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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 66 Documents
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Search results for , issue "Volume 9 Issue 10" : 66 Documents clear
Investigation of Oxidative Stress in Patient with Varicella Zoster Virus (VZV) Infection Nisreen Kaddim Radi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Varicella zoster virus (VZV) is a member of the eight known herpes virus that infect humans. VZV infection is specific to humans. It causes chickenpox (varicella), the most common disease affecting children, adolescents, young adults and herpes-scale (shingles) in the elderly; shingles are rare in children. In direct immune flourescens assay for determination of antibodies IgG/IgM against varicella Zoster virus in the samples collected from patient serum show 98%positive result. The patients groups, had greater levels of SOD in contrast with control groups result at significant differences (P≤ 0.05) .Conclusion these results suggest that severity infection within vortesella zoster virus causes high level of sod.Keywords: Antitoxidant, Immuno flourescens, Zoster, varicella, Oxidative.
The Relationship Between the Intestinal Parasitic Infections with Leptin Concentration and Some Biochemical Parameters in Babylon Province/Iraq Nebras A.J. Hussien
Journal of Global Pharma Technology Volume 9 Issue 10
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The current study aimed to determination of the relationship between intestinal parasitic infections with leptin, reactive oxygen species (ROS) and total antioxidants in patients in Babylon province, Iraq from the December 2015 to April 2016. The total exanimated person who visited the hospitals (male and female) are 863 person, 85 (9.8%) persons were infected with intestinal parasites (Entamoeba histolytic and Giardia lamblia) included 56 females and 29 males. The  patients were divided by age into three groups included 52 ( 1-10 ) years ( 35 females and 17 males ), 19 ( 11-20 ) years ( 13 female 6 males ) and 14 ( 20> ) years ( 8 females and 6 males ). The healthy group included 40 persons which divided to the same groups of patient  20 ( 1-10 ) years ( 10 females and 10 male ), 10 ( 11-20 ) years ( 5 females and 5 males ) and 10 ( 20> ) years (5 females and 5 males ).The results showed significant increase (p<0.05)  in  serum ROS level in patients infected with parasite infections compare to healthy group, and significant elevated (p<0.05) in leptin level in female patients compared to male patients. When compare between age groups, the results obtained significant decrease (p<0.05) in leptin level in patients aged (1-10 &11-20) years and elevated in age group (>20) years compare to healthy group in the same age, also significant elevated in ROS level in patients aged (1-10 & >20) years compare to healthy groups. The results of parasite type showed significant increased (p<0.05) in ROS level in patients infected with E. histolytic compared to patients infected with G. lamblia. The result showed the infected with parasite effected both leptin and ROS levels, but the total antioxidant did not affect parasitic infections.
Effects of Topiramate Drug on Biological, Hormonal and Histological Parameters in Pregnant Albino Rats and Embryos Amel A. Altaee
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The present study aimed to elucidate the effect of Topiramate drug (100 mg/kg b.wt) on some parameter in pregnant albino rats including serum reproductive hormones level , Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) and Estradiol (E2)), body weight gain, uterus weight, on the implantation and  desorption of embryo, diameter of follicle in ovary and development of neural tube of embryos in pregnant albino rats for different periods (7,9,12,14 and 21 days) of gestation . The hormonal results showed no significant change (P ≤ 0.05) in the mean levels of LH and FSH hormone for treated groups when compared with control groups for days 7, 9, 12, 14 and 21 of pregnancy, but there was a significant increase (P ≤ 0.05) in the mean levels of E2 hormone for treated groups as compared with control groups. There is significant increase in the numbers of desorption embryos in treated groups for days 7, 9, 12, 14 and 21of pregnancy, as compared with control groups. While the study showed significant decrease in the number of implantation sites in treated groups as compared with control groups. The results of this study revealed no significant increase in the secondary follicle diameters in treated groups of 9 and 12 days and tertiary follicle of 7 days of pregnancy, as compared with control. The diameters of epithelial and marginal layers of neuro-ectoderm in days 9 of pregnancy for treated groups showed significant increase as compared with control groups.Keywords: Topiramate, Rats, Embryo, Neural tube, Ovary.
