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Mochamad Nashrullah
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Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcb.v1i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
The European Journal of Medical Genetics and Clinical Biology is a peer-reviewed journal that publishes articles in English on various aspects of human and medical genetics, the genetics of experimental models, and developmental anomalies. Original clinical and experimental research articles, short clinical reports and review articles are welcome on topics such as: Clinical genetics and genomics, including neurodevelopmental disorders and single or multiple malformations syndromes and dysmorphology; Inherited predisposition to cancer: rare inherited cancer predisposition syndromes and biology and pathophysiology of inherited cancers; Fetal medicine and prenatal diagnosis, including prenatal diagnosis, prenatal screening, fetal therapies and teratology; Diagnostic methods including sequencing studies (gene level), transcriptome studies, methylome and other Omics technologies, variant interpretation and functional validation; Bioinformatics and statistical methods in genetics; Personalized Medicine and therapies, including gene therapy and gene editing, non-genetic treatment of genetic disease, pharmacogenetics and genomics, theranostics and clinical trials; Molecular biology and pathophysiology of genetic and genomic diseases: biology of cell, pathways and systems, epigenetics and gene regulation, biology and pathophysiology of specific genes and non-coding DNA; Genetics and variants in populations: carrier screening, population genetics, evolutionary genetics, genetic epidemiology of diseases, genome variation and architecture in normal population;
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 223 Documents
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IN VITRO ANTIBACTERIAL ACTIVITY OF AQUEOUS EXTRACT OF CRANBERRY (VACCINIUM MACROCARPON) AGAINST E. COLI ISOLATED FROM URINARY TRACT INFECTION Ruqayyah Hussein Kazim Ghulam; Milad Munther Zahid Baniya; Adyan abd Al_khalq aziz nema; Messad Hammad Kadhim Edam; Muslim Hakim Nahi Thaher
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.821

Abstract

The present study was carried out to investigate in-vitro antibacterial activity of aqueous extract of Cranberry (Vaccinium macrocarpon) fruit against Escherichia coli isolated from urinary tract infection. The present study included two experiment; the first one is isolate and identify of E. coli; the second experiment include study in-vitro antibacterial activity of aqueous extract of Cranberry, consisting two steps, the first step involved collection of Cranberry fruit then they were identified and then squeezed by an electric mixer to obtain the aqueous extract. The fruit extract then dried. The second step was to study the in vitro antibacterial activity of Cranberry aqueous extract including minimum inhibitory concentration (MIC) against E. coli used as reference antibiotics. The yielding percentage of Cranberry (Vaccinium macrocarpon) fruit extract was (30%). The in-vitro antibacterial study showed the Cranberry aqueous extract was more effective than Gentamicin against E.coli, this organism was quite resistant to Ciprofloxacin. It could be concluded however that Cranberry aqueous extract was more effective in comparison with the standard antibacterial agent, and that the antibacterial activity of Cranberry aqueous extracts against urinary tract infection may be attributed to its essential particularly the important phenolic compound (Proanthocyanidin).
EFFECT OF TYPE2 DIABETES ON EYE DISEASES (LENOPATHY, GLAUCOMA, RETINOPATHY AND OPTIC NEUROPATHY) Estabraq Mufid Hamid Rashid; Zainab Ibrahim Harat Khalaf; Mariam Ahmed Abd alghfer Muscat; Omar Hammed Saleh Ibrahim; Haider Jassim Mohammed Hussein
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.822

Abstract

Awareness about diabetic eye complications and regular eye examinations plays an important role in avoiding blindness. Objective: To evaluate the level of awareness and knowledge about diabetic eye diseases among diabetic patients. Patients attending Ibn al-Haytham Teaching Hospital for Eye Diseases in Baghdad. Method: This is a cross-sectional study including a sample of 115 diabetic patients attending this center during the treatment period. The period is from 2023/8/15_2023/10/25. To achieve the objectives of the study, a closed study was conducted. A questionnaire that includes different variables related to diabetes awareness for each of them. The authors filled out the questionnaire during interviews with patients.
AWARENESS OF HEALTH CARE WORKERS TOWARDS ANTI-OBESITY MEDICATIONS IN A SAMPLE OF HOSPITALS IN AL-DIWANIYAH PROVINCE, IRAQ Sattar Abdul Ameer Merhej; Abeer Ghazie Al Sawafi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.823

