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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
The Spectrophotometric Determination of Thiamine Hydrochloride Drug by Coupling with Diazotized Procainamide Khansaa I . Abass
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

For the determination of thiamine hydrochloride (THC) in both pure and formulated  forms, a simple, sensitive and accurate spectrophotometric method was described. The technique is based on diazotization of the primary amine group of Procainamide with sodium nitrite and hydrochloric acid followed by combining with thiamine hydrochloride to create Light red azo dye showing peak absorption at (502) nm. Beer's law has followed the concentration range (2.5-40) μg.mL‾¹,with (0.1490) μg.mL‾¹ detection limit. The molar absorptivity and Sand ellʾs sensitivity were detected to be respectively (7285.0320) L.mol‾¹.cm‾¹and (0.0463) μg.cm‾². The method for determining in thiamine hydrochloride pharmaceutical preparation has been applied successfully.Keywords: Thiamine hydrochloride, Spectrophotometric determination, Procainamide, Diazotization and coupling.
Relative Expression of PPARγ and ADIPOQ mRNA as markers of Inhibition Adipogenesis on Mesenchymal Stem Cells after Pulsed Electromagnetic Field (PEMF) Exposure Puji Sari
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

ABSTRACTObjective: Obesity has become a major health problem in the world. PEMF is a modality for healing obesity because its ability to inhibit adipogenesis. Adipogenesis involves PPARγ transcription factor which plays a role in activating adipogenic genes, including ADIPOQ. PPARγ is highly expressed in the early stages of adipogenesis and ADIPOQ is highly expressed in the termination phase of adipogenesis. Both of these genes can be used as a marker of adipogenesis. This study aimed to determine the level of PPARγ and ADIPOQ expression in the group of MSCs that were exposed to PEMF and the group of MSCs that were not exposed to PEMF.Methods: The MSCs were exposed with PEMF intensity of Bmax = 2 mT, f = 75 Hz, 10 minutes a day for 14 days. Total RNA was extracted from MSCs from each treatment group on day 0 (calibrator), 2, 4, 7, and 14. PPARγ and ADIPOQ mRNA expressions were analyzed using the qRT-PCR method.Results: The results of the qRT-PCR analysis showed that the expression of PPARγ and ADIPOQ mRNA in the group that exposed to PEMF was lower than the group of MSCs that were not exposed to PEMF (p <0.05).Conclusion: PEMF exposure has an inhibitory effect on adipogenesis of MSCs. PEMF exposure decreased the relative expression of PPARγ and ADIPOQ mRNA.  Keywords: PEMF; Adipogenesis; Mesenchymal stem cells; PPARγ, ADIPOQ.
Efficacy of Carrageenan as Emulsifier and Breadfruit Flour as Substitute Ingredient on Physicochemical, Microbial and Organoleptic Properties of Fermented Ice Cream Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Breadfruit is a nutritious food but not widely utilized in industrial production. Carrageenan has excellent functionality on phase separation and cryoprotection. Ice cream is a delicious and nutritious frozen dairy product widely consumed. It is a complex microcrystalline network of liquid and solid phases. This study focused on the utilization of carrageenan as stabilizer and breadfruit flour as a substitute ingredient on physicochemical, microbial and organoleptic properties of fermented ice cream. Different supplementation ratio of carrageenan (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) and breadfruit: milk (30%:, 70%; 40:60%, 50%:50%, 60%: 40%; 70%: 30%) were demonstrated. The fermentation process was conducted with Lactobacillus sp. starter culture (ratio 0.2%) at loading cell 109 cfu/ml at 37oC in 48 hours. Results revealed that carrageenan (2.0%), breadfruit: milk (60%: 40%) were ideal for production of fermented ice cream. From this investigation, consumers have more chance to consume one kind of functional ice cream from breadfruit starch.Keywords: Breadfruit, Carrageenan, ice cream, Lactobacillus, physicochemical, Microbial, Organoleptic, fermentation.
Influence of Proteoglycanes on Reactive Changes of Cerebral Neurons under Stress Alexey Rozhentcev
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

The article presents research data on the effect of proteoglycans on reactive changes in cerebellum neurocytes under the action of a stressor. We simulated hypobaric hypoxia as a stress factor affecting cerebellar neurons. This is due to the fact that hypoxic conditions are widespread and can occur both in injuries and in various diseases. The histological and histochemical methods were used to determine the effect that proteoglycans have on changes that occur in cerebellum neurocytes under the influence of a stressor. Our comprehensive studies have helped to establish that the introduction of proteoglycans in order to correct the effect of hypobaric hypoxia on cerebellum neurocytes has a positive effect on intracellular production and excretion of high molecular weight compounds. So, in the neurons of the cerebellum of rats of the experimental group, a smooth increase in the processes of physiological regeneration was noted. In addition, destructive changes in neurocytes were less pronounced compared with the control group. The ultrastructural studies of rat cerebellum nerve cells in the control group showed that under the action of hypoxia in the early stages there was an increase in the volume of intracellular structures, and then, with prolonged exposure – a decrease in their volume. This, in turn, has a negative effect on metabolic processes inside the neuron and, as a consequence, the growth of destructive changes. An experimental study showed the effectiveness of the use of proteoglycans for the correction of changes in cerebellum neurocytes under the influence of a simulated stress factor.Keywords: Hypoxia, Cerebellum, Neuron, Proteoglycans, stress factor, Ultra-structure.
Methyl Violet Dye as Corrosion Inhibitor for Carbon Steel in Acidic Medium" Hamida Edan Salman
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

