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Dwi Endah Kusumawati
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INDONESIA
Indonesian Journal of Medical and Pharmaceutical Science
Published by Universitas Islam Sultan Agung
ISSN : -     EISSN : 28096576     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
This journal accepts and publishes academic articles focusing on theory, methods, and applications in: 1) Pharmaceutical science 2) Biomedical science 3) Herbal medicine 4) Clinical pharmacy 5) Drug discovery
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 2 Documents
 1 
Search results for , issue "Vol. 5 No. 1 (2026)" : 2 Documents clear
Aktivitas Peredaman Radikal ABTS (2,2'-azino-bis(3 - ethylbenzothiazoline-6-sulfonic acid)) oleh Ekstrak Etanol Kulit Nanas Madu (Ananas comosus L.Merr) Kusumawati, Dwi Endah; Chaqi, Muhammad Dhiya’ul
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.572

Abstract

Background: Free radicals trigger various degenerative diseases, making the exploration of natural antioxidants essential. Honey pineapple (Ananas comosus L.) peel, often considered agricultural waste, contains bioactive compounds such as phenolics and flavonoids with potential antioxidant activity. This study aims to quantify the antioxidant activity of honey pineapple peel ethanolic extract, expressed as the IC₅₀ value. Methods: Honey pineapple peel powder was macerated using 70% ethanol. The antioxidant activity was evaluated using the ABTS cation radical assay. Extract concentrations (10, 20, 30, 40, and 50 µg/mL) were mixed with ABTS solution, and absorbance was measured at 747 nm using a UV-Vis spectrophotometer. Results: The IC₅₀ value for Vitamin C was 6.173 µg/mL, whereas the honey pineapple peel extract yielded an IC₅₀ of 61.476 µg/mL. This indicates that the antioxidant potency of the extract is 9.958 times lower than that of Vitamin C. Conclusion: The ethanolic extract of honey pineapple peel exhibits antioxidant activity with an IC₅₀ of 61.476 µg/mL. Since the inhibition percentages within the tested range did not reach 50%, this value was determined through linear regression extrapolation. Future studies should employ higher concentration ranges to confirm the inhibitory effectiveness.
Optimization of Kolang-Kaling Seed Galactomannan Serum Using Response Surface Methodology Anggraeni, Rosiana Sofia; Nurulita, Nunuk Aries; Astuti, Ika Yuni
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.573

Abstract

Background: Ultraviolet (UV) exposure promotes free radical formation, leading to oxidative stress, lipid peroxidation, inflammation, and hyperpigmentation. Galactomannan derived from kolang-kaling (Arenga pinnata) exhibits antioxidant activity with potential protective effects against UV-induced damage. In serum formulations, carbomer and triethanolamine (TEA) are commonly combined as gelling agents to achieve desirable physicochemical properties. Objective: This study aimed to optimize a galactomannan-based facial serum by determining the most effective Carbomer–TEA concentration combination using Response Surface Methodology (RSM). Methods: A formulation optimization study was conducted employing the RSM approach with Design Expert software to evaluate the interaction effects of Carbomer and TEA concentrations on serum characteristics. Results: The optimal formulation predicted by the model consisted of 0.100% (w/v) Carbomer and 1.047% (w/v) TEA. Conclusion: Response Surface Methodology successfully optimized the galactomannan facial serum formulation. The identified combination of Carbomer and TEA is expected to provide suitable serum properties while supporting the antioxidant potential of galactomannan against UV-induced oxidative damage.

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