Genbinesia Journal of Biology
The Genbinesia Journal of Biology particularly focuses on the core disciplines in biology, they are: astrobiology, bacteriology, behavioural science, biochemistry, biodiversity, bioethics, bioinformatics, biomathematics, biophysics, biopolymers, biostatistics, biotechnology, botany, cell biology, conservation, crystallography of macromolecules, developmental biology, ecology, entomology, evolutionary biology, genetics, genomics, glycobiology, immunology, macromolecules, marine & aquatic biology, mathematical & computational biology, medicine, microbiology, molecular biology, mycology, nanoscience & nanotechnology, neurobiology, neuroscience, ornithology, paleobiology, paleontology, parasitology, pharmacology, physiology, plant biology, proteins & peptides, proteomics, radiation biology, reproductive biology, soil biology, structural biology, systems biology, techniques in biology, theoretical & mathematical biology, virology, zoology, and interdisciplinary applications in biology.
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<![CDATA[In silico study of secondary metabolites of Borneo endemic plant Shorea brunnescens as an anti-cancer drug candidate ]]>
<![CDATA[Andifa Anugerah Putra]]>;
<![CDATA[Huwaida, Nisriana Najla]]>;
<![CDATA[Takarini, Rinta Dwi]]>;
<![CDATA[Nur’ain, Rizka]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v2i2.31
<![CDATA[Borneo Island is one of the greenest islands in the world has thousands of endemic plants. Unfortunately, many of these plants are in endangered status. One of the endemic endangered plants from Borneo is Shorea brunnescens or locally named Selangan Batu Tinteng. Based on research, the bark of Shorea brunnescens contains the compound e-viniferin, which is recorded in the literature as an anti-cancer compound, especially breast cancer. The anti-cancer potential of Shorea brunnescens could be a driving force for conservation and protection of the plant, which has never been done before. Therefore, further research is needed regarding the effectiveness and capacity of Shorea brunnescens as an anti-cancer medicinal material. This study aims to examine the potential success rate of the anti-cancer properties of Shorea brunnescens through molecular docking of the compound e-viniferin against the proteotype of the main enzyme of breast cancer cells, Cytochrome P450. The method used was in silico modeling using PyRx and Discovery Studio software. First, screening of analog compounds through PubChem database (http://pubchem.ncbi.nlm.nih.gov/) based on Lipinski's rule, and obtained the three best analogs which will then be used as comparison ligands for docking simulation with Cytochrome P450 (CYP) receptors. The results obtained were that e-viniferin in Shorea brunnescens as the test ligand had the smallest affinity compared to the comparison ligand, which was -9.2 kcal/mol. It was concluded that Shorea brunnescens is able to inhibit cancer cells very well, so it has the potential to be developed as an anti-cancer drug candidate.]]>
<![CDATA[A novel antiviral candidate from Moringa oleifera through dual targeting mechanism of SARS-CoV-2 protease: Computational Sscreening ]]>
<![CDATA[Listiyani, Priscilla]]>;
<![CDATA[Dhea Kharisma, Viol]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v2i2.32
<![CDATA[COVID-19 is triggered by SARS-CoV-2 which is related in a similar way to SARS-CoV and MERS-CoV. RdRp is an essential component of the virus in replication and transcription. RdRp triggers polymerase activity through binding to cofactors such as nsp7 and nsp8. Mpro plays an important role in viral protease activity for the assembly process. RdRp and Mpro can be used as targets to inhibit the replicative activity of SARS-CoV-2. Moringa oleifera is used by people around the world as a traditional medicine because it has antioxidant, anti-inflammatory, and antiviral properties. This study reveals the molecular mechanism of Moringa oleifera as an inhibitor of key proteins in SARS-CoV-2 replication through a computational approach. Additionally, the in silico method in this study consists of sample preparation in the database, druglikeness prediction, antiviral probability, virtual screening, chemical bond interaction, and 3D visualization. Moringa oleifera may have potential as an antiviral candidate through Ellagic Acid activity as a dual inhibitor through inhibition of SARS-CoV-2 replication and assembly. The candidate compound can generate weak bonding interactions such as hydrogen and hydrophobic to trigger binding stability at specific domains.]]>
<![CDATA[Study of population dynamics silver rasbora (Rasbora argyrotaenia Bleeker, 1849) in PB Soedirman Reservoir, Banjarnegara ]]>
<![CDATA[Anggararatri, Yasinta]]>;
<![CDATA[Muslih]]>;
