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Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions
Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK covers the disciplines of medicine, pharmacy, and health with several types of articles, namely: 1. Research 2. Literature review 3. Case report 4. Evidence-based case report (EBCR), systematic review 5. Other scientific articles Based on the SK Kemendikbudristek Nomor 152/E/KPT/2023, CDK has obtained Rank 4 (SINTA 4) for Scientific Journals.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,288 Documents
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Infeksi TORCH Maternal dan Kongenital Brigitta Supit
Cermin Dunia Kedokteran Vol 48 No 9 (2021): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.133

Abstract

Infeksi perinatal secara kolektif disebut infeksi TORCH untuk toksoplasma, rubella, cytomegalovirus, HSV, dan organisme lainnya seperti HIV, parvovirus B19, enterovirus, EBV, VZV, virus hepatitis B, virus hepatitis C, campak, adenovirus, virus Zika, dan Treponema pallidum. Infeksi dapat asimptomatis atau menyebabkan gejala minor pada ibu; namun merupakan penyebab mortalitas fetal dan neonatal yang signifikan dan merupakan kontributor penting untuk morbiditas pada anak-anak. Diagnosis infeksi perinatal berpusat pada dua hal, yaitu identifikasi infeksi maternal akut (terutama infeksi primer) dan verifikasi keterlibatan fetus atau neonatus. Perinatal infections are collectively named TORCH infections, for toxoplasma, rubella, cytomegalovirus, HSV, and other organisms such as HIV, parvovirus B19, enteroviruses, EBV, VZV, hepatitis B virus, hepatitis C virus, measles, adenovirus, and Treponema pallidum. Those infections may be silent or cause only minor symptoms in the mother; however, are significant causesof fetal and neonatalmortality and important contributors to childhood morbidity. Diagnosis of perinatal infection centerson two issues, which are identification of acute maternal infection (particularly primary infection) and verification of fetus or newborn involvement.
Aspek Imunitas pada COVID-19 Nugroho Nitiyoso
Cermin Dunia Kedokteran Vol 48 No 9 (2021): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.134

Abstract

Gejala COVID-19 sangat bervariasi dari ringan hingga berat. Selain faktor komorbiditas, reaksi imun yang berbeda-beda antar pasien juga menjadi faktor yang memengaruhi berat-ringannya gejala COVID-19. Kenaikan kadar sitokin diduga menjadi faktor yang memperberat gejala COVID-19. Dalam artikel ini, akan dibahas aspek respons imun serta sitokin yang memengaruhi gejala COVID-19, serta beberapa pengobatan imunologi yang sedang diteliti untuk COVID-19. Symptoms in COVID-19 patients vary widely from mild to severe. In addition to comorbidities, different immune reactions among patients are also a factor that affects the severity of COVID-19 symptoms. The increase in cytokine levels is thought to be a factor that aggravates the symptoms of COVID-19. In this article, we will discuss aspects of the immune response and cytokines that affect the symptoms of COVID-19, as well as some of the immunological treatments currently being studied for COVID-19.
Microneedling dengan Platelet-rich Plasma (PRP) untuk Skar Akne Atrofi Restu Nur Rohmah
Cermin Dunia Kedokteran Vol 48 No 9 (2021): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.135

Abstract

Skar atrofi merupakan komplikasi umum akne dan sangat memengaruhi kualitas hidup pasien. Microneedling dengan PRP untuk memperbaiki skar akne atrofi tergolong sederhana, aman, dan efektif. Teknik ini menggunakan jarum mikro untuk menusuk kulit secara superfisial dan menghancurkan kolagen rusak di lapisan atas dermis, mengaktivasi kaskade penyembuhan luka secara normal yang menstimulasi pembentukan kolagen baru sehingga memperbaiki tampilan skar. Artikel ini memaparkan microneedling dengan PRP sebagai modalitas terapi untuk skar akne atrofi. Atrophic scars are common acne complication and affect patients’ quality of life. Microneedling with PRP is considered simple, safe, and effective for atrophic scars. The technique uses microneedles to puncture skin superficially and break damaged collagen in the superficial layer of dermis, resulting in activation of normal wound healing cascade which stimulates new collagen formation, thus improving scar appearance. This article describes microneedling with PRP as a treatment modality for atrophic acne scars.
Tatalaksana Dislipidemia Terkait Penyakit Kardiovaskular Aterosklerosis (ASCVD): Fokus pada Penurunan LDL-c Karina Puspaseruni
Cermin Dunia Kedokteran Vol 48 No 10 (2021): Continuing Medical Education - Edisi 4
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i10.136

