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Arifah Sri Wahyuni
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Pharmacon: Jurnal Farmasi Indonesia
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : https://www.doi.org/10.23917/pharmacon
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Universitas Muhammadiyah Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Volume 22, No 1 (2025)" : 12 Documents clear
The Relationship Between Rational Antibiotic Use and Theurapeutic Outcomes in Patients with Community Acquired Pneumonia Fortuna, Tista Ayu; Nuraini, Filla Rizky; Karuniawati, Hidayah
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.11678

Abstract

Pneumonia is an infection caused by microorganisms. Antibiotics are one of the treatments given to patients with pneumonia caused by bacterial infections. Rational use of antibiotics will prevent resistance. This study aims to determine the relationship between the rationality of antibiotic use and therapeutic outcomes in community-acquired pneumonia patients. We used a cross-sectional study and retrospectively collected data using purposive sampling. The inclusion criteria are non-ICU community pneumonia patients have complete medical record data, while the exclusion criteria are patients who died or had other infections. We evaluated the rationality of antibiotics using the Gyssens method. Based on the results, there are 240 patients, with 210 patients receiving rational therapy and 30 patients receiving irrational antibiotics. Based on the results, 6 patients did not receive antibiotics on time, 4 patients received the wrong dose, 2 patients did not get the correct interval, 16 patients received a dose that was too short, and 2 patients were prescribed alternative antibiotics that were more effective. The results of the analysis showed that there is a significant relationship between the rationality of antibiotic use and the therapeutic outcomes of community-acquired pneumonia patients (p-value < 0.001; OR 14.36).
Nothopanax scutellarium: Natural Hair Growth Plant Wijianto, Diski Wahyu; Wahyuni, Arifah Sri; Sukmawati, Anita; Bakar, Fazleen Izzany Abu
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.11693

Abstract

Hair plays an important role in supporting appearance and self confidence, but problems with hair loss and slow hair growth still often occur; Mangkokan leaves (Nothopanax scutellarium) are known to contain flavonoids such as quercetin which can stimulate hair growth through various mechanisms, and nanoemulsion formulations have been shown to increase the absorption of these active compounds, so this study aims to examine the effectiveness of mangkokan leaves on hair growth through a systematic review based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines with a literature search until November 16, 2024 in the Emerald Publishing, SpringerLink, EBSCO, Cochrane, ProQuest, Science Direct, Scopus, and PubMed databases, of the 68 articles found, only 5 studies met the inclusion criteria after screening, and the results showed that the formulation of mangkokan leaves in the form of ethosomal gel or phytosome lotion at a concentration of 25% was most effective in stimulating hair growth with a mechanism involving the activation of endothelial nitric oxide synthase (eNOS) to increase blood supply to follicles, regulation of nitric oxide (NO) balance and decreased inflammation by quercetin, inhibition of the enzyme 5-alpha reductase to reduce dihydrotestosterone (DHT) levels, as well as increasing the expression of growth factors such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF), and hepatocyte growth factor (HGF), which overall support the extension of the anagen phase (active hair growth phase) and improve hair health, so that mangkokan leaves have high potential as an active ingredient in hair care products, although further research is still needed to ensure their long-term safety and effectiveness.

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