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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
Fermented Juice Production from Persimmon (Diospyros kaki) Fruit Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Persimmon (Diospyros kaki) reveals beneficial health effects owing to nutritional components and antioxidant capacity. It is a good source of fiber, phenolics, minerals, vitamins and other bioactive compounds. However it’s sensitive to deterioration in a short harvest season. In this study, fermentation of persimmon juice with probiotic bacteria Lactobacillus acidophilus as well as effectiveness of several technical variables in pretreatment and fermentation were investigated.  Our results revealed that thermal treatment 650C in 4 minutes and then cooling at 40C in 20 minutes were appropriate for tannin reduction to mild astringent taste. The initial inoculations (108 cfu/ml) of Lactobacillus acidophilus, 8% sugar, pH 4.4, temperature 37oC were suitable for persimmon extract fermentation within 24 hours. Persimmon juice fermented probiotic Lactobacillus acidophilus was highly value for human health.Keywords: Persimmon, Lactobacillus acidophilus, Fermentation, Probiotic, Tannin, Thermal.
The Effects of Topical Adenosine Agonists (Limonene) on Induced Ocular Hypertension in Rabbits Amal Haitham Hameed
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Glaucoma is a multi factorial disease characterized by progressive loss of retinal ganglionic neurons, if glaucoma is not treated can progress to blindness. Controlling of intraocular pressure is the only approved medical therapy to decrease glaucoma progression. Limonene is a selective adenosine A2A receptors agonist, activation of this receptor can alter outflow resistance at the Schlemm’s canal cell level, and there by decrease IOP. Because vasodilatory effects of adenosine are primarily mediated by adenosine A1& A2A receptors. A fourth (40) rabbits (albino) included in this study &divided into 8 groups, travaprost 0.004% group A (n=8) used as positive control, isotonic buffer group B (n=8), limonene group C, D&E (1%, 2% and 4%) respectively (8) rabbits in each group. The present study was conducted to evaluate the intraocular pressures lowering effect of adenosine agonist (Limonene) and to explore their effect on adenylyl cyclase activity by measuring the level of cAMP changes in the aqueous humor in rabbits with induced ocular hypertension, and to explore the possible side effects of the tested agent on the eyes after instillation. The adenosine system is one of the potential target systems as new therapeutic approaches in glaucoma as concluded by the lowering IOP effect of limonene.Keywords: Intraocular pressure, Adenosine agonists, Limonene and travaprost.
Investigation of Macadamia Flour Fortified to Wheat Flour in Bread Making Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Bread is one of the most important staple foods in the world. Macadamia nut contains bioactive components and high levels of monounsaturated fatty acids that are beneficial to human health. It would be of therapeutic advantage if wheat flour could be replaced with phytochemical functional nuts other than wheat flour such as macadamia in bread-making. This research has been tried in the application of composite flour through the incorporation of macadamia flour into wheat flour to improve nutritional quality of bread. In this study, macadamia flours were used to substitute refined wheat flour in bread-making doughs at 2%, 4%, 6%, 8%, 10% substitution levels. Significant variations in physicochemical, biological and organoleptic attributes were thoroughly noticed. The substituted bread-making with 8% macadamia flour had enhanced firmness, rich in total phenolics, flavonoids but low in peroxide value. During 8 days of preservation in paper- aluminum foil polyethylene laminate pouch at ambient temperature, the physico-chemical, microbial and sensory characteristics of bread still conformed to overall acceptability.Keywords: Bread, Macadamia, Firmness, Phenolic, Flavonoid, Peroxide value.
The Effect of Nimodipine to Reactive Oxygent Species (ROS) in SHSY-5Y Cell-Line Culture Expressed by Chronic Hyperglycemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Diabetes mellitus is a metabolic disease with a chronic hyperglycemia condition. Diabetic peripheral neuropathy is a condition that arises from long-term damage due to chronic and hyperglycemia combination of various factors and pathways. One of them is the occurrence of oxidative stress caused by an increase in ROS intracellular. The accumulation of ROS can activate other pathways and result in an ion imbalance Ca2+. Nimodipine is a type L calcium channel blocker which has neuroprotective properties. Therefore, nimodipine is expected to reduce the expression of ROS in neurons that occur due to chronic hyperglycemia conditions. Objective: To determine the effect of nimodipine on ROS in culture of SH-SY5Y-induced cell-line neurons chronic hyperglycemia. Methods: Experimental research with in vitro methods using the exposed SH-SY5Y neuronal cell line chronic hyperglycemia. The study sample was divided into 9 groups, the control normoglycemic group, hyperglycemia control 25 mM and 50 mM, normoglycemia with nimodipine 10 nM and 100 nM, hyperglycemia 25 mM with nimodipine 10 nM and 100 nM, and 50 mM hyperglycemia group with nimodipine 10 nM and 100 nM. Nimodipine is given for 30 minutes on Sh-Sy5Y cells that have previously been exposed to hyperglycemia conditions chronic for 6 days. The intensity of intracellular ROS was observed by immunohistochemical methods on the sixth day. Results: In comparison of normoglycemic conditions (5 mM) and hyperglycemia 25 mM, normoglycemic conditions 5 mM resulting in a significantly higher ROS intensity (p <0.05). Whereas in comparison normoglycemia (5 mM) and hyperglycemia 50 mM had a significant increase in ROS intensity (p <0.05). Expose glucose 5 mM can increase ROS expression due to a series of processes due to hypoglycemic conditions. Exposure to high doses of glucose (50 mM) can increase ROS formation. Giving nimodipine to cells able to reduce the intensity of ROS on glucose exposure 5 mM, 25 mM and 50 mM significantly (p <0.05). Conclusion: Chronic hyperglycemia conditions can increase the formation of ROS in SH-SY5Y and cell cultures nimodipine can significantly reduce ROS levels.Keywords: Nimodipine, SH-SY5Y, ROS, Hyperglycemia, Neuropathy. 
