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Acceptance, safety, and impact on quality of life of exergame for elderly patients with neurodegenerative diseases: A systematic review and meta-analysis Tsurayya, Ghina; Duta, Teuku F.; Naufal, Muhammad A.; Alina, Meulu; Isitua, Chinwe C.; Ohanu, Ernest C.
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.94

The aim of this study was to evaluate the efficacy, safety, adherence, and acceptance of exergame in improving the quality of life (QoL) among elderly patients with neurodegenerative diseases. A systematic search was conducted in PubMed, Embase and Scopus for relevant studies up to 16 March 2023. Quality of the included studies were assessed using Cochrane’s Risk of Bias tool version 2.0. Meta-analysis using a random effect was conducted on outcomes reported at least by two studies to calculate the standard mean difference (SMD) and its 95% confidence interval (CI). The difference of influence between exergame and conventional therapy was judged based on Z- and p-values. Heterogeneity was determined by I2 score. As many as 15 studies were included (n=466 participants) published between 2013–2023. Nine studies had ‘high quality’ five studies had ‘some concerns’, and one had ‘high risk’. Results from meta-analyses suggests that the exergame does significantly not improve the QoL among patients with Parkinson’s diseases. Similarly, no statistically significant difference (p>0.05) of QoL improvement among Alzheimer’s disease patients receiving exergame intervention. No adverse effects were reported to be associated with the intervention, and in fact, the patients experienced reduced fatigue and fear of falling. Patients in intervention group showed high acceptance and adherence to the therapy, which could be attributed to exergame being enjoyable, easy-to-use, and motivational. In conclusion, despite exergame being highly acceptable and relatively safe, the intervention does not improve the QoL of the elderly patients.

Biochemical and Fe-resistant characteristics of indigene bacteria from a high iron concentration landfill in Indonesia Saputri, Purwati; Harahap, Diannita; Lubis , Syafrina S; Ilhami, Syarifa
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.95

Bacteria isolated from leachate with high heavy metal concentration mostly have potential for bioremediation. The aim of this study was to isolate bacteria from leachate of a landfill containing high concentration of Fe. The leachate sample was collected from Gampong Jawa Landfill, Aceh, Indonesia and used to isolate the bacteria by spread method. The purification of the isolates was carried out through four quadrant plate method. Pure isolates were characterized based on the microscopic or macroscopic appearance and biochemical tests. Fe-resistance was tested by disc diffusion method and constructing the growth curve based on the optical density of broth culture media. A total of 27 pure isolates were obtained and identified, representing eight different genera: Pseudomonas, Bacillus, Neisseria, Micrococcus, Staphylococcus, Proteus, Acinetobacter, and Escherichia. Of eight isolates (each genus was represented by a single isolate), Pseudomonas sp. and Bacillus sp. were considered resistant to Fe exposure (15 ppm) with inhibition zones of 1.00 and 0.81 mm, respectively. At Fe concentration of 20 ppm the inhibition zones exceeded 1 mm, but Bacillus sp. had smaller inhibition zone than that of Pseudomonas sp. (1.15 mm versus 2.86 mm). Growth inhibition of Bacillus sp. was concentration-dependent on Fe exposure but could survive at Fe exposure up to 20 ppm. In conclusion, Bacillus sp. had a resistance against Fe exposure and its bioremediation potential is subjected for future studies.

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials Putra, Muhammad IA.; Gusti , Naufal; Duta, Teuku F.; Alina, Meulu; Qanita, Intan; Naufal, Muhammad A.; Henira, Najlaika; Tsurayya, Ghina; Amirah, Shakira
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.104

