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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
Effectiveness of Lactic Fermentation and Convective Dehydration to Antioxidant Characteristics of Plumeria Flower Tea Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Fermentation is believed as one of the oldest and most useful approach to maintain or improve phytochemical values. Convective drying is an economical and versatile dehydration method commonly applied in food and herb production. Plumeria flower contains a large number of phytochemical constituents and pharmacological activities. The benefits of plumeria flowers can be enhanced remarkably by processing it into a probiotic tea through lactic fermentation and convective dehydration.  Lactic acid bacteria are able to accelerate the production of polyphenolic compounds as well as to improve antioxidant capability in this valuable herbal tea. This study penetrated on the utilization of lactic fermentation by Lactobacillus acidophilus culture in different innoculation ratio (0.05%, 0.1%, 0.15%, 0.20%, 0.25%) at the loading cell 109 cfu/g on plumeria flower during 37oC in 24 hours. Relying on bioconversion mechanism, we can obtain higher amount of active ingredients in the fermented tea. This study also emphasized on the convective drying temperature (45oC, 50oC, 55oC, 60oC, 65oC) in maintaining the active components inside plumeria flower tea during dehydration to safe mode (6.5% moisture). We noticed that the Lactobacillus acidophilus culture innoculation 0.20% (109cfu/g) and convective drying temperature 55oC were appropriate for plumeria flower tea production. From this production, consumers have better chance to use one kind of novel herbal tea from plumeria flower.Keywords: Plumeria flower, Lactobacillus acidophilus, Lactic fermentation, Convective dehydration, herbal tea.
Determination of the Fungicidal Properties of Plants and Herbal Combinations against Ascosphaera Apis l. Fitrat Yumaguzhin
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

The urgency of the problem under investigation is due to the need to develop plant means for the prevention and treatment of fungal diseases in bee colonies. The aim of the article is: * to search for medicinal plants with fungistatic activity in relation to the causative agent of chalkbrood; * to create herbal combinations and to comparatively evaluate their activity in laboratory and production conditions with the chemical compounds recommended for chalkbrood treatment. The main laboratory method for assessing the fungistatic activity of plants and herbal combinations is comparing the zones of delayed growth of the chalkbrood causative agent in experimental and control media. In the production environment, the influence of herbal combinations was assessed by comparing the quality of wintering of bee colonies, the rate of their spring development, the reduction of bee larvae infected with chalkbrood and the amount of collected honey. Laboratory conditions revealed that alcohol extracts of celandine (Chelidonium majus), fir needles (Abietis sibiricae) and pot marigold, or calendula (Calendula officinalis), had a pronounced fungistatic effect (comparable to that of the chemical compounds) on the growth of the mycelium of Ascosphaera apis. Several herbal combinations were prepared which, in vitro, also had a pronounced fungistatic effect. Under their influence, the preservation of bee colonies during wintering was improved, the incidence decreased, and honey production increased. The materials of the article can be of use for scientists working on developing drugs for the prevention and treatment of fungal diseases in bee colonies, as well as for beekeepers who do not use chemical compounds in their produce.Keywords: Medicinal plants, Wintering of bee colonies, Catalase, Spring development, Chalkbrood.
Evaluation of IL-27 Concentration in a Miscarriages Woman Infected with Toxoplasma gondii Raad Ajam Sayal Al. Jorany
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Toxoplasmosis is one of the most common zoonotic pathogens worldwide; Immune response against this parasite was affected by synthesis of specific interleukins like IL-27. The major objectives of this study detection of prevalence expression of IL-27 among ninety-six miscarriages women were tested; forty-eight of them was with miscarriages due to toxoplasmosis and forty-eight apparently healthy pregnant women (with out of any miscarriages) were enrolled as a control group in Najaf governorate. Methodology: Descriptive case-control, purposive (probability) sample among ninety six miscarriages women were tested, attending in Central Health Laboratory .The data collected from January 2019 to September 2019. The concentration level of IL-27 in miscarriages women was measured  by ELISA technique according to many parameters such as age, occupation, residence and number of miscarriages. The result indicated that the concentration of IL-27 was elevated in women with one or two miscarriages. The high concentration of IL-27 in infected miscarriages women with age group (20-24), (25-29).There was no significant differences in study groups according to occupation and there were differences in IL-27 concentration levels according to residency. It was demonstrated that the high concentration of IL-27 was appear in rural infected miscarriages women and low in urban miscarriages women with toxoplasmosis, results were analyzed by using statistical methods (Levene test, ANOVA test, t test). Conclusion:  Interleukins (IL-27) play a significant role in immunity against infection with Toxoplasma gondii. Recommendation: Further studies are recommended to know the concentration of IL-27 among miscarriages women to be one of an important laboratory tests in the induction of immune response against this type of infection.Keywords: Interleukins IL-27, Toxoplasma gondii, Miscarriages women.
