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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 56 Documents
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Search results for , issue "Volume 12 Issue 09 (2020) Sept. 2020" : 56 Documents clear
Association between obesity and depression among women in Indonesia: A questionnaire based study Susi Ari Kristina; Nur Aini Mardea; Suci Hanifah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Obesity is a global public health issue and the prevalence of obesity is growing worldwide every year. Studies have been performed since the early 1970s on the association between obesity and depression or other psychological disorders. In Indonesia, however, only a small number of studies have been carried out. The aim of this study was to examine whether obesity was associated with depression in a sample of women with overweight and obesity based on their BMI, anti-obesity treatment experience, and age among women in one province in Indonesia. Women aged 18 years and older who were selected from fitness centers in urban area of Yogyakarta province and self-reported BMI categorized as overweight and obese were eligible to participate. Voluntary participation in study survey was consented. A set of questionnaire consisting demographic characteristics and depression symptoms was developed and validated. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9), with a score of ≥10 used to indicate severe depression. Respondents who classified as overweight mostly had minimal depression level (33.58%) and none had severe depression level, whereas respondents who classified as obese mostly had moderate depression level (44.74%) and 3.95% had severe depression level. This study found that BMI, experience of using anti-obesity drugs, and age of respondents were significantly affected PHQ-9 score. Thus, these factors determined the level of depression among women surveyed. The study reported significant association between obesity and depression among women. This association depends on BMI, anti-obesity treatment experience, and age variables. Approaches to public health to reduce the burden of obesity or depression have to consider the strong link between these two common conditions.
A Review on Novel Biochemical Mediator Triggered on Demand Drug Delivery System Mithila Sawalwade; Anup Naha; Shubham Zende
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Unavailability of drug in appropriate amounts on apt time at the desired site of action can lead to further complications in the diseases which can turn into more deadly condition. Timely delivery of right amount of drug is very crucial in proper therapy, thereby avoiding the adverse effects of the drug. Feedback regulated closed loop delivery system can controllably deliver the drug on demand which means the release rates can be increased, decreased or totally stopped, as a response towards physiochemical response produced by the body. The system can be designed in such a way that the concentration of the drug released from the system is proportional to the degree of stimuli produced by the body. Various diseases and disorders progress by feedback loop mechanisms, owing to which biochemical signal triggered delivery of drug can be achieved in such conditions. The system is also advantageous in case of some drugs whose fluctuation in plasma concentrations is unenviable. In the current work, self-regulated drug delivery devices designed for various conditions like diabetes mellitus, hypercoagulation, cancer, microbial infections and opioid poisoning are reviewed. Various combinations of smart polymers are employed to design such devices that work by responding to the feedback produced by the body.
The Effectiveness of A Reproductive Health Active Learning Process Model in Improving Teen's Knowledge and Self-Trust in the First Middle School Teresia Retna P; Wahyuningsih Triana Nugraheni
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Adolescence is a transitional period between childhood and adulthood, which begins at the time of sexual maturity, namely between the ages of 11 or 12 years to 20 years, namely before young adulthood (Soejiningsih, 2004). To be ready to enter adulthood, adolescents begin to get acquainted and deal with various adult problems. Biologically, adolescents already have the ability like adults, but psychologically they have not got the right to use these abilities. The occurrence of psychological changes causes confusion among adolescents. They experience emotional turmoil and mental stress so that they easily deviate from the rules and social norms that apply in society. The design of this study was an experiment with a Posttest Only Control Group Design approach. In the experimental design of this study, there were two groups selected randomly. One group acts as a control group and the other group acts as an experimental group. The population in this study were students of health cadres at SMP Negeri 1 Merak Urak, Tuban Regency in 2019/2020, with a sample size of 36 students. The sample of this research was some students of health cadres at SMP Negeri 1 Merak Urak, Tuban Regency, with a sample size of 33 students. The sampling technique used was simple random sampling. The independent variable of this research is the active learning process of adolescent reproductive health, the dependent variable of this study is the level of knowledge and self-confidence of adolescents. The research instrument used in this study was to use a modified adolescent reproductive health active learning process module and a questionnaire to measure the level of knowledge and self-confidence of adolescents in junior high school. Data analysis was used to determine the effect of the independent variable and the dependent variable with the Manova test, with an error rate of α 0.05. Hypothesis testing shows that the significance value for the treatment and control groups tested by the Pillai Trace, Wilk's Lamda, Hotteling's T and Roy's Largest Root procedures is 0.005
