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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 25 Documents
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Search results for , issue "Volume 12 Issue 11 (2020) Nov. 2020" : 25 Documents clear
Potential of Pomelo Fruit (Citrus Maxima) Extract on T47D, WiDr, and HepG2 Cancer Cells Vevi Maritha; Aris Hartono; Mega Arianti Putri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Currently, alternative therapies are needed for breast, colon, and liver cancer patients. Those therapies are therapies that can selectively kill cancer cells without damaging other cells that have high development, such as hair and nails. One of those alternative therapies is the use of plants in cancer therapy. Pomelo has the potential as an anti-cancer agent because it contains phytochemical compounds, one of which is lycopene. Lycopene is a free anti-radical compound found in pomelo (citrus maxima). The lycopene content in pomelo fruit is more than in other parts, such as in leaves and fruit skin. Lycopene works by suppressing the proliferation or multiplication of cells through mutations in the initiation and progression phase of cancer. In cervical cancer patients, cell multiplication occurs quite rapidly, so that with the presence of lycopene, cervical cancer cell growth can be inhibited. Lycopene compounds can minimize the oxidation process and reduce the presence of free radicals in the body. Free radical compounds interact with DNA and reduce physiological functions that can increase cervical cancer cell growth. Lycopene is a compound that can counteract these free radicals and is also able to slow down or even prevent the oxidation process of other molecules and eliminate free radicals in the body that can cause cell damage. Through these two mechanisms, namely suppressing cell multiplication and eliminating free radicals, lycopene can be used as a cancer therapy. The cytotoxic activity test of pomelo fruit extract was carried out using the MTT method on T47D, WiDr, and HepG2 cells. The pomelo fruit was extracted by maceration method using 96% ethanol solvent. Cancer cell cultures were transferred as many as 1x104 cells/well in culture media consisting of FBS, penicillin-sterptomycin, amphoterizin-B, and RPMI 1640 into 96-well plates and incubated in a 5% CO2 incubator overnight. Furthermore, the test samples were given a series of levels and replications were made three times (triplo), and then they were incubated again overnight. On the third day of testing, MTT reagent was added, and after 4 hours, formazan crystals in living cells would be formed. Furthermore, SDS stoper was added to stop the MTT reaction. Then, the absorbance reading was carried out using an elisa reader at a wavelength of 595nm and the determination of the IC50 value was then carried out as well. The results showed that the IC50 value of pomelo extract in T47D 50 cells was 954.34 µg/mL, in WiDr cancer cells was 130.70 µg/mL, and in HepG2 cancer cells was 1,660.257 µg / mL. This shows that pomelo extract has the potential as an anti-cancer agent for breast and colon cancer, but not for liver cancer. This research could contribute to the development of breast and colon cancer drugs.
