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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Karinov Jurnal Ilmiah Medicamento Jurnal Kefarmasian Indonesia
Ni Made Dwi Mara Widyani Nayaka
Departemen Farmasi Bahan Alam, Fakultas Farmasi, Universitas Mahasaraswati Denpasar, Jl. Kamboja No.11A Denpasar, Indonesia, 80233.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Aktivitas Anti-Inflamasi Minyak Herbal Tradisional Dari Bahan Usada Bali Pada Mencit Inflamasi Yang Diinduksi Karagenan Putu Era Sandhi Kusuma Yuda; I Made Agus Mahardika; Erna Cahyaningsih; Maria Malida Vernandes Sasadara; Ni Made Dwi Mara Widyani Nayaka; Ni Luh Kade Arman Anita Dewi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.60529

Abstract

Peradangan sendi atau artritis merupakan salah satu penyakit inflamasi kronis yang memerlukan penggunaan obat jangka panjang. Penggunaan obat artritis seperti metotreksat dan NSAID dalam waktu lama dapat menimbulkan berbagai efek samping serius, sehingga diperlukan alternatif pengobatan yang relatif lebih aman terutama dari bahan herbal. Penelitian ini dilakukan untuk menguji aktivitas anti-inflamasi minyak herbal tradisional Usada Bali dari bahan Jahe (Zingiber officinale), Kunyit (Curcuma longa), Kencur (Kaemferia galanga), Bangle (Zingiber montanum), Cengkeh (Syzigium aromaticum) dan Kayu Manis (Cinnamomum burmanii) pada mencit inflamasi yang diinduksi karagenan melalui pengujian secara topikal. Mencit dibagi empat kelompok yang terdiri dari kelompok kontrol negatif (pembawa), kontrol positif (Natrium Diklofenak topikal), minyak herbal 150 dan 300 mg/ml. Volume peradangan kaki mencit diukur dengan alat pletismometer setiap jam selama empat jam setelah diinduksi dengan karagenan 0,5% (b/v) subplantar, kemudian diuji secara statistik (Mann-Whitney) dengan taraf kepercayaan 95%. Skrining fitokimia menunjukkan bahwa minyak herbal mengandung senyawa flavonoid, terpenoid dan steroid. Hasil uji aktivitas anti-inflamasi menunjukan adanya penghambatan peradangan yang signifikan (p<0,05) oleh minyak herbal konsentrasi 150 mg/ml maupun 300 mg/ml dengan persentase penghambatan pada jam ke-4 masing-masing sebesar 16,52% dan 11,30%, serta tidak berbeda bermakna dibandingkan kontrol positif (p>0,05). Hasil tersebut menunjukkan adanya potensi  minyak herbal Usada Bali sebagai anti-inflamasi topikal.
Essential Oil of Alpinia galanga: Effect of Aromatherapy Inhalation in Mice and Physicochemical Characterization Ni Made Dwi Mara Widyani Nayaka; Ni Luh Putu Swari; Putu Era Sandhi Kusuma Yuda; I Gusti Ayu Agung Kusuma Wardani
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3791

Abstract

Aromatherapy has been used for centuries to maintain body and mental health. In aromatherapy, the inhalation of essential oil provides physical and psychological benefit due to its volatile bioactive compounds. The current study was aimed to determine the effect of the inhalation of Alpinia galanga essential oil in mice using forced swim test. The refractive index, solubility, and Gas Chromatography-Mass Spectrophotometry (GC-MS) profile of AGEO were also investigated. The essential oil from Alpinia galanga showed an anti-depressive-like effect and it was as strong as the positive control (Lavandula angustifolia essential oil). The GC-MS analysis discovered some antidepressant compounds in the oil such as eucalyptol, fenchone, and α-terpineol.
Pengaruh Pemilihan Pelarut dalam Ekstraksi Klorofil pada Rumput Laut Gracilaria sp. dan Caulerpa sp. Segar dan Kering Maria Malida Vernandes Sasadara; Ni Made Dwi Mara Widyani Nayaka; Putu Era Sandhi Kusuma Yuda; Erna Cahyaningsih; Ni Luh Kade Arman Anita Dewi
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.5344

