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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Liver Regenerative and Hepatoprotective Effects OF Moringa Oleifera Extract in the Liver Fibrosis Animal Model Supriono Supriono
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: This study was conducted to know the liver regenerative and hepatoprotective effects of Moringa oleifera (MO) in the animal models of liver fibrosis. Methods: The study was a randomized post-test only controlled group design. Male Rattus novergicus of liver fibrosis caused by induction of CCl4 was treated with extract of (MO). Histological of the liver tissue with hematoxylin and eosin (H&E) staining were investigated by a light microscope. We calculate the number of hepatocytes expressing MDA and cytokeratin-7 (CK-7) in liver tissue using the immunohistochemical analysis. Results: Induction of CCL4 for 14 weeks results in liver fibrosis (METAVIR score F-3) and improves by the administration of MO. The number of hepatocytes expressing MDA in liver fibrosis models sevenfold higher than normal models and significantly lower after treated with MO. ALT and AST in the treated models significantly lower than in the liver fibrosis models. On the other hand, the number of hepatocytes expressing CK-7 in both normal and liver fibrosis models was lower. The CK-7 significantly higher after the administration of MO. Many ductular reactions develop in the treated animal models. Conclusions: in our knowledge, this is the first study reported a liver regenerative effect of MO in the liver fibrosis, beyond its hepatoprotective effect. The mechanism of liver regenerative probably through a hepatic progenitor cell proliferation. Keywords: Moringa oleifera, liver fibrosis, liver regenerative, CK7, MDA.
An Update of In Vitro Fertilization-Intra Cytoplasmic Sperm Injection: A Review of Sperm Selection Methods Marianne Ingrid Aror
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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In Vitro Fertilization (IVF)-Intra Cytoplasmic Sperm Injection (ICSI) is a well-known infertility management, but the success rate remains low. One of etiologies is the sperm factor. The objective of this review is to explore the update of sperm selection methods for selecting the best sperm quality for IVF-ICSI. Initially, semen analysis should be conducted hence sperm motile and morphology data are obtained. If there is standard sperm morphology in semen analysis, then in the motile sperm organelle morphology (MSOME), important sperm organelles are also obtained, such as nuclues, which are supplemented with vacuole data. Then, due to limitation of semen analysis, the analysis of sperm DNA fragmentation exists to analyze the quality of sperm DNA integrity. Sperm DNA fragmentation is caused by apoptosis. Magnetic Activated Cell-Sorting (MACS) is a sperm selection method that selects non-apoptotic sperms for IVF-ICSI. Finally, Physiological ICSI (PICSI) method is performed to select qualified sperms based on its binding with hyaluronan, immitating the physiological process in natural fertilization. It is important to select the best sperm quality through the most appropriate selection method to increase the success rate of IVF-ICSI. Keywords: IVF-ICSI, Sperm selection, DFI, MSOME, MACS, PICSI.
Evaluation of the Efficiency of the Isolated Fungi from Some Insect Species on White Fly Larvae: Bemisia Tabaci (Hemiptera: Aleyrodidae) H.D. Abdal-Jabar
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The study was carried out inorder to isolation and identification of fungi associated with Formicidae pp, Pyrrhocois apterus and Coccenilla septempunctata L. and evaluate of the pathogenic ability of fungi isolated from adult bodies. Isolated fungi represented by Penicillium compactum, Penicillium janczwskii, Aspergillus terreus, Alternar of black adult ants, while the fungi were isolated penicillium chrysogenum, Beauveria bassiana, Aspergillus parasticus, Aspergillus campestris. From firebug insect, the fungi were isolated Alternaria chlamydospora, Aspergllus niger, Penicillium compactum, Ulocladium atrum of beetle insect. The results showed that the highest incidence was for fungi. Aspergllus niger and Penicillium janczwskii with equal percentage % 24.6, while the lowest incidence was for the two Aspergillus terreus Ulocladium atrum 1.5, 3.07 Respectively. The results indicated the superiority of the fungus Alternaria chlamydospora Aspergillus terreus to the rest of fungi in attracting adults Bemisia tabaci with the highest rate of affint for adults 48.0, 49.0 respectively while the lowest rate of attraction was treated with fungi Penicillium janczwskii was 0.3 adult. After five minutes later. The results clear that the highest mortality percentage of white fly was killed in the treatment of fungi Aspergillus parasticus and Ulocladium atrum the transaction amounted to% 57.17, 58.32 Respectively, while the lowest mortality percentage in the treatment of fungi Aspergillus sterreus amounted to% 38.92, It was found that the mortality percentage increased with increasing exposure time as it reached after passing 48, 70, 96,120 hours of treatment. Keywords: Isolation, Biological control, Diagnosis, Effect, Fungi, White fly, Mortality percentage.