Caring Behavior Improvement Model on Nursing Students at Poltekkes Kemenkes Pangkalpinang Nurhayati Nurhayati
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

This study aims to establish models and measures of caring behavior in nursing students at the Poltekkes Kemenkes Pangkalpinang. The research method used is a quantitative method with survey techniques in phase I, and experiments by making a book as an experimental tool with the design of the One Group Pre-test Post-test for stage II. Furthermore, the data analyzed by qualitative methods in stage III. The sample consisted of 69 students; as a combination of first-year and second-year students. This study revealed that the Compassion variable influenced the formation of Competence, whereas the Conscience and Commitment variables did not affect the formation of Competency. Meanwhile, overall, the variable Compassion, Conscience, Commitment, and Competence influence the formation of Caring Behavior. Keywords: Behavior, Caring, Nursing, Students
Interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) as proinflammatory cytokines in traumatic brain injury (TBI) of rat (Sprague-Dawley) : A study of propofol administration Riyadh Firdaus; Franciscus Dhyana Giri Suyatna; Aida Rosita Tantri; Yetty Ramli; Ekowati Handharyani; Arni Diana Fitri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

The increase in the prevalence of traumatic brain injury (TBI) followed by increased morbidity and mortality challenges anesthetists to perform the treatment patients with TBI. Menwhile, interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) are the first pro-inflammatory markers expressed after secondary injury occurs. In addition, propofol (2,6-disopropylphenol) is a short-acting intravenous agent that reported to play role in inflammatory process. This study aims to determine the effects of propofol administration on the neuroinflammatory pathway. Thirty adult female Sprague Dawley rats were randomly assigned as TBI rats (T), rats that received propofol infusion (P), or TBI rats that received propofol infusion (TP). The rat model of TBI was developed using the Marmarou Weight Drop method. Clinical assessment was performed using the Neurobehavioral Severity Score-Revised (NSS-R). Brain tissues were taken 24 h after TBI and the levels of interleukin-1 (IL-1) and interleukin-6 (IL-6) mRNA expression levels were examined using qRT-PCR, while the concentration were examined using ELISA and immunohistochemistry. On clinical examination, a decrease in the median value of NSS-R in the TP group was found from 30th minute to 120th minute. 24 hours after the occurrence of TBI, there was a decrease in both the TP and T groups. However, the NSS-R values in the TP group were lower than those in the T group. The expression of IL-1β was found in the nuclei and cytosol, while IL-6 was found in the axons and cytosol. The expression and concentration of IL-1β and IL-6 were the highest in the TP group, followed by the P and then the T group. Propofol can improve neurological function in rats with TBI, probably through the mechanism involves neuroinflammatory pathways, particularly IL-1β and IL-6.
Development of Covid-19 Disaster Risk Instruments for Children Hery Sumasto
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background. Children need to get protection during the Covid-19 pandemic, in accordance with Presidential Regulation 12/2020 on The Determination of Non-Natural Disasters. The purpose of the research is to develop non-natural disaster risk instruments for children. Research methods. This type of research is Research and Development. Instrument development is carried out in 5 (five) stages, namely: 1) evaluation of instruments; 2) development; 3) experiment; 4) socialization; 5) recommendations. FGD population of 40 respondents is target-1 as many as 20 people, target-2 as much as 20. Experts in this research are methodology experts and child disaster experts. Research Result: Phase I disaster risk, namely threat, vulnerability and capacity, obtained 7 standard components of disaster instruments for children: 1) economic status; 2) knowledge; 3) attitude; 4) infrastructure; 5) institutional organization; 6) threat level; 7) disaster risk reduction behavior. Validity and reliability tests show that of the 32 valid items, 25 items are all reliable because the Cronbach alpha value is above 0.7. Not valid for 7 items. Phase 2: instrument testing was conducted on 267 respondents. Test with google form. The test results of instruments for children potentially exposed to Covid-19 amounted to 69% who were not exposed to 31%. Of those 69%, strong exposure is 2%, high exposure is 15% and medium exposure is 83%. Conclusion: There are 32 question points on non-natural disaster risk instruments, developed from 7 disaster risk variables for children. The instrument has good functionality in terms of efficiency, functionality and usability. Output: 1) disaster risk instruments for children; 2) intellectual property rights; 3) international journal publications 4) monograph books. Keywords: Instruments, Non-Natural Disaster Risk, Children