Abstract

Seaweed is a photosynthetic organism, thus a good source of pigment-producing. Pharmaceutical, food, and cosmetic industries widely use chlorophyll pigments for their products. Bulung Sangu (Gracilaria sp.) and Bulung Boni (Caulerpa sp.) are widely grown seaweeds in the waters of Bali. Pre-extraction steps such as drying and solvent selection can affect pigment extraction. This study aimed to evaluate the effect of solvent selection in the extraction of chlorophyll in fresh and dried Bulung Sangu (Gracilaria sp.) and Bulung Boni (Caulerpa sp.). The solvents used were ethanol, methanol, and acetone. Estimation of chlorophyll content was carried out using UV-VIS spectrophotometry. Data were analyzed statistically using one-way ANOVA with a 95% confidence level. The results showed that the extraction of Bulung Sangu (Gracilaria sp.) on dry samples using acetone produced a total chlorophyll of 574.1 ± 33.2 g/g. Bulung Boni (Caulerpa sp.) extraction of fresh samples using methanol resulted in the highest total chlorophyll (10235.3 ± 50.3 g/g). In conclusion, drying and solvent selection affect the extraction of chlorophyll from Bulung Sangu (Gracilaria sp.) and Bulung Boni (Caulerpa sp.).
EVALUASI MUTU FISIK DAN UJI IRITASI SEDIAAN SPRAY ANTINYAMUK DARI EKSTRAK ETANOL DAUN LEGUNDI (Vitex trifolia L.) Ni Made Dwi Mara Widyani Nayaka; I Gede Made Suradnyana; Ni Putu Gek Dyah Citra Vitaloka
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF SPECIAL ISSUE
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i01.30043

Abstract

Indonesia merupakan negara beriklim tropis dengan kondisi ideal bagi nyamuk untuk berkembang biak. Hal ini menyebabkan banyaknya kasus penyakit yang disebabkan oleh gigitan nyamuk, misalnya demam berdarah dengue. Masyarakat melakukan berbagai upaya untuk menghindari gigitan nyamuk, contohnya menggunakan sediaan antinyamuk pada kulit. Sediaan antinyamuk berupa spray lebih praktis digunakan dibandingkan jenis sediaan topikal lainnya, misalnya lotion dan krim. Legundi (Vitex trifolia L.) merupakan salah satu tanaman yang digunakan secara tradisional oleh masyarakat Indonesia untuk mengusir nyamuk. Penelitian ini bertujuan untuk melakukan evaluasi mutu fisik dan pengujian iritasi sediaan spray antinyamuk dari ekstrak etanol daun legundi. Simplisia daun legundi diekstraksi menggunakan etanol 96% secara maserasi. Ekstrak kental selanjutnya dibuat menjadi 3 jenis formula sediaan spray antinyamuk dengan variasi konsentrasi ekstrak masing-masing sebesar 3%, 5%, dan 8%. Sedian dari ketiga formula memiliki warna hijau kehitaman, tekstur cair dan bau khas serta pH dalam rentang 5,96 – 6,01 dan homogen. Uji iritasi menerapkan metode Draize pada hewan coba kelinci putih, dimana indeks iritasi dihitung berdasarkan skor eritema dan edema. Selama 72 jam pengamatan, hanya Formula 3 yang menunjukkan adanya edema. Hasil perhitungan indeks iritasi menunjukkan ketiga formula memiliki indeks iritasi 1,67-2,00. Berdasarkan indeks iritasi, ketiga formula tergolong dalam kategori sedikit mengiritasi dan iritasi sedang. Selain itu, kadar ekstrak dalam formula dapat mempengaruhi pH sediaan dan tingkat iritasi. Perbaikan formula diperlukan untuk mengurangi dampak iritasi sehingga diperoleh sediaan antinyamuk yang aman untuk penggunaan topikal.
Kandungan Flavonoid Total dan Aktivitas Antioksidan dari Ekstrak Polaritas yang Berbeda dari Daun Pereskia bleo Nayaka, Ni Made Dwi Mara Widyani; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes; Yuda, Putu Era Sandhi Kusuma; Indriani, Felia Riska
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6290

Abstract

Antioxidant agents are essential for the body due to its ability to scavenge free radicals. Medicinal plants contain phytochemicals that act as antioxidants. The current research aimed to determine the total flavonoid content (TFC) and antioxidant activity of Pereskia bleo leaves extracts from various solvents with different polarities. The nonpolar solvent (n-hexane) was used as the first step of extraction and its residues were then macerated using semi-polar (ethyl acetate) and polar (ethanol 96%) solvents consecutively. The TFC was determined using the colorimetric method while antioxidant activity was examined through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antioxidant activity was presented as Inhibitory Concentration 50 (IC50) and Antioxidant Activity Index (AAI). It is noticeable that among analyzed extracts, the ethyl acetate extract of P. bleo leaves contained the highest flavonoid content (15.052 ± 0.172 g quercetin equivalent/100 g extract). Furthermore, the greatest antioxidant activity was obtained from n-hexane extract with the value of IC50 and AAI being 217.307 ppm and 0.230, respectively. Pearson coefficient correlation (r) between TFC and AAI was -0.106. The current study concluded that P. bleo leaves extracts using solvents with different polarities showed variation in TFC values and antioxidant activity. Moreover, TFC was not the main contributor to the antioxidant activity of P. bleo leaves extracts.
Pelatihan Produk Herbal Sediaan Teh Batang Pisang kepada Warga Binaan Lapas Perempuan Kelas IIA Denpasar Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Prayitno, Putra Hilmi; Yuda, Putu Era Sandhi Kusuma; Santoso, Puguh; Putra, I Made Agus Sunadi; Nayaka, Ni Made Dwi Mara Widyani; Cahyaningsih, Erna; Udayani, Ni Nyoman Wahyu; Juliadi, Debby; Agustini, Ni Putu Dewi
Jurnal KARINOV Vol 7, No 1 (2024): Januari
Publisher : Institute for Research and Community Service (LP2M), Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um045v7i1p019

