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Hardyanto Soebono
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INDONESIA
Indonesian Journal of Biomedicine and Clinical Sciences
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 30323134     DOI : https://doi.org/10.22146/inajbcs.v56i01.11961
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
Indonesian Journal of Biomedicine and Clinical Sciences (InaJBCS) aims to promote the translational of basic research into clinical studies and of clinical evidence into practice. InaJBCS publishes studies that substantially enhance our standing of disease etiology and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments. InaJBCS invites authors to submit articles in the fields of biomedical sciences including biomedical genetics, bioinformatics, cardiovascular medicine, endocrinology, gastroenterology, geriatrics, infectious diseases, medical oncology, physiology, pharmacology and toxicology, and phytomedicine medicine.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol 57 No 1 (2025)" : 15 Documents clear
Misdiagnosed in double primary tumors: a case report Daru Cahayadi, Sigit; Mitchel
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.11877

Abstract

Multiple primary malignancies (MPM) refer to the presence of two or more malignant tumors that are unrelated to each other in the same individual. Double primary malignancies that occurred in the lungs and extremities were relatively rare. We present a case of lung adenocarcinoma as pseudo-lung metastasis and pleomorphic liposarcoma on the extremity. A 62 yo male chronic smoker came with a referral from another hospital with a growing mass on his thigh and some imaging that showed pulmonary metastasis. The patient underwent a transbronchial lung biopsy and wide excision for a tumor on his thigh. However, histopathological examination revealed that both malignancies originated from different cells or as primary malignant. At 8 wk post-surgery, positron emission tomography (PET) scan was performed to rule out residual pleomorphic liposarcoma or any metastasis and the result showed no residual or metastasis. We suggest that the management of MPM be more careful and disciplined, as an error in choosing a diagnosis method might harm or worsen the patient’s condition. In the case of multiple malignancies, particularly in organs with frequent metastasis sites, it is important to consider the possibility of MPM. The diagnosis and management strategy of double primary tumors was expected to provide important information for clinicians.
Cryotherapy and balloon dilatation for subglottic stenosis in a neonate: a case report Siswanto, Johanes Edy; Akira Prayudijanto; Muhammad I. Prayudijanto; David D. Putra; Istifa Amalia; Rifan Fauzie; Christophorus AS Pamungkas
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.12718

Abstract

Cryotherapy and balloon dilatation are combined treatments for subglottic stenosis (SGS) in newborns. Cryotherapy involves freezing the affected area with extremely low temperatures, which can result in tissue destruction. Balloon dilatation is a technique in which a balloon is inflated in the narrow subglottic area to widen the airway. We reported a case of SGS in a neonate who was treated with a combination of cryotherapy and balloon dilatation to contribute to the growing body of evidence of the therapy and provide information for clinicians in the care of the vulnerable patients. A 22-day-old female baby, who weighed 2,600 gr at birth, was transferred to our hospital from another facility. We conducted cryotherapy on the granulation tissue area until it was released, then inflated the balloon for 5 cycles (30 sec each) with a pressure of 5-6 atm. After cryotherapy and balloon dilatation, the patient was examined using direct laryngoscopy, which revealed subglottic stenosis up to 9.5 cm from the outer border of the mouth. To maintain airway patency for the next 24 hr, the patient was intubated with an endotracheal tube number 3.5. The patient's condition improved after this intervention, and they no longer required oxygen therapy support. The patient was discharged without the need for supported oxygen. In conclusion, to manage the challenges associated with post-intubation subglottic stenosis (PI-SGS), a comprehensive approach that includes a reliable referral system, thorough bronchoscopy training, and a multi-disciplinary team is essential.
Preoperative and intraoperative predictive factors affecting to the time interval of stoma closure in patients at Dr. Sardjito General Hospital, Yogyakarta in 2018-2023 Pajar Sigit Nugroho; Adeodatus Yuda Handaya; Anis Fuad
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.14158

