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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
Investigation of Sugar Concentration and Lactobacillus acidophilus Inoculation on Pickled Turmeric Rhizome Production Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Curcuma longa which is the source of the spice turmeric having different phytochemical constituents, and pharmacological activities. An alternative way of preserving surplus turmeric rhizomes could be fermented to pickle products. Preservation of the turmeric rhizomes by fermentation can eliminate the undesired taste and improve flavor of this herb. Different technical parameters such as sugar addition (1.5%, 2.0%, 2.5%, 3.0%, 3.5%) and Lactobacillus acidophilus (0.1%, 0.2%, 0.3%, 0.4%, 0.5%) affecting to the pickling process were examined. Our results revealed that 3.0% sugar, 0.3% Lactobacillus acidophilus (1010 cfu/g) as starter culture were adequate for lactic fermentation. The consumption of pickled turmeric rhizomes helps enhance balanced human nutrition. Lactic acid fermentation retains all the natural plant ingredients while improving the quality, taste and aroma. The benefits of pickled turmeric have been better understood in terms of high content of valuable curcumin. It becomes an important phytochemical source for human health. Production of pickle from this herb can help increase added values and reduce post-harvest losses.Keywords: Turmeric rhizome, Lactobacillus acidophilus, Pickled, Fermentation, Starter culture, Sugar.
Spectrum of Human Growth Hormone Receptor Gene Polymorphisms in Physiological Obese Subjects in Babylon Province, Iraq Hamzah H. Kzar
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: A peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals is called growth hormone. In human, growth hormone gene is encoded the protein growth hormone receptor that located on chromosome number 5. Obesity is a condition in which excess fat has accumulated in the body, such that it can have an adverse effect on health. Obesity is defined as a body mass index (BMI) of greater than 30 kg/m2. Aim: assessment of spectrum of human growth hormone receptor (HGHR) gene polymorphisms in obese subjects in Babylon province, Iraq. Subjects and Methods: this case-control study included two groups, the first 30 obese subjects (OS) and 30 non-obese subjects (NOS). We investigated GHR genetic polymorphism in both study groups by assessment of the genotyping, Fl/Fl, F1/D3, and D3/D3 of two alleles of GHR. We used allele specific PCR method to investigate the all genotypes and comparing the results with the levels of GH and leptin in serum of study groups. Results: the results of present study showed significant differences (p-value< 0.05) in levels of leptin (LEP) and human growth hormone (HGH) between OS and NOS groups. The genetic results suggested that F1/F1 genotypes have high prevalence in OS compare to NOS (odd ratio was 3.54, CI 95% 1.77-7.94). Conclusion: F1/F1 genotypes have higher levels of leptin and HGH and so it having more risk factor to induce obesity in Babylon population.   Keywords: Human growth hormone, growth hormone receptor, obesity, leptin.
Secondary Prevention of Cardiovascular Disease in Patients after Myocardial Infarction: Pharmacoepidemiological Study Oxana Bogaevskaya
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Diseases of the cardiovascular system are among the main factors of premature death in the 21st century. However, the effectiveness of secondary prevention of coronary heart disease in developed Western countries and CIS countries can vary greatly. The purpose of this study is to evaluate the effectiveness of the application of international recommendations for secondary prevention in Russia in patients after myocardial infarction. The time of the study covers a 9-year period (2010-2019) in Cardiological Dispensary No. 3 of Moscow (Russia). A total of 9000 medical records were processed, of which 900 met the selection criteria. The average age of the patients was 61.5±9.7 years in an age range of 30-89 years. A survey of 606 doctors from private (1 group, 303 doctors) and state (2 groups, 303 doctors) dental clinics was conducted. Results the sample recorded a large scatter of data - from the moment the patient suffered a first heart attack - from a period of less than one year at a minimum to 43 years at a maximum. The average value of the interval was 4.6±5.3 years. Doctors on medical records most often paid attention to measuring blood pressure. 2-10 times less often (p≤0.001) met anthropometric indicators and analyzes for the lipid profile, and an order of magnitude less - control of the level of physical activity (p≤0.001). Differences were found between the therapy of patients depending on the type of medical institution - patients in cardiological dispensaries, on average, are 2-4 times more likely to receive prescription drugs (p≤0.001) compared with patients in polyclinics. It is noted that doctors, as a rule, do not note at the first visit to the patient in the cardiologic dispensary what kind of therapy he underwent in the clinic.  It is necessary to promote a healthy lifestyle, with a complete cessation of smoking and the use of alcoholic beverages. This will minimize the cost of expensive drugs for the population. On the patient’s medical records: the minimum occurrence rates of the following risk factors were recorded: smoking (3%), as well as physical activity (less than 1%) and overweight (25%). Medications are rarely prescribed: anticoagulants in 1% of medical records, as well as statins (10%). The use of an articain-containing anesthetic with a vasoconstrictor concentration of 1:200000 or without a vasoconstrictor during dental surgery helps to prevent the risk of complications of the cardiovascular system, especially with prolonged dental surgery, and especially in patients at risk.Keywords: Myocardial infarction, Risk factors, Secondary prevention, Invasive therapy, Cardiovascular disease.
