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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 12 Documents
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Search results for , issue "VOLUME 14, NUMBER 2, AUGUST 2024" : 12 Documents clear
Bilimbi (Averrhoa bilimbi L.) Leaf Extract Cream: Formulation and Efficacy in Accelerating Wound Healing in Male White Mice Suena, Ni Made Dharma Shantini; Nayaka, Ni Made Dwi Mara Widyani; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Bilimbi (Averrhoa bilimbi L.) is known for its wound-healing potential due to its flavonoids, saponins, triterpenoids, and tannins. This study aims to develop a practical and stable dosage form of Bilimbi leaf extract, specifically a cream, and evaluate its efficacy as a wound-healing agent. Bilimbi leaf extract at 2% concentration was formulated into a cream with two variations of triethanolamine concentration as an emulsifier, F1 (2%) and F2 (4%). Data were collected through observation and measurement scales during the cream formulation stage. The effectiveness of the cream as a cut wound healer was assessed using a randomized control group pre-test and post-test design. Physical properties, including organoleptic properties, homogeneity, pH, and mechanical stability, were observed, and spreadability was measured. Both formulations met the criteria for creams with good physical quality and effectively reduced the wound length to 0 cm within the 7-day observation period. In contrast, in the control group, wounds still appeared to be 0.4-1 cm in size. In conclusion, the findings in this study indicate that the cream containing 2% Bilimbi leaf extract (Averrhoa bilimbi L.) has favorable physical characteristics and effectively heals incision wounds in male white mice. This formulation shows promise for further development regarding efficacy, safety, stability, and market acceptability.
Optimization of Formula Fast Disintegrating Tablet (FDT) Antacids with Simplex Lattice Design Method Siswanto, Agus; Himawanti, Nanda Puspita; Khasanah, Fitria Nurrul
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Antacids are compounds that can neutralize stomach acid. Antacid preparations on the market are generally in the form of powders, suspensions, and chewable tablets. However, this dosage form is considered less practical, so an alternative dosage form is needed. FDT antacids are one of the quick-dissolving tablet strategies to neutralize stomach acid. The combination of Avicel PH 101 with a wicking mechanism and Sodium Starch Glycolate (SSG) with swelling action is expected to increase the effectiveness of the super disintegrant. The simplex lattice design method (Design Expert 7.1.5) was used to optimize the super disintegrant of SSG (A) and Avicel PH 101 (B). Tablets were prepared using the wet granulation method in an 8-run formula. The optimum formula for FDT antacids was determined by disintegration time and acid neutralization capacity parameters. The results showed that increasing Avicel PH 101 in combination with SSG decreased the disintegration time and increased the value of the acid neutralization capacity of the FDT antacid. Based on the optimization of the numerical method, the optimum composition of the FDT antacid formula was obtained with a combination of 38 % SSG and 101 % Avicel PH 101.

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