Abstract

Ostomy procedures, frequently indicated for malignancies, significantly impact patient well-being. In certain instances, stoma closure becomes imperative. Despite the lack of consensus regarding the optimal timeframe for temporary stoma closure, this study aimed to delineate predictors associated with the closure timing, thereby enhancing prognostic precision and augmenting patient care strategies. A cross-sectional study was conducted at Dr. Sardjito General Hospital, Yogyakarta, analyzing medical records of patients who underwent primary stoma creation and subsequent closure between January 2018 and December 2023. Factors, including preoperative, disease-related, and intraoperative variables, were analyzed using SPSS version 26.0. Bivariate and multivariate analyses were performed to identify predictors for stoma closure duration. In the colostomy group, body mass index (BMI), underlying disease, and complications were significantly associated with duration of stoma closure by bivariate analysis (p=0.016; 0.036; 0.040), and BMI and hemoglobin level associated with duration of closure by multivariate analysis (p=0.010; 0.044). Increasing BMI, disease stage, chemotherapy use, complications, and lower hemoglobin level predicted a longer closure duration, while chemotherapy reduced the risk. In the ileostomy group, factors such as underlying disease, cancer stage, chemotherapy status, complications, and type of surgery were associated with duration of closure by bivariate analysis (p=0.010; 0.024; 0.002; 0.013; 0.034), with complications associated with duration of closure by multivariate analysis (p=0.008). In conclusion, BMI, underlying diseases, and complications are associated with stoma closure duration. Understanding these factors can aid in risk stratification and optimizing patient management strategies during stoma closure surgeries.
Urethroscopy evacuation of glue stick polyembolokoilomania: a case report Sabudi, I Made Nugraha Gunamanta; Irzan, Muhammad Anwar; Ghinorawa, Tanaya
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.17134

Abstract

Insertion of a foreign body is an uncommon case in the urology emergency. It was reported one of the abnormal habits called polyemobolokoilomania, which involves inserting strange things into the self-body orifice, especially the urethra in the urological case. A male 56 yo came with a history of inserting a glue stick on his external urethral orifice and complained of dysuria. By physical examination, palpated solid things 6 cm from the external urethral orifice. The patient then planned to undergo urethroscopy and found the glue stick along 27 cm. Urethroscopy successfully evacuated the whole glue stick, and a silicone catheter 18 Fr was applied to monitor the urine. The next 2 wk, the indwelling catheter was removed, and the patient could normally urinate. Glue stick insertion is one of the things that is commonly inserted by polyembolokoilomania, or the act of insertion a foreign body into a human orifice. Psychological and psychiatric aspects also need to be evaluated, because the patient could have mental health issues that need to be treated to prevent recurrent habits in the future. Physical examination of foreign bodies could be found when palpated along the penis. Further diagnostic tools like BNO could be conducted if there was no clear information from history taking (patient dishonest or unable to communicate) and in doubt by physical examination. The approach to evacuation could be varied, it could be evacuated by a milking procedure, endourology using a urethroscope, or open surgery. Insertion of strange things or polyembolokoilomania was an uncommon case in a urology emergency setting. The treatment focuses on evacuating the foreign body, and the patient can urinate normally. Psychological and psychiatric aspects also need to be followed up to prevent recurrent habits as a risk factor for repeated cases.
Risk factors for type 2 diabetes mellitus in adolescents: a systematic review and meta-analysis Metta Lestari Utami; Welly Rustanto; Lucia Pudyastuti Retnaningtyas; Maria Goretti Marianti Purwanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.20298

Abstract

The prevalence of type 2 diabetes mellitus (T2DM) in adolescents worldwide has increased over the last three decades. Several clinical studies concerning risk factors for T2DM in adolescents were reported, however, the results varied and no systematic review of the studies are reported. This study aimed to systematically review the risk factors for T2DM in adolescents. Publications in English about adolescent with T2DM aged 10-19 yr and coexisting risk factors were searched in Medline and Cochrane. This systematic review and meta-analysis were in-line with MOOSE guidelines. Each publication was assessed the titles, abstracts, and full text, and then extracted the data, and assessed the risk of bias and evidence quality were conducted by 2 independent reviewer. Seven studies involving 52,779 adolescents were included in this review. Meta-analysis using a fixed effect model with the inverse variance method was conducted to calculate the odds ratio with 95% confidence intervals. Adolescents who smoke both actively and passively were at risk of 2.88 times (pooled OR 2.88; 95% CI 1.99-4.17; I² = 61%), the male gender was at risk of 1.31 times (pooled OR 1.31; 95% CI 1.09-1.57; I² = 0%), having parents with a history of T2DM was at risk of 2.48 times (pooled OR 2.48; 95% CI 1.83-3.36; I² = 82%), obesity was at risk of 1.28 times (pooled OR 1.28; 95% CI 1.15-1.43; I² = 57%), and hypertension was 1.14 times more likely to get T2DM than those who did not have risk factors. Hypercholesterolemia was not a risk factor for T2DM (pooled OR 1.00; 95% CI 0.95-1.05; I² = 0%). In conclusion, the main risk factor for T2DM in adolescents is smoking, followed by parental T2DM, male gender, obesity, and hypertension.

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