Abstract

Dislipidemia mengacu pada peningkatan kadar lipid darah dan merupakan prekursor utama penyakit terkait lipid seperti aterosklerosis, penyakit arteri koroner, dan terlibat dalam sindrom kematian mendadak. Penyakit Kardiovaskular Aterosklerosis (ASCVD- atherosclerotic cardiovascular disease) dan manifestasi klinisnya seperti infark miokard dan stroke iskemik merupakan penyebab utama morbiditas dan mortalitas di dunia. Dislipidemia dapat dikendalikan secara farmakologis dan paling penting melalui perubahan gaya hidup terutama diet. Penurunan kadar kolesterol lipoprotein densitas rendah (LDL-c) menghasilkan penurunan risiko ASCVD. Dyslipidemia is a medical condition characterized by elevation of any or all blood lipid components; dyslipidemia is the major precursor of lipidrelated ailment such as atheros clerosis, coronary artery disease, and also involved in sudden death syndrome. Atherosclerotic cardiovascular disease (ASCVD) and its clinical manifestations,such as myocardial infarction and ischaemic stroke, are the leading cause of morbidity and mortality throughout the world. Dyslipidemia can be controlled pharmacologically and most importantly change in lifestyle especially diet. Reduced low-density lipoprotein cholesterol (LDL-c) resulted in subsequent risk reduction.
Manifestasi Kulit Terkait Defisiensi Nutrisi pada Anak Putti Fatiharani Dewi; Ambar Aliwardani; Fiska Rosita; Suci Widhiati
Cermin Dunia Kedokteran Vol 48 No 10 (2021): Continuing Medical Education - Edisi 4
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i10.137

Abstract

Manifestasi kulit dapat menjadi gejala dan tanda awal defisiensi nutrisi pada anak. Defisiensi nutrisi tersebut antara lain malnutrisi protein energi, defisiensi asam lemak esensial, defisiensi vitamin A, pellagra, defisiensi kobalamin, scurvy, dan defisiensi zink. Beberapa malnutrisi dapat memberikan gejala kulit cukup khas dan terkadang tumpang tindih. Gejala kulit awal pada defisiensi nutrisi anak dapat didiagnosis dini, sehingga dapat segera diberi tatalaksana suplementasi yang tepat untuk mencegah komplikasi yang lebih berat. Skin manifestations can be an early symptom and sign of nutritional deficiency in children. Such nutritional deficiencies include energy protein malnutrition, essential fatty acid deficiency, vitamin A deficiency, pellagra, cobalamin deficiency, scurvy, and zinc deficiency. Some malnutritions can provide quite typical and sometimes overlapping skin symptoms. Early skin symptoms in a child’s nutritional deficiency can be diagnosed early and immediately given appropriate supplementation procedures to prevent more severe complications.
Suplemen Putih Telur dalam Tatalaksana Hipoalbuminemia Dedyanto Henky Saputra
Cermin Dunia Kedokteran Vol 48 No 10 (2021): Continuing Medical Education - Edisi 4
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i10.138

Abstract

Putih telur merupakan sumber protein dengan kualitas asam amino yang baik. Selain mengandung asam amino esensial, Digestible Indispensable Amino Acid Score dari putih telur juga tinggi. Berbagai penelitian (banyak dilakukan di Indonesia) menunjukkan bahwa suplemen putih telur bermanfaat memperbaiki kondisi hipoalbuminemia pasien rawat inap, hemodialisis, pasien TB paru, pre-eklamsia, dan luka bakar. Egg-whites are a source of protein with good quality amino acids. Apart from containing essential amino acids, the Digestible Indispensable Amino Acid Score of egg whites is also high. Various studies (mostly conducted in Indonesia) have shown egg white supplements benefits in improving hypoalbuminemia in hospitalization, hemodialysis, pulmonary tuberculosis, pre-eclampsia, and burns.
Peran Vitamin D pada Fungsi Sawar Permeabilitas Kulit Nita Damayanti
Cermin Dunia Kedokteran Vol 48 No 10 (2021): Continuing Medical Education - Edisi 4
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i10.139

Abstract

Salah satu fungsi utama kulit adalah membentuk sawar antara tubuh dan lingkungan eksternal. Fungsi sawar permeabilitas kulit salah satunya dipertahankan dengan proses diferensiasi dan proliferasi keratinosit pada lapisan epidermis. Efek vitamin D pada kulit termasuk memengaruhi proliferasi, diferensiasi, dan apoptosis keratinosit. Defisiensi serta kelainan aktivasi dan metabolisme vitamin D menyebabkan defek fungsi sawar permeabilitas kulit. Makalah ini membahas epidermis sebagai sawar permeabilitas kulit dan peran vitamin D pada sawar permeabilitas kulit. One of the skin’s main functions is to form a protective barrier towards external environment. The protective function is maintained by differentiation and proliferation of keratinocytes in the epidermal layer. Vitamin D effects on the skin include proliferation, differentiation, and apoptosis of keratinocyte. Deficiency and abnormalities of vitamin D activation and metabolism impair skin’s function as permeability barrier. This paper discusses the epidermis as permeability barrier and the role of vitamin D in the skin permeability barrier.
Pengembangan Aplikasi Seluler Kesehatan Terkait Diabetes Melitus Johan Indra Lukito
Cermin Dunia Kedokteran Vol 48 No 10 (2021): Continuing Medical Education - Edisi 4
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i10.140

