classes in Iraq Ahmed Kadhim Abdulkareem
Journal of Global Pharma Technology Volume 11 Issue 6.
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The research consisted of two axes: the level of communication skills and their comparison among the handball trainers for the category of applicants in Iraq. The training communication skills standard was developed and the descriptive method was used in a comparative manner to suit the nature of the research. The research sample included (20) trainers, and the comparisons between training skills were obtained using statistical means.Keywords: Training skills and handball trainers.
Utilizing Bioidentical Hormone as Efficacious and Safe Hormone Jopy Wikana
Journal of Global Pharma Technology Volume 11 Issue 6.
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Background: The relative safety and efficacy of bioidentical hormone compared with synthetic version of hormone replacement therapy (HRT) is still the subject of debate. Some data suggest that bioidentical hormones have opposite physiological effects to synthetic hormones, which associated with lower risk of breast cancer and cardiovascular events. Nevertheless, there is still little evidence to support claims that bioidentical hormones are safer and more effective. Methods: Published papers were identified from PLOS, PubMed/MEDLINE, ProQuest, ScienceDirect, Google Scholar, and Elsevier (SCOPUS) databases, written in English, and fully accessible by reviewers, for studies enrolled postmenopausal women using bioidentical hormones vs. synthetic hormones as HRT. Results: A hundred and eighteen of 341 citations were reviewed. The results of this study found the disparities between bioidentical and synthetic hormones with respect to safety and efficacy. Bioidentical hormones have demonstrated effectiveness in addressing menopausal symptoms. Clinical data has indicated that bioidentical hormone, especially progesterone is associated with a diminished risk for breast cancer and cardiovascular disease, compared with commonly used synthetic versions. Conclusions: The use of bioidentical hormone therapy is well tolerated, provides symptom relief and can address the safer and more efficacious forms of HRT with respect to the lower risk for breast cancer and cardiovascular disease. Thus, bioidentical hormones remain the preferred method of HRT.Keywords: Progesterone, Estradiol, Synthetic progestins, Breast cancer, Cardiovascular disease,
Interaction Model Parents-Adolescents in Adolescents are Risk Addiction of Drugs Ah. Yusuf
Journal of Global Pharma Technology Volume 11 Issue 6.
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Background: One of problems in adolescents is risk of addiction to drugs that negative behavior disturbs the society. Adolescent had more spending time with friends in school and other places that have risk to addiction too Purpose: The aim of this study is analyzed interaction model of parents-adolescents in risk addiction of drugs based on King’s Goal Attainment theory. Method: This study was used cross-sectional design. 124 parents and adolescents from Senior High School through probability sampling that is simple random sampling. Questionnaire data were taken by parents’ (transactional factor, perception, judgment, and action), adolescents’ (transactional factor, perception, judgment, and actions), and parents-adolescents ’reaction, and parent-adolescents’ disclosure. Analysis method was used Partial Least Square (PLS). Results: Parents’ transactional factor influenced on parents’ perception (t=2,074), parents' perceptions influenced parent's judgment (t=2,697), parent’s judgment influenced parent’s action (t=2,396), parent’s action influenced parents-adolescents’ reaction (t=2.774), adolescents’ transactional factor not influenced adolescents’ perception (t=0,594), adolescents’ perception influenced adolescents’ judgment (t=5,744), adolescents’ judgment influenced adolescents’ action (t=2,118), adolescents’ action influenced parents-adolescents’ reaction (t=2.831), parents-adolescents’ reaction influenced parents’-adolecents’ interaction (t=3.048), parents’-adolescents’ interaction influenced parents’-adolescents’ disclosure (t=8,062). Conclusion: Many factors are being adolescent to risk addiction of drugs and can control with interaction models. Using interaction model of parents-adolescents so that practitioner can improve adolescent’s health promotion activities in community.Keywords: Adolescent, Parent, Risk addiction, Interaction.
Teaching Curriculum Using the Effect Competitive Learning Style According To the Training Network Exercises Learn Some Offensive Skills of Basketball Emad Toma Radi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Research objectives of preparing an educational platform for educational units using the teaching and learning style of individual and collective competition according to exercises training network to learn some offensive skills of basketball.The researcher pilot curriculum sample that consisted of the first grade students of faculty of Physical Education in the  Mustansiriyah  University, whose number reaches 57 students divided into three experimental groups used tools and means of information collection and tests the skill and experience of the scientific Choose foundations of exploratory pretest curriculum dimensional tests and statistical means. And then present, analyze and discuss the results of the three aggregates, and then the researcher arrived to conclusions as follow:That the teaching curriculum using competitive learning network, according to the training exercises had a positive impact on learning performance level skilled in the handling of the Invite long over your shoulder shots jumping among students in the sample.Keywords: Teaching curriculum, Competitive learning, Training network exercises and offensive skills.
Clinical Use of Ultrasound in Obstetrics Saba Kamal Mahmood
Journal of Global Pharma Technology Volume 11 Issue 6.
