cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
 1   2   3   4   5 
Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Marital Satisfaction, Anxiety, and Health-Related Quality of Life in Myocardial Infarction Patients Devi Wulandari
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.684 KB)

Abstract

Anxiety is predictor of cardiac incidents and mortality, its relationship with Health-Related Quality of Life (HRQL) remains unclear, especially in married couples, yet a marital relationship as part of the immediate environment that can be a source of support or stress. The objective of this study is to shed light on the relationship between anxiety and HRQL by adding marital satisfaction as an independent predictor and moderator. A cross-sectional study was conducted on 214 myocardial infarction patients. The patients completed three questionnaires (McNew Health-Related Quality of Life, Couple Satisfaction Index, Cardiac Anxiety Questionnaire), analysed using a four-step moderated hierarchical multiple regression. In conclusion, anxiety and marital satisfaction significantly predict patients’ HRQL. There were no significant interaction effects between anxiety and marital satisfaction in predicting HRQL. These findings could spur further research in addressing the limitations of this study and similar studies, which in turn may direct future policies in healthcare.
Effect of Cinnamon (Cinnamomum burmannii) Bark Oil on Testicular Histopathology in Streptozotocin Induced Diabetic Wistar Male Rats Mustofa Helmi Effendi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.294 KB)

Abstract

The purpose of this study was to determine the effect of cinnamon bark oil (CBO) on testicular histopathology. The variables taken were the diameter of the seminiferous tubules and the number of leydig cells in the testes of white male rats (Rattus norvegicus) which had been induced by streptozotocin. Twenty white male rats adult Wistar strains aged 2-3 months with an average weight of 150-250 grams were used in this study. The rats were divided into five experimental groups (4 rats each group) treated with a combination of streptozotocin and cinnamon bark oil (CBO) which were designed as follows: K(-), K(+), P1, P2, and P3. P is white rat injected with streptozotocin with a single dose of 45 mg / kg body weight intraperitonially, followed by therapy. K(-) without streptozotocin and only given drug solvent, K(+) given drug solvent, P1 treated with CBO 100 mg / kgBB orally, P2 treated with CBO 200 mg / kgBB orally, P3 treated orally with CBO 400 mg / kg orally for 14 days. White rat animals were then mutilated and testicular organs were taken for histopathological preparations using HE staining, then the diameter of the seminiferous tubules and the number of Leydig cells were calculated. Data were analyzed with One Way ANOVA and followed by Duncan's test. The results showed that streptozotocin had the potential to reduce the size of the seminiferous tubule diameter and the number of Leydig cells, while CBO at a dose of 400 mg / kgBW could increase the size of the seminiferous tubule diameter and the number of Leydig cells. It can be concluded that CBO can be used to reduce testicular dysfunction induced in diabetic rats.Key words: Cinnamon bark oil, Seminiferous tubule diameter, Leydig cells, Streptozotocin, Male rat.
Factors Affecting Amputation in Patient with Diabetic Foot Ulcer at Sardjito General Hospital Andreas Wahyu Wicaksono
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.642 KB)

Abstract

Background: Diabetic foot ulcer (DFU) can cause significant morbidity and need for surgical intervention due to the high prevalence of diabetic foot problems in general population. The incidence of DFU is 15% of all diabetic patients. Eighty-two percent (82 %) of DFU will lead to lower extremity amputation. Therefore, the factors that affecting the needs of distal limb amputation should be described for prevention and decrease the need of amputation and morbidity of the patients. Objective: The aim of this study is to determine factors affecting distal limb amputation in patient with DFU. Methods: The design of this study is retrospective cohort, using data of DFU patient treated surgically from January 2012 to September 2016. Socioeconomic factors, Blood profile, Diabetes Mellitus (DM) profile and Ankle Brachial Index (ABI) were collected. All the data were then analyzed using SPSS. Result: There were 119 patients were enrolled in this study. Thirty-nine patients (32.7%) had distal limb amputation. The amputation level was forefoot (34 patients, 87%), mid foot (2 patients, 5%), hind foot (2 patients, 5%) and Trans tibial (1 patient, 3%) amputation. This study showed that socioeconomics factors were not significantly correlated with distal limb amputations in patients with diabetic ulcer. The level of DLA was not affected by patient’s blood profile, DM profile and ABI. Conclusion: Decision to perform surgical intervention can not only rely on the laboratory profile and socioeconomic factors of the patients. Clinical judgement of the doctor and the patients' general conditions should also be considered.
Path Analysis of the Influence of Nurses Role on Family Caregiver Diabetes Self-Management Capabilities with Empowerment as Intervening Variables in Indonesia Rondhianto Rondhianto
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.071 KB)

