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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Molecular Detection of New Delhi Metallo Beta Lactamase 1 (NDM-1) - Producing Salmonella Typhi in Patients with Typhoid Fever Qasim S. Al-Mayah
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Background: Antibiotic resistance among different pathogenic bacteria becomes a major therapeutic change and requires prompt solutions. Aims: this study aimed to investigate the prevalence of New Delhi metallo-β-lactamase-1 (blaNDM-1) gene in Salmonella Typhi isolated from patients with typhoid fever. Materials and Methods: This a cross-sectional study including 100 patients with typhoid fevers. A blood sample was collected from each patient, and cultivated on a selective media for Salmonella where the diagnosis was made phenotypically and by API20E system. Disk diffusion test was used to examine the microbial sensitivity to imipenem and meropenem, while the ability of the bacteria to produce the carbapenemase was examined using Modified Hodge’s test. For blaNDM-1gene detection, the plasmid DNA was extracted and a specific set of primers was used to amplify this gene in conventional polymerase chain reaction (PCR). Results: Out of 100 patients, 37 (37%) had a positive blood culture, of which 13 isolates showed some antibiotic resistance: 7 isolates for imipenem, 4 isolates to meropenem, and 2 isolates both antibiotics. Of those 13 isolates, 10 (76.9 %) were positively showing their ability to produce carbapenemases, while 9 isolates (69.2%) showed a successful blaNDM-1 gene amplification. Conclusions: There is a relatively high rate of carbapenemases-producing and as well as NDM-1 producing S. Typhi strains among Iraqi patients with typhoid fever
Integrated View of Formaldehyde in Lung Toxicity: Molecular Mechanisms, Cellular Aberrations and Pathological Considerations Soheir E. Kotob
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Formaldehyde (FA) is an indoor and occupational pollutant, with marked carcinogenic impact on the airways. The current investigation was initiated to determine the molecular, immunohistochemical and histopathological alterations in lung tissue of rats subjected to FA inhalation and to provide new reliable biomarkers of the hazardous insults of FA on the lung. Adult female Wistar rats were assigned into five groups; (1): negative control; (2): 10 ppm FA inhalation for 15 days; (3): 20 ppm FA inhalation for 15 days; (4): 10 ppm FA inhalation for 30 days and (5): 20 ppm FA inhalation for 30 days. After the experimental periods; rats were killed and lung tissues were harvested and prepared for molecular genetics, immunohistochemical and histopathological procedures. Molecular genetic results indicated significant overexpression in pulmonary Cyp2c6 gene in the group of rats submitted to FA inhalation (20 ppm) for 30 days. The expression level of pulmonary Bhmt gene showed significant upregulation in the groups of rats inhaled 10 and 20 ppm FA for 30 days. Pulmonary Mapk12, HLA-A and GsTpi gene expression levels revealed significant over expression in the groups of rats subjected to FA inhalation (10 ppm) for 30 days and (20 ppm) for 15 as well as 30 days. Meanwhile, the level of expression of pulmonary gene HLA-A recorded significant downregulation in the group of rats inhaled FA (10 ppm) for 15 days versus the control counterparts. In addition, immunohistochmical findings denoted positive immunoreactive responses for PCNA and cytochrome c in the lung tissue with different degrees according to the dose and duration of FA exposure. Histopathological description of lung tissue sections of rats underwent FA inhalation revealed various levels of histoarchitectural alterations depending on the dose and time interval of FA subjection. According to the before mentioned data, it seems that extreme FA burden on the lung leads to devastating effects on the molecular level (genotoxicity) and on the cellular level (proliferation and apoptosis). Also, morophological deformation depicted by histopathological investigation indicated the induction of conformational and structural alterations of lung tissue as a consequence of FA inhalation.
Cytological Diagnosis of Ovarian Tumors Ahmed Al Qteishat
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Ovarian cancer is one of the most common oncology disorders of the female reproductive system. The aim of the study is to estimate the efficiency of cytological methods in identification of specific characteristics of ovarian cancer and other cancers of female reproductive system. The research was conducted in oncology clinics of Moscow (Russian Federation) and Sofia (Bulgaria) within a period between 2012 and 2019. The study involved 373 cancer female patients who were divided into two groups: the study group (242 women, average age 38.5 ± 7.8 years) and the comparison group (131 women, average age 42.1 ± 9.0 years). The study group included patients diagnosed with ovarian, breast, and endometrial cancer, while the comparison group comprised patients with stomach and lung cancer. The methods of light microscopy, immunocytochemistry and cytological methods were applied in this research. Two types of breast cancer (with ductal breast cancer predomination over the lobular one) and three types of ovarian cancer were specified. The final diagnosis of small cell lung cancer was 15% of lung cancer cases. This cytocentrifuge method was applied in 20% of ovarian cancer cases. Immunocytochemistry revealed a significant response to epithelial antibodies and a negative response to mesothelial ones in breast cancer (p ≤ 0.001). Also, there was no response to monoclonal antigens in ovarian cancer (p ≤ 0.001). This enabled the researchers to recognize and diagnose the mentioned cancer types. A one-year mortality of breast and ovarian cancer was established in 45-47% of patients, which indicated that disease was diagnosed at advanced stages. The study showed the cytological methods to be not equally used in different cancer types: mostly used in breast and ovarian cancers of the study group and almost not applied in lung cancer. In the comparison group, such results were obtained only in stomach cancer. Cell vacuolization was detected in 65% of ovarian cancer cases, while in 80% of ductal breast cancer cases there were specified clusters of spherical cells. Cell structures in the form of bands and chains were found in 75% of lobular breast cancer cases. Single signet ring cells were identified in 20% of stomach cancer cases in the comparison group. The results of the study proved the cytological methods to be significantly important in facilitating the diagnosis of adenogenous ovarian and breast cancer in the study group. Keywords: Ovarian cancer, Breast cancer, Endometrium, cytological methods, Monoclonal antigens.
