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All Journal VALENSI Jurnal Penelitian Pendidikan Jurnal Pendidikan Ekonomi & Bisnis DIJB (Diponegoro International Journal of Business) Jurnal Medik Veteriner Journal of Applied Veterinary Science and Technology Makara Journal of Science Borneo Journal of Pharmacy Biosaintifika: Journal of Biology & Biology Education Svāsthya: Trends in General Medicine and Public Health Genbinesia Journal of Biology Journal of Strategic Innovation and Business Management

Adi Sofyan Ansori, Muhammad

Unknown Affiliation

Author-ID : 795288

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

Published : 19 Documents Claim Missing Document

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Profesionalisme Guru Akuntansi Pasca Sertifikasi Muhammad Ansori; Sandy Arief; S Sukirno
Jurnal Pendidikan Ekonomi Dan Bisnis (JPEB) Vol 5 No 1 (2017): Jurnal Pendidikan Ekonomi & Bisnis (DOAJ Indexed)
Publisher : Faculty of Economics, State University of Jakarta.

This study will be discussed related to the professionalism of teachers after certification, the efforts made to develop the professionalism of teachers, and the impact of certification policy on the quality of education. This research subject is accounting certified teacher with a population of 7 informants, and informants are the principal supporter and 3 learners. This research method is a descriptive qualitative approach, with this type of case studies. Collecting data using the model interviews, observation, and documentation. Data analysis techniques to 1) Data collection 2) reduction of data 3) data presentation 4) conclusion / verification. The results showed that 1) accounting certified teachers have a good level of professionalism. The teacher can understand the characteristics of students, mastering both subject areas of a scientific or educational field, is able to organize teaching well, mastering the material in depth, mastering the technology and professionalism are able to develop in a sustainable manner. 2) the efforts of teachers to develop professionalism is with workshops, seminars, training, training, writing books, looking for a new regulation, to follow the teacher association continues studies to improve the qualifications and buy gadgets as supporting tools in learning. 3) certification of a positive impact on the quality of education. It is suggested that could be given to teachers, namely that the purpose of the certification is not to get professional allowance alone, but that teachers can master the competence of teachers well and make teachers more professional in carrying out his profession. Professional allowances simply as a consequence of this capability.

The effect of perceived organizational support and psychological capital on OCB: mediating role of engagement Muhammad Ali Ansori; Nury Ariani Wulansari
Diponegoro International Journal of Business Vol 4, No 2 (2021)
Publisher : Department of Management | Faculty of Economics and Business | Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dijb.4.2.2021.69-81

This paper aims to investigate the effect of psychological capital (PsyCap) as an intrinsic factor and perceived organizational support (POS) as an extrinsic factor on OCB and to verify the mediating role of work engagement (WE) in the relationship of PsyCap, POS and OCB. The population in this study are state university lecturers especially at Universitas Negeri Semarang. Using proportionate random sampling technique, the data was collected from 145 lecturers. The structural equation model-partial least square (SEM-PLS) was used to test the hypotheses with analysis tools in the form of SmartPLS 3.0. The result showed that PsyCap had a positive and significant effect on work engagement and OCB, then POS had an insignificant effect on OCB and work engagement. The result found that work engagement has a mediation effect in the relationship between PsyCap and OCB. This study also showed that PsyCap as an intrinsic factor is considered more capable than POS as an extrinsic factor to improve lecturer’s OCB. It is highly recommended for the organization to focus on lecturer’s psychological capital investment, because lecturer’s PsyCap will be directly affect to lecturer’s positive behaviour such as work engagement and OCB.