Antimicrobial Pharmacotherapy of Community-acquired Pneumonia in Liver Cirrhosis Patients: Accent on the Antibiotic Resistance Risk Stratification Natalia Kobelevskaya
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

There is a proliferation of bacteria that are resistant to many drugs. This has created the need to: identify risk factors for the acquisition of resistant pathogens; stratify patients infected with pathogens. Such pathogens should be considered when choosing the starting antimicrobial therapy for pneumonia associated with cirrhosis. Therefore, the aim of the work is to study the profile of antimicrobial resistance of community-acquired pneumonia (CAP) pathogens that are detected in patients with cirrhosis. While stratifying patients with the risk of infection by pathogens. A retrospective analysis was carried out of 216 patients who were hospitalized in a multidisciplinary hospital in 2016-2018 with CAP. The patients were with a positive result of a respiratory bacterial culture sampling. As a result, the most common microorganisms in patients with CAP and cirrhosis of the liver of alcoholic etiology were E. coli (34.6%), St.aureus (26.9%) and Klebsiella pneumoniae (23.1%). In patients with cirrhosis of the liver of mixed alcohol-viral etiology, the following microorganisms prevailed: St.aureus (36.1%), E.coli (31.2%) and Klebsiella pneumoniae (22.9%). After analyzing all the results, the authors came to the conclusion that the microorganisms (that cause CAP in patients with cirrhosis) differ depending on the etiology of cirrhosis and are mostly gram-negative (K.pneumoniae and E.coli). Besides, S.aureus appears frequency. In general, causative agents of CAP with multidrug resistance in patients with cirrhosis are detected in 28.5% of patients: 24.6% MDR and 3.96% XDR.Keywords: Pneumonia; Antimicrobial therapy; Antibiotic resistance; Risk stratification.
Toxoplasmosis: A Review Sadiya A. Anah
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Toxoplasmosis one of the common human-animal diseases (Zoonotic diseases) caused by a parasite belongs to the group of coccidian, class of sporozoa known as the Toxoplasma gondii, an intracellular obligate parasite, especially in nucleic cells, as noted inside the nucleus.Keywords: Human-animal diseases; Zoonotic diseases; Parasite; Tissues.
Anti-Amnestic Effect of Iridoids Fraction from Pentas Lanceolata Leaves against D-Galactose Induced Brain Aging in Rats Azza F. Arafa
Journal of Global Pharma Technology Volume 12 Issue 01
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In this work the anti-amenstic effect of the iridoids-rich fraction isolated from Pentas lanceolata (IFPL) leaves was investigated using D-galactose (D-gal) to artificially create aging in rats. Thirty-two rats were divided as follows: 1st group served as control; 2nd, 3rd and 4th rat groups were injected intraperitoneally with 100 mg/kg D-gal five days/ week for two months. The 2nd group was left untreated. While, 3rd and 4th groups were treated daily orally with IFPL (50 mg/kg b. wt.) and the reference drug donepezil (10 mg/kg b. wt.), respectively for one month. Behavioral tests, T-Maze and beam balance, showed deterioration in cognitive ability of aging rats. D-gal caused a remarkable decrease in oxidative biomarkers except lipid peroxides which revealed a significant increase. In addition, D-gal-treated rats showed a significant decrease in the levels of neurotransmitters, while, a significant increase in acetylcholineasterase (AChE) was recorded. Furthermore; caspase-3 levels were elevated in aged brains which were confirmed by immunohistochemical analysis. Histopathological alterations were observed in these rats. Treatment of these rats with IFPL exhibited improvement in behaviour, neurobehavioral changes, modulated oxidative stress as well as apoptotic markers which is confirmed by histopathological investigations.These findings provide scientific evidence that IFPL extract has antioxidant, anti-inflammatory, immunomodulatory, anti-apoptotic and anti-amnesic properties against D-gal induced brain aging.Keywords: D-galactose, Brain aging, Pentas lanceolata, Iridoid-rich fraction
Isolation of Silica from Some Species of Diatoms in Iraqi Water Shaimaa Setae M. Ali
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

We obtained these diatoms species growth from diatoms (Nitechia acuta, cocconeis pediculus, Nit dissipata, stephanodiscus astrea, syndra ulna, Diploneis).According to scanning electron microscope, the SiO 2 morphologies of having microspores and fibers in the surface of 59.81 m 2 /g. All results refer that the basilica specimens get found in this study. The prepared basilica material having Porous structures which its ability, it can be used in other industrial applications.
