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INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 40 Documents
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Search results for , issue "Vol. 1 No. 3 (2024): Desember" : 40 Documents clear
The Architecture of Protoliterate Period: Arsitektur Periode Protoliterasi Al-Yasiri, Farah Shaker
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.40

Abstract

Mesopotamian architecture was characterized by a number of important elements created by ancient builders in line with the nature of the region, the layout and formations of buildings, as well as their association with the types of structural materials used in the construction process. The achievements of the ancient Iraqis in architecture were many, and among their innovations was their high ability to innovate elements from early times based on the results of archaeological excavations. One of the things that draws attention in the architecture of this era is the magnitude of the buildings and the interest in the defensive fortifications represented by the walls, so they were very huge, reaching about two meters approximately, but in terms of aesthetics, this era was famous for a kind of decoration of facades and columns known among researchers for the decoration of beautiful mosaics, which has become a feature of this era. Highlights: Mesopotamian architecture emphasized massive structures and defensive fortifications. Innovations included decorative mosaics and aesthetic facade designs. Ancient builders adapted designs to regional materials and environment. Keywords: Mesopotamia; architecture; mosaic decoration; defensive fortifications; fences
The Outcome of One-Stage Surgery (Open Reduction, Femoral Osteotomy, Pelvic Osteotomy) in the Treatment of DDH Between 1.5 and 6.5 Years in Basrah: Hasil dari Pembedahan Satu Tahap (Reduksi Terbuka, Osteotomi Femoralis, Osteotomi Panggul) dalam Pengobatan DDH Antara 1,5 dan 6,5 Tahun di Basrah Akber, Mohamad A
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.42

Abstract

Abstract. Background: A broad range of hip developmental anomalies that may be identified at birth or develop later are included in developmental dysplasia of the hip (DDH). It involves a range of disease severity, from full hip dislocation to mild acetabular dysplasia. Methods: The study (prospective cohort) was performed at Ibn-Albettar Orthopedic Center. The period was between February 2019 to March 2024, patients with frank dislocation between 1.6 to 6.5 years were included. Exclusion criteria include those with a neuromuscular disorder, Arthrogryposis, failed previous surgery, and previous hip infection. Results: One hundred six patients were included (118 hips, 94 unilateral, and 24 bilateral), at the time of surgery the mean age was between 18 to 80 months, group A (61 hips) those less than 28 months while group B (57 hips) include those 28 months age and older. All hips underwent the same procedure which included single-stage open reduction, femoral osteotomy, and modified Salter osteotomy, and the mean follow-up was between 27-32 months. Regarding demographic data, the difference was for the age with the female and the left side most commonly affected. Conclusion: A single-stage operation consisting of open reduction, femoral osteotomy, and pelvic osteotomy yielded favorable radiological and clinical results for the treatment of DDH in patients between the ages of 1.5 and 6.5. Highlights: DDH ranges from mild dysplasia to severe hip dislocation. Prospective cohort study of 118 hips (2019–2024); single-stage surgery. Single-stage surgery showed favorable outcomes for DDH (ages 1.5–6.5). Keywords: one-stage surgery, open reduction, femoral osteotomy, pelvic osteotomy, DDH
Assessment of Immune and Oxidative Stress Biomarkers in Toxoplasmosis Patients: A Comparative Study with Healthy Controls: Penilaian Biomarker Kekebalan Tubuh dan Stres Oksidatif pada Pasien Toksoplasmosis: Sebuah Studi Perbandingan dengan Kontrol yang Sehat Mustafa, Hamssa Majid
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.43