MODEL PENDIDIKAN KESEJAHTERAAN KELUARGA BAGI KELUARGA MISKIN DI PEDESAAN Asih Kuswardinah; Muhammad Ansori; Rosidah Rosidah
Jurnal Penelitian Pendidikan Vol 31, No 2 (2014): October 2014
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jpp.v31i2.5691

Development model of study aimed to describe: level of identifying the meaning of welfare family; determinant of welfare family; needs analysis for poor family through FGD. The result of FGD then would be the foundation of planning the textbook and education model for poor family in village area. The subject of this study was 61 poor families in Wonosobo by the particular consideration of local government.The result of the study showed that the level of understanding the family welfare for poor family was Good with the percentage of 18.4%; Average of 52.0%; Fair of 20.9%; Poor of 8.7%. The determinants of family welfare based on the highest mean score for each indicator were: Praying (mean=3.48); Children Education (mean=3.30); Husband-wife communication (mean=3.16); The major determinant was prayer. On the other hand, the textbook material refer to the result of FGD such as: the identification of education and family welfare; interrelationship in the family; parent’s role in educating the children; family financial control; safety and health plan. From the result of the study, it is suggested that Local Government provide both formal and informal education facilities for poor family; Increase the quantity of teaching learning process and workshop especially for creative food processing to poor family. For poor family in village area, it is suggested that they have to improve their knowledge about family welfare.

In Silico Analysis of C-Type Lectins as Co-Infection Receptors of Dengue and Chikungunya Viruses in Aedes aegypti Sazali, Munawir; Soesilohadi, R. C. Hidayat; Wijayanti, Nastiti; Wibawa, Tri; Ansori, Arif Nur Muhammad
Makara Journal of Science Vol. 28, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Aedes aegypti is a primer vector of dengue virus (DENV) and chikungunya virus (CHIKV). The susceptibility of mosquitoes to DENV and CHIKV depends on their recognition receptor of pathogens. C-type lectins (CTLs) are an important mediator of virus infection in A. aegypti. This study aims to identify potential receptors and determine the binding affinity between ligand–receptor interaction, CTLs and virus envelopes (DENV-1, 2, 3, and 4 and CHIKV) interaction based on in silico analysis. Sample sequences were obtained from GenBank (NCBI), and 10 CTLs were acquired from VectorBase. Homology modeling based on a minimum standard of 20% was processed using the SWISS-MODEL server. Molecule interaction was visualized as tertiary protein structure in PyMol V1.7.4. Homology modeling revealed all 3D protein model scores to be at 20%. The highest homology modeling score of 98.72% is obtained for CHIKV envelope protein (KF925315.1). The CTL GenBank ID: AAEL014382-PA has the lowest score at −1407.20 kcal/mol. The predicted mechanism of DENV-1, 2, 3, and 4 co-infections with CHIKV-1 is through the binding of the viral envelope to the CTL. Interaction analysis showed that the viruses enter through an endocytic mechanism. The results of homology modeling and lowest interaction energy could serve as the basis for in vivo studies on virus co-infection in A. aegypti. This information illustrates that CTL receptors facilitate DENV and CHIKV co-infection in A. aegypti.

In Silico Study of Cladosporol and Its Acyl Derivatives as Anti-Breast Cancer Against Alpha-Estrogen Receptor Herdiansyah, Mochammad Aqilah; Ansori, Arif Nur Muhammad; Kharisma, Viol Dhea; Alifiansyah, Mochamad Radika Tory; Anggraini, Dhea; Priyono, Qiara Amelia Putri; Yusniasari, Putri Antika; Fetty, Amelia Julia Tria; Zainul, Rahadian; Rebezov, Maksim; Kolesnik, Evgeniy; Maksimiuk, Nikolai
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 1 (2024): April 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i1.949

Breast cancer is a chronic health problem that causes 690,000 deaths worldwide. The development of secondary metabolite compounds from natural preparations through an in silico approach is needed as a predictive tool to prevent breast cancer, one of them is cladosporol from Cladosporium spp. This study aims to utilize an in silico approach to predict the potential of cladosporol against alpha-estrogen receptors. The alpha-estrogen receptor with code 6CBZ was selected based on group function as pharmacophore in ligand-receptor interaction. The methods used in this study are by using an in silico approach with Molegro Virtual Docker (MVD) Ver 5.5 for the docking process and CABS-flex 2.0 for identifying the stability of the complexes. ADMET properties analysis was also performed to know the pharmacokinetics attributes of cladosporol. Based on research conducted, stated that cladosporol octanoate has the lowest rerank score with a -84.3593 value and the RMSD value is 1.195 Å so it’s valid for molecular docking. Exploration of cladosporol for anti-breast cancer from Cladosporium spp fungi can be a novelty for the development of future pharmaceutical research. Thus, the development of anti-cancer drugs for early prevention can be carried out to reduce the number of breast cancer cases worldwide.