Serum vitamin D level is associated with the development of diabetic foot ulcer (DFU), and it is intriguing to determine if the vitamin supplementation could reverse the diabetic complication. The aim of this study was to investigate the efficacy of vitamin D supplementation in DFU management through qualitative and quantitative systematic review. A systematic search was conducted to screen the records identified in PubMed, Scopus, Embase, Scillit, Sci-Finder, LILACS, EuropePMC, medRxiv, bioRvix, Google Scholar, Semantic Scholar, and Garuda databases as of 10 March 2023. Studies investigating the efficacy of a single dose supplementation of vitamin D in DFU management were included. Quality of the included studies was appraised by Cochrane ‘Risk of Bias’ 2.0. Random-effects-based pooled analysis using Cohen’s d was performed on the wound healing progress as the primary outcome. A sensitivity test with leave-one-out method and meta-regression were also conducted to analyze the effect of heterogenous data. Five studies with a total of 245 patients (123 versus 122 for experimental and control groups, respectively) were finally included in the qualitative and quantitative analysis. The pooled estimate suggested that administering vitamin D to DFU patients could reduce the wound area or depth significantly as compared to control group (p<0.001; Cohen’s d: 2.72; 95% CI: 1.02 to 4.42). The value remained positive throughout the leave-one-out analysis. Vitamin D supplementation significantly contributed to the increased level of serum vitamin D (p=0.026, Cohen’s d: -0.719; 95% CI: -1.35 to -0.09). Elevation of high-density lipoprotein was observed in pooled estimate with p=0.016 and Cohen’d: 1.34 (95% CI: 0.25 to 2.44). Qualitatively, significant reduction of HbA1C, total cholesterol, and C-reactive protein were reported in at least two trials. Significantly improved quantitative insulin sensitivity check index (QUICKI) and decreased malondialdehyde, fructosamine, and fasting blood glucose were reported in at least one trial each. There were conflicting results on the change of low-density lipoprotein level. This study highlights that vitamin D supplementation promotes wound healing process among DFU patients; however, it is too premature to draw solid conclusions as the efficacy could be affected by multiple factors. Therefore, clinical trials from various demographics and ethnicities by using a high- versus low-dose model are needed.

Willingness-to-pay for urban green space: A meta-analysis of surveys across China Wikurendra, Edza A.; Aulia, Aulia; Fauzi, Muhammad L.; Fahmi, Iqbal; Amri, Ikhwan
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.105

Sustainable ecosystem services are increasingly recognized amid rapid regional transformation. While the rate of urbanization in China continues to rise, there is an urgent need to evaluate public preferences and their associated economic values concerning urban green space (UGS). The aim of this study was to calculate the overall willingness-to-pay (WTP) for UGS across China. Literature search was performed systematically on Scopus, Scilit, PubMed, and Google Scholar databases on 11 November 2023. Studies reporting the WTP in China were included in the analysis. Quality of the included studies were appraised by using Q-SSP tool consisting of 20-item quality of survey studies in psychology. To calculate the overall willing to pay rate and WTP, a meta-analysis was performed using restricted maximum-likelihood model on raw proportions. A total of nine studies were included comprised of 9381 valid responses with high quality according to Q-SSP (score: 70–90%). Findings from the meta-analysis indicated that the rate of willing to pay for UGS was 70.8% (95%CI: 60%, 82%; p-Het<0.001, I2= 99.37%). The rate was not affected by sample size, age, gender, and education (p>0.05). Among mainland Chinese population alone, the average minimum WTP was 2.97 USD/month, and increased to 3.36 USD/month if combined with Hong Kong population. A majority of over 70% Chinese population were willing to pay for UGS. Nevertheless, high heterogeneity in the pooled estimates suggest the importance of addressing contextual variables and presence of regional disparities.

Soya-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) for the management of severe acute malnutrition among children: A systematic review and meta-analysis Tsurayya, Ghina; Nazhifah, Cut A.; Pirwanja, Muhammad R.; Lemu, Yohannes K.
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.111

