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Bioactivities
Published by Pandawa Institute
ISSN : -     EISSN : 2963654X     DOI : https://doi.org/10.47352/bioactivities
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Bioactivities is a double-blind peer-reviewed journal for research activity on bioactivities of materials or compounds. This journal aims to provide a means for sustained discussion of relevant issues that fall within the focus and scopes of the journal which can be examined empirically in the following fields: 1) antioxidant; 2) antibacterial; 3) antifungal; 4) antiviral; 5) antibiotic; 6) anticancer; 7) antitumoral; 8) anti-fouling; 9) anti-inflammatory; 10) antihypertensive; 11) anti-obesity; 12) antiproliferative; 13) anti-opioid; and 14) biosorption. The Bioactivities is an open-access journal containing original research articles, review articles, and short communications in the areas related to bioactivities. The Bioactivities publishes 2 issues in a year in June (first issue) and December (second issue). This journal has adopted a double-blind reviewing policy whereby the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol. 2 No. 2 (2024): Bioactivities" : 5 Documents clear
Fight for Cancer Diseases using Natural Compounds and Their Semisynthetic Derivatives Yehezkiel Steven Kurniawan; Kasta Gurning; Iksen Iksen; Ahmad Bikharudin
Bioactivities Vol. 2 No. 2 (2024): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.221

Abstract

Cancer stands as one of the deadliest diseases afflicting contemporary human societies, encompassing over 100 distinct forms, including oral, salivary glands, oropharynx, nasopharynx, hypopharynx, colorectal, liver, pancreas, lung, skin, breast, cervix, ovary, prostate, kidney, brain, thyroid, and leukemia cancers. At the cellular level, the uncontrolled growth of cancerous cells can disrupt the body's normal functions. Chemotherapy, a widely recognized cancer treatment, utilizes anticancer agents to target specific cancer cell lines effectively. Natural compounds are favored for their compatibility with the body, minimal harm to healthy cells, and easy extraction from natural sources. These natural compounds and their derivatives hold promise for cancer therapy, boasting diverse structural and pharmacological characteristics. Additionally, chemical modifications can enhance their anticancer properties. This review explores the anticancer potential of terpenoids, flavonoids, alkaloids, xanthones, and epoxides, as well as elucidates their molecular mechanisms, such as their antiproliferative, apoptotic, antiangiogenic, and antimetastatic actions. Furthermore, the effect of the functional group on the anticancer activity through the structure-activity relationship will be discussed in detail, supported by molecular docking and molecular dynamic simulations. Combining experimental in vitro and in vivo assays with computational in silico assays significantly helps us understand how we shall fight cancer diseases in the modern era.
A Ride on The Current State of Silver Nanoparticles in Health: What is The Next Stop? Adrián Gil-Korilis; Jorge Ergui-Arbizu
Bioactivities Vol. 2 No. 2 (2024): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.223

Abstract

Silver nanoparticles (AgNPs) are known for their broad scientific and technological applications, among which those related to their bioactivity stand out the most. Its antimicrobial, antioxidant, anti-inflammatory, anti-obesity, antifouling, and biosorption properties have been widely studied and analyzed. Furthermore, numerous strategies are being investigated to overcome the main limitation of AgNPs, their cytotoxicity, such as the development of green chemistry synthesis methods using plant extracts or the use of support materials for controlled release of nanoparticles. However, the methodologies currently used in this line of research limit these nanomaterials from eventually being used in the clinic. It is necessary to implement animal models and interdisciplinary collaboration with biomedical research groups to develop therapies based on AgNPs that may be able to have an impact on the health of patients.
Extraction, Characterization, and Encapsulation of Cinnamon Hydrosol Obtained via Microwave-Assisted Hydrodistillation: Analysis of Antioxidant and Antimicrobial Activities Bruno Estela; Campañone Laura Analía
Bioactivities Vol. 2 No. 2 (2024): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.229

