cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Hardyanto Soebono
Contact Email
hardyanto@ugm.ac.id
Phone
+62274-560300
Journal Mail Official
jmedscie@ugm.ac.id
Editorial Address
Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Farmako Street, Sekip Utara ,Yogyakarta 55281 Indonesia
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Indonesian Journal of Biomedicine and Clinical Sciences
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 30323134     DOI : https://doi.org/10.22146/inajbcs.v56i01.11961
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
Indonesian Journal of Biomedicine and Clinical Sciences (InaJBCS) aims to promote the translational of basic research into clinical studies and of clinical evidence into practice. InaJBCS publishes studies that substantially enhance our standing of disease etiology and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments. InaJBCS invites authors to submit articles in the fields of biomedical sciences including biomedical genetics, bioinformatics, cardiovascular medicine, endocrinology, gastroenterology, geriatrics, infectious diseases, medical oncology, physiology, pharmacology and toxicology, and phytomedicine medicine.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "vol 58 no 3 (2026)" : 7 Documents clear
The association between PD-L1 expression and the survival rate of patients with undifferentiated nasopharyngeal carcinoma Indrawati; Auliya Suluk Brilliant Sumpono; Vivin Febriani; Kartika Widyawati Taroeno-Hariadi; Sagung Rai Indrasari; Camelia Herdini; Rheza Gandi Bawono; Ery Kus Dwianingsih
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.19542

Abstract

Programmed cell death ligand-1 (PD-L1) plays a key role in tumor immune evasion. However, its prognostic significance in nasopharyngeal carcinoma (NPC) remains unclear. This study evaluated the association between PD-L1 expression and clinicopathological features and survival outcomes in patients with NPC. We conducted a retrospective analysis of 80 patients diagnosed with non-keratinizing undifferentiated NPC between 2015 and 2019. PD-L1 expression was assessed by immunohistochemistry using the 22C3 antibody and quantified as the tumor proportion score. Associations with clinicopathological variables were analyzed, and overall survival was evaluated using Kaplan–Meier and Cox regression analysis. PD-L1 expression was negative in 72.5% of cases, positive in 18.8% of cases, and strongly positive in 8.7% of cases. PD-L1 expression was not significantly associated with age, sex, disease stage, treatment modality, or overall survival (HR 1.71; p = 0.494). PD-L1 expression on tumor cells was not associated with clinicopathological characteristics or survival in non-keratinizing undifferentiated NPC. These findings suggest that PD-L1 alone is not a reliable prognostic biomarker for this NPC subtype, highlighting the need for integrated immune and molecular analyses in future studies.
Clinical profile, manifestation, and treatment of dermatophytosis patients at Ngoerah Hospital Bali in 2021-2023 Kevin Jonathan Djuanda; I.G.A.A. Dwi Karmila; Kevin Jonathan Djuanda
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.27749

Abstract

Dermatophytosis is a common superficial fungal infection of keratinized tissues, caused by the fungal family of Microsporum, Epidermophyton, and Trichophyton. It is highly prevalent in tropical regions due to favorable environmental conditions. Local hospital-based data are still needed to describe the clinical pattern of dermatophytosis in Bali. This study aimed to describe the clinical profile, manifestations, laboratory findings, and treatment of dermatophytosis patients treated at the Dermatology and Venereology Outpatient Clinic of Ngoerah Hospital Bali. This descriptive observational study utilized a cross-sectional retrospective design, analyzing medical records of dermatophytosis patients treated since January 2021 to December 2023, and the data were analyzed descriptively. A total of 135 patients were included, with a mean patient age of 30.4 ± 17.5 years old (range 1–73 years old), most cases occurring in females (53.3%), students (35.6%), and showed high prevalence in the 25-44 age group. The majority of patients live in private residences (57%) with the primary transmission route being intrafamilial contact (39.3%). Based on 153 clinical presentations, the most frequent type was tinea corporis (39.2%), followed by tinea cruris (19.0%), tinea unguium (19.0%), and tinea capitis (18.3%). The potassium hydroxide (KOH) examination was documented in 124 patients and fungal culture results were available in 99 patients. Dermatophytosis remains a significant health concern, with tinea corporis as the predominant type in our study. Antifungal systemic and topical treatment were used in this study. Awareness and early diagnosis are essential for effective disease control.
Brief cognitive behavioral therapy for chronic insomnia in a primary care setting: a case report Dellma Anggini; Mualimin
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.28287

