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All Journal MNJ (Malang Neurology Journal) Jurnal Kesehatan Prima Majalah Kedokteran Neurosains Journal of Pain, Vertigo and Headache Journal of Global Pharma Technology Journal of General-Procedural Dermatology & Venereology Indonesia IJRETINA - International Journal of Retina Magna Neurologica

Shahdevi Nandar Kurniawan, Shahdevi Nandar

Neurology Department, Medical Faculty, Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia.

Author-ID : 5362994

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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DIAGNOSIS AND MANAGEMENT OF NONCONVULSIVE STATUS EPILEPTICUS (NCSE) Pramesti, Fathia Annis; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Rahayu, Masruroh
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Status epilepticus is an emergency condition in the field of neurology are often undiagnosed and are associated with high mortality and long-term disability. One type of status epilepticus is nonconvulsive status epilepticus (NCSE) in which the diagnosis of NCSE is very difficult because the clinical manifestations appear is agitation or confusion, nystagmus or bizarre behavior such as lip smacking or take goods in the air.The diagnosis was based on clinical features, especially the mental status or the disrupted of consciousness and the changes in the EEG. Diagnosis of NCSE is an important first step, which can avoid the delay in therapy in order to prevent irreversible brain damage. Treatment is by administering benzodiazepines and antiepileptic drugs, while the prognosis is determined by the etiology and associated with brain damage there.

BIOMOLECULAR MECHANISM OF ANTI EPILEPTIC DRUGS Husna, Machlusil; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Epilepsy therapy is almost always chronic and often used more than one drug. Currently, antiepileptic drugs are still the mainstay of therapy for epilepsy. An understanding of the pharmacodynamics and pharmacokinetics of these drugs would be very helpful in choosing the right medication and develop a study to determine the drugs mechanism further. Mechanism of action of AED (anti epileptic drug) can be categorized into four main groups: (1) modulation of voltage-gated ion channels, including sodium, calcium, and potassium; (2) increase in GABA inhibition through an effect on GABA-A receptors, the GAT-1 GABA transporter, or GABA transaminase; (3) direct modulation of the synaptic release of such SV2A and Î±2Î´; and (4) inhibition of excitatory synapses through ionotropik glutamate receptors including AMPA receptors. AED work to balance the process of inhibition and excitation in the brain, so it can be used both for epilepsy and other diseases with similarities with the pathophysiology of epilepsy.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSONâ€™S WISTAR STRAIN RAT (RATTUS NORVEGICUS) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Anggraini, Dini Jatiya
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background.Â BetaÂ glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson'sÂ disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the boneÂ marrow into the damaged tissues.Objective.Â To find out the effects of the addition of Saccharomyces cerevisae toward the number ofÂ brain cells in substantia nigra Parkinsonâ€™s rat model.Methods. Experimental researchÂ in vivo using the draft of randomized post test only controlledÂ group design.Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells.Conclusion.Â The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinsonâ€™sÂ Strain Wistar rat model significantly.

NEURONAL SIGNALING Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Intracellular processes in neurons begins when the extracellular chemical signals such as neurotransmitters, attached at specific receptors which then activates a cascade of intracellular reactions included herein are proteins GTP, second messengers, protein kinases, ion channels, and other effector proteins that will change the instantaneous state of the physiology of the cell the target. The intracellular signal will also change the long-term performance by interfering with the transcription of genes that will change the protein composition of the target cell. Many components are involved in intracellular signal that will control the neurons, so that the necessary coordination of electrical and chemical signals in the nervous system. Also discussed here regarding the conducting various signals in neurons, including signaling pathways, type receptors, G proteins and molecular targets, second messengers, the target of second messengers, NGF/TrkA, long-term depression (LTD), and tyrosine phosphorylation hidrosilase.Â

OCCIPITAL LOBE SYNDROME Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

The ability to recognize objects and words is not just depend on the integrity of visual pathway andÂ primary vision area on cerebral cortex (Brodmann area 17), but also secondary vision area 18 and tertiary vision area 19 on occipital lobe. Lesion in occipital lobe could disturb of human visual function such as visual field defects, inability to recognize colors, inability to recognize words, visual hallucinations and illusions, occipital lobe epilepsy, and Antonâ€™s syndrome. Some causes of occipital lobe lesion are head trauma, chemical intoxicity, neoplasma, stroke, degenerative disease, and vascular disease. Prognosis of occipital lobe syndrome is depend on the initial condition but prognosis from the majority of cases with occipital lobe lesions is not good because the exact intervention is not discovered yet and included one ofirreversible disease.