Abstract

Background; Toxoplasmosis, caused by the intracellular protozoan Toxoplasma gondii, is a widespread zoonotic infection that affects nearly one-third of the global population. While often asymptomatic in immunocompetent individuals, the disease can manifest severe complications in immunocompromised individuals, pregnant women, and neonates. Aims of the study; This study evaluates immune and oxidative stress biomarkers in toxoplasmosis patients to explore their role in disease severity and progression. Methodology; This study investigated biomarkers in 100 toxoplasmosis patients and 50 healthy controls, evenly divided by gender, from January 2023 to January 2024. Venous blood (5 mL) was collected, clotted, centrifuged, and serum stored at -20°C. Biomarkers measured included cytokines (IFN-γ, TNF-α, IL-10, CRP) and oxidative stress markers (MDA, SOD, CAT) using ELISA. Measurements followed manufacturer protocols, with absorbance readings taken via microplate reader. Statistical analysis assessed differences between patients and controls, with significance set at p<0.05. Results aimed to explore the role of immune and oxidative stress biomarkers in toxoplasmosis pathophysiology.Result; The study found no significant differences in demographic or lifestyle factors between Toxoplasma patients and controls, including age, gender distribution, residence, and smoking status. However, significant differences were observed in biomarker levels. Immune markers (IFN-γ, TNF-α, IL-10, and CRP) were elevated in patients compared to controls, indicating heightened immune activation. Oxidative stress markers showed contrasting trends: MDA levels were significantly higher in patients, reflecting increased lipid peroxidation, while antioxidant enzymes (SOD and CAT) were markedly lower, indicating reduced antioxidant defenses. These findings highlight the role of immune dysregulation and oxidative stress in Toxoplasma pathophysiology. Conclusions; This study highlights significant immune activation and oxidative stress in toxoplasmosis patients, with elevated inflammatory markers and reduced antioxidant enzymes. These biomarkers may serve as indicators of disease severity and progression. Highlights: Toxoplasmosis affects one-third globally, severe in immunocompromised individuals. Analyzed immune, oxidative biomarkers in 100 patients vs. 50 controls. Elevated cytokines, oxidative stress markers; reduced antioxidant enzymes in patients.. Keywords: Toxoplasmosis, immune response, cytokines, oxidative stress, biomarkers, disease progression.
Physiological Adaptation to Left Ventricular Enlargement: Adaptasi Fisiologis terhadap Pembesaran Ventrikel Kiri Hasan, Mahfoudh Falih; Khalaf, Fias Hadi; Mutashar, Mohammed Kadhim; Mahdi, Weam Saleh; Atiyah, Maher Abdulameer
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v1i3.44

Abstract

Background: Physiological adaptations, especially in sports exercise, usually occur through stress on the body. The changes that occur in the functions of the body's systems are what cause development in the responses of its organs and muscles, which leads to improved athletic performance. Adaptations in response to training include: decreased the heart rate, increased the stroke volume, increased the oxygen uptake, increased the blood hemoglobin levels, and the muscle hypertrophy. Objective of the study: To evaluate the rates of the left ventricular enlargement after years of aerobic training. The research sample: includes (24) athletes and all them practice aerobic activities at the present time, as follows: Six they have (1-2) years of training. Six they have (2-4) years of training. Six they have (4-6) years of training. Six they have (6-8) years of training. The left ventricular mass was examined and diagnosed using the Echocardiogram. Data analyses: The data was analyzed using the SPSS program V. 26. Conclusions: 1-Left ventricular hypertrophy increases with the increase in the years of the aerobic training. 2-During the four years of training, left ventricular enlargement remains within the normal range. 3-after four years, Left ventricular hypertrophy begins to rise above the normal range. 3- The left ventricular hypertrophy in an aerobic athlete is not considered a pathological condition. Highlights: Adaptation: Aerobic training increases left ventricular hypertrophy over time. Timeline: Enlargement stays normal for 4 years, increases beyond normal after. Conclusion: Hypertrophy in athletes is non-pathological and a physiological adaptation. Keywords: Physiological Adaptation; Ventricular Enlargement, Athletic Heart Syndrome.
Prodominance and Incidence of Pseudomonas Bacteria in Urinary Samples from Women with Chronic Urinary Tract Infections: Dominasi dan Insidensi Bakteri Pseudomonas pada Sampel Urin dari Wanita dengan Infeksi Saluran Kemih Kronis Saleem, Hanan Kareem
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.45