Abstract

Tujuan kegiatan pelatihan ini untuk memberdayakan warga binaan Lapas Perempuan Kelas IIA Denpasar agar memiliki keahlian sebagai bekal berwirausaha untuk meningkatkan produktivitas dan ekonomi selepas masa tahanan, disamping untuk menumbuhkan rasa percaya diri. Kegiatan pelatihan ini juga merupakan upaya diseminasi hasil penelitian tim dosen kepada mitra binaan, yang dalam hal ini ditujukan kepada warga binaan Lapas Perempuan Kelas IIA Denpasar. Metode yang digunakan dalam pelaksanaan kegiatan ini adalah dengan memberikan pengetahuan dan pelatihan keterampilan. Pengetahuan yang diberikan dalam bentuk penyuluhan manfaat farmakologi secara empiris maupun saintifik dari tanaman pisang secara umum maupun mengkhusus pada bagian batang pisang. Pengetahuan tambahan juga diberikan berupa strategi pemasaran produk sediaan herbal. Pelatihan keterampilan diberikan kepada warga binaan dalam bentuk pelatihan mengolah batang pisang menjadi produk sedian teh herbal dari proses awal berupa bahan segar, pembuatan simplisia batang pisang, pencampuran simplisia batang pisang dengan simplisia tambahan (daun mint dan daun stevia) sebagai komposisi teh, sampai dengan pengemasannya. Kegiatan ini dimonitoring dan dievaluasi dengan mengacu kepada keberhasilan warga binaan membuat produk herbal sediaan teh batang pisang, yangmana produk hasil karya warga binaan tersebut dipasarkan di lingkungan internal Kantor Wilayah Kementerian Hukum dan HAM Denpasar. Kata kunci— Pengabdian Kepada Masyarakat, Lapas Perempuan, Teh Herbal Abstract The aim of this training activity is to empower the inmates of the Denpasar Class IIA Women's Prison to have skills to prepare for entrepreneurship to increase productivity and the economy after prison, in addition to growing self-confidence. This training activity is also an effort to disseminate the research results of the lecturer team to partners, which in this case is aimed at residents of the Class IIA Denpasar Women's Prison. The method used in implementing this activity is to provide knowledge and skills training. The knowledge provided is in the form of counseling on the empirical and scientific benefits of pharmacology of banana plants in general and specifically on the banana stem. Additional knowledge is also provided in the form of marketing strategies for herbal preparation products. Skills training is given to inmates in the form of training in processing banana stems into herbal tea products from the initial process in the form of fresh ingredients, making banana stem simplicia, mixing banana stem simplicia with additional simplicia (mint leaves and stevia leaves) as a tea composition, up to packaging. This activity is monitored and evaluated with reference to the success of the inmates in making herbal products made from banana stem tea. Keywords— Community Services, Women’s Prison, Herbal Tea
Antidepressant-Like Activity and Physicochemical Analysis of Essential Oils from Michelia alba and Plumeria alba Flowers Nayaka, Ni Made Dwi Mara Widyani; Swari, Ni Luh Putu; Widnyani, Dewa Ayu Sri Bintang; Sukmayanti, Ni Kadek; Yuda, Putu Era Sandhi Kusuma; Wardani, I Gusti Ayu Agung Kusuma; Sanjaya, Dwi Arymbhi
JST (Jurnal Sains dan Teknologi) Vol. 11 No. 2 (2022)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.576 KB) | DOI: 10.23887/jstundiksha.v11i2.45291