Clinical and Pharmacological Approaches to Optimize Outpatient Treatment of Bronchial Asthma Olga Pashanova
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Asthma is a common chronic disease. There is no age-related predisposition to the disease, occurring in both adults and children. The study presents clinical trial of ANAFERON FOR CHILDREN® effect on URTI remission process in combination with mild and moderate bronchial asthma in children. The studies were based on a sample of 150 children (age 3-6 years, average age 4.1 ± 0.1), conducted during 2017-2019 in Moscow, the Russian Federation. The first group included 89 children taking ANAFERON once a day for 3 months; the second (control) group included the remaining 61 who took a placebo-treatment during the same time period. The presence of an autoimmune disease was an exclusion criterion. Significant difference of 2.5 times less occurring of the disease (p = 0.0002) was found between the average number for the experimental group compering to the control. Children from the experimental group were 2.2 times less likely to have exacerbations of bronchial asthma (p = 0.013). 3 days is the duration and maintenance period of symptoms for the experimental group, that’s 3 times lower comparing to the control group-9 days (p = 0.041). The Mean Neutrophil Volume (MNV) was significantly reduced (p = 0.001), in a month, Squamous Epithelium Index (SEI) (p = 0.009) in the experimental group. The experimental group maintained significantly low values of MNV and DRE at the end of ANAFERON therapy (p = 0.001). Current management of bronchial asthma includes a Treatment Effectiveness Assessment (TEA) and Patient Safety with medications prescribed, as well as improving of therapeutic cooperation and the patients’ quality of life. The use of ANAFERON reduces the frequency of URTI by 2.4 times in the 3-6-year-old children with bronchial asthma. Additionally, ANAFERON is well tolerated for children. The use of ANAFERON (as a preventive drug) reduces 1) occurring of mild and moderate bronchial asthma by 1.5 times; 2) the number of cases of bronchial asthma exacerbation by 2.2 times; 3) the duration of asthmatic attacks by 3 times. This is associated with cytoprotective effect of the drug on the olfactory epithelium, as well as its influence on reducing the number of children with low IFNƛ (by 3.4 times in 3 months of therapy). Keywords: Bronchial asthma, Prevention, ANAFERON, Placebo, Cytological indicators.
Synthesis, Characterization and Antimicrobial Evaluation of Some New 1, 3, 4-oxadiazoline Compounds Khaldoon S. Alhadad
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

This study involve synthesis of some new 1,3,4-oxadiazoline compounds and screening the antibacterial activity against Staphylococcus aureus , Escherichia coli and pseudomonas aeruginosa bacteria and the antifungal activity against  Aspergillus flavus and Candida albicans.  The structures of newly prepared compounds (5a-5f) were confirmed by spectroscopic methods like elemental analysis (CHN), FT-IR and 1H-NMR spectroscopy. All the compounds showed good antibacterial activity as compared with the standard drugs (cefepime and amoxicillin) against Staphylococcus aureus , Escherichia coli and pseudomonas aeruginosa while the compounds (5a, 5b, 5c and 5d) displayed a good inhibition zone of growth against Aspergillus flavus and Candida albicans.Keywords: 1, 3, 4-oxadiazoline, Antimicrobial, Heterocyclic compounds, Hydrazone derivatives.
The Microwave-assisted Extraction of Anthocyanins, Total Phenolic Compounds and the Antioxidant Activity in Morus nigra L. (Black mulberry) Grown in the Da Lat City, Lam Dong Province, Vietnam Nguyen Hong Khoi Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Morus nigra L. (Black mulberry) is a nutritious fruit that contains many bioactive compounds such as anthocyanins, polyhenol and antioxidant activity. The microwave-assisted extraction method (MAE) is an advanced method with due to its advantages of short extraction time and lower  solvent consumption. The objective of this research is to find the appropriate conditions to extract the highest contents of anthocyanin, polyphenol and antioxidant activity in black mulberry by MAE method. The pH-differential method is used to determine the anthocyanin content, the polyphenol content is determined by the Folin-Ciocalteu method and the antioxidant activity is determined by the DPPH method. The highest contents of these coumponds were obtained as follows anthocyanin contents 128.07 mg/L, polyphenol contents 4305.38 mg/L and antioxidant activity 2715.68 μmol/L when extracted under conditions of concentration of ethanol 60o, solid to solvent ratio 1:30, microwave power 600W, microwave-assisted extraction time 2 minutes.Keywords: Black mulberry, Anthocyanin, Polyphenol, Antioxidant activity, Microwave-assisted extraction.