Abstract

Background; Chronic urinary tract infections in women are often associated with Pseudomonas aeruginosa, a significant pathogen causing recurrent and persistent infections. Aims of the study; To assess the predominance and incidence of Pseudomonas aeruginosa in urinary samples from women with chronic urinary tract infections. Methodology; A cross-sectional study at Al-Habbobi Teaching Hospital (10/11/2023–11/11/2024) examined bacterial infections in urinary samples from 1000 UTI patients (aged 35–45). Samples were cultured and analyzed for bacterial identification and antimicrobial susceptibility. Sociodemographic and clinical data were collected using questionnaires, ensuring ethical compliance and participant confidentiality. Result; The study included 1000 participants, with 60% in the 35–40 age group, 75% married, 60% having a college education, and 50% employed. Forty percent had a UTI history of 1–3 years. The most common bacteria in urine samples were Escherichia coli (45%), followed by Pseudomonas aeruginosa (22%), Klebsiella pneumoniae (15%), and Enterococcus faecalis (7%). Infection rates of Pseudomonas aeruginosa were highest in patients with UTIs lasting 4–7 years (40.91%), followed by those with >7 years (36.36%) and 1–3 years (22.73%). The 35–40 age group had the highest prevalence of Pseudomonas (59.09%). Conclusions; The study concludes that Escherichia coli and Pseudomonas aeruginosa are the most prevalent bacteria in UTIs, with Pseudomonas being more common in patients aged 35–40 and with longer infection durations. Highlights: Chronic UTIs often involve Pseudomonas aeruginosa, causing persistent infections. Escherichia coli (45%) and Pseudomonas aeruginosa (22%) dominate UTI pathogens. Pseudomonas prevalence increases with age (35–40) and longer infection durations. Keywords: Escherichia coli, Pseudomonas aeruginosa, Urinary tract infections (UTIs), Chronic infections, Biofilms, Antibiotic resistance
Role of Clinical Chemistry in Hemodialysis: Assessment of Biochemical Markers and Electrolyte Imbalances: Peran Kimia Klinis dalam Hemodialisis: Penilaian Penanda Biokimia dan Ketidakseimbangan Elektrolit Al-Rubayee, Wasan T.
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.48

Abstract

Background; Chronic kidney disease (CKD) and renal failure are significant global health concerns, affecting millions of individuals and contributing to high morbidity and mortality rates. Aims of the study; This study aims to assess biochemical, inflammatory, and oxidative stress markers in renal failure patients to identify biomarkers and guide therapeutic strategies. Methodology; This case-control study, conducted between January 1, 2023, and January 1, 2024, included 100 renal failure patients and 50 healthy controls, aged 35-55 years. The participants’ gender distribution was 60% male and 40% female in the patient group, and 50% male and 50% female in controls. Renal function parameters (serum creatinine, BUN, GFR, urine output) were measured using an automated chemistry analyzer. Biochemical markers (potassium, calcium, phosphorus, PTH) were assessed with an electrolyte analyzer and immunoassay techniques. Inflammatory markers (CRP, TNF-α) and oxidative stress markers (MDA, GPx) were quantified using ELISA and spectrophotometric methods. Result; This study compared 100 renal failure patients and 50 healthy controls. Age differences were significant (p=0.045), with the renal failure group being older (53.2 ± 12.5 years). Gender, occupation, marital status, and smoking history showed no significant differences. Renal function parameters revealed significant differences: serum creatinine (7.4 ± 3.2 mg/dL vs. 0.9 ± 0.2 mg/dL, p<0.001), BUN (55.2 ± 19.1 mg/dL vs. 12.3 ± 4.5 mg/dL, p<0.001), GFR (15.6 ± 8.3 mL/min vs. 95.3 ± 10.2 mL/min, p<0.001), and urine output (450 ± 230 mL/day vs. 1600 ± 200 mL/day, p<0.001). Biochemical markers like potassium, calcium, phosphorus, and PTH also showed significant differences. Inflammatory and oxidative markers (CRP, TNF-α, MDA, GPx) had notable disparities, all with significant p-values. Conclusions; This study demonstrates significant differences between renal failure patients and healthy controls in renal function, biochemical markers, and inflammation. Renal failure patients had higher serum creatinine, BUN, and phosphorus levels, along with altered potassium, calcium, and PTH levels. Elevated inflammatory markers (CRP, TNF-α) and oxidative stress markers (MDA, GPx) suggest enhanced inflammation and oxidative stress Highlights: CKD study: Renal function, biochemical, inflammatory, oxidative stress markers analyzed. Significant differences in creatinine, BUN, GFR, CRP, TNF-α observed. Results highlight inflammation, oxidative stress in renal failure patients. Keywords: Renal failure, Biochemical markers, Inflammation, Oxidative stress, Serum creatinine, Parathyroid hormone
Evaluation of Histopathological Features and Some Immunological Markers in Diabetic Foot Ulcer Patients: Evaluasi Gambaran Histopatologi dan Beberapa Penanda Imunologi pada Pasien Ulkus Kaki Diabetes Faisal, Ahmed Nassir; Abbas, Abbas Muhsin
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.49

