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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
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Search results for , issue "Volume 12 Issue 10 (2020) Oct. 2020" : 3 Documents clear
Antimicrobial Activity Test of Ginseng bugis (talinum paniculatum gaertn.) Leaves Ethanol Extract against Pseudomonas aeruginosa, Propionibacterium Acnes, Streptococcus Mutans and Candida Albicans Andi Emelda
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Ginseng bugis (Talinum panicullatum Gaertn.) leaf is traditionally used in the treatment of diarrhea, ulcers, wounds and skin infections by the people of South Sulawesi province. The leaves contain chemical compounds such as saponins, alkaloids, tannins, flavonoids and triterpenes which can be a source of antioxidants and bactericidal. This study aims to determine the antimicrobial activity of ginseng bugis leaf extract against the microbes. The test microbes used were Pseudomonas aeruginosa, Propionibacterium acnes, Streptococcus mutans, and Candida albicans which has been matured. The antimicrobial activity test used agar well diffusion method with ginseng bugis leaf extract solution with a concentration variation of 0.1%; 0.5%; 1%; 2%; 4%; 8%; 16%; and 32%. The inhibition zone observations were carried out on bacteria incubated at 37oC for 24 hours and fungi incubated at 25oC for 72 hours. The results of the inhibition zone measurement showed that the higher the concentration of the test solution for the ethanol extract of ginseng bugis leaves, the greater the inhibition zone given. Based on the results, the ethanol extract of ginseng bugis leaves had antimicrobial activity at the minimum inhibitory concentration of 1% against Pseudomonas aeruginosa, Propionibacterium acne, Candida albicans and a minimum inhibitory concentration of 4% against Streptococcus mutans. Keywords: Antimicrobial, Ethanol Extract, Talinum panicullatum Gaertn.
CRUSADE Bleeding Score as a Predictor for the Risk of Bleeding Events in Patients with Acute Coronary Syndrome: A Prospective Study from Tamil Nadu Aneena Suresh
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The CRUSADE bleeding risk score is an accurate and robust risk-stratification tool for predicting hemorrhagic complications in patients with Acute Coronary Syndrome (ACS). However, studies assessing and validating this score especially within Indian population are scarce to almost non-existent. Objective: To evaluate the Crusade Bleeding Score in predicting the risk of bleeding events in patients with acute coronary syndrome. Methods: This cross-sectional study was conducted at a secondary care hospital in Tamil Nadu, India. A total of 72 patients with ACS on treatment with anti-thrombotics that fulfilled the inclusion criteria of the study were prospectively recruited. The patient’s demographic data along with their past medical history pertinent to the study was collected and the scores for each patient was calculated. Results: Significant major bleeding was found among considerably older, female patients, diabetic and hypertensive patients, as also among patients having lower GFR values. Five patients classified under the Very High-Risk Category of the CRUSADE bleeding score further went on to develop hemorrhagic complications thereby validating the score among the study population. Conclusion: The CRUSADE bleeding score was found to be an accurate predictor of bleeding events within our study population with good validity. We further recommend the suitable use of the CRUSADE bleeding risk score in clinical practice as there is a need for stronger evidence to support the use of risk stratification systems to optimize therapy and improve patient outcomes in India.
Estimation and Comparison of the Levels of Elastase in Saliva, GCF & Serum of Smokers and Non-smokers with Chronic Periodontitis -A Clinico-biochemical Study S. Srinivasan
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This study was done to estimate and compare the levels of Elastase in Saliva, GCF & Serum of smokers and non-smokers with chronic periodontitis. Materials and Method:125 male subjects in the age group of 21-50 years were enrolled and categorized as Group 1, Non-smoking subjects with healthy periodontium Group 2, Smoking subjects with healthy periodontium Group 3, Non-smoking subjects with Chronic periodontitis Group 4, Smoking subjects (10 Cigarettes/day) with Chronic periodontitis. Plaque Index, Gingival Bleeding Index, Probing Pocket Depth, Clinical Attachment Level, Salivary, GCF and Serum Elastase levels were recorded and evaluated using sandwich ELISA method. Results: The clinical parameters expressed a significant difference between diseased group and healthy group. Elastase levels (Saliva, GCF and Serum) showed significant difference between diseased group and healthy group. In between the diseased group comparison, GCF and Saliva showed Lower Elastase levels in smoking periodontitis group. Whereas, Serum showed higher Elastase levels. Conclusion: Elastase can be used as a reliable biomarker for smokers and non-smokers with chronic periodontitis to denote disease activity. Keywords: Periodontitis; Smoking; Elastase; Saliva; Gingival crevicular fluid.

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