In managing severe acute malnutrition (SAM) among children, the World Health Organization has endorsed the use of ready-to-use therapeutic foods (RUTF), especially the peanut and milk-based (PM-RUTF), which has been proven for its efficacy. Unfortunately, the distribution of PM-RUTF is challenged by high financial cost and reliance on imports for milk and peanuts. Researchers explore the Soy-Maize-Sorghum (SMS)-RUTF as the alternative, in which the formulation has two types; milk-free soya-maize-sorghum (FSMS)-RUTF and low milk content SMS (MSMS)-RUTF. The aim of this study was to evaluate the efficacy, safety, and acceptance of SMS-RUTFs in the management of SAM among children as compared with PM-RUTF. Eligible studies were searched through PubMed, Scopus, and Embase up to July 14, 2023. Studies reporting the effects of SMS-RUTF, FSMS-RUTF, or MSMS-RUTF intake on SAM with PM-RUTF as the control were considered eligible. The included randomized controlled trials were then assessed for the risk of bias using Cochrane Risk of Bias 2.0. Odds Ratio (OR) and mean difference (MD) were calculated using a random-effects meta-analysis. The analysis focused on investigating the recovery, mortality, weight gain, and hemoglobin levels. Five randomized controlled trials involving a total of 5,513 children were incorporated in this review. Of which, four studies were included in the statistical analysis. Those receiving SMS-RUTF was 0.77 times less likely to recover from SAM as compared to control (95% CI: 0.66–0.90, p<0.01). The SMS-RUTF group had 1 kg lower weight gain as compared to control (95% CI: -1.25–0.75, p<0.01). However, the SMS-RUTF group had significantly higher increase of hemoglobin level than control (MD: 0.80 g/dL [95% CI: 0.68–0.93], p<0.01). Adverse effects were observed similar in both SMS-RUFT and control groups. SMS-RUFT received low acceptance from the participants suspected to be caused by poor packaging. In conclusion, SMS-RUTF is less effective than PM-RUTF in managing SAM among children but can be used to improve anemia as indicated by increased hemoglobin levels.

Acceptance, safety, and impact on quality of life of exergame for elderly patients with neurodegenerative diseases: A systematic review and meta-analysis Tsurayya, Ghina; Duta, Teuku F.; Naufal, Muhammad A.; Alina, Meulu; Isitua, Chinwe C.; Ohanu, Ernest C.
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.94

The aim of this study was to evaluate the efficacy, safety, adherence, and acceptance of exergame in improving the quality of life (QoL) among elderly patients with neurodegenerative diseases. A systematic search was conducted in PubMed, Embase and Scopus for relevant studies up to 16 March 2023. Quality of the included studies were assessed using Cochrane’s Risk of Bias tool version 2.0. Meta-analysis using a random effect was conducted on outcomes reported at least by two studies to calculate the standard mean difference (SMD) and its 95% confidence interval (CI). The difference of influence between exergame and conventional therapy was judged based on Z- and p-values. Heterogeneity was determined by I2 score. As many as 15 studies were included (n=466 participants) published between 2013–2023. Nine studies had ‘high quality’ five studies had ‘some concerns’, and one had ‘high risk’. Results from meta-analyses suggests that the exergame does significantly not improve the QoL among patients with Parkinson’s diseases. Similarly, no statistically significant difference (p>0.05) of QoL improvement among Alzheimer’s disease patients receiving exergame intervention. No adverse effects were reported to be associated with the intervention, and in fact, the patients experienced reduced fatigue and fear of falling. Patients in intervention group showed high acceptance and adherence to the therapy, which could be attributed to exergame being enjoyable, easy-to-use, and motivational. In conclusion, despite exergame being highly acceptable and relatively safe, the intervention does not improve the QoL of the elderly patients.

Biochemical and Fe-resistant characteristics of indigene bacteria from a high iron concentration landfill in Indonesia Saputri, Purwati; Harahap, Diannita; Lubis , Syafrina S; Ilhami, Syarifa
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.95