Abstract

Background; diabetic foot patients are affected by complications with any injury, more than healthy people, as a result of the delay in discovering the problem, as the patient’s lack of awareness of repeated injuries leads to complications with difficulty in treatment, these disorders are related to controlling the level of sugar in the blood. 39 samples of diabetic foot patients were collected from Al-Rifai General Hospital and the Diabetes Center in Nasiriyah city to conduct histological examinations. Aims of the study; the current study aims to characterize the histopathological features of diabetic foot ulcer cases. And assess immune and biochemical parameters associated with diabetic foot ulcer. In addition to evaluate the correlation between histopathological changes and immune responses. Methodology; Samples (blood, tissue specimen) were collected from diabetic patients with diabetic foot ulcer from Al-Rifai General Hospital and the Diabetic Center in in Nasiriyah city from April 2022 to september2022. Histopathological sections were prepared according to (Bancroft and Steven, 2008) , cytokines (TGF- β, IFN- γ and IL-17A) measured using the enzyme-linked immunosorbent technique ELISA. Result; the current study aims to demonstrate the histopathological changes associated with diabetic foot. results show purulent ulcer with a large gap between the edges of the lesion necrotic foci in the dermis tissue, Fibrin deposition with focal melanin pigmentation, degenerative changes with compaction of nuclei and extensive granulation formation in the dermis with inflammatory activity. The results showed a significant increase in the concentration of some cytokines (TGF- β, IFN- γ and IL-17A) and some Biochemical parameters such as (HbA1C and Triglycerides) in patients with diabetic foot compared to the healthy group. Conclusions; The present study concluded that the severity of diabetic foot ulcers is closely related to the high level of cytokines in diabetic patients with a preponderance in type 1 diabetes Highlights: tudy examines histopathological changes in diabetic foot ulcer patients. Findings show necrosis, inflammation, elevated cytokines (TGF-β, IFN-γ, IL-17A). Diabetic foot severity linked to cytokines and biochemical imbalances. Keywords: Diabetic foot, gangrene, ulcer, TGF- β, IFN- γ and IL-17A
Effectiveness of Entomopathogenic Fungi Against Adult Red Flour Beetles (Tribolium castaneum) (Coleoptera: Tenebrionidae): Efektivitas Jamur Entomopatogen Terhadap Kumbang Tepung Merah Dewasa (Tribolium castaneum) (Coleoptera: Tenebrionidae) Falhy, Majida Mohammad Abid; Azeez, Zahraa Falah
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.52

Abstract

The current study aimed to isolate some insect pathogenic fungi from the soil of wheat crops in different areas and test their effects on the adult stages of the red flour beetle Tribolium castaneum. Five species of fungi naturally infecting the flour beetle were recorded, and these genera were Beauveria bassiana and Metarhizium anisopliae, identified morphologically. Five local strains of insect pathogenic fungi were isolated, based on their macroscopic and microscopic characteristics. The concentrations of fungal spore suspensions affected the adults of the studied insect, with Beauveria bassiana being the most effective. The mortality rate of adults reached 93.33% when the highest concentration of the fungal suspension (17x108) was used after 10 days of treatment, while the mortality rate was 86.67% when using the suspension of Metarhizium anisopliae at the same concentration. One strain matched the species B. bassiana and four strains matched M. anisopliae. The identity of the strains was confirmed by amplifying and sequencing the ITS5-ITS4 region, and comparing the sequences to molecular databases and phylogenetic analyses. 99% identity values ​​were recorded with B. bassiana and M. anisopliae strains in molecular databases. Phylogenetic analyses confirmed that the sequences extracted from these strains fall within the group containing the reference sequences of B. bassiana and M. anisopliae, respectively, in the database. These results contribute significantly to the understanding of entomopathogenic fungi, which will aid in the development of biotechnological products in the field of biological control. Highlights: Soil fungi Beauveria bassiana and Metarhizium anisopliae infect red flour beetles. Fungal spore suspensions showed high mortality rates in beetle adults. Molecular analyses confirmed strains' identity, supporting biological control development. Keywords: Tribolium castaneum, entomopathogenic fungi, Beauveria bassiana. Metarhizium anisopliae. identification, contact toxicity
Probiotic Applications of Leuconostoc Mesenteroides: Antibacterial Activity Against MDR Pathogenic Bacteria: Aplikasi Probiotik Leuconostoc Mesenteroides: Aktivitas Antibakteri Terhadap Bakteri Patogen MDR Hammadi, Noor Alhuda Nadhim; Hasson, Shaimaa Obaid; Al-Awady, Mohammed Jabber
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.53