Morphometric and Molecular Identification of Eimeria Bovis and Eimeria Zuernii on Beef Cattle in Lamongan, East Java, Indonesia Kurniawan, Muhammad 'Ahdi; Suwanti, Lucia Tri; Mufasirin, Mufasirin; Suprihati, Endang; Hastutiek, Poedji; Kusnoto, Kusnoto; Ansori, Arif Nur Muhammad; Puspitasari, Yulianna; Khairullah, Aswin Rafif; Moses, Ikechukwu Benjamin; Pratama, Bima Putra; Riwu, Katty Hendriana Priscilia
Jurnal Medik Veteriner Vol. 8 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss1.2025.153-166

Lamongan Regency, located in East Java, Indonesia, is a significant center for beef cattle production. Despite its prominence, studies on the identification and differentiation of Eimeria spp. parasites in this region are notably lacking. This research aims to address this gap by evaluating the prevalence of Eimeria spp. and identifying two pathogenic species: Eimeria bovis and Eimeria zuernii. The study involved the collection of 250 fecal samples from beef cattle raised on smallholder farms across Lamongan. Sampling was conducted during the rainy season to optimize the detection of Eimeria infections. Using the sugar flotation method, Eimeria oocysts were isolated from 5–10 g of fecal matter per sample. Molecular identification employed polymerase chain reaction (PCR) assays targeting ribosomal RNA’s internal transcribed spacer 1 (ITS-1) region to detect the pathogenic species. Fecal examination using the Whitlock test revealed a prevalence of Eimeria spp. at 44.45% (111/250). PCR analysis further identified E. bovis with a 238 bp amplicon in Solokuro District and E. zuernii with a 344 bp amplicon in Tikung District, highlighting the presence of these two pathogenic species in distinct geographic areas. The findings underline the need for further research that includes expanded sampling from different regions and cattle breeds and the application of varied diagnostic methods. Such studies will contribute to a more comprehensive understanding of the genetic diversity, distribution, and epidemiology of E. bovis and E. zuernii in Indonesia, supporting improved cattle health and management practices in the region.

Human metapneumovirus (HMPV): A brief overview Ansori, Arif Nur Muhammad
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 3 (2025): May 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i3.89

Human metapneumovirus (HMPV), discovered in 2001, is a significant respiratory pathogen in the Paramyxoviridae family that is responsible for substantial global morbidity and mortality. Despite its clinical impact, HMPV remains underdiagnosed and lacks specific treatments and vaccines. This perspective aims to provide a comprehensive analysis of HMPV as an emerging respiratory pathogen, examining its virological characteristics, epidemiology, clinical manifestations, pathogenesis, diagnostic methods, and management approaches. This review synthesizes the current literature on HMPV, examining its virological characteristics, epidemiology, clinical manifestations, pathogenesis, and management approaches through an analysis of peer-reviewed publications from 2001-2025. HMPV accounts for 5–10% of pediatric respiratory hospitalizations globally, with an estimated 14.2 million lower respiratory tract infections in children under five annually, resulting in 643,000 hospital admissions and 16,100 in-hospital deaths annually. The virus predominantly affects children, elderly individuals, and immunocompromised patients, who present with symptoms ranging from mild upper respiratory infections to severe pneumonia. Diagnostic advances, particularly in molecular techniques, have improved detection capabilities. Current management relies primarily on supportive care, whereas therapeutic research focuses on antiviral agents, monoclonal antibodies, and vaccine candidates utilizing novel platforms, including nanoparticle and mRNA technologies. Increased global surveillance, accelerated vaccine development, and novel therapeutic approaches are needed to address HMPV. Research priorities include understanding long-term immunity, immune evasion mechanisms, and the environmental influences on transmission. Collaborative efforts among academia, industry, public health institutions, and regulatory bodies are essential to translate scientific discoveries into effective interventions that reduce the public health burden of HMPV.