Bacteria isolated from leachate with high heavy metal concentration mostly have potential for bioremediation. The aim of this study was to isolate bacteria from leachate of a landfill containing high concentration of Fe. The leachate sample was collected from Gampong Jawa Landfill, Aceh, Indonesia and used to isolate the bacteria by spread method. The purification of the isolates was carried out through four quadrant plate method. Pure isolates were characterized based on the microscopic or macroscopic appearance and biochemical tests. Fe-resistance was tested by disc diffusion method and constructing the growth curve based on the optical density of broth culture media. A total of 27 pure isolates were obtained and identified, representing eight different genera: Pseudomonas, Bacillus, Neisseria, Micrococcus, Staphylococcus, Proteus, Acinetobacter, and Escherichia. Of eight isolates (each genus was represented by a single isolate), Pseudomonas sp. and Bacillus sp. were considered resistant to Fe exposure (15 ppm) with inhibition zones of 1.00 and 0.81 mm, respectively. At Fe concentration of 20 ppm the inhibition zones exceeded 1 mm, but Bacillus sp. had smaller inhibition zone than that of Pseudomonas sp. (1.15 mm versus 2.86 mm). Growth inhibition of Bacillus sp. was concentration-dependent on Fe exposure but could survive at Fe exposure up to 20 ppm. In conclusion, Bacillus sp. had a resistance against Fe exposure and its bioremediation potential is subjected for future studies.

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials Putra, Muhammad IA.; Gusti , Naufal; Duta, Teuku F.; Alina, Meulu; Qanita, Intan; Naufal, Muhammad A.; Henira, Najlaika; Tsurayya, Ghina; Amirah, Shakira
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.104

Serum vitamin D level is associated with the development of diabetic foot ulcer (DFU), and it is intriguing to determine if the vitamin supplementation could reverse the diabetic complication. The aim of this study was to investigate the efficacy of vitamin D supplementation in DFU management through qualitative and quantitative systematic review. A systematic search was conducted to screen the records identified in PubMed, Scopus, Embase, Scillit, Sci-Finder, LILACS, EuropePMC, medRxiv, bioRvix, Google Scholar, Semantic Scholar, and Garuda databases as of 10 March 2023. Studies investigating the efficacy of a single dose supplementation of vitamin D in DFU management were included. Quality of the included studies was appraised by Cochrane ‘Risk of Bias’ 2.0. Random-effects-based pooled analysis using Cohen’s d was performed on the wound healing progress as the primary outcome. A sensitivity test with leave-one-out method and meta-regression were also conducted to analyze the effect of heterogenous data. Five studies with a total of 245 patients (123 versus 122 for experimental and control groups, respectively) were finally included in the qualitative and quantitative analysis. The pooled estimate suggested that administering vitamin D to DFU patients could reduce the wound area or depth significantly as compared to control group (p<0.001; Cohen’s d: 2.72; 95% CI: 1.02 to 4.42). The value remained positive throughout the leave-one-out analysis. Vitamin D supplementation significantly contributed to the increased level of serum vitamin D (p=0.026, Cohen’s d: -0.719; 95% CI: -1.35 to -0.09). Elevation of high-density lipoprotein was observed in pooled estimate with p=0.016 and Cohen’d: 1.34 (95% CI: 0.25 to 2.44). Qualitatively, significant reduction of HbA1C, total cholesterol, and C-reactive protein were reported in at least two trials. Significantly improved quantitative insulin sensitivity check index (QUICKI) and decreased malondialdehyde, fructosamine, and fasting blood glucose were reported in at least one trial each. There were conflicting results on the change of low-density lipoprotein level. This study highlights that vitamin D supplementation promotes wound healing process among DFU patients; however, it is too premature to draw solid conclusions as the efficacy could be affected by multiple factors. Therefore, clinical trials from various demographics and ethnicities by using a high- versus low-dose model are needed.

Willingness-to-pay for urban green space: A meta-analysis of surveys across China Wikurendra, Edza A.; Aulia, Aulia; Fauzi, Muhammad L.; Fahmi, Iqbal; Amri, Ikhwan
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.105