Spectrophotometric Determination of Copper (II) by using Amoxicillin Drug as Reagent Abbas Noor Alshirifi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Trace amount of Copper was determined by spectrophotometric technique by using   amoxicillin-Sodium drug as new reagent.  Amoxicillin-Sodium reacted in highly basic solution at pH 11 with Copper (II) to give a violet colored product which has a maximum absorbance at wavelength 540 nm. The reaction was immediate and its observance remained stable above 1 an hour.   The molar absorptivity   was found to be 0.3 × 104  L mol-1 cm-1, Shandell's sensitivity was 2.08 ×10-1μg cm-2 . And the linearity of the calibration curve, which obeyed to beer's low limits was obtained for 5-32 µg mL-1of Cu (II). The stoichiometric composition of the colored   product   was 1: 1 [Copper: Amoxicillin-Sodium] by using Job’s method, mole ratio method and molar conductivity.The Limit of Detection (LOD) and limit of quantifications (LOQ) were calculated by using suitable equations, which were found to be 0.29 μg/mL-1 and 0.97µg/mL-1 respectively.Interferences    due to Fe (III), Co (II), Ni (II), Zn (II), Ag (I) were investigated. The method is high selectivity and used for determination of copper in samples.Keywords: Copper(II) ,Amoxicillin drug , Reagent. 
Molecular Identification of Phlebotominae Sand Flies (Diptera: Psychodidae) in Al-Diwaniyah Region/Iraq Hadi M.H. Al-Mayali
Journal of Global Pharma Technology Volume 9 Issue 10
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In this study, the  Polymerase chain reaction technique (PCR)  and morphological identification were used in identification of sand flies ,the vectors of leishmaniasisin diseases  in Al-Diwaniyah region for the first time in Iraq,  Morphological  identification  showed presence three different species of sand flies, two belong to Phlebotomusgenus it P.papatasiand P. sergenti and one belong to Sergentomiya genus it S. sintoni. It has been observed that the most species density was the genus P. papatasi (53.09%) followed by the S.sentoni species (28.54%) then  P. sergenti (18.35%). Molecular identification through detection of the   Mitochondrial cytochrome b gene DNA (Cytbgene)   and molecular length output 575base pairs (bp) of species P.papatasi and a molecular length 325 bp of the species of P.sergenti While the species S. sintoni was excluded because it is one of the species that tend to feed on the blood of animals and rarely found indoor and there no indication of its relationship to leishmaniasisin disease in human. Molecular identification results for extracted DNA samples of 2250 sand flies females by PCR method showed two species of sand flies are P.papatasi and  P.Sergenti, P. papatasi species The PCR amplified products showed bands of molecular weights 325 and 575 base pair . Analysis of individual sequences belonging to P. papatasispecies and P.sergenti.Keywords: Molecular identification Phlebotomus, Sand flies, Al-Diwaniyah Iraq.
Human Pabilloma Virus (HPV) and Cervical Cancer in Al-Najaf Governorate Musa Nima Mezher
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: Human Papilloma virus causes benign and malignant tumours of squamous cells, many different types of HPV well known to infect a different portion of the body, also many HPV strains cause carcinoma of cervix.Objective To find the role of the virus in the cervical tumour and the extend of the effect of some tumour markers in the virus and its absence.Methods Seventy three  cases of cervical  cancer were obtained from Histopathological archival of central laboratory of AL-Sadder Hospital  and out laboratory in Najaf AL-Ashraf Governorate. Clinical data were analysed from  the medical records and formalin fixed, paraffin embedded tumour tissue were examined by Immunohistochemistry technique to the detection of  the L1 protein of HPV in cervix tissue blocks. Results The expression of HPV in tissues ,women patients with cervical cancer in the present study was 69.86% (51out of 73), where strong correlation was found between expression of HPV and women patients with cervical cancer. Also found relationship between women state, residency and differential ratio between five years ago (2012-2016) in AL Najaf City. ConclusionBased on the results of the current study, Human Papilloma virus  infection plays a major role in the pathogenesis of cervical cancer.Keywords: Cervical cancer, Human Papilloma virus, Human Papilloma virus  L1 protein, Immunohistochemistry technique.
