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Deka in Medicine
Published by PT. DEKA RESEARCH GROUP
ISSN : 30472024     EISSN : 30472024     DOI : https://doi.org/10.69863
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Deka in Medicine is the open-access journal of Deka Institute (PT. Deka Research Group), which is established to support open access and knowledge sharing among medical scientists. The journal publishes three highly informative issues every year (in April, August, and December) at the appropriate intervals to circulate research findings properly throughout the year. As a beacon of high standards in academics, Deka in Medicine observes very stringent measures in peer reviewing and kindly welcomes the contributions of world scholars and researchers with open arms. The journal aims to promote knowledge by being disseminated across the globe in English and further advocates for a platform that would enable scholars and researchers to carry on scientific discussion and collaboration within the discipline. The key objective of this journal is to serve as a medium through which clinical and basic research can be promoted in the varied medical sciences. The journal was noted for its broad material cover, embracing topics in different areas under the dominion of medical sciences—from clinical and basic medical sciences to medicine and applied medical sciences. It is through such comprehensive coverage that the journal hopes to provide an integrated view of the dynamic complexities within the sphere of medical sciences, from which the spread of new insights and innovations in clinical practices, research methodologies, and therapeutic interventions may emanate. It additionally aims to contribute to the development and improvement of medical knowledge and practices around the world. To address the wide range of interests of clinical practitioners and researchers, it is a leading forum whereby different scholars, intellectuals, and practitioners from diverse regions across the globe present their academic perspectives and research activities. These are intended to foster mutual intellectual interchange internationally, open up educational opportunities, and initiate collaborations. Deka in Medicine publishes diversified scholarly contributions, ranging from original research articles, review articles, brief reports, case studies, and case series elucidating enlightening editorial reports, and commentaries. The breadth of publication by the journal is an attempt to be more than just a vehicle for the dissemination of the latest research but aims to be a channel that allows for scholarly exchange, facilitates the distribution of knowledge, and advances medical sciences.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Vol. 1 No. 3 (2024): December 2024" : 6 Documents clear
A complex case of severe thrombocytopenia in systemic lupus erythematosus complicated by Corynebacterium spp. infection Akbar, Muhamad; Kalim, Handono
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e472

Abstract

BACKGROUND: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease the course of which is still indefinite. Thrombocytopenia concurrent with Corynebacterium spp.—an infrequent complication in SLE patients—is seldom reported. CASE A 34-year-old female was admitted for continuous bleeding from the gums that had been ongoing for three days. The patient had been suffering from SLE since 2018 and took immunosuppressive medication regularly. The anemia, lymphocytopenia, and severe thrombocytopenia were shown in her laboratory tests. Besides, the infection of Corynebacterium spp. was detected in the patient. In fact, hematologic abnormalities and infections in SLE patients usually mutually overlap for the reason that these conditions possess the potential to influence each other. Infection can be both the cause and result of hematologic abnormalities in SLE. Thus, the pathophysiology of hematologic abnormalities in SLE patients can often be related to the use of immunosuppressive drugs. However, some theories suppose that increased SLE activity correlates with infection occurrence in SLE—even without the use of immunosuppressive drugs. CONCLUSION Thrombocytopenia and Corynebacterium spp. infection in SLE patients is a case rarely reported, and establishing the diagnosis requires detailed examination.
Comparative performance of prognostic models in predicting mortality in cirrhotic patients with spontaneous bacterial peritonitis Rizqiansyah, Chrisandy; Supriono, Supriono
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e445

Abstract

BACKGROUND: Prognostic models are widely used to predict mortality and management outcomes in liver cirrhosis patients with spontaneous bacterial peritonitis (SBP). However, it remains unclear whether these prognostic models can be applied to SBP. OBJECTIVES: To determine the predictive value of prognostic models, including Child-Turcotte-Pugh (CTP), Model for End-stage Liver Disease score- Sodium (MELD-Na), Albumin to Bilirubin (ALBI), and Neutrophil-to-Lymphocyte Ratio (NLR) in cirrhotic patients with SBP. METHODS: Seventy-four hospitalized cirrhotic patients with SBP were selected. Diagnosis was based on clinical, biochemical, ultrasonographic, and ascitic fluid analysis. CTP, MELD-Na, ALBI, and NLR scores at admission were calculated. The area under the ROC curve (AUC) was used to measure accuracy. Sensitivity and specificity were calculated for the optimal cut-off points. RESULTS: Our results revealed that patients who died had higher scores in NLR (MD: 7.51; 95% CI: 1.46–13.56; p: 0.0150), MELD-Na (MD: 10.09; 95% CI: 6.91–13.27; p: 0.0000), CTP (MD: 2.57; 95% CI: 1.82–3.32; p: 0.0000), and ALBI (MD: 0.47; 95% CI: 0.22–0.73; p: 0.0000) compared to survivors. Among these scores, the highest AUC in univariate logistic regression analysis were CTP, MELD-Na, NLR, and ALBI with 0.87, 0.82, 0.73, and 0.72, respectively. CONCLUSION: The combination of CTP and MELD-Na scores was superior to ALBI and NLR prognostic models. These can be used to assess liver function and prognosis in cirrhotic patients with SBP.
Acute liver failure caused by paracetamol intoxication in a severely depressed patient with suicidal intent: A case report Pratama, Erdilian; Rosandy, Milanitalia
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e470

