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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Nutritional Status in Breast and Cervical Cancer Survivors: Differences in Each Stage of Survivorship Ni Putu Wulan Purnama Sari
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: Nutrition is one important physical aspect supporting the achievement of optimum quality of life (QOL) in cancer survivors. This study aimed to 1) compare and analyze the differences in nutritional status between breast and cervical cancer survivors (BCS and CCS) generally, and between stages of survivorship specifically in both cases, and 2) determine the best predictor of nutritional status in both cases.  Method: This cross-sectional study involved 58 BCS and 47 CCS (n=105). The questionnaire of PG-SGA was used in data collection. Various statistical tests were used in data analysis (α<0.05). Result: Nutritional status was not significantly different between BCS and CCS (p=0.116), but significant differences found in activities and function between cases (p=0.040). In BCS, nutritional status was not significantly different between survivorship stages (p=0.068), which indicates that this aspect is stable/stagnant across the survival life span in this case. While in CCS, nutritional status was also not significantly different between survivorship stages (p=0.382), but the intake and physical exam were significantly different in this case (p=0.040 and p=0.008, respectively) which indicate that these two aspects change over time along with the survivorship stages in CCS. Body Mass Index (BMI) is the best predictor of nutritional status in BCS, which were accounted for 15.9% variance of nutritional status (R2=0.159); while weight loss is the best predictor of nutritional status in CCS, which were accounted for 49.6% variance of nutritional status (R2=0.496). Discussion: More significant predictors of nutritional status were found in CCS compared to BCS.Keywords: Breast cancer, Cancer survivors, Cervical cancer, Nutrition, Nutritional status.
Synergistic Effect of 1-MCP Fumigated with Chitosan Coating on Shelf-life and Physico-Chemical Quality of Marian Plum (Bouea macrophylla) Fruit Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Marian plum fruit has high nutritional and functional components which are beneficial for human health. However it has a short shelf-life owing to its high respiration and ethylene production. 1-methylcyclopropene is an inhibitor of ethylene action even at low concentration to hinder ripening and improving storage stability on variety of fruits. Chitosan has strong antimicrobial and antifungal properties that could effectively adjust the permeability of gas exchange, slow down respiration rate, hinder fruit decay. Objective of this study focused on the evaluation of 1-MCP fumigation at different levels (20 ppm, 40 ppm, 60 ppm, 80ppm, 100 ppm) in combination with chitosan coating (0.1%, 0.15%, 0.2%, 0.25%, 0.3%) on shelf-life and quality of marian plum during 14 days of storage at ambient temperature. Our findings will provide better insights for manufacturers in postharvest management.Keywords: Marian plum, Chitosan, 1-MCP, Fumigation, Coating, Posthavest
Toxicopaphological Effects of Intravenous Injection of Layer Double Hydroxide (LDH) Nanoparticles in Male Rats Samia Kh. Mahmood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The rapid growth of using nanoparticles in different field of science, lead to the urgent necessity to study the toxicpathology of this submicron particle. Layer Double Hydroxide NPs have qualified features such as bio-compatibility, ion exchange and pH effect which make LDH NPs potential candidate for various biological applications such as drug delivery. Hence, in this study Mg-Al LDH NPs have been prepared by co precipitation method and injected intravenously. Twenty rats were divided into two groups as follows: Group I: Rats served as control and injected 1ml of distilled water intravenously for one month. Group II: Rats served as experimental and received by I/V injected in the tail vein 1ml of 0.00276 of Mg-Al LDH NPs g/ml. daily for one month. The sizes of LDH NPs have been measured by SEM which resulted size ranging between 50- 80nm in diameter. The liver, kidney, heart, lung, spleen and testes were examined histologically. The toxicopathological results were very severe in kidneys, lung, spleen and heart, while being moderate in liver and testes. In general, all organs showed necrotic changes with inflammatory cell infiltration, congestion and thrombosis in blood vessels.Keywords: LDH, Toxicopathological study, Nanoparticles, Rat.
