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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 66 Documents
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Search results for , issue "Volume 9 Issue 10" : 66 Documents clear
Typing of Acinetobacter baumannii Isolates from some Iraqi Children infected with Head Lice Eman N. Najii
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

Head lice invasion a worldwide health care problem, which obligatory human hematophagous ectoparasites belong to pediculide family, it caused by pediculus humans capitis [1] in fact the USA was recorded 6-12 million of head lice invasion appeared every year [2].
Structural, Morphological and Optical Properties of Mg: ZnS Nanoparticle for Future Contribution in Different Biological Uses Jinan A. Abd
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The wet chemical co- precipitation technique has been used to prepare magnesium doped zinc sulfide nanocrystal powder at room temperature for future contribution in technological and biological applications. The crystal structural, morphology, optical properties, and the emission spectrum of the powder were characterized by x-ray diffraction (XRD), atomic force microscopy (AFM), UV-VIS spectrophotometer, and photoluminescence (PL) spectra. The analysis of XRD diffraction indicated that the powder had cubic zincblende structure and the calculated value of crystallite size was (15.9 nm) for the preferential orientation diffraction peak (111). The calculated energy gap of the Mg:ZnS nanoparticles was ( 3.87 eV) from absorbance spectrum. The PL spectrum of the nanoparticle confirmed two peaks located on (367 nm) and (485 nm).
Novel Mutations Related with Von Willebrand Disease in Iraqi Patients Ali H. AL-Musawi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Von Willebrand Disease (VWD) is the most common hereditary bleeding disorder in humans, with an estimated prevalence ranging upward to 1% of the general population. Males and females are both approximately equally affected. VWD arises from a deficiency or dysfunction of von Willebrand factor (VWF). The aim of this study was to detection of mutations of VWF gene in 15 unrelated patients. Polymerase chain reaction (PCR) and direct sequencing was performed for two functionally regions of the gene (exon 18 and exon 19). This study showed many mutations occurred in males and females patients that is impact  for the change  arrangement the amino acid  causing change VWF protein (as a carrier and protection of F8 protein responsibility for hemophilia A)function, and leading to Von willebrand disease. This study showed several mutations within the VWF gene in fifteen Iraqi patients by the molecular analysis revealed 35 point mutations in this study. These mutations included 15 missense variant and 9 silent mutations, while the rest were intrinsic mutations .These mutations may be related with   Von willebrand disease.Keywords: Von willebrand, Mutation, PCR.
Evaluation and Comparison the Antibacterial Activity of Silver Nano Particles (AgNPs) and Silver Nitrate (AgNO3) on Some Pathogenic Bacteria Halah Dawood Salman
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Resistance of bacteria to some antibiotics increased tremendously therefore demanding for solutions and new medicine becomes essential as this problem related to human health. For this purpose, using of nanoparticles increased rapidly during the last years. In this study, the effect of silver nanoparticles (AgNPs) and silver nitrate (AgNO3) on bacteria had been evaluated and compared.  Commercial purchased silver nanoparticles (with the particles size 20nm and Scanning Electron Microscopy (SEM) image) were characterized by X-ray diffraction (XRD). Antimicrobial activity of nanoparticles Silver and  silver nitrate were evaluated on some pathogenic bacteria including  samples  including: Streptococcus pyogenes  and Staphylococcus aureus (Gram Positive Bacteria)and Escherichia coli , Klebsiella pneumonia, Salmonella  typhi, Acine to bacter baumannii  and Vibrio cholerae   (Gram Negative Bacteria).In this research,  antibacterial activity for nanoparticle silver and silver nitrate at different concentrations started from 10 to 150μg ml−1against bacterial isolates was measured by agar diffusion technique and Minimum Inhibitory Concentration (MIC)/ Minimum bactericidal Concentration (MBC).These pathogens caused different hazardous infections and some of these bacteria are multi-drug resistant, the results exhibited  remarkable antibacterial activity of silver nanoparticles (AgNPs) compared to moderate effect of silver nitrate (AgNo3) against most tested isolates including serious Gram Negative Bacteria resistant bacteria K.pneumonia , S.  typhi and V. cholerae , the exception was A. baumannii as these bacteria didn’t affected definitely by any concentrations of Ag NPs or AgNo3 in the detection tests  of  MIC and MBC.  Keywords: Silver Nan particles, Silver Nitrate, Pathogenic Bacteria
Determination of the Excretion of TSH, T3, T4 Hormones in Blood According to the Pulse Index (160) for Female Tennis Players of Kufa University Nazar Hussein al-Naffakh
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The research included a number of axes focused on these axes on the analysis of the hormones involved in the study and this is by giving a particular effort to raise the pulse to 160 N / d where the pulse is measured after an exercise or effort to raise the pulse of the player and when the completion of exercises The pulse is measured by the player through a device to measure the pulse and when the arrival to the pulse specified blood is drawn to the player and then the analysis of the hormones involved to study at the pulse of the specific measurement and know what changes in these hormones at this pulse and after the analysis in the laboratory allocated and a special device The results are collected Obtained and then deal with these results statistically to extract what extent attributed the changes that have taken place for these hormones for each player. The results showed that there were clear changes in hormone levels at pulse 160 and these changes vary from one player to another.Keywords: Sports Performance, Thyroid hormone analysis (T3, T4), Thyroid stimulating hormone (TSH) and effect of hormones on pulse index (160).
Review of Pharmacokinetics of Levothyroxine, with Specific Focus on Patient with Thyroid Carcinoma Vasudev Shenoy
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Total or near to Total thyroidectomy with Radio Iodine treatment is current therapy for Thyroid cancer. Post thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels. Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. This article would evaluate the pharmacokinetics of levothyroxine and in specific focus in patients with papillary carcinoma followed with thyroidectomy with Radio iodine treatment.Materials and Methods: The references are review from published literature and web based information.Results: Levothyroxine is considered as a narrow therapeutic index drug and hence individualization of the dose in a particular patient is important for optimal therapeutic effect.Conclusion: Review of pharmacokinetics of levothyroxine in various disease condition, coexisting disease and concomitant medication suggested for optimization of the dose of levothyroxine for avoiding the toxic adverse effects due to hypothyroid or hyperthyroid conditions.
Immunological Study for Patient with Verruca Vulgaris and Verruca Plana Caused by HPV in Hilla/ Iraq Nisreen Kaddim Radi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Verruca vulgaris and verruca planathey are benign growth  caused by human papilloma virus.Thirty six sample (biopsy, blood serum) collated from patient infected with Verruca  vulgaris  and Verruca  plana whom visit marjan hospital , twenty  blood sample collected from healthy individual person serve as control group .The diagnosis of infection  and the immunological study were  done by using ELISA test ,IgG to HPV and fasligand level (FASL) at blood serum of patient.The result reveled that: histological study for two types of wart show a distinct feature such as the presence of kilobyte in the tissue infected with hpv. There were a significant Mean Differences of FSAL Concentration by wart’s location at the hand 44.4% with Mean± SD of FASL [78.43± 12.46], presence of previous wart Mean± SD of FASL [84.22± 12.51]    and type of warts such as common wart 47.2% withMean± SD of FASL[87.47±11.84]. There was high significant Mean Difference of FSAL and IgG Concentration between patient and control group, (p value ≤ 0.05 is significant).Keywords:-HPV, FASL, IgG, Verruca vulgarus, Apoptosis, Wart.
Impact of TGF B1 level and single nucleotide polymorphism in gall bladder inflammation Abdalnabi J. Abid
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The current study was conducted to investigate the association of TGF B1levels in serum and polymorphism in cholecystitis patients. The study include 100 blood samples collected from patient undergoing cholecystectomy at the general teaching Hilla Hospital from September 2016 to June 2017. Tgf-B1 concentration pointed significantly increase in the patients compared  with control group with mean value (82. 2pg/ml) for chronic cholecystitis patient  and (46.1pg/ml) for acute cholecystitis patient with   high significant  differences  between patient  and control. p=0.007. The results revealed increased level of TGF-B1 concentration in patient had cholesterol stone with value (65.33  pg/ml) followed pigment stone(60.11pg/ml) and mixed stone(27.62 pg/ml). Single nucleotide polymorphism of  TGF-B1 (-869 T/C showed high appearance of  TC heterozygous With (64) (75.2%)  than others genotypes ,  TT  and CC homozygous and  with (13)( 15%) (8)(9.4%) respectively .there is no significant differences in alleles frequency with severity of disease  while the genotype association of TGF-B1 appeared significant differences ( p=0.04, OR=4.56)  for acute infection in over dominate model compare with chronic ,cholesterol, pigmented and mixed stone patients  shows high appearance of  TC heterozygous  than other genotypes. Keywords : gallbladder , Polymorphism ,SNPs, TGF B1, Gallstone     
Synthesis and Characterization of Some Heterocyclic Compounds from Chalcone Derivatives and Studying of their Biological Activity Lina Saadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