Abstract

Depression is a mental disorder with an increased prevalence. Other than conventional antidepressants, essential oils have been used in aromatherapy as a complementary and alternative medicine to reduce depression. In the current study, the antidepressant-like activity of the inhalation of essential oils from Michelia alba (MAEO) and Plumeria alba (PAEO) flowers was analyzed using the forced swim test. The immobility time of mice from tested groups was evaluated statistically by the non-parametric Kruskal Wallis test, followed by the Mann Whitney post hoc test. Also, the characterization of both essential oils was determined by refractive index, solubility, and Gas Chromatography-Mass Spectrophotometry (GC-MS) analysis. PAEO showed stronger antidepressant-like activity than MAEO (p<0.05) and it was equal to the positive control (essential oil of Lavandula angustifolia) (p>0.05). The GC-MS analysis revealed some calming agents in MAEO and PAEO such as linalool, linalyl acetate, phenylethyl alcohol, and methyl anthranilate.
Bilimbi (Averrhoa bilimbi L.) Leaf Extract Cream: Formulation and Efficacy in Accelerating Wound Healing in Male White Mice Suena, Ni Made Dharma Shantini; Nayaka, Ni Made Dwi Mara Widyani; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bilimbi (Averrhoa bilimbi L.) is known for its wound-healing potential due to its flavonoids, saponins, triterpenoids, and tannins. This study aims to develop a practical and stable dosage form of Bilimbi leaf extract, specifically a cream, and evaluate its efficacy as a wound-healing agent. Bilimbi leaf extract at 2% concentration was formulated into a cream with two variations of triethanolamine concentration as an emulsifier, F1 (2%) and F2 (4%). Data were collected through observation and measurement scales during the cream formulation stage. The effectiveness of the cream as a cut wound healer was assessed using a randomized control group pre-test and post-test design. Physical properties, including organoleptic properties, homogeneity, pH, and mechanical stability, were observed, and spreadability was measured. Both formulations met the criteria for creams with good physical quality and effectively reduced the wound length to 0 cm within the 7-day observation period. In contrast, in the control group, wounds still appeared to be 0.4-1 cm in size. In conclusion, the findings in this study indicate that the cream containing 2% Bilimbi leaf extract (Averrhoa bilimbi L.) has favorable physical characteristics and effectively heals incision wounds in male white mice. This formulation shows promise for further development regarding efficacy, safety, stability, and market acceptability.
ETHNOBOTANICAL STUDY OF MEDICINAL PLANT USAGE DURING COVID-19 PANDEMIC: A COMMUNITY-BASED SURVEY IN INDONESIA Nayaka, Ni Made Dwi Mara Widyani; Yuda, Putu Era Sandhi Kusuma; Sanjaya, Dwi Arymbhi; Ernawati, Desak Ketut; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Sasadara, Maria Malida Vernandes
BIOTROPIA Vol. 30 No. 2 (2023): BIOTROPIA Vol. 30 No. 2 August 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1784

Abstract

Before the availability of a vaccine, Indonesian population relied on traditional medicines to prevent COVID-19. Any species used by indigenous people could lead to further investigations in modern pharmacology, to preserve ancient knowledge, and to plan for plants’ conservation. The study aimed to discover and record species, methods of preparation, route of administration, and motivation in using medicinal plants by the Indonesian population during the COVID-19 pandemic. Participants of survey were selected from the people who live in Java and Bali for responding to an online structured questionnaire. Relative Frequency of Citation (RFC) was employed in the quantitative analysis of the collected data. The pharmacological relevance of the five plants with the highest RFC was further reviewed. The results showed that respondents used 59 plants from 28 families. Five species with the highest RFC were Curcuma longa (0.707), Zingiber officinale (0.674), Cymbopogon citratus (0.269), Kaempferia galanga (0.174), and Curcuma zanthorrhiza (0.165). Most plants were prepared by boiling (77.97%) and administered orally as a single ingredient or mixed with other herbals. Respondents believed that the plants were beneficial as immune-booster (71.26%), maintain good health (24.85%) and stamina (12.28%), and prevent viral infection, including COVID-19 (5.39%). The most commonly used plants might be scientifically based to boost immunity. However, their usage against COVID-19 and the medicinal value of herbal mixtures should be further investigated.
Co-Authors Agustini, Ni Putu Dewi Debby Juliadi Desak Ketut Ernawati Dwi Arymbhi Sanjaya Erna Cahyaningsih Erna Cahyaningsih Galuh Bela Pertiwi I Gusti Agung Ayu Kartika I Made Agus Mahardika Indriani, Felia Riska Maria Malida Vernandes Sasadara Megawati, Fitria Ni Ketut Sinarsih Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Putu Swari Ni Made Dharma Shantini Suena Ni Nyoman Wahyu Udayani Ni Putu Gek Dyah Citra Vitaloka Ni Putu Udayana Antari puguh santoso, puguh Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putu Era Sandhi Kusuma Yuda Sasadara, Maria Malida Vernandes Sukmayanti, Ni Kadek Suradnyana, I Gede Made Swari, Ni Luh Putu Wardani, I Gusti Agung Ayu Kusuma Wardani, I Gusti Ayu Agung Kusuma Widnyani, Dewa Ayu Sri Bintang