Association between Hypothyroidism and Herpes Simplex Virus with Interleukin-23 Sahar H. Al-Hindawi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Hashimoto’s thyroiditis and Hypothyroidism play a distinct role in the suppression and reactivation of herpes viruses. Herpes simplex virus infections have been assumed as one of the factors that may trigger autoimmune thyroid diseases; however, IL-23 has an important role in the pathogenesis of several inflammatory and autoimmune conditions. Objective: This study aimed to investigate the association between thyroid hormones in hypothyroid state and the Herpes simplex virus status in such patients; besides detecting the role of IL-23 in these cases. Materials and Methods: The present study included 65 Iraqi female hypothyroid patients with age ranged between 26-54 years and 25 healthy controls with age ranged between 25-50 years. Serum samples were collected from the study groups. Levels of thyroid hormones (TSH, T4, and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. The detection of herpes simplex virus IgG and IL-23 levels in the serum samples were determined by an enzyme linked immunosorbent assay (ELISA) kits. Results: The current study results revealed that serum IL-23 and HSV levels are increased significantly (P<0.001) in the hypothyroid patients group as compared with control. There was a significant positive correlation between TSH and (IL-23, HSV); also between IL-23 and HSV (P<0.01). Moreover, there was a significant negative correlations (P<0.01) between IL-23 with (T4, T3) and between HSV with (T4, T3).  Conclusion: The present study pointed to the association between thyroid hormones deficiency in Hashimoto thyroiditis cases and IL-23 levels through disruption of the patient’s immune system; and with Herpes simplex viruse-1by their role in the replication.Keywords: Hashimoto Thyroiditis, Hypothyroidism, Herpes Simplex Virus, IL-23.
Degradation of Erythromycin in Seafood Products by Different Thermal Treatments Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Prawn (Macrobrachium rosenbergii) and tilapia (Oreochromis niloticus) are two important seafood farming species cultivated in Mekong river delta, Vietnam. Intensive aquaculture of these species has high risk of disease outbreaks caused by virus, bacteria, fungi, and other pathogens. Erythromycin is the most widely used antibiotic in the macrolide. Erythromycin has a low cytotoxicity for aquaculture. Prawn and tilapia intended for export have to meet the antibiotic residue standards of the importing countries. In the present research, different factors affecting erythromycin residue on prawn and tilapia muscles after thermal treatments were carefully investigated. The present results proved that among frozen, cooked, oil-fried and baked methods; the oil-frying treatment strongly degraded erythromycin at 86.88% in prawn and 87.02% in tilapia samples. Thermal processing by oil heating medium at high temperature caused a significant degradation in the concentration of erythromycin residue.Keywords: Prawn, Tilapia, Erythromycin, Thermal, Degradation, Antibiotic residue.
Synthesis, Characterization and Antifungal Activity of Some Indolo [2-3-b] Quinoxaline Derivatives Khitam Abdul Kareem Ismail
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this research the focus was to synthesis new series of indolo [2-3-b] quinoxaline through the reaction of Isatin with 4-methyl-o-phenylenediamine in the presence of water to obtain 2-methyl-6H-indolo [2-3-b] quinoxaline (A1). Compound (A2) was prepared by refluxing  of compound (A1)  with chloroacetyl chloride in the presence of triethylamine, compound (A2)  was treated with hydrazine hydrate to give 2-hydrazino-1-(2-methyl-indolo[2,3-b]quinoxalin-6-yl)-ethanone (A3), While the Schiffe bases (A4- A8) were synthesized by the condensation of compounds (A3)  with aromatic aldehydes. The prepared compounds identified by spectral methods [FTIR, 1H-NMR] and measurement some of its physical properties. Furthermore we were studied the effects of the preparing compounds on some strains of Antifungal activity.Keywords: Isatin, Indolo [2-3-b] quinoxaline, Antifungal Activity, Schiffe base. 