Self-Belief and Social Support Factors on the Emotional Response of Patients with Hypertension Riza Fikriana
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Emotional responses that occur in patients with hypertension will affect the compliance of healthy life behaviors and treatment of hypertension. The study aims to analyze the effect of self-belief and social support on the emotional responses of patients with hypertension. Method: The study was analytic observational design with a cross-sectional study approach. Samples were taken by multistage random sampling as many as 225 people with hypertension who have systolic blood pressure above 160 mmHg and or diastolic pressure above 100 mmHg. Research instruments of the study are in the form of self-belief questionnaires, social support, and emotional responses. Data analysis performed using Pearson test and linear regression. Result: The results of the study describe all the variables of self-belief showing that more than 50% of sufferers have self-belief in the moderate category. Moderate social support variables describe more than 50% of sufferers have less social support. Pearson test found a significant relationship between self-belief and social support to emotional responses on patients with hypertension. Linear regression analysis found self-belief in the form of perceived severity, perceived threat and health worker's support affect the emotional response of patients with hypertension. Conclusions: The emotional response of patients with hypertension is influenced by health worker's support, perceived severity, and perceived threat.Keywords: Self-belief, Social support, Emotional response, Hypertension.
The Impact of Smoking, Including Hookah, on the Human Body Elena Emelina
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Smoking is a social problem in society. For smokers, the problem is to quit smoking, for non-smokers-to avoid the influence of smokers and not "catch" their habit, and also-to maintain their health. Tobacco use is the only truly avoidable cause of death worldwide, with approximately half of all long-term smokers dying. World Health Organization (WHO) estimates that there are 1.3 billion people who smoke in the world and forecasts that the number of people who smoke will increase to 1.6 billion by 2025. Currently, 47% of men and 12% of women consume tobacco globally, while only in Europe about 30% of the adult population smokes. In recent decades, the growth of the tobacco epidemic is mainly due to an increase in the proportion of people who smoke in developing countries. At the same time, the smoking epidemic is growing among women and the younger generation. In Russia, the prevalence of smoking is one of the highest in the world. The increase in the prevalence of tobacco smoking in recent years in our country has been facilitated by freer trade in cigarettes, low prices for them and aggressive, widespread, large-scale advertising of tobacco products in all media.Keywords: Tobacco smoking, Hookah smoking, Health, Safety, Smoker.
Ferrimagnetism in the Mean-field Approximation of a Mixed Spin Ising Nanowire System Hadey K. Mohamad
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

A ferrimagnetic mixed spin square Blume-Capel Ising nanowire system consists of spin-1 core and spin-3/2 outer shell has been investigated. The general formula for the temperature dependence of the equilibrium magnetization of the system is presented. The ferrimagnetic core-shell nanosystem shows a compensation point when the exchange interactions are changed at various values of the single-ion anisotropies of shell sublattices and core ones, respectively. So, one can examine interesting phenomena are compensation behaviors and the free energy of the nanosystem, where these phenomena found that the mixed-spin square Blume-Capel Ising nanosystem which is being considered has two spin compensation temperatures in the range of ,  when , for two different values of core anisotropy for sublattices of atoms A, , and , respectively.
The Implementation of Controlling in Nursing Care Management Regarding Ventilator-Associated Pneumonia Bundles on Post Heart Surgery Patient in Intensive Care Unit Nursalam .