Evaluation the Efficiency of Magnesium Oxide Nanoparticles in the Reduction of Ochratoxin A and in the Inhibition of Asperillusniger Shahbaa H Majeed
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This study was conducted in Mycotoxins Laboratory /Department of Plant Protection/College of Agriculture at" University of Baghdad". This study aimed to determine the efficiency of magnesium oxide nanoparticles (MgO) (NP) in the inhibition of Aspergillusniger growth and in the degradation ocra a toxin. The results found that MgOnanoparticles significantly inhibited the growth of A. niger. There were significant differences between all the concentrations of MgOnanoparticles in comparison to control groups, while no significant difference was fund between the concentration of 2% and 3%;a significant differences also was detected between the concentrations (2 and 3)% for the first concentration (1%) and the 95% for concentration of(3%). Moreover, the results observed that MgO nanoparticles was potential in the reduction of ocra Atoxin A that produced from A. nigerusing Performance liquid chromatography (HPLC) technique; the percentage of reduction of toxin were 90.1%, 92.2%, 93.7% for concentrations of NaO2 1%, 2% and 3% respectively, however the best reduction percentage was 92.2% with concentration of 0.06 μg/kg after the treatment with MgOnanoparticles at 2%. Keywords: Ochratoxin A, MgO (NP), inhibition of Aspergillusniger, Reduction.
Donor Site Morbidity after Anterior Iliac Bone Graft Harvesting Rahadyan Magetsari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Bone substitutes are being increasingly used especially in oncologic surgery, traumatology, revision prosthetic surgery and spine surgery. Bone substitute can be defined as a synthetic, inorganic or biologically organic combination which can be inserted for the treatment of a bone defect instead of autogenous or allogenous bone. Despite the improvement of research, human bone grafts persist to be the most effective bone substitutes to replace bone loss. This research was retrospective study conducted in consecutive sampling in Sardjito General Hospital Yogyakarta from January 2014 to Desember 2018. Patients underwent anterior iliac crest bone graft harvesting was included. 4 months after the procedure, the donor site morbidity was identified. The parameters used in this study are pain score using visual analog scale, paresthesia, problem in walking, wound infection, scar satisfaction and major morbidity. Anterior iliac bone graft harvesting resulted in minimal morbidity and neither pain or functional limitations. It also provides the optimal bone graft material, yields minimal morbidity, and is an acceptable choice in autologous bone graft harvesting.
Thermal Resistance of Epoxy Resin and Phenol Formaldehyde Compound Mixed with Mixed Inhibitors Mustafa A. Rajab
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The properties of flammability and the effect of zinc oxide with antimony trioxide were examined on the thermal corrosion testing of epoxy resin and formaldehyde. Zinc borate was added to the resin and then reinforced with silica fiber and woven glass fibers (90 ° -0º) with thickness (4 mm). Then expose the system to Acetylene Oxide flame (3500 ° C) directly with different exposures of flame (10 mm, 20 mm), to study flame retardant resistance and protection of the substrate. Animein trioxide was then added to zinc porcine in different quantities (10%, 20% and 30%) to form hybrid flame retardants for hybrid exposure to the same flame temperature and exposure distances. The method of measuring the surface temperature of the flame was used to determine the temperature transferred to the composite material. The results showed that the best exposed distance and a large proportion of protective layer of zinc boron with antimony trioxide was at 30%. Keywords: Hybrid Flame Retardants, Composite Material, Inorganic Retardants.
Asymptomatic Tremendous Lung Shadow in a Young Man: A Case Report Li Min Wang
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The study is devoted to a unique asymptomatic case of pulmonary sequestration with no infection detected and offers an appropriate treatment solution.The study was carried out in the Surgery Department of the polyclinic No.47011661433010211A1001, Hangzhou, China, in 2019. The patient diagnosed with pulmonary sequestration was 26 years old. No associated symptoms were detected. CT Angiography (CTA) was applied to diagnose pulmonary sequestration, whereas Digital Subtraction Angiography (DSA) was conducted before operation in order to localize abnormal vessels. CT Angiography (CTA) suggested thickening and tortuous regional arteries in the right lower lung, with obvious increasing in branches. The 12th thoracic level aorta branched out into the right lower lobe of the lung, the vein drained back into the pulmonary vein. The surgical treatment of pulmonary sequestration was performed with the embolic thread and involved embolization with an embosphere of 0.5 mm diameter and a spring coil. The post-surgical angiography revealed the disappearance of distal blood flow, indicating success of the therapy. After the intervention, the patient developed a recurrent fever. After the oral administration of low-dose glucocorticoids, the patient’s body temperature dropped to the normal level. The final CT scan of the chest conducted a year after treatment showed shadow absorption.The embolization therapy turned out to be effective and hence is suitable for the treatment of pulmonary sequestration. It was established that lung malformations may manifest as an asymptomatic condition. This finding expands what we know about the pulmonary sequestration. Keywords: Pulmonary sequestration; Interventional embolization, Angiography, Clinical case.