Correlation of Serum Cu and Zn with Some Cytokines in Major Depressive Disorder Hussein Kadhem Al-Hakeim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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There is an association of major depressive disorder with different changes in the immune functioning which associate with activation of inflammatory processes. Trace elements such as copper (Cu) and zinc (Zn) have many physiological functions. In the present study, serum levels of Cu, Zn, inflammatory (IL-6), and anti-inflammatory (IL-10) cytokines have been measured in MDD patients and compared with the apparently healthy group. The correlation between the measured trace elements and IL-6 and IL-10 is another purpose of the study to find out the trace elements effect on the secretion of the interleukins in MDD patients. The study involved 60 pretreatment males with MDD and 30 apparently healthy as controls (age matched). The results indicated that there was significantly increase (p
Effect Specific Cooling Times on Motility and Membrane Integrity of Cauda Epididymal Bovine Bull Sperm Asmaa Sh. Aliawy
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Cauda epididymides (CEs) collected post-mortem could be an important source of genetic material from male for conservation and use for assisted reproductive technologies. In this study, we characterize the epididymal sperm (ES) collected post-mortem from CEs of bull cow raised locally. Testicles (n=30) were sliced off from bull cow post-mortem, placed in a box at ambient temperature and transported to the laboratory within 2 hr. The CEs were detached from the testicle and the tail were sliced longitudinally and dropped into a 50-ml conical tube with 15 ml TRIS citric acid. The ES was collected after 10 min, washed through centrifugation and measured. The Live Epididymal Sperm Cooling Sperm 76.40±0.93, 48 hours 68.94±2.38, initial motility, 72 hours 64.23±2.47, 96 hours 60.62±2.40 and 56.62±2.31 per cent, Membrane integrity with initial motility cooling time had the lowest values compared to the gap in initial motility cooling period and 120 hours cooling time .sperm motility whereas through CASA, For CASA (VAP, VSL, VCL, ALH, WOB, LIN), there were no interactions between different cooling times. In addition, different cooling times (P>0.05) affected sperm motion kinematics, i.e. VAP, VSL, VCL, ALH, WOB and LIN, but these parameters are influenced during the cooling process. With epididymal sperm cry presets, both VSL and VAP values were the highest. Cry retained (VSL: 66.25±2.21μm / s, VAP: 81.42±1.46μm / s) compared with 48 hours (VSL: 59.09±1.52μm / s, VAP: 76.67±1.43μm / s), During the cryopreserved cooling period of 5.29±0.14μm (P
Evaluation the Antibacterial Effect of Rosemary and Lemon Grass Essential Oils against Planktonic and Biofilm of MRSA Zainab Zamel Khalaf
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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There has been increasing interest in volatile oils in recent years due to the need for new treatments against microbes. Bacterial resistance is widespread worldwide and the first cause of this resistance is the excessive use of antibiotics and bad practices to combat infection in hospitals, making it one of the biggest issues at present. In this study, twenty bacterial isolates of methicillin-resistant Staphylococcus bacteria were diagnosed and all were diagnosed using Vitek. The synergistic effect of the rosemary and lemongrass essential oil against these bacteria was studied in the form of suspended or single cells and when they formed the biofilm. Different concentrations of both essential oils were used to experiment the minimal inhibitory (MIC) effect on these bacteria. The effect of each oil was studied separately and then their synergistic effect was investigated. The bacteria's ability to produce the biofilm using the Tissue culture plate method Whether it was strong, moderate, or weak, and then investigated the inhibitory properties of each oil against the biofilm of the bacteria and also studied the synergistic effect of both oil against the biofilm of the bacteria. The findings proposed that all isolates were affected and inhibited with lemon grass essential oil except for one isolate and was an oil effect Lemon grass is larger compared to rosemary essential oil, but the synergistic effect was better in compare with the effect of each oil alone. The results of the biochemistry of the bacteria showed that 15 isolates of Staphylococcus aureus were formed of a strong biofilm and 4 isolates formed for a medium biofilm and one isolate only for a weak. The results also find that the lemon grass and rosemary essential oil had an effect against the biofilm but with different concentrations. There were 3 isolates that were not affected by each one of plant oil (3, 6 and 10). The synergistic effect of both essential oils showed that all isolates were inhibited except (6, 9 and 10). Keywords: Essential oils; Synergistic effect; MRSA; Antibacterial activity, Biofilm.