Abstract

Introduction:  Nurses have a responsibility to empower the family that is a preventive promotion effort to improve the ability of the family caregiver to manage diabetes. The purpose of this study was to analyze the role of nurses on the ability of family caregivers through family caregiver empowerment. Methods: This study was an analytic observational study with a cross-sectional design. This study was conducted in the Jember Regency, East Java Province of Indonesia, with a sample size of 150 respondents using a multi-stage random sampling technique. The instrument were namely the Role of the Nurse Perception Questionnaire, Psychological Empowerment Scale, and Diabetes Management Self Efficacy Scale. The data analysis used descriptive analysis and inferential analysis with Structural Equation Modeling-Partial Least Square (SEM-PLS). Results: The results showed that nurse's role had a direct effect on family caregiver empowerment by 93.80% (t = 89.558; p = 0.000 <0.005), but did not have a direct effect on the diabetes self-management capabilities (t = 0.508; p = 0,600> 0,005). However, nurse's role has an indirect effect on the diabetes self-management capabilities through family caregiver empowerment of 64.50% (t = 4.036; p = 0,000 <0.005). This path analysis model is fit model and  has an accurate predictive relevance to the existing constructor has a relevant ability to predict (SRMR Value = 0.053 <0.8; Q2=0.331 >0). Conclusion: The nurse's role has a direct influence on family caregiver empowerment and has an indirect effect on the diabetes self-management capabilities through family caregiver empowerment. The efforts to empower family caregivers by nurses through enabling, reinforcing, and supporting as a preventive-promotion intervention need to be improved to enhance the ability of family caregivers in type 2 diabetes management.Keywords: Diabetes Self-Management Capabilities; Family Caregiver Empowerment; Nurse's Role; Type 2 diabetes.
Urease Activity Level in Crude Extract From Peels of Some Legumes and Cucurbits Zainab M. Dahham
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.689 KB)

Abstract

Ureases are an important group of enzymes with various applications in the analysis of food and water, chemicals, clinical, agricultural and pharmaceutical industry, besides having great interest for the treatment the industrial waste. The main objective of the present project is to extract urease enzyme from economical sources which can be utilized in biotechnology, medicine and industrial fields, as well as clean the environment from the plant wastes and recycle it. In this study urease was extracted from peels of some legumes and cucurbits: (bean, pea, water melon and melon), as well as bean seeds were also used as a known main source of urease for comparison. The enzyme was extracted from peels by electrical blender homogenization with phosphate buffer (0.2 M, pH 7), then protein concentration, urease activity, pH stability, thermal stability and storage stability were determined in crude extract. Urease activity and specific activity extracted from pea peels was the highest among the other extracted wastes, which showed stability at neutral pH 7 at room temperature, also it was very stable when incubated at (40-50 °C) for 20 min, and during storage at -18 °C at pH 7 for 3 months indicating that this enzyme was very stable. No significant differences were found between urease activity using pea peels with that measured by standard kit for the blood urea determination in serum of normal and patients. So, pea peels considered as an important economic source of urease enzyme.Keywords: Urease activity, Pea peels, PH stability, Thermal stability.
Treatment for Patients with Primary Immunodeficiency Diseases Anastasia Gradskaya
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.013 KB)

Abstract

Primary immunodeficiency diseases occur with a frequency of 1: 10,000 pp. among population. The purpose of this study is to evaluate the most common forms of primary immunodeficiency among patients in Moscow based on the Russian registry for primary immunodeficiency, as well as to analyse the treatment tactics of three patients. The studies were conducted in 2016-2018 among 73 patients aged 5-12 from Russian Children's Clinical Hospital (RCCH), all diagnosed with primary immunodeficiency. The classification of patients was carried out according to the Russian registry by type of primary immunodeficiency. Lethal cases, gender and age distribution were considered. The treatment tactics of three patients were analysed. The number of boys exceeds the number of girls by 7.2 times (p ≤ 0.001) for defects in antibody production, by 6.0 times (p ≤ 0.001) for combined immunodeficiency, by 1.4 times (p ≤ 0.05) for phagocytic defects, and by 2.5 times (p ≤ 0.01) for other types of immunodeficiency. The patients with defects in antibody production predominated, namely by 1.5 times - patients with combined immunodeficiency (p ≤ 0.05), by 2.8 times - patients with phagocyte defects (p ≤ 0.01), by 4.7 times - patients with other types of immunodeficiency (p ≤ 0.001). 73 patient patients under the age of 12 years with primary immunodeficiency had their anamnesis analysed that helped to identify 4 main forms. Boys prevailed in gender composition (80.8%), and there were no significant differences between boys and girls in age. The lethality prevailed among patients with combined type immunodeficiency. Thus, there were 1.3 times less lethal cases among patients with phagocyte defects comparing to the combined type (p ≤ 0.05), but 2.4 times more compering to the other types of immunodeficiency (p ≤ 0.01).Keywords: Primary immunodeficiency diseases, Patient registry, Combined immunodeficiency, Defects in antibody production.
Chromosomal Abnormalities as a Cause of Recurrent Abortions in Iraq Samia Khalil Mahmmod
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.044 KB)