In this work a preliminary step was preparation of 1-(3-((1H-imidazol-2-yl)diazenyl)phenyl)ethan-1-one (1) via coupling of diazonium salt of m-amino acetophenone with imidazole in alkaline alcoholic media which is followed to condensation with different aromatic aldehydes (p-tolualdehyde ,4-dimethyl amino benzaldehyde ) by aldol condensation in the presence of base in ethanol to give chalcones derivatives (2,3), that consider as excellent starting material for synthesis of many heterocyclic derivatives through its reaction with (hydrazine ,phenyl hydrazine ,2,4 dinitrophenyl hydrazine) to get pyrazol derivatives (4-9), likewise (2,3) react with hydroxylamine hydrochloride to get isoxazole (10,11), also (2,3) react with (urea, tiourea) to get oxazine and thiazine derivatives (12-15) , as well (2,3) react with (ethyl cyanoacetate, malononitrile) to get pyridine derivatives (16-19) ,too (2,3) react with guanidine hydrochloride to get pyrimidine derivatives (20,21). All these compounds characterized by means of FT- IR, 1H-NMR, and 13C-NMR, and follow reaction by Rf- TLC and measurements melting points. After that we studied the biological activity for all prepared compounds to ward two types of bacteria.Keywords: Azo, Chalcone, Pyrazole, Isoxzazole , Oxazine, Thiazine,  Pyridine , Pyrimidine, Biological activity.
New Record for Science Salvia margasurica Al-Musawi & Al-Hussaini, (Labiatae) in Iraq Aseel F. A. Al-Hussaini
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: The study covered thirty-three species which grown wildly in Iraq and a comparative study for all kinds of morphological characters were done. Principal Findings: The most stable and important taxonomic characters were pointed out, diagrams, illustrations, scheduals, micrographs were also documented. Stamens, nutlets, basal leaves, bracts, bracteoles, calyces, corollas and their trichomes were very important taxanomic characters. The trichomes were variable in variable species therefore used as a diagnostic characters for the species. Conclusions: New species Salvia margasurica Al-Musawi & Al-Hussaini was suggested to be new record for science.Keywords:  Salvia, Morphology, Spec. Nov.

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