Abstract

Chronic insomnia with anxiety disorders is a common non-specialist mental health condition frequently encountered in primary care. Although the WHO Mental Health Gap Action Programme (mhGAP) recommends psychosocial interventions at this level, skepticism persists regarding the feasibility of implementing brief psychotherapy within the high-volume workflow of Indonesian community health centers. This case report aims to illustrate the clinical application and operational feasibility of Brief Cognitive Behavioral Therapy (BCBT) in a primary health center setting. We report a 40-year-old female with chronic insomnia accompanied by somatic symptoms, including palpitations and tachycardia, without underlying medical comorbidities. The patient exhibited significant cognitive distortion in the form of sleep state misperception. As the primary treatment modality, a four-session BCBT intervention was conducted every two weeks (30–45 minutes per session). The curriculum included autonomic, behavioral, and cognitive (ABC) model psychoeducation, cognitive restructuring, scheduled worry period, behavioral activation, relaxation, lifestyle modification, and relapse prevention. Evaluation was performed using the insomnia severity index (ISI), subjective units of distress scale (SUDS), and collaborative patient-reported outcome measures (PROM) encompassing three domains: sleep duration, frequency, and anxiety levels. The collaborative goal setting (CGS) of at least 5 hours of sleep, 5 days a week without anxiety, was fully achieved by the third session and remained stable until thereafter. This case illustrates that structured psychotherapy such as BCBT is potentially feasible within a busy PHC workflow, provided there is institutional commitment from facility leadership, a dedicated psychotherapy schedule for trained mental health providers at least once a week, and functional early detection within general outpatient services. While these results are promising for this individual case, further studies are needed to evaluate the scalability and standardized implementation of this model across diverse primary care settings in Indonesia.
The relationship between psychological stress, salivary cortisol levels, and psoriasis severity Nyoman Suryawati; Ketut Kwartantaya Winaya; I Gusti Ayu Agung Praharsini; I Nyoman Wande
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.29208

Abstract

Psychological stress has been associated with psoriasis, possibly through neuroendocrine pathways involving the hypothalamic-pituitary-adrenal axis. However, evidence on salivary cortisol levels in psoriasis vulgaris remains inconsistent, and data from Indonesian populations remain limited. This analytical cross-sectional study was conducted at Ngoerah Hospital, Bali, Indonesia, from July to October 2024. The study included 44 patients with psoriasis vulgaris and 41 non-psoriasis controls. Psychological stress was assessed using the Perceived Stress Scale; psoriasis severity was evaluated using the Psoriasis Area and Severity Index; and salivary cortisol levels were measured using an enzyme-linked immunosorbent assay. Between-group comparisons and correlation analyses were performed to evaluate the relationship between psychological stress, salivary cortisol levels, and psoriasis severity. Psychological stress scores and salivary cortisol levels did not differ significantly between the psoriasis and non-psoriasis groups. In the psoriasis group, salivary cortisol levels were not correlated with psychological stress. However, salivary cortisol levels showed a weak negative correlation with psoriasis severity, as measured by the PASI score (r=-0.33; p=0.03). This study found no significant correlation between salivary cortisol levels and psychological stress, but revealed a weak negative correlation between salivary cortisol levels and psoriasis severity.
Squamous cell carcinoma of the tongue in an elderly female: a case report Ardisa Pramudita; Inges Prawita Sari; Gina Niscita Amisesani; Hanggoro Tri Rinonce; Fajar Waskito; Dyah Ayu Mira Oktarina
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.29082

Abstract

Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of oral malignancies and most frequently involves the mobile tongue, where it is associated with substantial functional impairment and mortality. Although OSCC is classically associated with tobacco and alcohol exposure, it may also occur in patients without a history of active smoking or alcohol use. We report a case of HPV DNA-negative, well-differentiated invasive squamous cell carcinoma of the ventrolateral mobile tongue in a 72-year-old woman. The patient presented with a three-month history of a progressively enlarging tongue lesion accompanied by pain, difficulty eating, and unintentional weight loss. She denied active smoking, alcohol consumption, and betel quid use but reported passive exposure to tobacco smoke. Clinical examination revealed an exophytic erythroleukoplakic lesion involving the ventrolateral tongue, along with multiple missing teeth and untreated dental caries. Histopathological examination of a punch biopsy demonstrated invasive nests of malignant squamous epithelial cells with keratin pearl formation, prominent intercellular bridges, and invasion into the underlying connective tissue and muscle, consistent with well-differentiated HPV-negative squamous cell carcinoma.. Following multidisciplinary evaluation, the patient underwent induction TPF chemotherapy (docetaxel, cisplatin, and fluorouracil), followed by hemiglossectomy with modified radical neck dissection and adjuvant radiotherapy. This case highlights that persistent lesions of the mobile tongue in elderly patients warrant careful evaluation, even in the absence of active smoking and alcohol use history. Early biopsy, thorough histopathological assessment, and multidisciplinary management are essential for timely diagnosis and appropriate treatment planning.
The association between risk factors and the occurrence of retinopathy of prematurity in premature infants: An exploratory study Vera Sumual; Anugrah Handini Masloman; Salam Surbakti; Angelina Patricia Chandra
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.25650