Abstract

Leuconostoc mesenteriodes is an important probiotic bacteria with impact characteristics and benefits for human health. Last year, probiotic bacteria were used as an alternative to traditional antibiotics in treat of different diseases especially in the broad distribution of MDR bacteria. L. mesenteriodes isolate was purchased from (Al-Amin Center for Research and Biotechnology\ Najaf, Iraq) and re-diagnosis using MRS media in anaerobic condition then diagnosis by vitek 2 system. The antibacterial activity of L. mesenteriodes was assessed using the agar well diffusion method against MDR pathogenic bacteria isolated from different clinical cases. The L. mesenteriodes crude was obtained by centrifuging the bacterial isolates. Five different concentrations of probiotic bacteria crude were tested against MDR pathogenic bacteria revealing the antibacterial activity of L. mesenteriodes crude concentrations (stock, 90%, 75%, 50% and 25% ) against MDR Staphylococcus aureus (22, 20, 20, 17, 14 mm), MDR Micrococcu. leuts (24, 23, 18, 16, 11 mm), MDR Proteus. mirabillis (22, 22, 18, 17, 14 mm), MDR Escherichia. coli (22, 20, 18, 12, 11 mm) and MDR Klebsiella pneumoniae were (20, 18, 14, 12, 11mm) an respectively. L. mesenteriodes probiotics improve antibacterial activity especially when used against multi-drug resistant bacteria Highlights: mesenteroides shows antibacterial potential against MDR pathogens. Tested using agar well diffusion with five crude concentrations. Effective against MDR bacteria strains including S. aureus, E. coli, and K. pneumoniae. Keywords: probiotic, L. mesenteriodes, MDR, Crud extract, pathogenic bacteria.
Comparative Study of Serum Electrolytes in Diabetic and Non-Diabetic People of Different Age and Gender from Basrah Province, Iraq: Studi Perbandingan Elektrolit Serum pada Penderita Diabetes dan Non-Diabetes dengan Usia dan Jenis Kelamin yang Berbeda dari Provinsi Basrah, Irak Hassan, Saged S.; Salman, Nader A.; Hussein, Shahla A.
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.55

Abstract

The present study aimed at investigating differences in the levels of the most important blood electrolytes in diabetic patients of different age and gender and compare it with levels recorded in normal control group from Basrah Province. The theoretical hypothesis of the research relay on the possible impact of hyperglycemia caused by this disease on the osmotic status and electrolyte distribution between extra- and intracellular fluids. Blood samples were collected from 50 diabetic patients ranging in age from 27 to 62 years and are registered in the Diabetes Department of Al-Faiha’a Educational Hospital in Basrah and compared with 50 control group of nearly same ages. The sample include both males and females. Results of the present investigation revealed significant differences in electrolyte levels between diabetic and non-diabetic groups. Both Na+ and Cl- showed a significant decrease in diabetes patients suggesting the occurrence of hyponatrmia and hypochloromia cases respectively. On contrary K+ ion showed a significant elevation in diabetes patients compared with control which reflects hyperkalemia cases. No significant changes were noticed in the case of serum Ca++ and phosphorus. Results were discussed in view of the findings of other studies on the osmotic status of diabetic patients Highlights: Analyzed electrolyte differences in diabetic vs. non-diabetic individuals. Compared Na+, Cl-, K+, Ca++, and phosphorus levels in 100 participants. Significant hyponatremia, hypochloremia, and hyperkalemia found in diabetic patients. Keywords: Serum Electrolytes, Diabetes, Age, Gender , Basrah.

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