Molecular Docking Analysis of Flavonoids from Syzygium cumini (L.) Skeels: Proapoptotic Potential as an Anticancer Mechanism Aini, Nur Sofiatul; Ansori, Arif Nur Muhammad; Widyananda, Muhammad Hermawan; Kharisma, Viol Dhea; Murtadlo, Ahmad Affan Ali; Herdiansyah, Mochammad Aqilah; Rebezov, Maksim; Burkov, Pavel; Gudz, Petr; Derkho, Marina; Bezhinar, Tatyana; Maksimiuk, Nikolai; Sazali, Munawir; Purnobasuki, Hery; Rollando, Rollando; Khairullah, Aswin Rafif; Sucipto, Teguh Hari
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.9843

Non-small cell lung cancer (NSCLC) presents a significant global health challenge, with its prevalence and mortality rates rising steadily. In Indonesia, Syzygium cumini (L.) Skeels, known for its flavonoid richness, has a long history in traditional medicine. However, its specific mechanisms of action against cancer, particularly in inducing apoptosis in NSCLC, have not been fully elucidated. This study utilized an in silico approach to evaluate the pro-apoptotic potential of S. cumini flavonoids against NSCLC by targeting key proteins: Bcl-2, Bax, and Caspase-3. We retrieved flavonoid structures from PubChem and protein data from the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB). The drug-likeness of these compounds was assessed using Swiss ADME, adhering to Lipinski's rule of five, while their anti-NSCLC probability was predicted using PASS Online. Molecular docking and screening were performed with PyRx, and the results were visualized using Discovery Studio. Our findings identified epigallocatechin 3-O-gallate and ellagic acid as the most promising anti-NSCLC candidates. Ellagic acid demonstrated the strongest binding affinity to Caspase-3, suggesting a potent pro-apoptotic effect. Epigallocatechin 3-O-gallate, on the other hand, exhibited the lowest binding energy across multiple target proteins, particularly Bcl-2 and Bax, indicating its broad pro-apoptotic potential. These results collectively suggest that flavonoids from S. cumini may hold significant promise as a source of novel anti-NSCLC agents, warranting further in vitro and in vivo investigations.

Vaccine construction for human papilloma virus (HPV) type 16 and 18 Infection using in silico approach to combat cervical cancer Dharmawan, Muhammad Alsyifaa; Ansori, Arif Nur Muhammad; Dian, Farida Aryani; Probojati, Rasyadan Taufiq; Tamam, Muhammad Badrut; Kharisma, Viol Dhea
Genbinesia Journal of Biology Vol. 1 No. 1 (2021): November 2021
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v1i1.3

Human papillomavirus (HPV) is a virus that causes infection on the surface of the skin and has the potential to cause cervical cancer. This viral infection is characterized by the growth of warts on the skin in various areas of the body, such as the arms, legs, mouth, and genital area. Because the virus can endanger health, it is necessary to design an HPV vaccine to overcome this problem. In this study, we performed a study characterization of HPV types 16 and 18 sequences to obtain immunogenic epitopes retrieved from the National Center for Biotechnology Information (NCBI) web server. Then, epitope prediction was performed using the immune epitope database (IEDB) web server and selected to get the best vaccine candidate for HPV types 16 and 18. We recommend 16P1 as an epitope-based peptide vaccine candidate for HPV type 16 and 18P4 for type 18. Both vaccine candidates are antigenic, non-allergenic, and non-toxic. The 16P1 and 18P4 have the lowest global energy values among the other candidates. However, further research is needed to be able to develop the best vaccine (in vitro and in vivo experiments).