Comparative Analysis of Pharmacopeial Requirements to Extem-poraneous Medicines Galyna Melnik
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract. The article presents a comparative analysis of pharmacopoeial requirements for extemporaneous medicines on the example of the articles of State Pharmacopoeia of Ukraine 2.0 “Nonsterile medicines made in pharmacies” and Guide for the Compounding Practitioner USP on Compounding “795” “Pharmaceutical Compounding – Nonsterile Preparations”. These articles have been shown to differ in structure and title, but many sections are close in content. It is established that State Pharmacopoeia of Ukraine contains, to date, a very limited list of general pharmacopoeial articles for individual extemporaneous dosage forms unlike USP. In this regard, it is necessary to expand and improve the basic regulatory documentation, including general articles of State Pharmacopoeia of Ukraine, in order to improve the quality of extemporaneous medicines.
Growth Performance and Haematological Indices in Calves Fed with Probiotic Supplement 'Bacticor' Almaz Basharov
Journal of Global Pharma Technology Volume 12 Issue 01
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The paper presents the study results on the effect of a feed probiotic supplement ‘Bacticor’ on biochemical and morphological parameters of blood, absolute and average daily live weight gains in calves and   economic efficiency of raising the animals.  The farm experiments conducted before showed that 20 g per head was the optimal daily dose of the supplement. The established dose of the feed probiotic supplement increased the final live weight by 1.77 % and absolute live weight gain rose by 8.3 %. The viability of the study calves for all groups was reported 100 % throughout the experiment. The study feed supplement had a positive effect on the formation of specific immunity in calves. A noticeable decrease in the concentration of lymphocytes was observed in the middle of the experiment, where the concentration of these specific cells was 3.6*109/l compared to 8.9*109/l in the control group. The feed supplement ‘Bacticor’ slightly increased the concentration of total protein by 1.73-3.22%, glucose by 7.0-14.5% in the blood serum of calves.  Rearing one calf for three months of the experiment required 3.89-3.93 EFU (Energy Feed Unit); the costs for 1 kg of live weight gain were by 7.2 % lower in the test group than in the control group.Keywords: Probiotic supplement, Bacillus subtilus, Strains, Microorganisms, Lactobacilli, Pre-weaning calves, Haematological parameters, Immune resistance, Feed conversion.
Methylene Blue Reduction by Using Multistage Filtratio Ouhood Hassan Saleh
Journal of Global Pharma Technology Volume 12 Issue 01
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Slow sand filtration (SSF) is established and workable equipment for drinking water handling in small societies. However, this technology is sensible to depressed water temperatures which can result in reduced biological treatment, and excessive water turbidity quantities which can result in early plugging of the filters and repeated cleanup necessities, leading to raised danger of-pathogen development. Multistage filtration (MSF), comprising of roughing filtration (RF) tracked by slow sand filtration, can cope these treatment restrictions and give a strong treatment option for surface water resources of changeable water characteristics in northern climates, that normally water temperatures ranging below 2oC. The main objective of this study was to reveal the accuracy of MSF to remove methylene blue (MB) dye from water. In this research, testing was achieved by pilot multistage filtration system and fed with synthetic water polluted with MB dye. A system consisted from roughing filters filled with limestone media with different sizes and slow filter filled with glass media (SGF). The removal of MB of pilot plant was tested at hydraulic loading rates (0.5 and 1) m/h and initial concentration of (10 and 30) mg/L. The percentage reduction of MB dye reduced with increasing the influent MB dye concentration and increasing filtration rate. Limestone roughing filter (LRF) and slow glass filter gave good MB removal with average removal efficiency of 99.20% and 99.85% at least influent MB concentration of 10 mg/L and least velocity of 0.5 m/hr.Keywords: Slow sand filtration, Multistage-filtration (MSF), Roughing-filtration, Methylene Blue, Glass, Limestone.

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