Abstract

Background: The most common medical condition in low-, middle-, and high-income countries is obesity. Thus, diet, lifestyle, and anti-obesity drugs are becoming popular adjuvant treatments for this medical condition. Knowing the community's opinion and awareness is crucial. Materials and methods: This cross-sectional study was conducted at Al-Diwaniyah province hospitals. A convenience sample of 200 health care workers in Al-Diwaniyah province hospitals who are enrolled in the three hospitals (Al-Diwaniyah teaching, the general Al-Hamiza, and the general Al-Shamia). This study includes health care workers (HCWs) of both genders and ages over 20 years of morning shift. While this study excludes those with an educational level below secondary school, administrative staff were excluded from the study. The data collect started from the 3rd of November 2023 till the 13th of February 2024. Results: The results of this study indicate that 52.5% of health workers have a moderate awareness score, followed by 24.5% of the participants have a poor awareness score, and only 23.0% of HCWs have a good awareness score. the results of this study reveal that there is significant relationship between demographic characteristics and overall awareness score (P. value <0.05), except for residence. Conclusions: The study report that most HCWs have a moderate awareness about anti-obesity drugs. These results explain that old age, males’ gender, high education and physician have good assessment scores for awareness about anti-obesity drugs. The study recommends developing and focusing on community-based educational programs and campaigns on anti-obesity medications to improve their views on obesity management.
REVEAL THE ROLE OF GARLIC SILVER NANOPARTICLES AND GARLIC ZINC NANOPARTICLES ON CANDIDA ALBICANA ISOLATED FROM WOMEN WITH VULVOVAGINAL CANDIDIASIS Hawazin Ahmed Abid
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.824

Abstract

The current investigation aimed to reveal the role of garlic silver nanoparticles and garlic zinc nanoparticles on Candida albicana isolated from women with Vulvovaginal Candidiasis. 120 clinical samples were collected during the period from February to May 2024 from married female patients, collected from Salah al-Din General Hospital. Samples were collected for women with vaginal candidiasis whose ages ranged from (20-50 years). The initial diagnosis and examination for follow-up examinations were conducted with the assistance of a female gynecologist. The results of the microscopic and morphological examination of the total number of samples (120) showed that there were 69(57.5%) positive samples, while the number of negative samples was 51(42.5%). The molecular assay was positive for all DNA samples from the patients with Vulvovaginal Candidiasis, with Cq values ranging (24.402- 29.437) for ALS1 gene, (14.748-29.562) for HWP1 and (23.699-28.23) for ACT1. Results showed 9(90.0%), 10(100.0%) and 7(70.0%) of C. albicans isolates had ALS1, HWP1 and ACT1 gene respectively, which is one of the virulence factors in yeast C. albicanes. On the other hand, the results of the current study demonstrate the effectiveness of both AgNPs and ZnO NPs against Candida albicans. A concentration of 250 and 500 ppm was used for both AgNPs and ZnO NPs. It was found that the average diameter of the inhibition zone for 10 isolates tested was (8.04±3.47) and (21.25±3.18) for AgNPs. prepared with garlic, and the average diameter of the inhibition zone for 10 isolates tested was (8.99±2.24) and (19.57±2.54) for ZnO NPs prepared with garlic. It is concluded from the current study that both AgNPs and ZnO NPs prepared with garlic extract have inhibitory activity against Candida albicans.
CLINICAL APPLICATIONS OF STEM CELL THERAPY IN THE FIGHT AGAINST CANCER Marwan Saleh Mahdi; Sajjad Jawad Kadhim; Murtadha Hadi Ajmi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.825

