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Rizal Irfandi
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rizalirfandi043@gmail.com
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+6285215254648
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rizalirfandi043@gmail.com
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Jl. Bumi 18 Blok A 15 No. 1 Bumi Permata Hijau, Makassar, Sulawesi Selatan, Indonesia
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INDONESIA
Hayyan Journal
Published by Education and Talent Development Center Indonesia
ISSN : -     EISSN : 30466679     DOI : https://doi.org/10.51574/hayyan.v1i1.1130
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology
Focus and Scope This journal publishes articles related to chemistry. The scope of this journal includes: Inorganic Chemistry Organic Chemistry Physical Chemistries Chemical Instruments Analytical Chemistries Materials Chemicals Industrial chemistry Biochemistry Applied Science Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol. 2 No. 2 (2025): June" : 7 Documents clear
Utilization of Natural Products as a Source of Novel Antibiotics: A Literature Review Afni, Nur
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3128

Abstract

Antibiotic resistance is a growing global health concern that threatens the effectiveness of current treatments against bacterial infections. Natural products have long served as essential reservoirs for the discovery of bioactive compounds, including antibiotics, owing to their structural diversity and ecological functions. This literature review highlights recent advances (2016–2025) in the identification and development of novel antibacterial compounds derived from natural sources such as medicinal plants, soil actinomycetes, marine organisms, endophytes, and extremophiles. It also discusses the molecular mechanisms underlying their antibacterial actions and addresses modern approaches in natural product-based drug discovery, including genome mining, metabolomics, artificial intelligence, and synthetic biology. Despite various challenges, such as the rediscovery of known molecules and low yields, innovative strategies continue to drive the development of promising antibiotic candidates. This review emphasizes the untapped potential of natural resources and advanced technologies in tackling the global antimicrobial resistance crisis.
Review of Transition Metal Dithiocarbamate Complexes: Novel Fluorescent Materials for Biosensor Applications Irfandi, Rizal
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3149

Abstract

Transition metal complexes with dithiocarbamate ligands have attracted significant attention in recent decades due to their unique electronic and optical properties. This article presents a comprehensive review of transition metal-dithiocarbamate complexes as fluorescent materials and their potential in biosensor development. Focus is given on their chemical structure, fluorescence mechanism, as well as their application in detecting important biomolecules. With the increasing need for sensitive, selective, and low-cost biosensors, these materials offer promising prospects in various biomedical and environmental applications.
Abundance of Endophytic Bacteria in Sauropus androgynus and Evaluation of Chitinolytic Activity Sri Ayu Anggita
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3175

Abstract

This study aimed to isolate and evaluate the biological safety and potential of endophytic bacteria from Sauropus androgynus (katuk) and their Chitinolytic activity for use as biological agents. A total of 14 endophytic bacterial isolates were obtained from different plant parts: 5 from the roots (T1, T2, T3, T4, P14), 5 from the stems (T7, T8, T9, T10, T11), and 4 from the leaves (T5, P6, KB12, T13). The safety of these isolates was assessed through hypersensitivity (HR) and hemolysis (HL) tests. In the HR test, none of the isolates induced necrotic symptoms in tobacco leaves, indicating they are not pathogenic to plants. In the HL test, two bacterial which were T4 from roots and T5 from leaves, isolates were found to produce clear zones on blood agar, indicating α-hemolysin production. However, the other isolates did not form hemolysis zones, suggesting they are safe for mammals. Antibacterial activity against the plant pathogen Ralstonia solanacearum was evaluated using spot inoculation methods. The results showed that none of the isolates were able to inhibit the growth of R. solanacearum. Further testing revealed that one bacterial isolate which was T8 obtained from the stem produced chitinase, as evidenced by the formation of a clear zone around the bacterial colony on chitin-containing media.
Caulerpin: Biosynthetic Significance and Cytotoxic Activity Against Artemia salina Leach Dini, Iwan
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3261