THE RELATIONSHIP OF CARPAL TUNNEL SYNDROME CLINICAL SYMPTOMPS AND ELECTRONEUROMYOGRAPHY RESULTS IN RSSA MALANG Kurniawan, Shahdevi Nandar; Husna, Machlusil; Rasyid, Harun Al; Bilqis, Nadiya Elfira
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Carpal tunnel syndrome (CTS) is caused by entrapment neuropathy of the median nerve in the carpal tunnel that can be detected with electroneuromyography (ENMG).Objective. To determine whether there are significant differences in parameters of ENMG examination between CTS groups with mild-to-moderate and severe clinical symptoms.Methods. The study design was observational analytic using cross sectional design approach of the patient's medical record data as many as 61 samples.Results. From 61 samples, there were dominancy of age â‰¥ 40 years old as many as 80.32% and gender female as many as 88.52%. There was no significant differences in age and gender between the two groups (p=0.073 and p=1.000 respectively). Sensory amplitude, MSDL, and Ring Diff are significantly different between the two groups (p=0.005, p=0.020, and p=0.031 respectively). There are no significant difference of motor amplitude and MMDL between the two groups (p=0.384 and p=0.196 respectively).Conclusion. Sensory amplitude value having a relationship with the severity of clinical symptoms. ENMG examination and clinical symptoms of CTS were independent parameters, that should not be used alone to make a diagnosi both of them could enhance the accuracy of diagnosis.

PARKINSON AND STEM CELL THERAPY Gunawan, Gerry; Dalhar, Mochamad; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Parkinson's disease is a neurodegenerative disorder that is progressive about the movement or control of movement. The disease often occurs in people over the age of 60 years. The etiology of Parkinson's disease caused by a combination of genetic and environmental factors. Because overall life expectancy increases, the number of people with Parkinson's disease will increase in the future. Treatment of Parkinson's disease can be used with pharmacological therapy and nonpharmacological therapy. Pharmacological therapy can use levodopa, monoamine oxidase-B inhibitors, dopamine agonists, anticholinergics and amantadine, while nonpharmacological therapies may use the method of stem cell therapy. Stem cells are master cells that have two important characteristics that can perform self-renewing through cell division and can be induced to become cells with specific functions. The aim of Stem cell therapy in Parkinson's disease to replace the damaged dopaminergic cells.

AMPLITUDO SENSORY NEURON ACTION POTENTIAL USING AS INSTALLATION OF POLYNEUROPATHY DIAGNOSIS Kinesya, Billi; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Ridwan, Mochammad
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. Polyneuropathy is the pathologic changes and functional disturbances in the peripheral nervous system. These changes manifest as sign and symptoms such as numbness, burning, allodynia, atrophy, and lose of stimulation responses. Diagnosing polyneuropathy can use electrodiagnostic method like electroneuromyography (ENMG). One of the most sensitive ENMG parameters for polyneuropathy is SNAP amplitude which can be measured at Sural Nerve.Objective. The goal of this study is to know whether SNAP amplitude can be used to diagnose polyneuropathy.Methods. The study design is diagnostic test in cross-sectional method.Results. Samples were taken from 108 ENMG medical records of Neurology Department Saiful Anwar General Hospital during the whole 2014. Two variables which are compared are polyneuropathy diagnosis and SNAP amplitude. Fisher test shows significant differences between the two with p = 0.04. Diagnostic test shows sensitivity 68.3%, spesifisity 80%, positive predictive value 97.1%, and negative predictive value 20.5%.Conclusion. There is a significant relationship between SNAP amplitude reduction with the diagnosis of polyneuropathy.

INTERPRETATION OF NERVE CONDUCTION STUDY IN POLYNEUROPATHY WITH MULTIBACILLARY LEPROSY TYPE 2 REACTION Sari, Diane Tantia; Widasmara, Dhelya; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Leprosy reaction contributes to disability due to peripheral nerve damage. Nerve conduction study (NCS) provides a profound physiological description of peripheral nerves. This study aims to report a case of polyneuropathy in leprosy with type 2 reactions (T2R) which is evaluated using NCS. A 33-year-old woman complain of painful bumps in her arms and legs, fever, swollen feet since 2 days ago, and history of leprosy. Dermatologic examination on the right superior palpebra, right and left arms and legs revealed multiple tenderness erythematous nodules; right claw hand; and both legs oedema. Slit skin smear revealed positive result. Histopathologic examination supported T2R description. The NCS examination concluded severe axonal demyelinating motoric sensoric polyneurophaty, with left worse. She was treated with MDT-MB, bed rest, orally methylprednisolone, vitamin B, paracetamol, ferrous sulfas, and topical olive oil. Clinical improvement was achieved after 2 weeks. The NCS is used to assess the nerve impuls conduction along the peripheral nerves. In this case, it was found that NCS could showed early neuropathy in nerves that were clinically undetectable. It can be concluded that the NCS examination is an important diagnostic modalities for early detection of neuropathy and confirmed the diagnosis of clinical neuropathy in leprosy.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSONâ€™S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Hermawan, Hanestya Oky
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae.Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group.Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinsonâ€™s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.