The Study of all the Optical, Electrical and the Performance Coefficients for the (Rhodamine B - Acriflavine) Laser Dyes Solar Cells Doped with Nanoparticles Mithaq M. Mehdy Al- Sultani
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

In this study of the effect of nanomaterials on the performance of Solar cells with laser dyes. The study included visual measurements of the dye solutions with different concentrations on the optical properties such as absorption and transmittance (A, T), the absorption coefficient, refractive index, reflectivity and optical conductivity at the wavelengths (400-800) nm. Using the UV-visible spectrum device, the value of the energy gap was calculated. The changing in the values of the previous variables the focus. The electrical properties as ( dielectric constant 14ε "> , the permittivity of  14ϵ "> , medium impedance 14Z">  , electrical conductivity 14 σE ">  were also calculated. the electrical response time 14tE">   dielectric time 14tdie "> ,  and the permeability 14μ">  were also calculated, and the solar cells Parameters ( 14Voc"> ), ( 14Isc"> ), ( 14Rsh"> ), ( 14Rs"> ), ( 14Pin"> ), (ŋ), F.F) with silver nanoparticles of higher efficiency than the cell coated with zinc oxide particles Zno is 16.9%.Keywords: Rhodamine B dye, Acriflavine dye, Ag,Zno nanoparticles, Solar cell, laser dyes.
Influence of the Probiotics of Lactobifadol on the Exchange Processes, Literal Microbiocenosis, Productive Indicators of Goslings Ayrat Khabirov
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Inclusion of the probiotic supplement based on lactobacilli L.acidophilus and bifidobacterium B. Adolescentis to the diet of young poultry (goslings) at a rate of 0.2 g per 1 kg of body weight weekly, with subsequent weekly intervals, throughout the growing period provided: an increase in live goslings weights at 62 days of age by 3.7% compared with the intact group. The introduction of probiotic Lactobifadol to the body of goslings had a stimulating effect on protein and carbohydrate metabolism. The average total protein content from 20 days to 62 days in the control group increased by 12.6%, compared to the control group. In the blood serum of goslings, the average glucose content from 20-day to 62-day in the experimental group increased by 4% compared with intact birds. The average content of calcium and phosphorus in the blood serum of goslings of the experimental group from 20 days to 62 days of age was 14.8% less than in the control group of goslings. In the intestinal microbiocenosis, changes have occurred in the direction of an increase in the number of lactobacilli and bifidobacteria, with a significant decrease in the representation of E. coli. The use of Lactobifadol allowed to obtain a higher yield of gutted carcasses from goslings, to increase the mass of gutted carcasses by 6.64%. The use of Lactobifadol in growing of goslings allowed to receive an additional income of 23 rubles per 1 head.Keywords: Probiotic Lactobifadol, Goslings, Live weight, Daily average growth, Morphological blood parameters, Serum biochemical parameters, Microflora, Lactobacilli, Bifidobacteria, E. coli, Meat quality, Eviscerated carcass yield, Economic efficiency.
Synthesis Characterization and a Physical Study of New Polyborate Compounds with Some Transitions Metal Mohsin. E. Aldokheily
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

This Study include preparation of polyborate compounds containing some transition metals cations  complexes which are:  [Ag (NH3)2][B5O6(OH)4].7H2O(1), [Hg(NH3)(H2O)][B5O6(OH)4]. 10H2O(2),[Hg(NH3)(H2O)][B5O6(OH)4][B3O3(OH4)].9H2O(3),[Zn(NH3)3(H2O)3][B5O6(OH)4].3H2O(4),[Zn(NH3)2(B6O7(OH)6)](5),[Zn(NH3)(H2O)5][B5O6(OH)4][B3O6(OH)4].4H2O(6),[Cd(en][B6O7(OH)6](7),[Cu(en)3][B5O6(OH)4]2.4H2O(8),[Zn2en3(B6O7(OH)6)2].3H2O(9),[Cu(1,2dmp)3] [B5O6(OH)4]2. 6H2O(10). The prepared polyborate compounds were characterized by elemental analysis (C.H.N), Infrared (FT-IR), Nuclear Magnetic Resonance Spectroscopy (1H-NMR), (13C-NMR), (11B-NMR). Some of the prepared compounds was a physically studied by measuring the molar conductivity which were used to determine thermodynamic parameters i.e the ion association constant Ka, Enthalpy ΔH 15°"> , Entropy ΔS 15°">  and Gibbs free energy ΔG 15°">  implenting Shedlovsky technique with matlab program. The values of Ka, ΔG 15°">   for pentaborate compounds were always greater than other compounds, due to the fact the pentaborate compounds more favored in ion-pair formation than other followed by hexaborate compound then the compound that containing double composition of penta and Triborates. All reactions are endothermic which were supported by the positive values of the enthalpy ΔH 15°.">Keywords: Pentaborate(2-), hexaborate(2-), polyborate, Shedlovsky technique.

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