Abstract

To evaluate the incidence of chromosomal abnormalities in Iraqi couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis. The present study examined 70 couples with at least two pregnancy losses were referred to the Iraqi Center for Cancer and Medical Genetics Research. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Among the 70 couples tested, Chromosomal abnormalities were detected in 16 (11.42%) of 70 couples, seven males (4.99%) and nine females (6.42%). Fifteen of chromosomal abnormalities were structural and one of them was numerical. These abnormalities included four balanced reciprocal translocations, one Robertsonian translocation, one case of trisomy X-chromosome and the other cases have a different chromosomal aberration inversion, deletion and derivative. Our results showed that 11.42% of couples with recurrent abortion had chromosomal abnormalities, with no other abnormalities. Couples who experience ≥2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.Keywords: Recurrent abortion, Chromosomal abnormality, Balanced carrier.
Study the Effect of Ribavirin Drug on the histological structure of the testes in Albino mice (Mus musculus) Thekra Atta Ibrahim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (675.139 KB)

Abstract

The results have gotten from this study was showed that all animals of two experiment groups that inoculated with Ribavirin drug appeared change in the thickness of seminiferous tubule wall of the testes and contraction in them where its appearance became irregularly and crooked as well as observed emergence of Vaculation. Also some sections of the sperm tubules Seminiferous tubule revealed increased in the widening of the distance between the germ cells and ecdysis of the epithelial tissue and aggregation in the cavity of some Seminiferous tubule also the occurrence of degeneration and raised the distance between neighboring Sertoli cells.Keywords: Testes, Sertoli cells, Ribavirin, Seminiferous tubules, Leydig cells, Mus musculus.
Purify and Characterize the Xylanase from the Local Isolation of Trichoderma Longibrachiatum Shimal Younis Abdel-Hadi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.228 KB)

Abstract

Fungi are well known for their ability to produce extracellular enzymes into their surrounding environment. Xylanases are an important class of hydrolytic enzymes involved in degradation of xylene a backbone of hemicellulose, in this study; we have isolated three isolates of xylene analytic fungi taken from five samples of sand gathered from different sites in the University of Mosul. Depending on the halo's diameter of analysis and by using the Congo red indicator, one isolate has got a high activity in producing the exocellular xylanase enzyme related to Trichoderma longibrachiatum on the base of morphological, microscopic and internal area (ITS) features. The xylanase has been purified from the raw extracted enzyme of the selected isolate throughout four subsequent steps included: sedimentation by Ammonium Sulphate, dialysis, gel filtration in column (Sephadex-G 100) and the Ionic exchanger (DEAE Cellulose). After this step, the number of filtrations is (49.22) with enzymatic outcome reaching to (33.93%). Studying the description of the filtered enzyme, PH the optimal for the enzyme activity is 0.5 and the optimal range of PH for enzyme stability is (4-6). Moreover, the optimal temperature degree for enzyme activity is (50 °C), whereas the optimal temperature degree for enzyme stability is (50-60 °C).Keywords:  Mosul university, Xylanase, Trichoderma longibrachiatum.
Doppler Study and Cell Free DNA Biomarkers by using PCR in Hypertensive and Diabetic Pregnant Iraqi Wom Dhelal Qasim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (738.883 KB)

Abstract

Doppler ultrasonography has been used to assess both the fetal and placental circulation, to facilitate the diagnosis and monitoring of important conditions. Circulating cell-free (cf-DNA) in plasma is considered a novel biomarker with promising clinical applications. This biomarker was reported in prenatal diagnosis and in adverse pregnancy outcomes. Hypertensive disorders of pregnancy and both type 1 diabetes and type 2 diabetes in pregnancy represent a significant cause of maternal and perinatal morbidity and mortality. The aim of the study is to relate the Doppler study of the umbilical cord and uterine artery to the presence of different primers in hypertensive and diabetic pregnant women. Ninety women had been enrolled in this study. Thirty (33%) of them with diabetes mellitus and the other 60 (67%) women were with hypertension. The mean age of study sample was (29.7 ±6.33 years (. Careful history was taken from all women. Uterine blood flow for women below 28 weak gestational age, and umbilical artery blood flow for 28 weak pregnancies and more was done by Doppler Ultrasound. Blood samples were taken from all women and cf-DNA was measured using PCR technique. There is significant association (P ≤ 0.05) between Autism primers 3 with the Doppler study in hypertensive pregnant women. Also there is significant association between Sirti primers 3, 4 with the Doppler study in diabetic pregnant women, and there is significant association between Trisomy primers 3 with the Doppler study in hypertensive pregnant women. There is no difference between the negative and positive results in relation to Doppler study regarding hypertensive and diabetic pregnant women except for the above primers.  Keywords: Doppler study, Cf-DNA biomarkers, PCR, Hypertension, Diabetes.

Page 3 of 12 | Total Record : 120

 1   2   3   4   5 

Filter by Year

2020 2020


Reset
Filter By Issues
All Issue Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue