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PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.

PREVALENCE OF HELICOBACTER PYLORI IN OBESE PATIENT Altaee, Mohammed J.; Mohammed, Bilal; Jasim, Ahmed S.; Abdulkadhm, Hasanin
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Helicobacter pylori is a widely recognized pathogen that exhibits a high prevalence among the global population. The infection caused by H. pylori poses significant health risks due to its association with various gastrointestinal disorders, including gastric ulcers, duodenal ulcers, chronic gastritis, and gastric carcinoma. The regulation of gastric hormones, such as ghrelin and leptin, plays a crucial role in energy homeostasis. Ghrelin, secreted by P/D1 cells in the stomach during periods of hunger, stimulates appetite and promotes food consumption. Conversely, leptin, released by P cells in the stomach and adipocytes after food intake, reduces appetite and fosters a sense of fullness. Individuals infected with H. pylori tend to have lower plasma levels of both ghrelin and leptin compared to those who are not infected. Consequently, the reduced serum leptin levels can delay the sensation of satiety during meals, leading to increased energy intake and a potential development of obesity. Aim: Our study has been proposed and structured to achieve the below objectives: Prevalence of H. pylori associated with overweight. Presence or absence of some clinical signs among patient. Prevalence of infection among age group. Methods: Blood seem were collected from 30 person during the period from February to April 2023 and both gender were participate in this study with age ranging from 20-50 years old.Blood tests were used to measure the antibodies against H pylori. The sample were collected and small amount of it applied in to well In the test line area, anti-human IgG is rendered immobile. Following its addition to the device's specimen well, the specimen reacts with the test's H. pylori antigen-coated particles. This mixture interacts with the immobilized anti-human IgG and migrates chromatographically over the course of the test. A colored line will show up in the test line region, signifying a positive result, if the samples contain H. pylori antibodies. A colored line indicating a negative result won't show up in this area if the specimen is devoid of H. pylori antibodies. To act as a methodical. Result: Our study shows that Middle age group were the highest percentage among other age group (35 %). In another hand the overweight patient suffering from H. pylori infection constitutes about 36.7 %. Keywords: Helicobacter Pylori, Obese Patient, Infection.

PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.

PREVALENCE OF HELICOBACTER PYLORI IN OBESE PATIENT Altaee, Mohammed J.; Mohammed, Bilal; Jasim, Ahmed S.; Abdulkadhm, Hasanin
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Helicobacter pylori is a widely recognized pathogen that exhibits a high prevalence among the global population. The infection caused by H. pylori poses significant health risks due to its association with various gastrointestinal disorders, including gastric ulcers, duodenal ulcers, chronic gastritis, and gastric carcinoma. The regulation of gastric hormones, such as ghrelin and leptin, plays a crucial role in energy homeostasis. Ghrelin, secreted by P/D1 cells in the stomach during periods of hunger, stimulates appetite and promotes food consumption. Conversely, leptin, released by P cells in the stomach and adipocytes after food intake, reduces appetite and fosters a sense of fullness. Individuals infected with H. pylori tend to have lower plasma levels of both ghrelin and leptin compared to those who are not infected. Consequently, the reduced serum leptin levels can delay the sensation of satiety during meals, leading to increased energy intake and a potential development of obesity. Aim: Our study has been proposed and structured to achieve the below objectives: Prevalence of H. pylori associated with overweight. Presence or absence of some clinical signs among patient. Prevalence of infection among age group. Methods: Blood seem were collected from 30 person during the period from February to April 2023 and both gender were participate in this study with age ranging from 20-50 years old.Blood tests were used to measure the antibodies against H pylori. The sample were collected and small amount of it applied in to well In the test line area, anti-human IgG is rendered immobile. Following its addition to the device's specimen well, the specimen reacts with the test's H. pylori antigen-coated particles. This mixture interacts with the immobilized anti-human IgG and migrates chromatographically over the course of the test. A colored line will show up in the test line region, signifying a positive result, if the samples contain H. pylori antibodies. A colored line indicating a negative result won't show up in this area if the specimen is devoid of H. pylori antibodies. To act as a methodical. Result: Our study shows that Middle age group were the highest percentage among other age group (35 %). In another hand the overweight patient suffering from H. pylori infection constitutes about 36.7 %. Keywords: Helicobacter Pylori, Obese Patient, Infection.

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
I Wayan Sudarsa

Contact Email
sudarsa@unud.ac.id

Phone
-

Journal Mail Official
globalpharmatechnology@gmail.com

Editorial Address
India

Location
Kota denpasar,

Bali

INDONESIA

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name I Wayan Sudarsa

Contact Email sudarsa@unud.ac.id

Phone -

Journal Mail Official globalpharmatechnology@gmail.com

Editorial Address India

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Contact Name
I Wayan Sudarsa

Contact Email
sudarsa@unud.ac.id

Phone
-

Journal Mail Official
globalpharmatechnology@gmail.com

Editorial Address
India

Location
Kota denpasar,

Bali

INDONESIA