Effectiveness of Drugs Therapy of Hypertensive Patients in Undata General Hospital Palu Ingrid Faustine
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Increased blood pressure above normal will result in increased morbidity and mortality by improving risk factor for other diseases. Data obtained from Undata General Hospital Palu, showed the number of hypertensive patients died in 2016 as many as 513 patients, this number increased in 2017 as many as 637 patients. This study aims to determine the accuracy of the selection of antihypertension therapy and dose as well as determine the effect of antihypertension drugs to decrease blood pressure in hypertensive patients in hozpitalized Undata Generala Hospital Palu in 2016-2017. This study uses a quantitative method with retrospective approach. The results showed that the most significant decrease in blood pressure based on length of stay occurred in patients with 4-7 days of stay ie 42.64/21.17 mmHg and the most significant reduction in blood pressure based on the treatment regimen occurred in three combination antihypertension 57.14/28.57 mmHg with a significance value of<0.05. So we concluded the accuracy of therapy and dose in hypertensive patients based on the guidelines JNCVII showed a patient diagnosed with mild, moderate, and severe hypertension overall proper drug selection and dose received by all patients with hypertension better use of antihypertension drugs singly or in combination in accordance with the standards of the JNCVII, and paired t-test for hypertensive patients with a single drug decreased blood pressure 37.80/16.19 mmHg (p=<0.05), hypertensive patients with two combinations of drugs decreased blood pressure 29.26/18.94 mmHg (p=<0.05) and hypertensive patients with three combinations of drugs decreased blood pressure 57.14/28.5 mmHg (p=<0.05).Keywords: Effectivenes, Drugs Therapy, Undata General Hospital, Hypertension.
Quality efficiency indicators of pharmacy management: characteristics, current features, opportunities and threats of the development Iryna Volodimirivna Pestun
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The purpose of this work is a comprehensive research, analytical study and systematization of the pharmacies` management (networks) feature and trends in Ukraine in accordance with qualitative criteria. The objective is to determine the features and possibilities of improving the quality of pharmacies' management (networks), existing threats (risks) of their achievement, which allowed to highlight the topical issues and directions of the decision in the management of pharmacies and their networks. On the bases of scientific literature, regulatory documents, statistical data, information sites of the Internet and structural-logical, analytical methods, generalization, comparison, grouping, and formalization of reasoning were identified problems and trends in this area. The main groups of qualitative criteria for the pharmacies’ (networks) management effectiveness are: provision of pharmacy (network) management process; managerial decisions making; customer service; social management efficiency; the personality of the head; work with personnel. According to the results of the research, individual differences in ensuring the effective management of pharmacies and their associations (networks) are highlighted. It is shown that qualitative indicators of effective management of pharmacies (networks) are characterized by their dependence on the social and economic processes in society, changes in legislation, state and change of health protection, implementation of government social programmes, market and pharmacies informatization, consumer attitudes to treatment and their solvency, etc.Keywords: Pharmacies, Qualitative criteria of management efficiency, Possibilities of strengthening the management efficiency qualitative criteria, Threats.
Synthesis New Polymeric Composite Materials Derivatives from thiosemicarbazide Maha T. Sultan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this work tow monomers were prepared by using Thiosemicarbazide free-radical polymerization was used to polymerize monomers one with itself to produce tow polymers (P1, P2) and the second with Nano silica grafted meth acrylic acid to produce tow Nano composite (C1,C2) All the prepared compounds were characterized by FT-IR Spectroscopy. The structures of standard Nano silica and Nano composite were studied by Atomic Forces Microscopy (AFM).The X-ray diffraction offer information on molecular structure configuration of the Nano composite after modification which showed different in intensity between Nano silica and their Nano composite.Keywords: Triazole polymer, Nano composite, Modification.
Effect of Intraperitoneal versus Oral Drench of Beta-Amino Butyric Acid on Platelets in Sprague Dawley Rats Mustafa Salah Hasan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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To study the effect of oral and injected BABA on platelet production this study was done, The first group (intra peritoneal injection group): This group consisted of 20 animals given (BABA) after dilution with 2 ml distilled water by intra peritoneal injection for four weeks, this group was divided according to BABA concentration into three secondary groups (5 animals per group): first concentration (1g/ kg), second concentration (0.5 g / kg), third concentration (0.25 g / kg) and control group was injected with distilled water 2 ml once a week for four weeks, The second group (orally drenching group): This group included 20 animals also given the substance (BABA) at the same concentrations and doses of the first group at the same time using oral route. Keywords: BABA, Rat, Platelets.

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