Corrosion Protection Enhancement using Electropolymerized Aniline Coating on Carbon Steel Pipelines in Industrial Water Abdulkareem M.A. Al-Sammarrai
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Corrosion of carbon steel in different water system utilities exhibited serious source of financial loses. In this study, electrochemical polymerization of aniline on carbon steel were studied in three types of industrial water (cooling water, waste water and treatment water) as corrosive media. The corrosion parameters; corrosion potential, corrosion current, polarization resistance, corrosion rates, and thermodynamic functions were estimated from Tafel and potentiodynamic procedures at four temperatures; 293,303,313and 323K. Protection enhancements were recorded at all industrial water used in this study and efficiencies of 78-91% were achieved. The results are supported by surface morphology examination before and after coating of carbon steel using atomic force microscope (AFM) and optical light microscopy (OM). Keywords: Electrochemical polymerization, Polyaniline, Nanofibers, carbon steel, Industrial water.
Temporary Loop Occlusion using Vessel Loops on Bilateral Common iliac Arteries to Reduce Blood Loss in Total Abdominal Hysterectomy on Adherent Placenta Patient at Sanglah General Hospital, Bali-Indonesia I Nyoman Semadi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Background: In pregnancy, there may be an invasion of the placenta into uterine wall, causing post-partum haemorrhage. This Hemorrhage may cause maternal death. Therefore a total abdominal hysterectomy (TAH) needs to be done to stop the bleeding. Temporary loop occlusion (TLO) is an additional procedure to reduce blood loss when doing TAH. This study aims to determine the intraoperative outputs of TLO when doing TAH on adherent placenta patient. Material & Method: This research is a retrospective study conducted at Sanglah Hospital from January 1st to 31st December 2019. There were two groups consist of four patients each, namely TLO intervention and non-intervention. Each group was analyzed based on the estimated blood loss, the number of packed red cell (PRC) transfusion, operating time, length of intensive care unit (ICU) and ward stay. Result: Intraoperative blood loss revealed a statistically significant difference in results (p=0.037), with mean 2125 ± 853.9 ml in TLO intervention and 3750 ± 866 ml in non-intervention. Comparison between both groups on other variables such as PRC transfusion were 694.75 ± 394.18 ml and 1298.5 ± 716.19 (p=0.384), operating time were 220,05 ± 39,5 minutes and 264,5 ± 69,84 minutes (p=0.468), length of ICU stay were 2.75 ± 0.95 days and 3.25 ± 0.96 days (p=0.488), length of ward stay were 2.25 ± 0.5 days and 2.75 ± 1.5 days (p=0.85). Conclusion: TLO is an additional procedure that can be performed on TAH because it provides good output. Keywords: Temporary loop occlusion, Hysterectomy, Adherent placenta, Haemorrhage, outcome.
Risk Factors Recurrent Respiratory Papilloma (RRP) on Juvenile and Adult Type in Tertiary Hospital, Indonesia Rizka Fathoni Perdana
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Introduction: Recurrent respiratory papillomatosis (RRP) is the most common benign neoplasm of the larynx among children as a result of HPV infection mainly type 6 and 11. RRP is still a serious problem in which papillomas in the airway cause hoarsness and obstruction as then described as an aggressive form and less aggressive form. Patients undergo multiple surgeries to keep the airway patent and in order to communicate vocally. There are several risk factor that affect on disease aggressivity. That factors include sex, age at diagnosis, papilloma implantation, tracheostomy, number of surgery, and histopathology. Aim: to determine the relationship between risk factors for RRP with the level of aggressiveness in juvenile type and adult type. Method: This research used analytic retrospectively, the data obtained from the medical record of outpatient unit of the otolaryngology-head and neck surgery department. The data obtained in the study are displayed in tables and analyzed statistically using the Chi-Square test. The research sample was taken according total sampling. Result: The statistic test result was indicating the statistical test using Chi-Square results (p
The Recurrence of Stricture in Postoperative Patients at Dr. Soetomo Hospital from 2013-2017: A Case-Control Study I Dewa Gede Reza Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Background: Urethral stricture is one of urology disease that commonly occurs in men with the incidence increase above 54 years old. Urethroplasty was an effective management option for almost all types of stricture and remained as the gold standard. Recurrence of stricture is one of complication that can occur after operative treatment. Methods: A case-control study with secondary data of all patients treated and undergoing operative management of the anterior-posterior urethral stricture in Dr. Soetomo Hospital from January 2013 to December 2017. Diabetes mellitus, hypertension, urine culture, and previous history of sachse were as independent variables. The data described by the distribution table and continued by Chi-square test using the SPSS application. P-value

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