Abstract

Peningkatan kualitas hidup pasien diabetes melitus (DM) membutuhkan pengelolaan komprehensif. Beberapa tantangan dihadapi baik oleh pasien maupun profesional kesehatan dalam tatalaksana DM. Penggunaan dan pengembangan aplikasi seluler kesehatan berbasis telemedicine dan teknologi informasi kesehatan diharapkan dapat membantu mengatasi tantangan ini. Improving the quality of life of patients with diabetes mellitus (DM) requires comprehensive management. Several challenges are faced by both patients and health professionals in the management of DM. It is hoped that the use and development of mobile health applications based on telemedicine and health information technology can help overcome this challenge.Johan Indra Lukito. Development of Diabetes Mellitus Mobile Health Applications.
Cancer Stem Cells Dito Anurogo
Cermin Dunia Kedokteran Vol 48 No 11 (2021): Penyakit Dalam - COVID-19
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i11.141

Abstract

This mini-review will discuss Cancer Stem Cells (CSCs) on their definition, history, characteristics, models, origin, tumorigenesis, targeting Cancer Stem Cells with nanomaterials, niche interactions, CSCs therapeutics, vaccination, the role of autophagy in CSCs, artificial intelligence, and clinical trials targeting CSCs. Mini review ini membahas sel punca kanker (Cancer Stem Cells), meliputi: definisi, sejarah, karakteristik, model, asal-mula, tumorigenesis, menarget CSCs dengan nanomaterial, interaksi niche, terapeutik berbasis CSCs, vaksinasi, peran autofagi pada CSCs, kecerdasan buatan, dan uji klinik menarget CSCs.
Konjungtivitis pada COVID-19 Airina Stefanie; Stefanny Haryady; Yufilia Suci Amelia
Cermin Dunia Kedokteran Vol 48 No 11 (2021): Penyakit Dalam - COVID-19
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i11.142

Abstract

Corona Virus Disease 19 (COVID-19) pertama ditemukan di Wuhan, Cina, pada Desember 2019 dan telah menjadi ancaman kesehatan global. COVID-19 disebabkan oleh Severe Acute Respiratory Corona Virus 2 (SARS-CoV-2), ditransmisikan melalui droplet pernapasan atau kontak erat. Penelitian terbaru menyatakan bahwa konjungtiva dapat menjadi port d’entree SARS-CoV-2, dan menyebabkan gejala konjungtivitis. Jalur transmisi SARS-CoV 2 ke okuler diduga melalui inokulasi langsung dan melalui reseptor ACE2 yang diekspresikan di konjungtiva. Karakteristik konjungtivitis COVID-19 adalah sekret mukoid ataupun aqueous berlebih, sensasi tidak nyaman pada okuler seperti gatal, benda asing, atau rasa terbakar, serta hiperemis konjungtiva. Pada pemeriksaan RT PCR swab okuler ataupun nasofaring dapat positif pada 3 hingga 21 hari setelah onset gejala. Studi ini merupakan literature review. Artikel diambil dari database Google scholar, Pubmed, Lange, Elsevier, dengan kata kunci “ocular manifestation in COVID-19”, “characteristics of conjunctivitis in COVID-19”, “mechanism of COVID-19 in conjunctiva”. Artikel yang dipilih adalah jurnal yang dipublikasi sejak tanggal 1 Desember 2019 sampai 30 Oktober 2020. Corona Virus Disease 19 (COVID-19) was first discovered in Wuhan, China, in 2019 and has been declared as global health emergency. COVID-19 is caused by Severe Acute Respiratory Corona Virus 2 (SARS-CoV 2) transmitted through droplet and physical contact. Studies stated that conjunctiva is a potential port of entry of SARS-CoV2, which then leads to conjunctivitis. This literature review is based on analytic study on conjunctivitis in COVID-19. The transmission route is thought from direct inoculation and expression of ACE2 receptors from conjunctiva. Most common characteristics of conjunctivitis in COVID-19 are increased conjunctival secretions both mucoid and aqueous, and ocular discomfort such as itching, foreign bodies sensations, burning, and conjunctival hyperemia. RT PCR from both ocular and nasopharyngeal swabs were detectable from days 3 to 21 after the onset of symptoms. This study is a review on published articles from December 1st 2019 to October 30th 2020, in Google Scholar, PubMed, Lange, and Elsevier; selected with keywords “ocular manifestation in COVID-19”, “characteristics of conjunctivitis in COVID-19”, “mechanism of COVID-19 in conjunctiva”.

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