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Khairil Anam
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khairil_anam@dosen.umaha.ac.id
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Perumahan Sidorejo, Jl. Sidorejo Gg. Sadewa No.D3, Sonopakis Kidul, Ngestiharjo, Kapanewon, Kasihan, Kabupaten Bantul, Daerah Istimewa Yogyakarta 55184
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International Journal of Health and Information System (IJHIS)
Published by Indonesian Journal Publisher
ISSN : -     EISSN : 29874637     DOI : https://doi.org/10.47134/ijhis
Core Subject : Health, Science,
Computer Science & IT Health Professions Library & Information Science Medicine & Pharmacology Public Health
International Journal of Health and Information System (IJHIS) is officially registered in the National Research and Innovation Agency, Directorate of Multimedia Repository and Scientific Publishing, ISSN INDONESIAN NATIONAL CENTER with ISSN Number 2987-4637 (online). This journal is published three times a year (May, September and January) by Indonesian Journal Publisher. IJHIS a scientific journal, double-blind peer-reviewed and open-access journal. IJHIS is an academic journal organized which focus and scope : Public Health (Biostatistic, Enviromental health, Occupational Health and Safety, Epidemiology, Health Policy and Administration, Nutrition, Health Promotion), Health of Information system, Medical record, Electronic Health Record & Information Technology.
Arjuna Subject : Umum - Umum
Articles 1 Documents
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Search results for , issue "Vol. 3 No. 3 (2026): January" : 1 Documents clear
Acute Oral Toxicity Assessment of Rutinoside on Renal Histopathology in Wistar Rats Normasari, Rena; Pratiwi, Yulia
International Journal of Health and Information System Vol. 3 No. 3 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v3i3.79

Abstract

This study aimed to evaluate the acute oral toxicity of rutinoside by assessing renal histopathological changes in Wistar rats. Twelve Wistar rats (Rattus norvegicus), consisting of equal numbers of males and females and aged approximately three months, were randomly assigned to control and treatment groups. After an acclimatization period under standard laboratory conditions, the treatment group received a single oral dose of rutinoside (5000 mg/kg body weight) via gastric gavage in accordance with OECD Guideline 423, while the control group received the vehicle only. Animals were observed daily for 14 days for mortality, behavioral changes, and clinical signs of toxicity. At the end of the observation period, rats were euthanized, and both kidneys were collected for histopathological evaluation. Kidney tissues were fixed in 10% buffered formalin, processed, and stained with hematoxylin and eosin. Histological examination was performed at 400× magnification using a standardized scoring system, and statistical analysis was conducted using the Mann–Whitney U test. No mortality or treatment-related clinical signs were observed during the study period. Histopathological findings demonstrated no significant differences between the control and rutinoside-treated groups. Renal structures, including glomeruli and tubules, remained intact, with no evidence of degeneration, inflammation, or other pathological alterations. In conclusion, acute oral administration of rutinoside at a high dose did not induce renal toxicity in Wistar rats, suggesting a favorable acute safety profile. Further studies are required to evaluate the safety of rutinoside following repeated or long-term exposure.

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