Synthesis and Characterization of Some New Ni, Cu and Co Complexes with Azo-Shciff Base Ligand Mosa Jaafar Mosa
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Azo-schiff base lig and prepared by other obvious studies but we use special amine compound amino acid lysine, bath of azo and schiff base were characterized by FT-IR and H1NMR spectroscopy to notice the different resulting from condensation reaction [Co (AHDB)2] +2,[ Co (AHDB)2] +2 and [ Ni (AHDB)2] +2 complexes with a two molecules of bidentate ligand were synthesized  and identified by using various spectroscopic techniques. Obtained difference in UV-Vis spectrum between ligand and complexes indicates on successful of complication reaction appearance of band belong to d-d transition and didn’t found in ligand spectra, another indication of complication is the H1NMR spectrum show the same chemical shifts in both ligand and complexes cases with small shifting in ppm region which is expected result.Keywords: Azo-schiff base ligand, Cobalt tetra coordinate complexes, Amino acid schiff base.
Study Electronic Properties of Adsorption of CO and H2S Gas Molecules on the Surface of Fullerene and Heterofulleren as a Gas Sensor for Environmental Protection of Organic and Pharmaceutical Material Hussam Shoab Mohmmed
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The aim of this research paper is to study two properties of fullerene molecules.The first are electronic properties of heterofullerene C58Cl2 using Density Functional Theory (DFT). The geometrical structures, electronic properties, of the doped of fullerene molecules were studied systematically and compared with the pristine fullerene C60. A series of dodecahedral functionalized derivatives have been studied at the functional B3LYP and basis set 6- 31G (dip) level of density functional theory (DFT). The relative and formation energies of compounds, occupancy, the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), the (LUMO -HOMO) energy gap (Egap) were calculated. The adsorption behavior of the CO and H2S on the surface of Fullerene is studied by DFT. The chemical potential or Fermi energy for Fullerene (C58Cl2) and gas molecules have been systematically explored. The adsorption energy values of gas molecule are short. So, the sensor will possess short recovery times. Our results indicate that larger values of EHOMO for adsorption CO and H2S fullerene C60 at site (a) is (-6.234 and -6.163 ) eV, show that a propensity of the molecule to donate electrons and smaller value ELUMO for fullerene C60  at site (a) is (-3.365 and -3.295) eV, these values show that a propensity of the molecule to accepter electrons and smaller values of Eads of C58Cl2 at site (b) is (-0.465 and -0.463) these values show that a propensity of the molecule used as a sensor.Keywords: Fullerene, Gas adsorption, density functional theory, HOMO and LUMO.