Co-Authors Abdul Gofur Afiyfah Kaysa Waafi Al-Rasyid, Harun Aldita Husna Violita Aldita Husna Violita Andaru Cahya S Anggraini, Vivi Laras Anggraini, Vivid Prety Anisa Syahfitri Hanum Annisatul Hakimah Asmiragani, Syaifullah Auliya Nur Muthmainnina Badrul Munir Badrul Munir, Badrul Basya Adnani Basyar Adnani Chozin, Iin Noor Dalhar, Mochamad Damayanti, Ria DAMAYANTI, ZUHRIA PUSPITA Dessika Rahmawati Devi Annisa Devita Anggraeni Soeroso Dewi Permata Sari Dheka Sapti Iskandar Dhelya Widasmara Didi Candradikusuma Dini Jatiya Anggraini, Dini Jatiya Dwi, Pratiwi Suryanti Dyah Kusuma Wardhani Edi Widjajanto Eko Arisetijono F, Fahimma Fahrani Yossa Prachika Farida Widyastuti Fitria Nikmahtustsani, Mulika Ade Gerry Gunawan, Gerry Gyang Hanandita Gusti Putri Hanestya Oky Hermawan, Hanestya Oky Harbiyanti, Novita Titis Hardi Adiyatma Harun Al Rasyid Helena Era Millennie Heri, Sutanto Herwinda Brahmanti Husnul Khotimah Husnul Khotimah I Ketut Suada Irawan Satriotomo Irsyah Dwi Rohmayanti Izza Ayudia Hakim Janet, Karensa Abby Jatmiko, Sarazata Indi Rozaany Kadek Putri Paramita Abyuda Kartika Agustina Kinesya, Billi Lestari, Dwi Indriani Machlusil Husna Machlusil Husna, Machlusil Made Ayu Hariningsih Sunaga Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu, Masruroh Masykur, Umar Jundullah Maziya, Yulianda Mega Yulia Rusmayanti Michelle Anisa Misnasari, Putri Priela Mochammad Istiadjid Eddy Santoso Mokhamad Fahmi Rizki Syaban Mondiani, Yeni Quinta Muhammad Welly Dafif Nadia Artha Dewi Nadiya Elfira Bilqis, Nadiya Elfira Nasution, Ali Napiah Nata Sanjaya Nectarine Natasya Regitta Yasmin Nidia Suriani Nurvia Andriani Petrarizky, Alfred Julius Pramesti, Fathia Annis Pratiwi, Made Dinda Pringga, Gutama Arya Pudji, Rosalyna Purbasari, Bethasiwi Putri, Dwi Sandhi Aulia Pramesti Putri, Mutiara Kristiani R, Rahmad Rahma, Annisa Rahmasari, Herisa Rahmawati, Dessika Raisa, Neila Reza Rachmantoko Rislan Faiz Muhammad Rislan Faiz Muhammad Ristiawan Muji Laksono Rizki Rahamatullah Noer Rodhiyan Rakhmatiar Rulli Rosandi Safira Dita Arviana Sari, Diane Tantia Sari, Diane Tantia Sela Pricilia Siti Nurlaela Sri Budhi Rianawati Sri Budhi Rianawati, Sri Budhi Sri Budi Rianawati Suratmono, Mia Fajarningtyas Syafiatul Azizah Titin Andri Wihastuti Tri Wahju Astuti, Tri Wahju Vely Eva Meria Wa Ode Intan Nur Octina Wahyuni Ramadhani Suaib Widiatmoko, Arif Widodo Mardi Santoso Widodo Mardi Santoso, Widodo Mardi Wirathmawati, Andina Yudiansyah, Anggi Gilang Yuyun Yueniwati Zahra, Farah Shabri Alifia Zamroni Afif

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