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Control in the nursing care management for Ventilator-Associated Pneumonia (VAP) bundles of post-cardiac surgery patients is related to using predetermined standards and actions taken to correct mismatches between standards and actual performance. The purpose of this study was to apply the identification of controls in the nursing care unit to the VAP collection in the intensive care unit. Design research using quasi-experiments before and after with the control group. The population in this study was nurses invited to pediatric Intensive Care Unit (ICU). The number of samples was 32 people, divided into two groups consisting of intervention and control, taken by purposive sampling technique and General Linear Model Repeat Measure (GLM-RM) analysis method.  The results of this study were analyzed by the dependent t-test. Dependent t-test results obtained in the average VAP bundle before the intervention were 3.3462 and after the intervention were 3.8362 with an average change of 0.41707 andp-value (0,000) < (0.05).The application of controls in the nursing care management to the VAP bundle in accordance with the Standard Operational Procedure (SOP) emphasizes better accountability in providing nursing care to patients who are fitted with work safety and improves the actual performance of officers. Implement the control of a part of a continuous improvement strategy in quality control of special health services in relation to pneumatic infections installed in mechanical facilities in the Intensive Care Unit.Keywords: Controlling, Nursing Care Management, VAP Bundles
Probiotic Drugs Impact on the Innate Immunity Factors Oksana Nikolaeva
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Probiotics are the drugs containing living microorganisms related to normal physiological intestinal flora. Recently probiotic drugs are made based on microorganisms’ pp. Bifidobacterium, Lactobacterium, apathogenic strains pp. Streptococcus, Enterococcus, acquired from the humans and animals’ gastrointestinal tract. These microorganisms have a certain impact on the innate immunity factors, interacting with the lymphoid intestinal system. The studies were aimed at examination of the probiotic drugs impact on the innate immunity factors. 60 newborn calves of black-motley breed and 60 piglets of large white breed of 45-day weaning became the object of the study. Blood draw of newborn calves and weaned piglets for immunological studies was performed before the study and then on the 10th, 20th and 30th day of the study. When examining the innate immunity factors there were defined such factors as lysozyme activity in blood serum, blood serum bactericidal factors value and phagocytosis system factors. It was stated that the animals treated with the probiotic drugs based on L. plаntаrum 8P-А3 and synbiotic drugs based on L. plаntаrum 8P-А3 as well as on the medicinal plant materials have the innate immune factors activated with age.Key words: L. plаntаrum 8P-А3, innate immunity, Chеlidоnium mаjus L., Bеrbеris vulgаris, blood phagocytic activity.
Shigella Flexneri Ghost Cells as a Vaccine with Correct Surface Antigens Orooba Meteab Faja
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Increasing interest was shown in the last five years concerning preparation of the microbial ghosts including the bacterial cells as a vaccination method by using the newly-introduced protocol, the sponge-like protocol. The current study is concerned with preparing Shigella flexneri cell ghosts (SFGs) for generating vaccine against the intestinal infection caused by S. flexneri to minimize the incidence of watery and dysentery diarrhea among people. SFGs were successfully produced in vitro with and their surface antigens were evaluated with specific antibodies. The oral vaccination with SFGs through a challenge test proved that both of (O) and (H) antigens in rat sera were confirmed after treatment with SFGs. The agglutination test showed correct in vitro and in vivo antigen-antibody binding. That demonstrated the validity of SFGs in rat immunization against viable S. flexneri. This study is the first in showing the feasibility of SFGs as a vaccine and in different immunological applications such as the preparation of the adjuvants and the antibodies, the production of the diagnostic kits and experiments aimed to study the surface antigens of S. flexneri. This study is an important process for establishing proper SFGs for different immunological directed applications.Keywords: Ghost cells, Shigella flexneri.
A Case Report on Diabetic Ketoacidosis in Children Keerthana Chandrasekar; Diya C; Vignesh Kumar K
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Abstract:Introduction: Diabetic Ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycaemia, ketonemia and acidosis. It oocurs as a complication of diabetes that results in accumulation of ketone bodies and acidosis in large quantities in the blood. It occurs as a result of a complication of Type 1 Diabetes Mellitus (T1DM) and rarely in Type 2 Diabetes Mellitus (T2DM) in children and adult.Presentation of the case: A 10 year old female child had the complaint of polyuria and polydipsia and within 2 weeks her weight has reduced to 10 kg; she also had itching, burning sensation during micturition and history of vomiting 2 episodes. She was diagnosed as T1DM with DKA and was treated with Intravenous Fluids, cefotaxime, ranitidine and insulin. She was re-admitted with complaints of fever, cough, headache and vomiting for which she was managed symptomatically and discharged.Conclusion: DKA is found to be common; hence early diagnosis and proper education and public awareness should be initiated.Key Words: Diabetic Ketoacidosis, Children, Polydipsia, Polyuria, Type 1 Diabetes Mellitus 

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