Fabrication of palatable medicated chocolate of salbutamol and ambroxol for pediatric delivery Gayathri Rajaram
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Chocolate as a dosage form is the most adaptable and versatile form that attracts children of all age groups. The present research work is to design and fabricate a palatable medicated chocolate to deliver salbutamol and ambroxol for pediatric care or prescription. Preformulation studies such as DSC, FTIR, melting point and solubility were carried out to detect any incompatibility and purity of the drugs. Medicated chocolate was formulated by incorporating the drugs into the chocolate base, with desirable viscosity. Three formulations were prepared and evaluated for physical appearance, drug excipient compatibility, weight variation, thickness, drug content, in-vitro drug release, bloom strength, stability and release kinetics. The parameters were within official specifications for formulation F3. The in-vitro drug release for optimal formulations is 86.7% and 89.4% for salbutamol and ambroxol, respectively and followed zero-order kinetics and fickian transport from the dosage form. No significant changes in the physical and chemical properties were observed during stability studies, which indicate that the formulated medicated chocolate was stable and could ensure a good therapeutic effect with patient compliance. The fabricated chocolate was elegant, smooth and creamy in texture and was excellent for taste masking unpleasant flavors associated with the drugs and excipients. The formulated chocolate may improve patient compliance as it can be used easily by pediatric patients with high preference. Keywords: Ambroxol, Chocolate delivery, Mucolytic, Bronchodilator, Salbutamol, Pediatric
Safety, Health and Feasibility Local Wisdom and Regulation of Marine Products: Convergence and Case Study of Mare Island, Tidore Islands Husen Alting; Suwarti Suwarti; Irfan Ahmad
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Purpose: to finds a convergence between the local regulation and wisdom in Mare regarding the sustainability of resources and marine products and its safety, feasibility and health standards. Methods: this study is a descriptive qualitative study which describes regulations on the safety, feasibility and health standards of processing seafood and local wisdom regarding the preservation of marine resources. Result: Local wisdom in Mare has not been able to achieve regulations related to safety, feasibility and health standards of seafood but the local wisdom was able to maintain the sustainability of marine resources. Both of these things can be converged with technology so that the sustainability of marine resources can be achieved while realizing the safety, feasibility and health standards of marine produce. Conclusion: local wisdom is not a static thing so that between local wisdom and the preservation of marine resources and safety regulations, feasibility and health standards of seafood can be converged upon them.
Assessment of the Effectiveness of Simulation and Recitation Training for Traffic Control Volunteers (Supeltas) on Cervical Spinal In-Line Position Stabilization with Helmet Removal Maneuvers Ferry Efendi
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Motor vehicle traffic accidents are a leading cause of death for an individual in Indonesia. This study aimed to evaluate the effectiveness of training using simulation and recitation models focusing on the achievement of the pre-hospital performance of traffic-control volunteers (Supeltas) in stabilizing cervical spinal in-line position in helmet removal maneuver. This study applied pre-test and post-test design with 248 respondents. Data were collected using questionnaires and evaluation papers to assess volunteers during practical tests. Data statistical analysis procedures included One-Way ANOVA, Wilcoxon-signed rank test, and N-gain score test. Differences were noted in the demographic data with significant findings and effects associated with age (p= 0.041) and education (p= 0.046) of Supeltas in stabilizing the cervical spine. The intervention group exposed to SMT training model showed a difference in the average scores of knowledge (mean 60.85 to 85.67; p= 0.010) and skills (mean 59.80 to 86.81; 0.002), which were greater than the scores of the group receiving RMT (mean 53.65 to 65.06; p = 0.028) and skills (mean 59.20 to 84.73; p= 0.043). The knowledge (N-gain score = 61.35%) and skills (N-gain score= 61.41%) of the group receiving a role-playing model (SMT) increased more effectively, compared to the increase experienced by the group receiving an assignment (RMT) (N-gain score knowledge= 23.57%; skills= 17.29%). This study suggests that the simulation model is more effective than the recitation model in improving the ability of Supeltas in stabilizing the cervical spinal in-line position for helmet removal in trauma situations. Keywords: Recitation, Simulation, Stabilization, Training.