Viroinformatics study: polytope mapping of envelope glycoprotein to tackle HIV-2 infection and develop vaccine candidate Kharisma, Viol Dhea; Widyananda, Muhammad Hermawan; Probojati, Rasyadan Taufiq; Ansori, Arif Nur Muhammad; Murtadlo, Ahmad Affan Ali; Tamam, Muhammad Badrut; Wicaksono, Adhityo; Turista, Dora Dayu Rahma
Genbinesia Journal of Biology Vol. 1 No. 1 (2021): November 2021
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v1i1.6

Human Immunodeficiency Virus type 2 (HIV-2) has been identified to exhibit an ability to resist antiretroviral administration and many scientists has predicted increases in the pathogenicity of HIV-2. The development of a vaccine against the type 1 virus (HIV-1) infection has reached the phase 3 clinical trial stage, but currently there is no information on the development of a vaccine against HIV-2. Vaccine development to trigger an increase in the coverage of the expansion of protection can be done through B cell polytope. This study aims to provide an important preliminary for the construction of vaccine candidates by identifying the peptides that make up the B cell polytope in the HIV-2 envelope glycoprotein region. The HIV-2 sequence was obtained from the database. The study followed by 3D modelling, prediction of linear B-cell epitope mapping, antigenicity, allergenicity, peptide properties, and immune simulation was carried out via a webserver. The 3D structure of the peptide was displayed through molecular visualization software. The results showed that the 23-mer peptides E1 'HPRYTGVKNIRDITLTEPGRGSD', F1 'NFIENRKGTQHN' 12-mer, M1 'YLKDQARLNS' 10-mer, N1 'PWVNDSIQPNWNNMTWQQWELQVRD' 25-mer, and O1 'KLQNSWNMGVQTO' can be used as a candidate polytope HIV-2 vaccine because it is recognized by B cells is an antigenic peptide with stable molecule, non-allergenic. The peptides trigger proliferation and activation of B cells to produces a humoral response and work as functionally protective antibody for neutralization of HIV-2. Key words: Acquired Immune Deficiency Syndrome, B-cell, Bioinformatics, Human Immunodeficiency Virus, Retrovirus

Co-Authors Agung Ulan Tirta Sari, Anak Aini, Nur Sofiatul Alifiansyah, Mochamad Radika Tory Amaq Fadholly Anggraini, Dhea Arli Aditya Parikesit Asih Kuswardinah Bezhinar, Tatyana Burkov, Pavel Chandra, Nelson Dasilva, Jasmine Aulia Deky Aji Suseno, Deky Aji Derkho, Marina Dewi Astriany Dharmawan, Muhammad Alsyifaa Dhea Kharisma, Viol Dian, Farida Aryani Dings, Tim Godefridus Antonius Endang Suprihati Fajilago, Ria Santos Fetty, Amelia Julia Tria Fimaputra, Jatu Maranatha Gudz, Petr Herdiansyah, Mochammad Aqilah Hery Purnobasuki Hikam, Agus Mohammad I Gede Widhiantara I Made Gde Sudyadnyana Sandhika Jakhmola, Vikash Joana, Amanda Bernadette Khairullah, Aswin Rafif Kharisma, Viol Dhea Kolesnik, Evgeniy Kurniawan, Muhammad 'Ahdi Kusnoto Kusnoto, Kusnoto Lucia Tri Suwanti, Lucia Tri Maksimiuk, Nikolai Melvia Sundalian Moses, Ikechukwu Benjamin Mufasirin Munawir Sazali Murtadlo, Ahmad Affan Ali Nastiti Wijayanti NI KADEK YUNITA SARI Nurul Jadid Mubarokati Nury Ariani Wulansari Panjaitan, Novaria Sari Dewi Perez, Elizabeth Furio Permatasari , Anak Agung Ayu Putri Poedji Hastutiek Pratama, Bima Putra Priyono, Qiara Amelia Putri Putri, Fadillaisyia Riandani Putu Angga Wiradana R.C. Hidayat Soesilohadi Rahadian Zainul Rasyadan Taufiq Probojati Rebezov, Maksim Riwu, Katty Hendriana Priscilia Rollando, Rollando Rosidah Rosidah Sandy Arief Sukirno Sukirno Tacharina, Martia Rani Tamam, Muhammad Badrut Teguh Hari Sucipto, Teguh Hari Tri Wibawa Turista, Dora Dayu Rahma Ullah, Md. Emdad Umi Baroroh, Umi Waruwu, Ernawati Wicaksono, Adhityo Widyananda, Muhammad Hermawan Yee, Jonie C. Yulianna Puspitasari Yusniasari, Putri Antika

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