Abstract

Retinopathy of prematurity (ROP) remains a leading cause of preventable childhood blindness. Although gestational age and birth weight are well-established risk factors, the contribution of other clinical factors may vary across settings, particularly in low-and-middle-income countries such as Indonesia. The study aimed to evaluate risk factors associated with the incidence of retinopathy of prematurity, including gestational age, birth weight, duration of oxygen therapy, and infection, in a tertiary-care hospital in Indonesia. This retrospective study reviewed medical records of premature infants with and without ROP at Prof Dr. RD Kandou General Hospital, Manado, Indonesia. Eligible infants underwent initial ophthalmologic examination at or before 1 years old. Data collected included sex, gestational age, birth weight, duration of oxygen therapy, presence of infection or sepsis, and ROP status. Associations were evaluated using Chi-square tests and bivariate logistic regression to estimate crude odds ratios (ORs). Multivariable logistic regression analysis was performed to adjust for potential confounding, with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) reported. Multivariable results were interpreted as exploratory due to the limited number of ROP cases. A total of 51 infants were included, of whom 14 (27.5%) developed ROP. Lower gestational age (≤34 weeks), lower birth weight (≤1500 grams), and oxygen therapy duration ≥1 weeks were significantly associated with ROP in bivariate analyses. After multivariable adjustment, none of the variables remained statistically significant, although the direction of association persisted for gestational age, birth weight, and oxygen therapy. Infection or sepsis was not significantly associated with ROP. In conclusion, lower gestational age, lower birth weight, and prolonged oxygen therapy are associated with an increased incidence of ROP in this cohort. These findings emphasize the importance of targeted screening and careful oxygen management in premature infants. Larger prospective multicenter studies are needed to clarify independent risk factors for ROP in Indonesia.
Methotrexate therapy in generalized pustular psoriasis: a report of two cases: Clinical Characteristics and Treatment Outcomes of Methotrexate Therapy Rizka Fauziyah; Hardyanto Soebono; Sri Awalia Febriana
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.29384

Abstract

Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease associated with systemic complications and significant morbidity. Management remains challenging because of the lack of standardized treatment protocols. Methotrexate is a conventional systemic therapy for psoriasis; however, evidence regarding structured pulse-dose regimens for GPP is limited. We report two adult patients with generalized pustular psoriasis managed at the Dermatology and Venereology Clinic of Sardjito General Hospital, Yogyakarta. Diagnosis was established through clinical evaluation, laboratory examination, and histopathological assessment. Both patients received weekly pulse-dose methotrexate injections (50 mg) for six cycles, with serial clinical monitoring using the Generalized Pustular Psoriasis Area and Severity Index (GPPASI). Both patients demonstrated marked clinical improvement following treatment. GPPASI scores decreased significantly after six cycles of therapy, accompanied by an improvement in laboratory inflammatory parameters, without significant hepatic or renal impairment. This report highlights the use of structured pulse-dose methotrexate therapy with serial GPPASI monitoring in adult patients with generalized pustular psoriasis managed in a resource-limited setting. Significant clinical improvement was observed after six cycles of therapy. Further studies are required to evaluate its long-term efficacy and safety.

Page 1 of 1 | Total Record : 7

 1 

Filter by Year

2026 2026


Reset
Filter By Issues
All Issue Vol 58 No 3 (2026) Vol 58 No 2 (2026) Vol 58 No 1 (2026) Vol 57 No 4 (2025) Vol 57 No 3 (2025) Vol 57 No 2 (2025) Vol 57 No 1 (2025) Vol 56 No 01 (2024) Vol 56 No 4 (2024) Vol 56 No 3 (2024) Vol 56 No 2 (2024) More Issue