Sustainable ecosystem services are increasingly recognized amid rapid regional transformation. While the rate of urbanization in China continues to rise, there is an urgent need to evaluate public preferences and their associated economic values concerning urban green space (UGS). The aim of this study was to calculate the overall willingness-to-pay (WTP) for UGS across China. Literature search was performed systematically on Scopus, Scilit, PubMed, and Google Scholar databases on 11 November 2023. Studies reporting the WTP in China were included in the analysis. Quality of the included studies were appraised by using Q-SSP tool consisting of 20-item quality of survey studies in psychology. To calculate the overall willing to pay rate and WTP, a meta-analysis was performed using restricted maximum-likelihood model on raw proportions. A total of nine studies were included comprised of 9381 valid responses with high quality according to Q-SSP (score: 70–90%). Findings from the meta-analysis indicated that the rate of willing to pay for UGS was 70.8% (95%CI: 60%, 82%; p-Het<0.001, I2= 99.37%). The rate was not affected by sample size, age, gender, and education (p>0.05). Among mainland Chinese population alone, the average minimum WTP was 2.97 USD/month, and increased to 3.36 USD/month if combined with Hong Kong population. A majority of over 70% Chinese population were willing to pay for UGS. Nevertheless, high heterogeneity in the pooled estimates suggest the importance of addressing contextual variables and presence of regional disparities.

Soya-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) for the management of severe acute malnutrition among children: A systematic review and meta-analysis Tsurayya, Ghina; Nazhifah, Cut A.; Pirwanja, Muhammad R.; Lemu, Yohannes K.
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.111

In managing severe acute malnutrition (SAM) among children, the World Health Organization has endorsed the use of ready-to-use therapeutic foods (RUTF), especially the peanut and milk-based (PM-RUTF), which has been proven for its efficacy. Unfortunately, the distribution of PM-RUTF is challenged by high financial cost and reliance on imports for milk and peanuts. Researchers explore the Soy-Maize-Sorghum (SMS)-RUTF as the alternative, in which the formulation has two types; milk-free soya-maize-sorghum (FSMS)-RUTF and low milk content SMS (MSMS)-RUTF. The aim of this study was to evaluate the efficacy, safety, and acceptance of SMS-RUTFs in the management of SAM among children as compared with PM-RUTF. Eligible studies were searched through PubMed, Scopus, and Embase up to July 14, 2023. Studies reporting the effects of SMS-RUTF, FSMS-RUTF, or MSMS-RUTF intake on SAM with PM-RUTF as the control were considered eligible. The included randomized controlled trials were then assessed for the risk of bias using Cochrane Risk of Bias 2.0. Odds Ratio (OR) and mean difference (MD) were calculated using a random-effects meta-analysis. The analysis focused on investigating the recovery, mortality, weight gain, and hemoglobin levels. Five randomized controlled trials involving a total of 5,513 children were incorporated in this review. Of which, four studies were included in the statistical analysis. Those receiving SMS-RUTF was 0.77 times less likely to recover from SAM as compared to control (95% CI: 0.66–0.90, p<0.01). The SMS-RUTF group had 1 kg lower weight gain as compared to control (95% CI: -1.25–0.75, p<0.01). However, the SMS-RUTF group had significantly higher increase of hemoglobin level than control (MD: 0.80 g/dL [95% CI: 0.68–0.93], p<0.01). Adverse effects were observed similar in both SMS-RUFT and control groups. SMS-RUFT received low acceptance from the participants suspected to be caused by poor packaging. In conclusion, SMS-RUTF is less effective than PM-RUTF in managing SAM among children but can be used to improve anemia as indicated by increased hemoglobin levels.

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Iqhrammullah

Contact Email
m.iqhram@narraj.org

Phone
+62895600103052

Journal Mail Official
m.iqhram@narraj.org

Editorial Address
Jl. T. Tanoeh Abee, Durussalam, 23111, Banda Aceh

Location
Kota banda aceh,

Aceh

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Iqhrammullah

Contact Email m.iqhram@narraj.org

Phone +62895600103052

Journal Mail Official m.iqhram@narraj.org

Editorial Address Jl. T. Tanoeh Abee, Durussalam, 23111, Banda Aceh

Location Kota banda aceh, Aceh INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Iqhrammullah

Contact Email
m.iqhram@narraj.org

Phone
+62895600103052

Journal Mail Official
m.iqhram@narraj.org

Editorial Address
Jl. T. Tanoeh Abee, Durussalam, 23111, Banda Aceh

Location
Kota banda aceh,

Aceh

INDONESIA