Abstract

Stem cell therapy is emerging as a novel approach in the fight against cancer, with over 300 clinical trials exploring various stem cell types, including embryonic, adult, fetal, amniotic fluid, and human embryonic-like stem cells. These trials aim to treat a range of diseases, notably cancer, by leveraging the regenerative capabilities of stem cells. Cancer stem cells (CSCs), a subpopulation within tumors, are integral to tumor growth and resistance to conventional treatments due to their self-renewal properties. Innovative strategies, such as suicide gene therapy using genes like Cytosine Deaminase (CD), show promise in targeting these CSCs and enhancing treatment outcomes. This review discusses the dual role of stem cells in cancer therapy, highlighting their potential to both promote and inhibit tumor development, and underscores the need for well-characterized therapeutic stem cell banks equipped with anti-tumor genes. Future research directions and the potential of stem cell-based therapies to revolutionize cancer treatment are also explored.
THE PREVALENCE OF URINARY TRACT INFECTIONS AND THE AGENTS RESPONSIBLE FOR THEM IN PREGNANT WOMEN IN THE PROVINCE OF KARBALA Shahad Kadhem Jafar Al-baiaty; Sarah Akar Ali; Riyam Ghazi Kareem Al-Sarray; Hawra Raad Mahdi; Jinan Talib Jassab; Basim Jawad Hussein
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.830

Abstract

Along with anemia and hypertension, urinary tract infections (UTIs) are among the most frequent medical problems of pregnancy, occurring in between 5% and 10% of pregnancies. This study set out to ascertain the frequency of urinary tract infections (UTIs) and the presence of uropathogens in expectant mothers. 417 urine samples were examined between December 2021 and August 2022 of that research period. When a urinary tract pathogen grew to at least 10 5 CFU/ml in a culture of a midstream urine sample, the diagnosis of UTI was made. Biochemical assays were used to identify the isolated microorganisms. According to the results, 49.4% of expectant mothers had a UTI. The most often isolated organism was E. Coli (56.79%), which was followed by Proteus sp (5.8%), Pseudomonas sp (6.3%), and Klebsiella sp (19.9%)..
ELIMINATION OF BIOFILM PRODUCED BY ESCHERICHIA COLI AFTER EXPOSURE TO STRONTIUM SR90 AND CESIUM CS137 RADIOACTIVE SOURCE IN DIFFERENT DOSES Nebras Rada Mohammed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.831

Abstract

Objective:. The purpose of this research in order to remove biofilm produced from E. coli with different radioactive sources.Study design: Case–control in analytical and cross-sectional in descriptive study design. Backgrounds: The bacterium E. coli which is pathogenic to the urinary tract, depends on a wide number of virulence determinants, as it is the most important bacterium responsible for urinary tract infections. Radiation is power in the appearance of undulations or spout of mote. There are several types of radiance overall concerning us. Alpha dissolution occurs while the mote throw of the nucleus that constitute of two no and two P+. Beta dissolution a no is convert a P+ and an e- is released of the nucleus. Gamma dissolution happen through residuum power in the nucleus next alpha or beta dissolution or subsequent no catch (a kind of atomic response) in a nuclear reactor. Methodology: Study populations and bacterial isolates with diagnosing E. coli from catheter and several diseases from patients in Baghdad hospitals in 2023/ 2024. Expose the bacteria to radiance released of Sr90 and CS137 radioactive sources in various doses with screening biofilm production before and after exposure to radiation. Results: The results show that there is a high killing rate of E. coli during exposure to Cesium-90 and Cesium-137 radioactive sources. As well as loss of biofilm production at different doses. Conclusion: Firstly, the impact of radiance of various radioactive sources occasion the homicide of E. coli. Secondly, the impact of radiance released of radioactive sources in various doses is analogous in homicide of E. coli.
THE IMPACT OF HUMAN ACTIVITIES ON ENVIRONMENTAL SUSTAINABILITY Mohammed Jabar Odah Inbit; Mohamed abdulhassan eliwi alkolany; Ahmed Abd Ali Kazem; Hussain Hamza Hussein; Raed Abd AL-kadum mageed Brism
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.832