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During the past three years, ultrasound diagnostic procedures have been important and useful means in clinical practice of obstetrics and gynecology. Ultrasound images of the flow, whether color flow or spectral Doppler, are obtained from motion measurements. In ultrasound scanners, a series of pulses are transmitted to detect blood movement. Echoes of fixed tissues are the same from pulse to pulse. The echoes of the transition from scatter to slight differences appear at the time of signal return to the receiver. These differences can be measured as a direct time difference, or usually, in terms of the phase shift from which the Doppler frequency is obtained. It is then processed to produce either a color flow display or Doppler ultrasonography.
In-silico Screening of Compounds Contained in Wera (Malvaviscus Arboreus Cav.) Leaves as Anti-alopecia with Androgen Receptors R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 6.
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Objective: Baldness (Alopecia) is a serious problem at this time because it is caused by stress, genetic factors, pregnancy, inadequate hair care, and less balanced nutrition. Previous studies have shown that ethanol extracts of Wera leaves (Malvaviscus arboreus) have anti-baldness properties. Research study was undertaken to investigate the potential of chemical compounds contained in the leaves of Wera as hair growers using androgen receptors with comparative drugs Minoxidil. Methods: This type of research is in silico where the results obtained are free energy values and hydrogen bonds that connect ligands with receptors. Results: From the 7 compounds contained in the Wera leaf, the results showed that trifolin compounds gave the lowest energy -7.08 kcal/mol and amino acids that were bound were Thr (877), Asn (705), and Phe (764) where more than the comparative drug Minoxidil namely Leu (873) and Asn (705) with free energy is -5.81 kcal/mol. In predicting pharmacokinetic properties and toxicity tests, compounds that are predicted as candidates for hair growth drugs do not meet pharmacokinetic parameters and are non-mutagenic and not carcinogenic so they cannot be administered orally. Conclusion: It is found that molecules with compounds 2- [2- (5-methyl-2-propane-2-ylphenoxy) ethoxy] naphthalene-1-carboxylate provides the lowest energy, which is -9.47 kcal/mol so that it has the potential to be a candidate for a new drug in the treatment of hair growth, namely alopecia either oral or topical usedKeywords: Wera leaves, In-Silico, Hair growers, Androgen receptors, Malvaviscus arboreus.
Tetanus Combined Immunization with Tetraxim and Pentaxim in Children from 3 Months to 4 Years Alla Philippova
Journal of Global Pharma Technology Volume 11 Issue 6.
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The causative organism of tetanus is the Clostridium tetani. Immunization is one of the effective methods of disease prevention, which is carried out from the first 2 months of life. Further vaccination continues, in combination with the measles vaccine. Thus, tetanus in modern medicine is one of the elements of the combined vaccinations. 300 children were vaccinated hosted by the Department of Infectious Diseases of the Hospital № 2 in Moscow (Russian Federation) during the first six months of 2017. The age interval of children is from 3 months to 4 years. 2100 vaccinations were carried out, 1810 of which were vaccinations with Pentaxim, and the rest with Tetraxim.  255 children (85% of all), immunization program with Tetraxim was prolonged after the Pentaxim vaccinations. This is due to the fact that the first immunization occurs in half of a year. The reasons for this are in the social incompetency of the most parents as they begin immunization from 6 months, not from 3. The proposed drugs showed high-potency in children of different age groups and in state of health. Tetraxim and Pentaxim are applicable for children with allergies, as well as with CNS involvement. Moreover, they can be included in combination vaccines against such diseases as whooping cough, diphtheria, tetanus, poliomyelitis, Haemophilus influenzae b. It is due to the same components used, namely DTwP, IPV.
Effect of Special Exercises for the Development of Some Biochemical Variables and the Level of Performance of Diagonal Spike Skill in the Volleyball Hamida Obaid Abdulamir
Journal of Global Pharma Technology Volume 11 Issue 6.
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Volleyball is one of the sports activities that need to apply the modern scientific methods through the development of the sport training science, which aims to improve the player's physical and functional abilities through careful planning of training courses for the development of its efficiency in the performance of all requirements for volleyball, The importance of research in the study of some chemical components of blood and the changes obtained by the training using special exercises because of its importance in developing the skill of beating overwhelming in the players the researchers used the experimental method to suit the nature of the problem on the players of the Kufa youth sports club for the season of 2018 (12) players, and was adopted a cohesive method of selection in the selection of the sample, the tests used in the research biochemical tests: measuring variables (cholesterol, sugar, And the test of the skill of beating the overwhelming country, after which the researchers carried out the tribal test, and then the exercise and then the post-test The researchers concluded that the exercises used, which were specialized exercises of the type of skill and complex exercises and exercises. The researchers recommended to emphasize the importance of speed of performance and stress on exercise. Specialization in the skill type especially in the volleyball game, the interest in training the ability to develop the strength of the chemical variables and the level of skill performance of volleyball players, and benefit from the measurement of the activity of enzymes and the proportion of sugar and cholesterol contribute to the processes energy and muscular construction in the training of volleyball players at all levels, and conducting similar research in the use of explosive force training exercises to develop muscle strength in the non-oxygen system and identify the biochemical variables of volleyball players.Keywords: Special exercises, Biochemical variables, Spike, Volleyball.