In Vitro Evaluation of Antibacterial Activity from Nephelium lappaceum L. Leaf Ethanolic Extract and Fraction against Some Foodborne Pathogens Imam Adi Wicaksono; Raden Bayu Indradi; Danni Ramdhani; Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Fooborne pathogens are causing foodborne illness with significant effects on human health. Some of the most common foodborne bacteria that cause foodborne illness are Bacillus cereus and Shigella dysenteriae. Nephelium lappaceum L. is known to have antibacterial potential because of these plants have secondary metabolites such as flavonoid and polyphenols. The ethanolic extract and fractions of Nephelium lappaceum L. was investigated for antibacterial activities including determine of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against foodborne pathogens. The extraction of N. lappaceum L. was done by maceration method with 70% ethanol and fractionationed by liquid-liquid extraction to obtain ethyl acetate, water, and n-hexane fractions. Secondary metabolite content and profile determination of N. lappaceum L. was done by phytochemical screening and thin layer chromatography. The antibacterial activities were determined using the agar diffusion method, MIC and MBC value determined by dilution method using the test tube. The results showed that the ethanolic extract, ethyl acetate fraction and water fraction of N. lappaceum L. had antibacterial activity against Bacillus cereus isolate and Shigella dysenteriae bacteria. The value of MIC and MBC of the extract in the concentration range between 0.08%(w/v) – 0.15%(w/v) against B. cereus isolate and 2.5%(w/v) – 5%(w/v) against S. dysenteriae, which the ethyl acetate fraction in concentration range between 0.04%(w/v) - 0.08%(w/v) against B. cereus isolate and 1.25%(w/v) – 2.50%(w/v) against S. dysenteriae bacteria. The ethyl acetate fraction is the most active fraction because it had the best activity, MIC and MBC values when compared to the results against both of test bacteria.
Expression of Adipocyte Binding Protein-2 (AP-2) on the Adipogenic Differentiation of Mesenchymal Stem Cell after Pulsed Electromagnetic Field (PEMF) Exposure Umiatin U
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Obesity is a health condition that can cause serious health problems in developing countries such as Indonesia and still a major health concern worldwide. Obesity increasing the risk of a number of pathological disorders including certain cancers, heart disease, stroke, and diabetes. It has been reported that Pulsed Electromagnetic Field (PEMF) have an inhibitory effect on adipogenesis of MSCs. However, it is not clear if this effect is direct or indirect. Various genes are involved in the development of obesity include adipocyte binding protein 2 (AP-2) which is associated with inflammation and the metabolic syndrome. In the present study, we investigated the effect of PEMF exposure with frequency 75 Hz and magnetic field 2 mT on the adipogenic differentiation of mesenchymal stem cells (MSCs). In the present study we used the MSCs second passage. The cells were stimulated by PEMF of 75 Hz/2mT for 14 days 10 in/day. The relative expression of AP-2 was measured on days 2, 4, 7 and 14 by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) method. The PEMF significantly inhibited adipogenic differentiation by down regulating the expression of AP-2 on days 2, 4 and 7. This result indicated that PEMF exposure may have potent effect to inhibit adipogenic differentiation. Keywords: Pulsed electromagnetic field, Adipogenic, Mesenchymal Stem Cells, AP-2
Comparative Analysis of the Level of Hygienic Dental Knowledge of Hard of Hearing and Hearing Disabled People in the City of Penza and the Penza Region Marina Suvorova; Anna Belousova; Galina Emelina; Anna Teplova
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Modern health care has a set of problems. Our native medicine is in great need in the socially oriented help to different groups of the population of the country. One of socially unprotected groups is hard of hearing persons. The special social status does this contingent of the population especially vulnerable in the questions of stomatologic education. It involves the low level of hygienic stomatologic knowledge, and also insufficient motivation to preservation and promotion of an oral cavity health. In Russia there aren't enough researches devoted to the appreciation of the preventive stomatologic help level and to the specified contingent’s needs in it. Creation of the program of prevention of stomatologic diseases of hard of hearing persons is one of the important problems of stomatology. It is available for their specific world’s perception. Relevance is caused by the high level of distribution of stomatologic pathologies among hard of hearing persons of Penza region. Keywords: Hard of hearing persons, Stomatologic education, Hygiene of an oral cavity, Prevention of stomatologic diseases.

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