Abstract

Caulerpin (1) is one of the bisindole alkaloid compounds isolated from the many macroalga species of the Halimeda and Caulerpa genera. The biosynthetic significance of 1 is suggested by the biotransformation of indole-3-acetic acid to indole-3-carboxaldehyde via tryptophan from the shikimate pathway. This compound has many biological activities reported and this time, the 1 were evaluated for their cytotoxicity in the brine shrimp assay against A. salina Leach. in vitro and showed moderate activity with IC50 value 81.28 µg/mL.
Valorization of Trash Fish Through Drying Innovations: Nutrient Stability of Protein, Calcium, and Phosphorus Salnus, Subakir; Zulfian Armah
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3274

Abstract

Trash fish, often regarded as low-value bycatch, actually holds significant potential as a source of protein and essential minerals such as calcium and phosphorus. This study aims to evaluate the effect of different drying methods—oven drying at varying temperatures (40°C, 60°C, 80°C, and 100°C) and sun drying on the protein, calcium, and phosphorus content of trash fish. Laboratory analyses were conducted using the Kjeldahl method for protein determination and atomic absorption spectrophotometry (AAS) for calcium and phosphorus content. The results revealed that increasing oven drying temperatures significantly reduced protein levels, while sun drying maintained a protein content close to the optimal range. In contrast, calcium and phosphorus levels showed no significant differences across drying methods. Therefore, low-temperature oven drying or sun drying is recommended to preserve the nutritional quality of trash fish effectively.
Voltammetric Sensing in Portable and Point-of-Care Devices A Review of Recent Trends and Applications Eka Kartika, Andi
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The growing demand for rapid, low-cost, and decentralized analytical technologies has driven the development of portable voltammetric sensors and point-of-care (POC) devices. This review examines recent advancements in miniaturized voltammetric systems, with a particular emphasis on innovations in screen-printed electrodes (SPEs), microfluidic integration, plug-and-play configurations, and smartphone-enabled electrochemical platforms. These technological developments exhibit substantial potential for real-time, on-site analytical applications across various fields, including medical diagnostics, environmental monitoring, food safety, and wearable health technologies. Several studies are highlighted to illustrate the practical implementation of voltammetric sensing, including glucose and uric acid detection, cancer biomarker analysis, heavy metal monitoring, pesticide screening, and nitrite and formaldehyde detection in food. The review also discusses major challenges such as signal noise, sensor stability, energy constraints, and the need for user-friendly interfaces. Finally, it outlines future research directions, focusing on the incorporation of artificial intelligence (AI), the Internet of Things (IoT), and low-power electronics to enable fully autonomous and smart diagnostic systems. These developments position voltammetric sensing as a vital tool in the future of accessible, real-time, and personalized analytical technologies.
A Review: Nanofiller for Chitosan Membrane in DMFC Application Alam, Muhammad Nur
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3401

Abstract

Chitosan, a biodegradable polysaccharide derived from chitin, is emerging as a sustainable, low-cost alternative to perfluorinated membranes (like Nafion®) in Direct Methanol Fuel Cells (DMFCs). However, pristine chitosan membranes suffer from low proton conductivity (~10⁻³ S/cm), excessive methanol crossover, limited thermal and oxidative stability, and poor mechanical strength. To address these challenges, significant attention has focused on reinforcing chitosan matrices with nanofillers—such as nanosilica, titanium dioxide (TiO₂), carbon nanotubes (CNTs), graphene oxide (GO), and sulfur- or phosphorous-doped nanoparticles—to tune hydrophilicity, proton transport pathways, and mechanical integrity.This review evaluates synthesis strategies, nanofiller types, and their concentration effects on key membrane properties. Fabrication techniques center on dispersion of nanofillers into chitosan–acid solutions, casting, drying, and crosslinking with agents like glutaraldehyde or tetraethyl orthosilicate (TEOS). Characterizations include SEM/TEM imaging for morphology, mechanical testing for tensile strength and elongation, proton conductivity via electrochemical impedance spectroscopy, methanol permeability assays, and thermal/oxidative resilience through TGA and Fenton’s reagent exposure.Findings demonstrate that silica and TiO₂ nanocomposites can elevate proton conductivity to ~10⁻² S/cm, while reducing methanol permeability to the order of 10⁻⁷ cm²/s. Conductive carbon nanofillers (CNTs, GO) introduced interconnected proton channels, further enhancing conductivity, though at potential cost to homogeneity.

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