The effect of Saccharomyces cerevisiae on the serum creatinine levels of chronic kidney disease mice model besut daryanto
Journal of Global Pharma Technology Volume 11 Issue 6.
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Title: The Effect of Saccharomyces Cerevisiae On The Serum Creatinine Levels of Chronic Kidney Disease Mice Model Besut Daryanto, M.D, Ph.D *, Givary Dymar Lazuardi, Dewi Mustika, M.DDepartment of Urology, Faculty of Medicine, Universitas Brawijaya, Indonesia*Author: Email: besut.daryanto@yahoo.co.idTel.: +628123104879; Fax: +62341333030 AbstractIntroductionChronic kidney disease is pathological condition with various causes, resulting in a progressive loss in kidney function and then ended in end-stage kidney disease. Chronic Kidney Disease become a health problem in the world with increasing number of patients, high progressivity, and bad prognosis. Saccharomyces cerevisiae which has high beta glucan content can increase the level of granulocyte-colony stimulating factor (G-CSF) in the body. The increase of G-CSF level will elevate the excess of hematopoietic stem cell (HSC) in the circulation. The excess HSC can regenerate damaged tubular cells. The study used serum creatinine levels as a marker of improved kidney function. The objective of this research is to determine the effect of S. cerevisae to the serum creatinine levels of mice model with chronic kidney disease and to determine the correlation between dose of S. cerevisae extract and serum creatinin levels of chronic kidney disease mice model.Materials & MethodsThis in vivo experimental study used a randomized post test only controlled group design. The samples were divided into five groups, each group consists of 5 mice, that were negative control group, positive control group, Treatment Group 1 (Aristolochic Acid + S. cerevisae extract 50 mg/kg), Treatment Group 2 (Aristolochic Acid + S. cerevisae extract 100 mg/kg), Treatment Group 3 (Aristolochic Acid + S. cerevisae extract 200 mg/kg). The induction of chronic kidney disease were using aristolochic acid 2,5 mg/KgBW 5 times a week for 2 weeks. The variables measured in this research is the serum creatinine levels.ResultsStatistical data obtained shows that the average number of serum creatinine levels at negative control group was 0,3788 mg/dl in the positive control was 0,6425 mg/dl; in the treatment 1 was 0,4575 mg/dl; in the treatment 2 was 0,3850 mg/dl; in the treatment 3 was 0,3263 mg/dl. ANOVA test results showed significant difference between groups (p < 0.05)Conclusions S. cerevisae was able to decrease the serum creatinine levels of chronic kidney disease mice model and there were correlation between increased dose of S. cerevisae and decreased in serum creatinine levels. Keywords Beta Glucan, Saccharomyces cerevisae, serum creatinine levels, Chronic Kidney Disease
Alleviation of Oxidative Stress and Suppression of Inflammatory Cytokines in STZ -induced Diabetes by Banana (Musa paradisiacal), Kiwi (Actinidiadeliciosa planch) and Olive (OleaeuropaeaL.), by-products, Extract: Comparative Study Hanan F. Aly
Journal of Global Pharma Technology Volume 11 Issue 6.
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The effect of peels (kiwi, banana and leaves (olive and banana)acetone extract 80%on streptozotocin (STZ) induced diabetic rats was investigated. Oral administration of 500 mg crude extract /kg body weight for 30 days post induction of diabetes, showed remarkable improvement in all biomarkers under investigation compared to standard drug. Olive leaves showed the highest percentage of improvement in glutathione (GSH), nitric oxide, (NO), glutathione peroxidase (GPX) glutathione –S-transferase (GST) ,catalase, lipid peroxide (MDA) , urea  ,creatinine, tumor necrosis factor- α(TNF-α) interleukin 1β(IL1-β)  (41.74,138.68, 48.77, 26.15, 27.84, 73.54, 97.92, 81.37, 52.96 and 40.24% , respectively).While, banana leaves and kiwi peels extracts showed the highest percentage of improvement in antioxidant enzyme paraoxonase (PON1) and transforming growth factor β(TGF β)reached  16.90 and 41.81%, respectively. From a histopathological point of view, treatment of diabetic rats with different extracts revealed regeneration and amelioration effects of extracts on the pancreas and renal tissues in diabetic rats and apparently normal. It could be concluded that the anti-hyperglycemic properties of plant extracts may offer a potential therapeutic source for the treatment of diabetes. Further work on isolation and characterization of active constituents in these wastes is needed.Keywords: Diabetes, Inflammatory cytokines, Antioxidant, Oxidative stress.

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