The present work involves study the Methyl Violet dye as a corrosion inhibitor with concentrations rang (25- 200) ppm for their influence on carbon steel corrosion in 1M H2SO4 at temperature range (303-323) K utilize"potentiodynamic polarization technique."Corrosion rates, Corrosion potential, current corrosion, inhibition efficiency, cathodic and anodic Tafel islopes were found."The study also examined influence of concentration and temperature on inhibition efficiency the results manifest that the dye utilized could be good and active inhibitor for carbon steel. Thus, the dwindle in the rate of corrosion is due to the of forming of a protective strata formed on the surface electode that which adsorbed physically and chemically on the surface of carbon steel. Energy values of activation (Ea), enthalpy (ΔH*), energies of Gibbs (ΔG*), and activation entropy (ΔS*), alongside along"thermodynamic amounts of corrosion and adsorption provision indicating the dye effect as a good inhibitor. The isotherm langmuir paradigm be obvious shaped well to enhanced the adsorption operation on carbon steel surface in acidic solution. 
Nursing Students Interests to Work Overseas: A Mixed Methods Study Pepin Nahariani
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Opportunities for nurses to work abroad are extensive. But in-fact 60% of nurses work in the country, 35% work outside of their competence and only 5% work abroad. The study aimed to analyze the interest of nursing students to work overseas. Methods: a mixed-methods design was conducted. The totals samples were 395 respondents of Diploma Nursing, Bachelor of Nursing, and Profession of Ners programs. The sample was taken using totals sampling. The data collection was taken by a nursing migration questionnaire, a statistical test using linear logistic regression. The qualitative approach used by an in-depth interview. Eight Participants who were from the Bachelor of Nursing students.  Results: The results showed that almost 62.5% (247) of respondents indicated an intention to work overseas. Whereas the most significant influence of a plan to work abroad was gender, 43% of females, the academic of nursing bachelor programs were 49%, English language skills were 29%, and income is less than 3 million 61%. The country chosen had the highest probability (OR 3.5), thus the planned future overseas (OR 1.47), the information (OR 1.26), and the study program (OR 1.25). But the lower grades of intention working abroad were income (OR 0.6). Conclusion: Based on this research showed that most students interest in working abroad in Kuwait (83.5%), Japan (15.7%) dan Arab Saudi (0.3%). Besides, the few students’ interests work in another country that has a foreign language from English. The implementation of increasing career paths and improving the quality of human resources through foreign language skills will provide excellent opportunities to work overseas.Keywords: Student; Nursing; Interest; Intention; Working overseas.
Oxidative Stress Status in Sera, Seminal Plasma and their Correlation with Lead (Pb) and Cadmium (Cd) in Iraqi Infertile Male Suha Hanoon Hasan
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Oxidative stress has been identified as a major mediator in various etiologies of male infertility. Lead and cadmium are two of the well-known reproductive toxicants to which human are exposed occupationally and environmentally. These heavy metals can lead to negative effects on the testicular functions. The aim of the current study is to look for the differences in the oxidative stress status in serum and seminal plasma of infertile male patients (oligo, azoospermia) groups compared to that of fertile healthy (control) group and to evaluate lead and cadmium levels in sera and seminal plasma of these groups in comparison to fertile healthy controls. The correlation between their level in seminal plasma and serum was also investigated. The current study included three groups of Iraqi male, 32 infertile patients with oligospermia, with 32 infertile patients with azoospermia, and 37 fertile healthy as a control group. The measured parameters included serum and seminal plasma total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), lead and cadmium concentration. The results in comparison with that of the control groups showed:-A highly significant increase differences in serum (TOS), (OSI), Pb, and Cd in serum of all infertile groups and between them.A significant decrease in serum TAC of azoospermia group, as well as a significant decrease in serum TAC of oligospermia group with significant differences between these two patients groups.No significant differences in seminal plasma TOS, TAC, and OSI in all of the infertile groups.In seminal plasma, a highly significant decrease in Cd and Pb of azoospermia group. Meanwhile a highly significant decrease in Pb of oligospermia group with highly significant differences between them. The results showed no correlation in the measured parameters between serum and seminal plasma of both studied patients.The Personal correlation analysis of TOS, TAC, OSI, Cd, and Pb revealed the presence of: - in oligospermia group, a strong negative correlation was found between serum, (TOS&TAC), and (TAC&OSI), meantime strong positive correlation between (TOS&OSI) also noticed. In serum azoospermia group a positive correlation between TOS&OSI and negative correlation between TAC &OSI were found. Meanwhile in seminal plasma a negative correlation was found between OSI&TAC. Furthermore, the result revealed, that the non-significant inverse relationship exists between lead and Cadmium concentration in serum and the number of sperm.Keywords: Male infertility, Serum & Semen, Total oxidant status, Total antioxidant capacity, Oxidative stress index, lead, Cadmium.