Correlation of IL-10 Gene Polymorphisms and Serum Level with Hepatitis C Virus Infection in Iraq Hassan M. Naif
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Hepatitis C virus (HCV) infection is a major health problem worldwide where130-150 million people are chronically infected with HCV, which progress to cirrhosis or hepatocellular carcinoma. A total of 120 subjects were recruited to assess the correlation between gene polymorphisms (IL-10-1082 and -819) with the susceptibility to HCV infection in Iraqi patients by using allele specific PCR. The serum level of IL-10 was assessed by ELISA. Gene polymorphism results of IL-10-1082A/G (rs1800896) showed significant increase in AA distribution (P=0.0076) and allele A frequency (P=0.049) among the control group while AG distribution were significantly higher in patients (P=0.0082). Although, G allele frequency had but an association (P=0.049), but the homozygous GG mutant genotype had no significant differences between the two groups. While the genotype analysis of the second SNPs of IL-10-819C/T (rs1800872) showed that neither CC nor CT genotypes distribution were associated with HCV infection (0.1627 and 0.2559, respectively) but the TT distribution and allele frequency had a suggestive association in patients (P=0.0483 and 0.0257, respectively). Results of IL-10 serum levels were higher by two-fold in patients than in healthy controls. It appeared that the IL-10-1082 AA genotype had a protective effect against HCV infection but the TT genotype of -819 mutations had a suggestive association with susceptibility to infection with HCV in Iraqi patients. Such correlation may indicate a protective role for IL-10 and could be used as a predictive risk susceptibility biomarker for progressive infection with HCV. Keywords: Hepatitis C virus, IL-10, Polymorphism, Cytokine, Iraq.
Dietary Diversity among Children Aged 12-23 Months in Urban Area Eka Mishbahatul Marah Has; Nursalam .; Yuni Sufyanti Arief
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

This study aimed to describe the dietary diversity among 12-23 months old children living in an urban area. A cross-sectional survey which involved 146 mothers who had children aged 12-23 months, living in Surabaya City, East Java, was conducted. Mother's, child's, household's characteristics, and child's dietary diversity were collected by using a questionnaire. Then, the frequency distribution and percentage analysis were performed. The result showed that most children (96.6%) met the minimum dietary diversity as recommended by WHO. The food groups which mainly consumed were vitamin A-rich fruits and vegetables (100%) and grains, roots, and tubers (96.6%). In reverse, the food groups which less consumed were other fruits and vegetables, and legumes and nuts. Integrated health promotion is needed to ensure low socioeconomic status household who lived in the urban area met the appropriate infant and young child feeding practice. Keywords: Dietary diversity; Children aged 12-23 months; Urban area.
A review of mobile applications for diabetes: could it replace the role of professional health care? Lusy Noviani; Ajeng Diantini; Anas Subarnas
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The prevalence of diabetes is increasing year to year, despite various attempts to reduce prevalence have been made. The role of professional health teams (PHTs) is critical to manage diabetes progression. Advances in technology such as Mobile Applications (MA) have provided new opportunities to support the success of diabetes treatment. This article aims to provide a critical analysis of the challenges that are not fully fulfilled and highlights directives for future research that can enhance the implementation of MA in diabetes management. Methods: A systematic review has been conducted. A number of articles related to mobile applications and diabetes mellitus published between 2011-2020 have been taken from Google Scholar, PubMed, and Medical ProQuest, and 15 articles were selected based on criteria set. Results: Each study appears to have different features in design MA, affecting the results varied in the 15 studies reviewed. Mobile technology-based applications demonstrated their role in improving communication, being accessible, facilitating self-management processes, improving compliance with treatment, and ultimately improving blood sugar control. Conclusion: The role of PHTs is important for the successful implementation of the fast-developing sensor and transfer app in the medical sector. It is the role of a PHTs to select adequate devices, apply them, and earnestly analyse their effectiveness and economic feasibility.