Long Term Use of Ovarian Stimulation Drugs May Affect Thyroid Function Ajile Elttayef
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: The use of ovarian stimulation drugs has increased worldwide; this is associated with physiological and biochemical alteration in different body systems. This study aims to evaluate the impact of different types of ovarian stimulation programs on thyroid hormone levels through different time exposure. Methods: Eighty women were involved in this study. Twenty women were considered as a control group (volunteers with no history of any health problems). The rest show no sign or symptom for thyroid impairment, they were divided into three groups, Group (A) contain twenty women treated with Clomid only, group (B) another twenty women treated with pergonal only, and the last twenty women group (C) were treated with both Clomid and pergonal (Mix). Measurement of TSH, T3, and T4 concentration before and after administration of different ovarian stimulation drugs and for a different time exposure. Results: This study proved a variation in thyroid hormone level during different time exposure and with different drugs used, some of them show no significant difference in the levels of thyroid hormones for two month after administration (group A) as compared to the control group, while in group (C) the increased of TSH hormone was significant (P
Endophytic Fungi from Piper retrofractum VAHL: Isolation, Phytochemical Analysis, Antibacterial and Antioxidant Activities Dwi Koko Pratoko
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Objective: Piper retrofractum Vahl. is an Indonesian plant that has several activities such as antibacterial, antifungal, antioxidant, etc. Endophytic fungi are fungal microbe which can produce secondary metabolites that associated with medical plants can be exploited for curing many diseases. This is the first study of endophytic fungi from P. retrofractum which can be an alternative source of natural product besides its host, P. retrofractum. Seven endophytic fungi were isolated from the fruits and leaves of P. Retrofractum and investigated for their antibacterial and antioxidant activities.Methods: All the isolated fungi were tested for their antibacterial activity using disc diffusion method with several series of concentrations and antioxidant capacity using the DPPH method.  Result: The highest activity both antibacterial and antioxidant was demonstrated by DPR-1 extract against Staphylococcus aureus and Pseudomonas aeruginosa. This extract contained alkaloids, steroids, and flavonoid compounds.Conclusion: This study reported that endophytic fungi from P. retrofractum indicate as a potential source of bioactive and chemically novel compounds.Keywords: Piper retrofractum, endophytic fungi, antibacterial activity, antioxidant activity
Investacte the Role of Weissella Confuse on TNF-α in Serum and Liver Tissue of Mice Infected with Leishmania Donovani Dhilal Abdulelah Ibraheem
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Leishmaniasis is one,of the vector-borne diseases, caused by obligate protozoan parasites, they are.transmitted by sand, flies as extracellular. Flagellatedepromastigotes thatereplicate as an intracellulareparasite in.mononuclear cells of mammalian.hosts. Probiotics are microorganisms that provide health benefits when consumed and characterized by being of human origin, probiotics have benefits in health and diseases, there is some clinical applications using probiotic like: immunity function by increasing the number of IgA-producing plasma cells, improving phagocytosis as well as increasing the proportion of T lymphocytes and Natural Killer cells. The present study it is efficiency against Leishmania donovani compared with pentostam drug in vivo by measuring the levels of immune cytokines (TNF-α) in serum and liver tissue of infected mice and treatment with Weissella confuse bacteria and its supernatant for three weeks. The results of measuring the levels of TNF-α showed significant increase in mice serum and the concentration of TNF-α in liver tissue by immunohistochimsry showed increase in TNF-α secretion of treated mice with Weissella confuse bacteria and pentostam compared to non infected mice while mice treated with Weissella confuse supernatant showed less increase compared to the two previous groups. Probiotic bacteria and its supernatant have an affect on Leishmania donovani parasite through induce pro and anti-inflammatory cytokines in vivo. Keyword: Leishmania, Probiotic, TNF-α, Weissella confuse, Immunohistochimsry.

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