Pre-coordinated Deployment of Emergency Medical Team (Emt) Orthopaedic Spine Specialist-Cell: Experience in An Acute-Phase of the 2018 Lombok Earthquake by Yogyakarta Team Gean Juniwan Syahputra Batong
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Indonesia is located at the meeting point of three major continental plate-the Pacific, the Eurasian, and the Indo-Australian plates-and also on the “Ring of fire”, which makes Indonesia vulnerable to earthquakes and volcanic eruption. As population density continues to increase, challenges grow for emergency responders in the aftermath of such disaster [1].Sudden Onset Disaster (SOD) occur with little or no warning and often cause excessive injuries far surpassing the national response capacities. Following SODs a large number of Medical Teams or Emergency Medical Teams often arrive in-country to provide emergency care to patients with traumatic injuries and other life-threatening injuries. Emergency Medical Teams are groups of health professionals (doctors, nurses, paramedics etc.) that treat patients affected by an emergency or disaster. Emergency Medical Teams, according to their capability, classified into 5 types; such as EMT-1 Mobile, EMT-1 fixed EMT-2, EMT-3, and EMT Specialized cell. Providing trauma care or medical care in disaster setting is very challenging. After an earthquake, local medical infrastructure was often damaged or destroyed, thus healthcare responders may not be able to rely on the medical resources of the afflicted region. Therefore, healthcare responders must provide the necessary medical equipment and supplies which requires good planning, efficient resource allocation, and understanding of the injuries that are likely to be encountered. Earthquake-related trauma results in severe injuries and requires rapid response in the acute-phase. Spinal injuries are important issue because the delay in adequate management can cause the patient to fall into a worse state, which can result in death or permanent disability. Orthopaedic spine surgeon on a disaster team could be an important asset during the response. The aim of this report was to evaluate whether the challenges faced in an acute-phase of earthquake can be obstacles to perform adequate orthopaedic spine management.
Characteristics of Biocompatible Coatings on Dental Implants Alexei Yumashev
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The purpose of this article is to give an overview of various biocompatible modifications of the implant surface and factors that mainly affect processes at the implant-bone interface. This review summarizes and explains the factors that are currently recognized as important for dental implants osseointegration: body materials and coatings, topography, hydrophilicity and polarity of the implant surface. Implant body materials (titanium, zirconium) are designed to provide mechanical stability. Their effect on bone cells can be improved with the help of surface treatment with various materials that include calcium phosphates, strontium, bio-glass, and diamond-like carbon. Surface topography can be changed using various methods, for example, plasma spraying, sandblasting, acid etching and microarc oxidation to increase bone contact with the implant. The hydrophilicity and polarity of the surface of the implants shows a significant cell adhesion effect. At the present time the currently used dental implant materials are showing satisfactory clinical results, ongoing research on innovative surfaces is necessary to improve and accelerate the of dental implant osseointegration.Keywords: Dental implants, Implant body materials, Biocompatible coatings, Osseointegration.
Preparation and In-Vitro, Ex-Vivo Evaluation of Oral Dosage Form Containing Mirtazapine Nano suspension Hiba Ezzat Hamed
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of this study is to formulate and evaluate mirtazapine nanoparticles using solvent anti solvent technology. Mirtazapine is practically insoluble in water which acts as antidepressant. Itis prepared as nano particles in order to improve its solubility and dissolution rate. Mirtazapine nanoparticles were prepared using anti-solvent precipitation method using different stabilizers (poloxamer 188, poloxamer 407, TPGS and SLS) at drug: stabilizer ratio 1:1 and 1:2, alone and in combination. Mirtazapine nanoparticles were characterized by particle size analysis, percentage of drug entrapment efficiency, in vitro dissolution study, ex vivo study, Fourier transform infrared spectroscopy, differential scanning calorimetry and atomic force microscope. Freeze dried nanoparticles were compressed into tablets by direct compression method using different excipients which are microcrystalline cellulose PH 102, starch, and Mg stearate as diluent, binder, and lubricant; The results showed that the particle sizes were ranged from 272 to 691 nm at drug: stabilizer ratio 1:1 and from 146 to 572 nm at drug : stabilizer ratio 1:2. Stabilizers combination has good surface affinity and could form a substantial mechanical and thermodynamic barrier at the interface of dug molecule. As the concentration of stabilizer increases the particle size decreases at fixed drug concentration. % EE was ranged from 75.5% to 95.9%. On the other hand dissolution rate increasing as the particle surface area is increase due to reduction of particle size to the nano range.Keywords: Mirtazapine, Nanoparticles, Particle Size, Poloxamer.

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