Community Satisfaction Survey in “Widodaren” Community Health Center Tutiek Herlina
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Community Health Center as health service unit that was the forefront of basic health services was expected to provide quality health services in accordance with community needs. Widodaren Community Health Center was one of Community Health Center in Ngawi Regency area which since 2015 has a full “BLUD” (Regional Public Service Agency) status, and all villages were still in pra advisory villages status. To saw how much quality of health services, it was necessary a Community Satisfaction Survey (CSS). The purpose of implementing CSS was to measure level of community satisfaction with basic health services by the Widodaren Community Health Center, Ngawi Regency in 2019. Community Health Center as health service unit that was the forefront of basic health services was expected to provide quality health services in accordance with community needs. Widodaren Community Health Center was one of Community Health Center in Ngawi Regency area which since 2015 has a full “BLUD” (Regional Public Service Agency) status, and all villages were still in pra advisory villages status. To saw how much quality of health services, it was necessary a Community Satisfaction Survey (CSS). The purpose of implementing CSS was to measure level of community satisfaction with basic health services by the Widodaren Community Health Center, Ngawi Regency in 2019. Methods: This research was survey. Samples were part of community who use health services at Widodaren Community Health Center who were selected by quota sampling technique. Variables studied were the level satisfaction of health services provided community health center. Collecting data with questionnaire. Data analysis with calculating the Community Satisfaction Index. Presentation of data in the form of tables and spider web diagrams. Results: The results showed that there was an influence of the physical activity model (Gambo Rasa) on blood glucose levels of type-2 diabetes mellitus. Results of this research are the service quality in all service units was above the target of 85, and an average of 88.187. Six service units were in excellent category and three service units in good category. Service quality based on service dimensions was above the target of 3,395 and an average of 3,530. Discussion and Conclusion: Four dimensions in excellent category and five dimensions in good category. The service quality of Widodaren Community Health Center in all service units and all dimensions are in good and excellent categories. As an effort to improve quality services, it is necesarry survey of needs or expectations of the latest, and satisfaction survey in 2020 as an evaluation of quality improvement efforts that have been made based on the results of CSS at 2019. Keywords: Survey, Satisfaction, Community, Service, Community Health Center
The Effectiveness of Using Pre-Screening Questionnaires to Improve Mother's Knowledge and Skills in Implementing Early Detection of Early Childhood Development Ningsih Jaya; Ambo Dalle; Bahtiar Bahtiar
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Early childhood development can be detected through developmental pre-screening, with the aim of detecting early developmental disorders. The research objective was to analyze the effectiveness of the use of pre-screening questionnaires to improve the knowledge and skills of mothers in detecting early childhood development. The design of this study was a pre test - post test, involving 60 mothers of children under five. Observations were made before and after the intervention. Data were analyzed using the Wilcoxon test. The results showed that there was an increase in maternal knowledge and skills after being given the intervention. Thus, it can be concluded that the use of developmental pre-screening questionnaires is effective in increasing the knowledge and skills of mothers under five in early detection of child development. Keywords: Child Development, Child Development Pre-Screening Questionnaire, Knowledge, Skills
Cytomorphological Monitoring of the Rate of Healing of Aft and Traumatic Injuries of the Oral Mucosa Anton Timoshin
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The oral mucosa is an indicator that shows the state and functioning of internal organs and systems of the entire body. Inflammatory diseases of the oral mucosa are a pathology that affects patients of various ages. And it causes some discomfort to the patient and disrupts the usual rhythm of life. With a long course of this pathology, there is a violation of the endocrine glands, the immune system, and against the background of a painful symptom, psycho emotional tension may occur. The inflammatory process on the oral mucosa can be caused by factors such as bacterial, viral, fungal, and others. Regardless of the etiological factor, the inflammatory process itself does not pose a threat to the patient's life, even in spite of the etiological factor, although it complicates it. However, in the absence of treatment and prolonged course, it can lead to malignancy of the process. This is facilitated by the constant impact on the pathological focus of mechanical, chemical and thermal stimuli when eating. Also, if the patient has chronic somatic diseases that occur against the background of a decrease in immunological protection, the threat increases. Keywords: Oral mucosa, Inflammation, Pathology, Farmadont III.
Shariah Models-Based on Ethics Innovation In Nursing Documentation Halimatussakdiah Halimatussakdiah; Hidayat Arifin; Wiwin Haryati; Alhuda Alhuda; Nur Asiah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Nurses who work full time require religious support in patient care and professional documentation tools. The purpose of this research was to test a model development of patients’ satisfaction through nurse performance with an empirical study on innovation in nursing services and shariah ethics. Methods: A quantitative design was used with a cross-sectional approach. The samples were 420 postoperative patients. Respondents were obtained through multistage sampling. The independent variables were innovation service with Electronic Nursing Documentation and shariah-based ethics. Nurse performance was the mediating variable and the dependent variable was patient satisfaction. Data collection was performed using a questionnaire and data analysis with SEM version 22. Results: The results of this study indicated there was use of standard operating procedures in patient care about shariah-based ethics, which can improve the quality of nursing services where nurses can document the patient's nursing process comprehensively using Electronic Nursing Documentation (END). All the variables tested in the model development, namely service innovation, shariah ethics, and nurse performance, affects patient satisfaction. SEM test results obtained GFI (Goodness of Fit Index) values which should be within the expected cut-off value range (p Value ≤ 0.05). Conclusion: The use of SOPs on shariah ethics with END is interrelated between service innovation, shariah ethics and nurse performance and affects patient satisfaction. It is expected that nurses will be able to provide shariah ethics-based services and documentation to improve patient satisfaction.

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