Abstract

BACKGROUND: Paracetamol poisoning has extensive implications, and one of the most dangerous is the involvement of liver dysfunction. Such cases are rare but require comprehensive evaluation and management. CASE: A 19-year-old female presented to the Emergency Department (ED) with nausea, vomiting, and epigastric pain after ingesting 20 grams of paracetamol with alcohol in a suicide attempt. Her history revealed severe depression with symptoms of anhedonia, anergy, and self-harming behavior. Laboratory results showed elevated liver enzymes and prolonged coagulation time, though other organ functions were normal. She was diagnosed with acute liver failure due to paracetamol intoxication and was treated with N-acetylcysteine (NAC), omeprazole, ondansetron, vitamin K, and psychiatric counseling. After seven days of hospitalization, her clinical condition improved, with plans for outpatient follow-up and prescribed medications. CONCLUSION: This case highlights the importance of addressing adolescent mental health and providing education on the dangers of drug overdose, along with access to psychological support to prevent self-harm.
Case report: Therapeutic approach to secondary polycythemia vera in an adult with eisenmenger syndrome Lil Alamin, Rahmatan; Raharjo, Fajar; Gunawan, Michelle; Wardhani, Shinta
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e433

Abstract

BACKGROUND: Secondary Polycythemia Vera due to Eisenmenger Syndrome remains a big challenge, and the reported cases regarding this condition are still scanty. CASE: This was a case of a 22-year-old girl who, since childhood, had complaints of fatigue most of the time and thus showed more intolerance to heavy physical work. She had a history of a congenital heart defect, with lip and finger cyanosis that increased upon fatigue, and she had undergone Bi-directional Cavo-pulmonary Shunt. Physical examination showed cyanosis with clubbing of fingers with low oxygen saturation. Further diagnosis testing revealed this was a case of Eisenmenger Syndrome due to congenital heart abnormalities, with Polycythemia Vera: Secondary to the diagnosis. The patient also had a hemoglobin level of 21.1g/dL and a hematocrit level of 64.2%. Based on the diagnosis, treatment was given in the form of hydration therapy along with medications. Additionally, phlebotomy was performed. Because the patient improved clinically from the applied treatment, the patient was discharged after 5 days. CONCLUSION: Early diagnosis, a multidisciplinary approach, and proper interventions are important in the management of Eisenmenger Syndrome and associated Polycythemia Vera to avoid complications and hence improve outcomes.
From joint to heart: Cardiovascular implications of rheumatoid arthritis Raharjo, Fajar; Anjarwani, Setyasih
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e361

Abstract

Rheumatoid arthritis is a commonly encountered autoimmune disease and a progressive chronic inflammatory condition that often leads to permanent joint damage. Systemic inflammation in rheumatoid arthritis is linked to various comorbid conditions such as interstitial lung disease, osteoporosis, metabolic syndrome, cardiovascular disease, infections, malignancies, cognitive dysfunction, depression, and fatigue, which can increase morbidity and mortality in rheumatoid arthritis patients. Approximately 36% of patients report worse health and limitations in daily activities, while nearly 30% require more assistance with personal care compared to individuals without rheumatoid arthritis. Epidemiological data from 1990 to 2017 show an incidence of rheumatoid arthritis of 246.6 per 100,000 people aged 33-54 years, with prevalence in women 2-3 times higher. In Southeast Asia, the incidence is 89 per 100,000 in individuals aged 13-22 years, while in Indonesia, it is estimated at around 5-7.5 per 100,000 population. Cardiovascular disease is the primary cause of mortality in rheumatoid arthritis patients, with myocardial infarction being the major contributor. The pathogenesis of rheumatoid arthritis is still complex and involves immunological processes that occur long before joint inflammation symptoms appear, including genetic modifications and environmental factors that lead to deimination and joint disturbances. Cardiovascular manifestations, particularly myocardial infarction, occur due to an atherosclerotic process triggered by rheumatoid antibody complexes. Given the higher cardiovascular risk in rheumatoid arthritis patients, early detection and awareness of these manifestations are crucial for better management.
Right ventricular strain: Cardiovascular challenges in pulmonary diseases Rahmianti, Nia; Vendarani, Yoni; Maulidiyah, Novita
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e359

Abstract

Right heart failure is associated with a poor prognosis, and right ventricular (RV) strain, assessed through echocardiography, is a valuable method for evaluating right heart function. However, discussions on this topic remain limited. This article explores RV strain induced by pulmonary diseases to increase awareness of how these conditions can exacerbate right heart failure. Pulmonary embolism leads to increased RV afterload, resulting in RV dilation and ischemia, which can progress to cardiogenic shock. Echocardiography is effective in detecting RV strain and assessing the severity of pulmonary embolism. In Chronic Obstructive Pulmonary Disease (COPD), increased pulmonary vascular resistance causes RV dysfunction, identifiable through speckle-tracking echocardiography (STE). Pulmonary fibrosis may contribute to right heart failure through pulmonary hypertension. RV Longitudinal Strain (RVLS) is an important prognostic marker in patients with pulmonary hypertension and COVID-19, where low RVLS (≤20.5%) is associated with higher mortality. In conclusion, right heart failure carries a poor prognosis, and RV strain evaluation using STE is a useful tool for early detection. Pulmonary diseases, including COPD, pulmonary embolism, pulmonary fibrosis, pulmonary hypertension, and COVID-19, can induce RV strain, which is critical for assessing prognosis and guiding disease management.

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