Abstract

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BIOELECTRICAL PRODUCTION BY MICROBIAL NANOWIRES Omar Adel Badawi Omar; Faysal Raed Abd Al Rahim; Salam Adil Abduljabar Saed; Yousif Zeyad Yassen Daoud; Abd Alrahman Mohammed Jasim Mohammed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.833

Abstract

Bacterial nanowires, which are electrically conductive appendages or threads that facilitate the transfer of electrons outside the bacterial cell, produced by a number of bacteria, have shown the potential to be useful in many fields, especially bioenergy and bioremediation. Bacteria have developed a group of nanowires in different forms, including Pilli, which are fine structures protruding from the surface of bacteria and used for adhesion, movement, and the formation of biofilms in some species that participate in extracellular respiration and use their filaments to transfer electrons. The world is currently witnessing an energy crisis due to the continuous increase in energy requirements around the world, so the trend today is to use microbial fuel cell (MFC) technology, which is an encouraging technology for generating electricity and a source of clean and environmentally friendly energy that uses microorganisms to convert the chemical energy of organic compounds into electricity using bacterial nanowires. Most MFC studies are being done for electricity generation, which is the primary application of the technology at the moment, and it is a fascinating technology that can use a variety of substrates, MFC cell with bacteria to achieve bioenergy production despite the fact that the energy levels in all these systems were relatively low
PROFESSIONAL BEHAVIOR OF DOCTORS WITH PATIENTS: A FIELD STUDY IN THE CITY OF MEDICINE Ahmed Emad Ali Hassan; Karar Haidar Falih Rashid; Zain Al-Abidin Kazim Karim Gno; Ali Thajeel Atiya Shebat
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.834

Abstract

Through research, we reached the following after the questionnaire forms were distributed to a sample of males and females from the community, which amounted to (50). We entered the answers and sorted them through the statistical program (spss) and obtained several results that we summarize in several points as follows: The study proved that there is a significant relationship between age and suffering from chronic diseases such as blood pressure, diabetes and heart disease, at a rate of 24% for the age of 50 years and over The study proved that there is a significant relationship between education and finding difficulty in reading a prescription written by the doctor, at a rate of 20% equally between the educational level of reading and writing and the educational level of middle school The study proved that there is a significant relationship between the economic status and always resorting to government hospitals, at a rate of 44% for those with an average income The study proved that there is a significant relationship between taking the medicine according to medical instructions and guidelines and the difficulty of reading a prescription written by hand, 54% The study proved that there is a significant relationship between suffering from chronic diseases such as blood pressure, diabetes and heart disease and directing the doctor to do tests before starting the diagnosis, at a rate of 34% The study proved that there is a significant relationship between always resorting to a government hospital and having previously been exposed to a medical error, at a rate of 64% The study proved that there is a significant relationship between feeling that doctors' fees in clinics are high and commitment to periodic examinations, at a rate of 24% The study proved that there is a significant relationship between preferring a doctor with a doctorate over a doctor with a bachelor's degree and commitment to periodic examinations, at a rate of 18% The study proved that there is a significant relationship between preferring an older doctor over a younger doctor and suffering from chronic diseases such as blood pressure, diabetes and heart disease, at a rate of 38% The study proved that there is no relationship between gender, whether male or female, and preferring a doctor with a doctorate over a doctor with a bachelor's degree, at a rate of 24% The study proved that there is no relationship between gender and reading and reviewing the past case before going to the doctor, at a rate of 28%

Page 18 of 23 | Total Record : 223

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