Comparative Anatomical and Histological Study of the Liver in Three Species of Wild Birds in Iraq Hussein A. Al-hamadawi
Journal of Global Pharma Technology Volume 9 Issue 10
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The present study aims to know the morphological description and histological structure of the liver for three species of Iraqi wild birds (Laughing dove, White-throated Kingfisher and Common Kestrel) which represent different modes of feeding habits. To make this purpose a 24 sexually mature healthy birds were hunted from different areas of Al-shamyia city in Al-Qadisiyah province (8 birds from each species) , all birds were anesthetized and sacrificed after catch directly. The results of anatomical study showed that the liver for three species of birds were located in the middle of coelom cavity and it composed of two lobes, large right lobe and small left lobe in Laughing dove and White-throated Kingfisher ; But the left lobe is bigger than right lobe in Common Kestrel. On the other side the results showed a significant difference (P<0.05) between width of right lobe and width and length of left lobe of Common kestrel compared with White throated kingfisher and Laughing dove. While there was no significant difference (P>0.05) between the length and width of the right and left lobes in throated Kingfisher compared with Laughing dove. The color of liver was light brown-drak red in Laughing dove and light red in White-throated Kingfisher while dark brown-red in Common Kestrel. The percentage of the liver weight in laughing dove represents the higher rate when it compared with Common Kestrel and White-throated Kingfisher. In histological study, our results explained that the liver in the three species of birds were surrounded by a thin layer of dense connective tissue called Glissons capsule. It divided into unclear and irregular lobules and the central vein represent the core of each lobule. From the central vein, the hepatic laminae which consist of one to two layers of hepatic cells were branched, anatomizing, and radically extend to the periphery of the lobule blood sinusoids lining with endothelium and few number of large. The lobules surrounded by portal are a peripherally which made from dense connective tissues , it constitutes of portal vein, hepatic artery, and bile duct, in addition to lymphatic vessels which lining by endothelium.­­­­­­­­­­­­­­­­­­­­­­­­Keywords: Liver, Common Kestrel, White-throated Kingfisher and Laughing dove.
The Relation of Angiotensin Converting Enzyme-1 Gene with Angiotensin II and Plasminogen Activator Inhibitor in Myocardial Infarction Maha F. Smaism
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

One of the very important causes of mortality worldwide is myocardial infarction (MI). Angiotensin converting enzyme-1 (ACE-1) gene plays a principal role in converting of angiotensin-I (ANG I) to angiotensin II (ANG II).  ANG II plays necessary role in promoting of hypertension, furthermore due to the improvement of cardiovascular disease, myocardial infarction. Plasminogen activator inhibitor-1(PAI-1) play a function in modulating intravascular thrombosis, impaired fibrinolytic linked to a high level of  (PAI-1).The aim of the study is to evaluate the role of ACE-1polymorphism in level of ANG II, and the relation between plasminogen activator inhibitor-1concentration and ANG II in (MI) and hypertension patients. The study includes (100) males: 25 control, 75 patient groups, the patient group subdivided into {25  hypertensive patients for 10 years (group A), 25 hypertensive patients for 20 years(group B), 25 patients with MI+ hypertension ( group C)}, ages between (50-60 years) and BMI (18.5-24.9).The results show: There is significantly increased of ANG II, PAI-1, TG, Total cholesterol(TC), LDL-c and VLDL-c concentration, while significantly decreased of serum HDL-c in all groups of patients compared with the control group. The result observed significantly increase of ACE-1 deletion –deletion (DD)in  group  (C)  (88%) compared with the control group (44%), while there were no significantly increased in groups (A,B) compared with control group, also the result showed ACE-1 (DD) genotype was (66%), insertion-deletion (ID) genotype was (34%) and ACE insertion-insertion( II )genotype was (0%) in all study groups. And there was a positive correlation between angiotensin II and plasminogen activator inhibitor-1 in all patient groups. Conclusion: The (DD) genotype of the Angiotensin converting enzyme-1 (ACE-1) polymorphism was the most frequent among Babylon patients with myocardial infarction. This suggests that Babylon individuals with the (DD) genotype might be at high risk for myocardial infarction .Furthermore, D allele of the ACE I polymorphism might confer increased risk for MI. plasminogen activator inhibitor 1(PAI-1) may consider as a risk factor of myocardial infarction. And there was a positive correlation between angiotensin II and plasminogen activator inhibitor-1 in all patient groups. Therefore DD genotype be lead to an increase of PAI-1level.Keywords: Myocardial infarction, Angiotensin converting enzyme-1, Plasminogen activator inhibitor-1, Angiotensin II.

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