Abstract

Microwave-assisted hydrodistillation (MAHD) method was employed to extract cinnamon oil and hydrosol (a byproduct). The total polyphenol content (TPC) of the cinnamon hydrosol (CH) was determined using the Folin-Ciocalteu method, and its antioxidant power was assessed through the DPPH radical reduction method. Gas chromatography was utilized to quantify the main bioactive compound (cinnamaldehyde). The disc agar diffusion method was applied to evaluate the inhibition of pathogenic microorganisms. To protect the bioactive compound, an encapsulation method involving cross-linking with calcium alginate was utilized. The capsules were examined using environmental scanning electron microscopy (ESEM). The TPC content was found to be 15.63 ± 0.21 mg gallic acid/g dry matter, and the DPPH radical inhibition rate was 84.26 ± 1.35%. CH exhibited a significant inhibitory effect against Escherichia coli, and a moderate inhibition effect against Shigella flexneri, Salmonella spp., Salmonella typhimurium, and Escherichia coli EPEC. Finally, successful encapsulation of CH was achieved using sodium alginate, resulting in bead sizes ranging between 1.75 and 2.75 mm.
Evaluation of Antagonistic Activity of Endophytic Bacteria from Dayak Onion Against Ganoderma boninense Desiana Sinta; Norwahyunie Norwahyunie; Noraini Noraini; Zulviana Zulviana; Frans Grovy Naibaho; Vinsen Willi Wardhana; Desimaria Panjaitan; Adrian Hartanto
Bioactivities Vol. 2 No. 2 (2024): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.239

Abstract

Basal stem rot (BSR) is one of the key contributors to the decline in palm oil production in Indonesia. BSR is caused by the pathogenic plant fungus Ganoderma boninense. Currently, the control of G. boninense growth relies on systemic fungicides. However, systemic fungicides have negative impacts as they can harm natural soil microorganisms. Biocontrol agents present an environmentally friendly alternative for G. boninense management. The objective of this research was to select and identify endophytic bacterial isolates from Dayak onion [Eleutherine bulbosa (Mill.) Urb.] with antagonistic activity against G. boninense. The investigation was initiated with the isolation of 34 endophytic bacterial isolates and G. boninense isolate. The hemolytic capabilities of endophytic bacterial isolates were evaluated on blood agar media. Antagonism assessments were conducted through the dual-culture method, and the inhibition of G. boninense was measured using the percentage inhibition of radial growth (PIRG). The endophytic bacteria exhibiting the highest PIRG values were identified through molecular analysis based on the 16S rRNA gene sequence. Results revealed that 27 isolates demonstrated no ability to hydrolyze blood agar (gamma hemolysis) indicating no pathogenicity. Isolate CED9 demonstrated the highest PIRG value at 70.26%. Genomic identification based on the 16S rRNA gene sequence confirmed that isolate CED9 was classified as Bacillus subtilis. The identification of biocontrol agents from Dayak onion represents valuable information and a potential arsenal for future strategies in mitigating (BSR) disease.
Effect of The Garlic as Chelation Therapy in Reducing Lead and Cadmium Deposition on Suckling Mice Bidyut Das; Md. Anwar Hossain; Md. Siddiqul Islam; Md. Aktaruzzaman Zullhash; Md. Mowdudul Hasan Talha; Shahab Uddin Munna; Dwija Sutradhar; Ahasan Ullah Khan
Bioactivities Vol. 2 No. 2 (2024): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.240

Abstract

The study was conducted on suckling mice to determine the effects of chelation therapy in reducing the deposition of lead (Pb) and cadmium (Cd). A total of 45 suckling mice were randomly divided into three main groups A (control), B, and C. Groups B and C contained Pb and Cd, respectively, at a concentration of 100 mg/kg bwt with 0, 1.70, 3.35, and 6.70% garlic given (B1, B2, B3, B4, and C1, C2, C3, C4). Mice exposed to Pb and Cd exhibited pronounced toxic symptoms along with a marked decrease in total erythrocyte and total leukocyte count, hemoglobin levels, and packed cell volume. Additionally, there is a significant increase in serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) levels. The mean body weight of mice of groups B4, and C4 was the highest among the treated groups. Groups B1 and C1, exposed to Pb and Cd without garlic, showed significant declines in all parameters. Group A (control) shows stable and normal SGOT and SGPT levels. Group C1, exposed to Cd without garlic, experiences the highest increases in both SGOT (98.53 U/L) and SGPT (132.83 U/L), indicating severe liver damage. The group treated with Pb and Cd showed a significant reduction in total erythrocyte count, packed cell volume, and hemoglobin levels after 42-d of treatment. However, mice treated with a combination of Pb, Cd, and 6.70% garlic exhibited nearly normal levels of hematological and biochemical parameters. SGPT and SGOT levels were significantly decreased in all treated groups along with garlic. This experiment demonstrates that garlic possesses both protective and curative effects against Pb and Cd toxicity.

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