<![CDATA[Rukayah, Siti]]>;
<![CDATA[Lestari, W.]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v2i2.33
<![CDATA[Silver rasbora (Rasbora argyrotaenia Bleeker, 1849) is one of the native species found in Panglima Besar (PB.) Soedirman Reservoir. High economic value of silver rasbora causes fishermen to tend overfishing. This over-exploitation threatens the native species of fish. Therefore, this study aims to determine several parameters of fish population dynamics so that they become the basis for fisheries management. Sampling was carried out at the PB. Soedirman Reservoir in November 2021, January 2022, and March 2022 using a survey method. The result of this research is, the population of silver rasbora was 3097 individuals dominated by male and small-size fish 0.5-8.5 cm. Length and weight relationship obtained b value <3 which means it is negative allometric. The condition factor ranged from 1.005 to 1.068. Total mortality value (Z) 6.21 per year, natural mortality (M) 1.69 per year, fishing mortality (F) 4.52 per year, with exploitation rate (E) 0.73 per year. The total length of silver rasbora fish obtained ranged from 0.5 to 8.5 cm. The maximum length (L∞) = 12.93 cm and K = 0.62 per year with the Von Bertalanffy growth equation, Lt = 12.93 (1-e(-0.62(t-0.3291))). The yield value per recruit analysis showed that the optimum exploitation was 0.224 and the current exploitation rate was 0.73. The population of silver rasbora was over-exploitation, especially in small-size fish.]]>
<![CDATA[Effect of kecombrang flower extract (Etlingera elatior) and basil leave extract (Ocimum afrinacum) to the growth of Streptococcus mutans ATCC 35668 and Staphylococcus aureus ATCC 33591 ]]>
<![CDATA[Tanahboleng, Katharina Devi Permata]]>;
<![CDATA[Masruhim, Muh. Amir]]>;
<![CDATA[Daru, Taufan Purwokusumaning]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v2i2.34
<![CDATA[Utilization of local plants is still not optimal. Experimental research has been carried out in Samarinda City by utilizing Kecombrang Flower (Etlingera elatior) and Basil Leaf (Ocimum afrinacum) extracts which were exposed to Streptococcus mutans ATCC 35668 and Staphylococcus aureus ATCC 33591. The aim of the study was to determine the effect of kecombrang flower extract (Etlingera elatior) , basil leaf extract (Ocimum afrinacum) on the growth of Streptococcus mutans ATCC 35668, and staphylococcus aures ATCC 33591. The research samples were kecombrang flowers ((Etlingera elatior) and basil leaves (Ocimum afrinacum). The research instrument was a measuring tool (ruler). Results Data analysis showed that kecombrang flower extract (Etlingera elatior), basil leaf extract (Ocimum afrinacum) significantly affected the growth of Streptococcus mutans and Staphylococcus aureus ATCC 33591 (p˂0.00).Active chemicals (secondary metabolites, namely tannins present in kecombrang flower extract and extract Basil leaves (Ocimum afrinacum) can inhibit or kill the growth of Streptococcus mutans ATCC 35668 and Staphylococcus aureus. The conclusion is kecombrang flower extract (Etlingera elatior) and basil leaf extract (Ocimum afrinacum) have a significant effect on the growth of Streptococcus mutans ATCC 35668 and Staphylococcus aureus ATCC 33591.]]>
<![CDATA[Health Impacts of Yoga: A Brief Review ]]>
<![CDATA[Ansori, Arif Nur Muhammad]]>
<![CDATA[ Genbinesia Journal of Biology Vol. 2 No. 2 (2023): March 2023 ]]>
Publisher : <![CDATA[Generasi Biologi Indonesia ]]>
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DOI: 10.55655/genbinesia.v2i2.36
<![CDATA[Yoga is a holistic practice that has been used for thousands of years to promote health and well-being. The physical postures, breath control, and meditation techniques used in yoga have been found to have numerous health benefits, including improving flexibility, strength, balance, and cardiovascular health, reducing stress and anxiety, and improving mental clarity and focus. Recent research has shown that yoga can also be an effective complementary therapy for a variety of health conditions, such as chronic pain, depression, anxiety, and insomnia. Yoga has been found to be particularly effective in reducing stress and anxiety, which are common risk factors for many chronic diseases. Yoga is a non-competitive practice that can be adapted to suit the needs and abilities of individuals of all ages and fitness levels. It is a safe and effective way to improve overall health and well-being, and can be easily integrated into a daily routine. Therefore, yoga is a valuable tool for promoting health and well-being on all levels - physical, mental, emotional, and spiritual. It has become increasingly popular around the world, and is now widely recognized as a valuable complementary therapy for a variety of health conditions.]]>
